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Murcko scaffold

Ring system with 3 rings and 20 atoms

38 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
38
With full pages
0
Scaffold SMILES

O=C1NC(c2ccccn2)C(=Cc2ccccc2)C1=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1NC(c2ccccn2)C(=Cc2ccccc2)C1=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 38 of 38 chemicals

1-[2-(Dimethylamino)ethyl]-4-[hydroxy(4-methoxy-3-methylphenyl)methylene]-5-(2-pyridinyl)-2,3-pyrrolidinedione chemical structure, C22H25N3O4, CAS 898795-77-2
1-[2-(Dimethylamino)ethyl]-4-[hydroxy(4-methoxy-3-methylphenyl)methylene]-5-(2-pyridinyl)-2,3-pyrrolidinedione
CAS 898795-77-2C22H25N3O4
1-(3-(Diethylamino)propyl)-3-hydroxy-4-(4-methylbenzoyl)-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one chemical structure, C24H29N3O3, CAS 618878-33-4
1-(3-(Diethylamino)propyl)-3-hydroxy-4-(4-methylbenzoyl)-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one
CAS 618878-33-4C24H29N3O3
4-Benzoyl-1-(3-(diethylamino)propyl)-3-hydroxy-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one chemical structure, C23H27N3O3, CAS 618878-32-3
4-Benzoyl-1-(3-(diethylamino)propyl)-3-hydroxy-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one
CAS 618878-32-3C23H27N3O3
1-(3-(Dimethylamino)propyl)-3-hydroxy-4-(4-methylbenzoyl)-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one chemical structure, C22H25N3O3, CAS 618878-42-5
1-(3-(Dimethylamino)propyl)-3-hydroxy-4-(4-methylbenzoyl)-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one
CAS 618878-42-5C22H25N3O3
4-Benzoyl-1-(3-(dimethylamino)propyl)-3-hydroxy-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one chemical structure, C21H23N3O3, CAS 618878-41-4
4-Benzoyl-1-(3-(dimethylamino)propyl)-3-hydroxy-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one
CAS 618878-41-4C21H23N3O3
1-(2-(Diethylamino)ethyl)-3-hydroxy-4-(3-methoxybenzoyl)-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one chemical structure, C23H27N3O4, CAS 618877-89-7
1-(2-(Diethylamino)ethyl)-3-hydroxy-4-(3-methoxybenzoyl)-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one
CAS 618877-89-7C23H27N3O4
4-(4-Chlorobenzoyl)-1-(3-(diethylamino)propyl)-3-hydroxy-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one chemical structure, C23H26ClN3O3, CAS 618878-35-6
4-(4-Chlorobenzoyl)-1-(3-(diethylamino)propyl)-3-hydroxy-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one
CAS 618878-35-6C23H26ClN3O3
1-[3-(Dimethylamino)propyl]-4-(4-ethoxybenzoyl)-3-hydroxy-5-(pyridin-2-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H27N3O4, CAS 618878-47-0
1-[3-(Dimethylamino)propyl]-4-(4-ethoxybenzoyl)-3-hydroxy-5-(pyridin-2-yl)-2,5-dihydro-1H-pyrrol-2-one
CAS 618878-47-0C23H27N3O4
4-(3,4-Dimethoxybenzoyl)-1-[3-(dimethylamino)propyl]-3-hydroxy-5-(pyridin-2-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H27N3O5, CAS 618878-49-2
4-(3,4-Dimethoxybenzoyl)-1-[3-(dimethylamino)propyl]-3-hydroxy-5-(pyridin-2-yl)-2,5-dihydro-1H-pyrrol-2-one
CAS 618878-49-2C23H27N3O5
4-Benzoyl-1-(2-(dimethylamino)ethyl)-3-hydroxy-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one chemical structure, C20H21N3O3, CAS 618878-04-9
4-Benzoyl-1-(2-(dimethylamino)ethyl)-3-hydroxy-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one
CAS 618878-04-9C20H21N3O3
1-(2-(Diethylamino)ethyl)-3-hydroxy-4-(4-methoxybenzoyl)-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one chemical structure, C23H27N3O4, CAS 618877-90-0
1-(2-(Diethylamino)ethyl)-3-hydroxy-4-(4-methoxybenzoyl)-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one
CAS 618877-90-0C23H27N3O4
1-(2-(Diethylamino)ethyl)-3-hydroxy-4-(4-methylbenzoyl)-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one chemical structure, C23H27N3O3, CAS 618877-86-4
