Murcko scaffold
Ring system with 2 rings and 16 atoms
54 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 16
- Chemicals
- 54
- With full pages
- 13
Scaffold SMILES
O=C(NN=Cc1ccccc1)c1cccs1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 54 chemicals
![N'-[(Z)-1-(3-Aminophenyl)ethylidene]-2-thiophenecarbohydrazide chemical structure, C13H13N3OS](/s/PMLFYBIRTNZFGK-UHFFFAOYSA-N.svg)
N'-[(Z)-1-(3-Aminophenyl)ethylidene]-2-thiophenecarbohydrazide
C13H13N3OS
![N-[(Z)-1-(3-Aminophenyl)ethylideneamino]thiophene-2-carboxamide chemical structure, C13H13N3OS, CAS 303215-59-0](/s/PMLFYBIRTNZFGK-DHDCSXOGSA-N.svg)
N-[(Z)-1-(3-Aminophenyl)ethylideneamino]thiophene-2-carboxamide
CAS 303215-59-0C13H13N3OS
![N'-[(1Z)-1-(4-Bromophenyl)ethylidene]thiophene-2-carbohydrazide chemical structure, C13H11BrN2OS, CAS 292611-66-6](/s/BXAAJAFTEHABIV-DHDCSXOGSA-N.svg)
N'-[(1Z)-1-(4-Bromophenyl)ethylidene]thiophene-2-carbohydrazide
CAS 292611-66-6C13H11BrN2OS
N'-(1-(3-Methoxyphenyl)ethylidene)-2-thiophenecarbohydrazide
CAS 315206-08-7C14H14N2O2S
![N'-[1-(4-Methoxyphenyl)ethylidene]-2-thiophenecarbohydrazide chemical structure, C14H14N2O2S, CAS 304905-95-1](/s/YCVKPUFYXAMCAQ-GDNBJRDFSA-N.svg)
N'-[1-(4-Methoxyphenyl)ethylidene]-2-thiophenecarbohydrazide
CAS 304905-95-1C14H14N2O2S
![N'-[1-(3-Aminophenyl)ethylidene]-2-thiophenecarbohydrazide chemical structure, C13H13N3OS](/s/PMLFYBIRTNZFGK-OQLLNIDSSA-N.svg)
N'-[1-(3-Aminophenyl)ethylidene]-2-thiophenecarbohydrazide
C13H13N3OS
![2,3-Dimethoxy-6-[(E)-(thiophene-2-carbonylhydrazinylidene)methyl]benzoic acid chemical structure, C15H14N2O5S, CAS 325989-36-4](/s/JYCNPZFYWHLFEG-LZYBPNLTSA-N.svg)
2,3-Dimethoxy-6-[(E)-(thiophene-2-carbonylhydrazinylidene)methyl]benzoic acid
CAS 325989-36-4C15H14N2O5S
N'-(3,4-Dimethoxybenzylidene)-2-thiophenecarbohydrazide
CAS 292611-77-9C14H14N2O3S
![N-[(E)-(2,4,5-Trimethoxyphenyl)methylideneamino]thiophene-2-carboxamide chemical structure, C15H16N2O4S, CAS 304905-89-3](/s/GEEQIGMLDOIKRH-CXUHLZMHSA-N.svg)
N-[(E)-(2,4,5-Trimethoxyphenyl)methylideneamino]thiophene-2-carboxamide
CAS 304905-89-3C15H16N2O4S
N'-(4-Nitrobenzylidene)-2-thiophenecarbohydrazide
CAS 304864-32-2C12H9N3O3S
N'-(4,5-Dimethoxy-2-nitrobenzylidene)-2-thiophenecarbohydrazide
CAS 337472-35-2C14H13N3O5S
N'-Benzylidene-2-thiophenecarbohydrazide
CAS 1269702-15-9C12H10N2OS
![N-[(E)-(3-Bromophenyl)methylideneamino]-3-methylthiophene-2-carboxamide chemical structure, C13H11BrN2OS, CAS 444998-08-7](/s/JMTXVOAWGQMBCM-OVCLIPMQSA-N.svg)
N-[(E)-(3-Bromophenyl)methylideneamino]-3-methylthiophene-2-carboxamide
CAS 444998-08-7C13H11BrN2OS
![3-Methyl-N-[(E)-(3,4,5-trimethoxyphenyl)methylideneamino]thiophene-2-carboxamide chemical structure, C16H18N2O4S, CAS 445000-22-6](/s/OXPATRLELNYLOX-RQZCQDPDSA-N.svg)
