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Murcko scaffold

1-Phenyl-4-(piperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine scaffold

28 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
21
Chemicals
28
With full pages
3
Scaffold SMILES

c1ccc(-n2ncc3c(N4CCNCC4)ncnc32)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenyl-4-(piperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine page
Murcko scaffold c1ccc(-n2ncc3c(N4CCNCC4)ncnc32)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 28 of 28 chemicals

1-Phenyl-4-(piperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine chemical structure, C15H16N6, CAS 245449-98-3
1-Phenyl-4-(piperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine
CAS 245449-98-3C15H16N6
4-(4-Ethylpiperazin-1-yl)-1-(m-tolyl)-1H-pyrazolo[3,4-d]pyrimidine chemical structure, C18H22N6, CAS 393846-51-0
4-(4-Ethylpiperazin-1-yl)-1-(m-tolyl)-1H-pyrazolo[3,4-d]pyrimidine
CAS 393846-51-0C18H22N6
1-(4-Chlorophenyl)-4-(4-methylpiperazin-1-yl)pyrazolo[3,4-d]pyrimidine chemical structure, C16H17ClN6, CAS 393845-60-8
1-(4-Chlorophenyl)-4-(4-methylpiperazin-1-yl)pyrazolo[3,4-d]pyrimidine
CAS 393845-60-8C16H17ClN6
1-(4-Methoxyphenyl)-4-(4-methylpiperazino)-1H-pyrazolo[3,4-d]pyrimidine chemical structure, C17H20N6O, CAS 393845-61-9
1-(4-Methoxyphenyl)-4-(4-methylpiperazino)-1H-pyrazolo[3,4-d]pyrimidine
CAS 393845-61-9C17H20N6O
1-(4-Chlorophenyl)-4-(4-ethylpiperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine chemical structure, C17H19ClN6, CAS 393846-48-5
1-(4-Chlorophenyl)-4-(4-ethylpiperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine
CAS 393846-48-5C17H19ClN6
1-(2,4-Dimethylphenyl)-4-(4-ethylpiperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine chemical structure, C19H24N6, CAS 393846-53-2
1-(2,4-Dimethylphenyl)-4-(4-ethylpiperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine
CAS 393846-53-2C19H24N6
Ethyl 4-(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazine-1-carboxylate chemical structure, C18H20N6O2, CAS 393846-37-2
Ethyl 4-(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazine-1-carboxylate
CAS 393846-37-2C18H20N6O2
Ethyl 4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]piperazine-1-carboxylate chemical structure, C18H19ClN6O2, CAS 393846-39-4
Ethyl 4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]piperazine-1-carboxylate
CAS 393846-39-4C18H19ClN6O2
Ethyl 4-[1-(3-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-yl]piperazine-1-carboxylate chemical structure, C19H22N6O2, CAS 393846-43-0
Ethyl 4-[1-(3-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-yl]piperazine-1-carboxylate
CAS 393846-43-0C19H22N6O2
Ethyl 4-(1-(2,4-dimethylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazine-1-carboxylate chemical structure, C20H24N6O2, CAS 393846-45-2
Ethyl 4-(1-(2,4-dimethylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazine-1-carboxylate
CAS 393846-45-2C20H24N6O2
2-(4-(1-(3,4-Dichlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl)ethanol chemical structure, C17H18Cl2N6O, CAS 872621-67-5
2-(4-(1-(3,4-Dichlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl)ethanol
CAS 872621-67-5C17H18Cl2N6O
1-(3,4-Difluorophenyl)-4-(4-ethylpiperazinyl)pyrazolo[5,4-d]pyrimidine chemical structure, C17H18F2N6, CAS 921055-59-6
1-(3,4-Difluorophenyl)-4-(4-ethylpiperazinyl)pyrazolo[5,4-d]pyrimidine
CAS 921055-59-6C17H18F2N6
Ethyl 4-(1-(p-tolyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazine-1-carboxylate chemical structure, C19H22N6O2, CAS 890941-47-6
Ethyl 4-(1-(p-tolyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazine-1-carboxylate
CAS 890941-47-6C19H22N6O2
Ethyl 4-[1-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]piperazine-1-carboxylate chemical structure, C18H19FN6O2, CAS 890881-18-2
Ethyl 4-[1-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]piperazine-1-carboxylate
CAS 890881-18-2C18H19FN6O2
Ethyl 4-(1-(3,4-dimethylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazine-1-carboxylate chemical structure, C20H24N6O2, CAS 890888-66-1
Ethyl 4-(1-(3,4-dimethylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazine-1-carboxylate
CAS 890888-66-1C20H24N6O2
Ethyl 4-[1-(3-chloro-4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]piperazine-1-carboxylate chemical structure, C19H21ClN6O2, CAS 890894-72-1
Ethyl 4-[1-(3-chloro-4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]piperazine-1-carboxylate
CAS 890894-72-1C19H21ClN6O2
Ethyl 4-(1-(5-chloro-2-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazine-1-carboxylate chemical structure, C19H21ClN6O2, CAS 890938-38-2
Ethyl 4-(1-(5-chloro-2-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazine-1-carboxylate
CAS 890938-38-2C19H21ClN6O2
1-(2-Chlorophenyl)-4-(4-methylpiperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine chemical structure, C16H17ClN6, CAS 946202-51-3
1-(2-Chlorophenyl)-4-(4-methylpiperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine
CAS 946202-51-3C16H17ClN6
1-(2-Chlorophenyl)-4-(4-ethylpiperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine chemical structure, C17H19ClN6, CAS 946304-04-7
1-(2-Chlorophenyl)-4-(4-ethylpiperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine
CAS 946304-04-7C17H19ClN6
1-(2,5-Dimethylphenyl)-4-(4-ethylpiperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine chemical structure, C19H24N6, CAS 946202-68-2
1-(2,5-Dimethylphenyl)-4-(4-ethylpiperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine
CAS 946202-68-2C19H24N6
1-(2,5-Dimethylphenyl)-4-(4-methylpiperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine chemical structure, C18H22N6, CAS 946356-66-7
1-(2,5-Dimethylphenyl)-4-(4-methylpiperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine
CAS 946356-66-7C18H22N6
1-(2-Methylphenyl)-4-(4-methylpiperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine chemical structure, C17H20N6, CAS 955319-59-2
1-(2-Methylphenyl)-4-(4-methylpiperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine
CAS 955319-59-2C17H20N6
4-(4-Ethylpiperazinyl)-1-(2-methylphenyl)pyrazolo[5,4-d]pyrimidine chemical structure, C18H22N6, CAS 946356-58-7
4-(4-Ethylpiperazinyl)-1-(2-methylphenyl)pyrazolo[5,4-d]pyrimidine
CAS 946356-58-7C18H22N6
1-(3,5-Dimethylphenyl)-4-(4-ethylpiperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine chemical structure, C19H24N6, CAS 955319-95-6
1-(3,5-Dimethylphenyl)-4-(4-ethylpiperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine
CAS 955319-95-6C19H24N6