1-(2-(Diethylamino)ethyl)-3-hydroxy-4-(4-methylbenzoyl)-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one
CAS 618877-86-4C23H27N3O3
1-(2-(Dimethylamino)ethyl)-3-hydroxy-4-(4-isopropoxybenzoyl)-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one chemical structure, C23H27N3O4, CAS 618878-01-6
1-(2-(Dimethylamino)ethyl)-3-hydroxy-4-(4-isopropoxybenzoyl)-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one
CAS 618878-01-6C23H27N3O4
1-(2-(Diethylamino)ethyl)-3-hydroxy-4-(4-propoxybenzoyl)-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one chemical structure, C25H31N3O4, CAS 618877-93-3
1-(2-(Diethylamino)ethyl)-3-hydroxy-4-(4-propoxybenzoyl)-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one
CAS 618877-93-3C25H31N3O4
1-(2-(Dimethylamino)ethyl)-4-(4-fluorobenzoyl)-3-hydroxy-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one chemical structure, C20H20FN3O3, CAS 618878-06-1
1-(2-(Dimethylamino)ethyl)-4-(4-fluorobenzoyl)-3-hydroxy-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one
CAS 618878-06-1C20H20FN3O3
1-(2-(Diethylamino)ethyl)-4-(4-ethoxybenzoyl)-3-hydroxy-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one chemical structure, C24H29N3O4, CAS 618877-91-1
1-(2-(Diethylamino)ethyl)-4-(4-ethoxybenzoyl)-3-hydroxy-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one
CAS 618877-91-1C24H29N3O4
1-(3-(Dimethylamino)propyl)-3-hydroxy-4-(4-methoxybenzoyl)-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one chemical structure, C22H25N3O4, CAS 618878-46-9
1-(3-(Dimethylamino)propyl)-3-hydroxy-4-(4-methoxybenzoyl)-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one
CAS 618878-46-9C22H25N3O4
1-(3-(Dimethylamino)propyl)-3-hydroxy-4-(4-methoxy-3-methylbenzoyl)-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one chemical structure, C23H27N3O4, CAS 618878-48-1
1-(3-(Dimethylamino)propyl)-3-hydroxy-4-(4-methoxy-3-methylbenzoyl)-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one
CAS 618878-48-1C23H27N3O4
1-(2-(Dimethylamino)ethyl)-4-(4-ethoxybenzoyl)-3-hydroxy-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one chemical structure, C22H25N3O4, CAS 618877-98-8
1-(2-(Dimethylamino)ethyl)-4-(4-ethoxybenzoyl)-3-hydroxy-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one
CAS 618877-98-8C22H25N3O4
1-(3-(Dimethylamino)propyl)-3-hydroxy-4-(3-methoxybenzoyl)-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one chemical structure, C22H25N3O4, CAS 618878-45-8
1-(3-(Dimethylamino)propyl)-3-hydroxy-4-(3-methoxybenzoyl)-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one
CAS 618878-45-8C22H25N3O4
1-(3-(Dimethylamino)propyl)-4-(4-fluorobenzoyl)-3-hydroxy-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one chemical structure, C21H22FN3O3, CAS 618878-43-6
1-(3-(Dimethylamino)propyl)-4-(4-fluorobenzoyl)-3-hydroxy-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one
CAS 618878-43-6C21H22FN3O3
1-(2-(Dimethylamino)ethyl)-3-hydroxy-4-(3-methoxybenzoyl)-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one chemical structure, C21H23N3O4, CAS 618422-98-3
1-(2-(Dimethylamino)ethyl)-3-hydroxy-4-(3-methoxybenzoyl)-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one
CAS 618422-98-3C21H23N3O4
4-Benzoyl-1-(2-(diethylamino)ethyl)-3-hydroxy-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one chemical structure, C22H25N3O3, CAS 618877-85-3
4-Benzoyl-1-(2-(diethylamino)ethyl)-3-hydroxy-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one
CAS 618877-85-3C22H25N3O3
1-(3-(Diethylamino)propyl)-3-hydroxy-4-(3-methoxybenzoyl)-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one chemical structure, C24H29N3O4, CAS 618878-36-7
1-(3-(Diethylamino)propyl)-3-hydroxy-4-(3-methoxybenzoyl)-5-(pyridin-2-yl)-1H-pyrrol-2(5H)-one
CAS 618878-36-7C24H29N3O4