3-Methyl-N-[(E)-(3,4,5-trimethoxyphenyl)methylideneamino]thiophene-2-carboxamide
CAS 445000-22-6C16H18N2O4S
![N-[(E)-(2,4-Dimethoxyphenyl)methylideneamino]-3-methylthiophene-2-carboxamide chemical structure, C15H16N2O3S, CAS 445001-66-1](/s/WRNGEOOKAUXZHU-CXUHLZMHSA-N.svg)
N-[(E)-(2,4-Dimethoxyphenyl)methylideneamino]-3-methylthiophene-2-carboxamide
CAS 445001-66-1C15H16N2O3S
![N'-[4-(Dimethylamino)benzylidene]-5-methyl-2-thiophenecarbohydrazide chemical structure, C15H17N3OS, CAS 515177-99-8](/s/OJOPNOFWDTWLOD-MHWRWJLKSA-N.svg)
N'-[4-(Dimethylamino)benzylidene]-5-methyl-2-thiophenecarbohydrazide
CAS 515177-99-8C15H17N3OS
![5-Bromo-N-[(E)-(4-ethoxyphenyl)methylideneamino]thiophene-2-carboxamide chemical structure, C14H13BrN2O2S, CAS 445004-88-6](/s/RJLUGYLSYLXMQE-CXUHLZMHSA-N.svg)
5-Bromo-N-[(E)-(4-ethoxyphenyl)methylideneamino]thiophene-2-carboxamide
CAS 445004-88-6C14H13BrN2O2S
N'-{4-Nitrobenzylidene}-3-methyl-2-thiophenecarbohydrazide
CAS 445007-18-1C13H11N3O3S
![N-[(E)-(2,6-Dichlorophenyl)methylideneamino]-3-methylthiophene-2-carboxamide chemical structure, C13H10Cl2N2OS, CAS 445007-27-2](/s/CVYIABOOVBEEFT-FRKPEAEDSA-N.svg)
N-[(E)-(2,6-Dichlorophenyl)methylideneamino]-3-methylthiophene-2-carboxamide
CAS 445007-27-2C13H10Cl2N2OS
N'-(3-Fluorobenzylidene)-5-methyl-2-thiophenecarbohydrazide
CAS 515175-52-7C13H11FN2OS
N'-(3-Hydroxybenzylidene)-3-methyl-2-thiophenecarbohydrazide
CAS 445007-89-6C13H12N2O2S
![N-[(E)-(2-Chloro-6-fluorophenyl)methylideneamino]-3-methylthiophene-2-carboxamide chemical structure, C13H10ClFN2OS, CAS 445008-14-0](/s/GUPRQEUJWZVIKZ-FRKPEAEDSA-N.svg)
N-[(E)-(2-Chloro-6-fluorophenyl)methylideneamino]-3-methylthiophene-2-carboxamide
CAS 445008-14-0C13H10ClFN2OS
![5-Bromo-N-[(E)-(4-ethoxy-3-methoxyphenyl)methylideneamino]thiophene-2-carboxamide chemical structure, C15H15BrN2O3S, CAS 445008-18-4](/s/HKYOYAJLEOSFLO-RQZCQDPDSA-N.svg)
5-Bromo-N-[(E)-(4-ethoxy-3-methoxyphenyl)methylideneamino]thiophene-2-carboxamide
CAS 445008-18-4C15H15BrN2O3S
![5-Bromo-N-[(E)-(2-bromophenyl)methylideneamino]thiophene-2-carboxamide chemical structure, C12H8Br2N2OS, CAS 445008-85-5](/s/VFEVKMKMTDHKHI-VIZOYTHASA-N.svg)
5-Bromo-N-[(E)-(2-bromophenyl)methylideneamino]thiophene-2-carboxamide
CAS 445008-85-5C12H8Br2N2OS
- 3-Methyl-N'-[4-(methylsulfanyl)benzylidene]-2-thiophenecarbohydrazide445013-71-8C14H14N2OS2
- 3-Methyl-N'-(2-methylbenzylidene)-2-thiophenecarbohydrazide445014-04-0C14H14N2OS
- 3-Methyl-N-[(E)-(2,4,6-trimethylphenyl)methylideneamino]thiophene-2-carboxamide445014-30-2C16H18N2OS
- N-[(E)-Benzylideneamino]-5-methylthiophene-2-carboxamide515120-27-1C13H12N2OS
