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Murcko scaffold

Ring system with 3 rings and 22 atoms

9 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
9
With full pages
3
Scaffold SMILES

O=C(c1ccccc1)N1CCN(C(=O)c2cccnc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1ccccc1)N1CCN(C(=O)c2cccnc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 9 of 9 chemicals

(4-Nitrophenyl)-[4-(pyridine-3-carbonyl)piperazin-1-yl]methanone chemical structure, C17H16N4O4, CAS 356075-74-6
(4-Nitrophenyl)-[4-(pyridine-3-carbonyl)piperazin-1-yl]methanone
CAS 356075-74-6C17H16N4O4
(3-Chlorophenyl)-[4-(pyridine-3-carbonyl)piperazin-1-yl]methanone chemical structure, C17H16ClN3O2, CAS 423751-39-7
(3-Chlorophenyl)-[4-(pyridine-3-carbonyl)piperazin-1-yl]methanone
CAS 423751-39-7C17H16ClN3O2
Pyridin-3-yl-[4-(3,4,5-trimethoxybenzoyl)piperazin-1-yl]methanone chemical structure, C20H23N3O5, CAS 143210-54-2
Pyridin-3-yl-[4-(3,4,5-trimethoxybenzoyl)piperazin-1-yl]methanone
CAS 143210-54-2C20H23N3O5
(4-Benzoylpiperazin-1-yl)(2-(methylthio)pyridin-3-yl)methanone chemical structure, C18H19N3O2S, CAS 852844-91-8
(4-Benzoylpiperazin-1-yl)(2-(methylthio)pyridin-3-yl)methanone
CAS 852844-91-8C18H19N3O2S
1-(5,6-Dichloropyridine-3-carbonyl)-4-[4-(propan-2-yl)benzoyl]piperazine chemical structure, C20H21Cl2N3O2, CAS 1090854-05-9
1-(5,6-Dichloropyridine-3-carbonyl)-4-[4-(propan-2-yl)benzoyl]piperazine
CAS 1090854-05-9C20H21Cl2N3O2
1-(5,6-Dichloropyridine-3-carbonyl)-4-(3-methoxybenzoyl)piperazine chemical structure, C18H17Cl2N3O3, CAS 1090861-03-2
1-(5,6-Dichloropyridine-3-carbonyl)-4-(3-methoxybenzoyl)piperazine
CAS 1090861-03-2C18H17Cl2N3O3
1-(5,6-Dichloropyridine-3-carbonyl)-4-(4-methoxybenzoyl)piperazine chemical structure, C18H17Cl2N3O3, CAS 1031092-40-6
1-(5,6-Dichloropyridine-3-carbonyl)-4-(4-methoxybenzoyl)piperazine
CAS 1031092-40-6C18H17Cl2N3O3
1-(2-Chloropyridine-3-carbonyl)-4-(4-methoxybenzoyl)piperazine chemical structure, C18H18ClN3O3, CAS 1119228-66-8
1-(2-Chloropyridine-3-carbonyl)-4-(4-methoxybenzoyl)piperazine
CAS 1119228-66-8C18H18ClN3O3
1-(5-Chloro-2-fluorobenzoyl)-4-(6-chloropyridine-3-carbonyl)piperazine chemical structure, C17H14Cl2FN3O2, CAS 1210951-90-8
1-(5-Chloro-2-fluorobenzoyl)-4-(6-chloropyridine-3-carbonyl)piperazine
CAS 1210951-90-8C17H14Cl2FN3O2