- 4-[(E)-(Thiophene-2-carbonylhydrazinylidene)methyl]benzoic acid315206-28-1C13H10N2O3S
- N-[(E)-(2-Chloro-6-fluorophenyl)methylideneamino]thiophene-2-carboxamide304905-83-7C12H8ClFN2OS
- N'-(4-Chlorobenzylidene)-2-thiophenecarbohydrazide292611-84-8C12H9ClN2OS
- N-[(E)-(2-Nitrophenyl)methylideneamino]thiophene-2-carboxamide304905-81-5C12H9N3O3S
- N'-(3-Methoxybenzylidene)-2-thiophenecarbohydrazide315206-29-2C13H12N2O2S
- N'-[3-(Trifluoromethyl)benzylidene]-2-thiophenecarbohydrazide329698-66-0C13H9F3N2OS
- N'-(1-{4-Nitrophenyl}ethylidene)-2-thiophenecarbohydrazide292611-67-7C13H11N3O3S
- N-[(Z)-1-(3,4-Dichlorophenyl)ethylideneamino]thiophene-2-carboxamide315206-16-7C13H10Cl2N2OS
- N'-(4-Fluorobenzylidene)-2-thiophenecarbohydrazide1378532-24-1C12H9FN2OS
- N'-(4-Isopropylbenzylidene)-5-methyl-2-thiophenecarbohydrazide445001-14-9C16H18N2OS
- N-{4-[(1E)-1-{2-[(5-methylthiophen-2-yl)carbonyl]hydrazinylidene}ethyl]phenyl}propanamide515177-18-1C17H19N3O2S
- 2-Ethyl-N-{3-[(1E)-1-{2-[(5-methylthiophen-2-yl)carbonyl]hydrazinylidene}ethyl]phenyl}butanamide515828-54-3C20H25N3O2S
- N-{4-[(1E)-1-{2-[(5-bromothiophen-2-yl)carbonyl]hydrazinylidene}ethyl]phenyl}acetamide445005-40-3C15H14BrN3O2S
- N'-(2-Hydroxy-3-methoxybenzylidene)-2-thiophenecarbohydrazide917367-91-0C13H12N2O3S
- (E)-N'-(3-Allyl-2-hydroxybenzylidene)thiophene-2-carbohydrazide292611-76-8C15H14N2O2S
- N'-(2-Hydroxybenzylidene)-2-thiophenecarbohydrazide96818-57-4C12H10N2O2S
- N'-[4-(Diethylamino)-2-hydroxybenzylidene]-2-thiophenecarbohydrazide304905-93-9C16H19N3O2S
- N'-[1-(2,4-Dihydroxyphenyl)ethylidene]-2-thiophenecarbohydrazide315670-31-6C13H12N2O3S
- 5-Bromo-N'-(3-ethoxy-2-hydroxybenzylidene)-2-thiophenecarbohydrazide444998-88-3C14H13BrN2O3S
- N'-(2-Hydroxybenzylidene)-5-methyl-2-thiophenecarbohydrazide514840-73-4C13H12N2O2S
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=C(CSc1nnc[nH]1)Nc1ccccc1](/scaffold/VJBDIQRNSVRUDP-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnc[nH]1)Nc1ccccc165 chemicals
O=C(COc1ccccc1)Nc1nccs143 chemicals
O=C(CCc1ccco1)Nc1ccccc134 chemicals
O=C(CSc1nncs1)Nc1ccccc134 chemicals![Scaffold O=C(NN=Cc1ccccc1)c1cc[nH]n1](/scaffold/UEBQXDJERRSAMF-UHFFFAOYSA-N/structure.svg)
O=C(NN=Cc1ccccc1)c1cc[nH]n129 chemicals
O=C(CCc1ccccc1)Nc1nncs125 chemicals
S=C(NCc1ccco1)Nc1ccccc124 chemicals![Scaffold O=C(CSc1nnn[nH]1)Nc1ccccc1](/scaffold/FDRBWKCIVMSABC-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnn[nH]1)Nc1ccccc122 chemicals![Scaffold O=C(CSc1ncc[nH]1)Nc1ccccc1](/scaffold/OMOYRSCPUXAYDW-UHFFFAOYSA-N/structure.svg)
O=C(CSc1ncc[nH]1)Nc1ccccc121 chemicals
O=C(NC(=S)Nc1ccccc1)c1ccco121 chemicals
O=C(CCN1CCCC1)Nc1ccccc120 chemicals
O=C(NN=Cc1ccco1)c1ccccc119 chemicals