Murcko scaffold
2-Cyclobutylthiophene scaffold
317 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 9
- Chemicals
- 317
- With full pages
- 6
Scaffold SMILES
c1csc(C2CCC2)c1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 97 to 144 of 317 chemicals
2-(Thiophen-2-yl)cyclobutan-1-ol
CAS 2144180-21-0C8H10OS
![2-[1-(5-Cyanothiophen-2-yl)cyclobutyl]acetic acid chemical structure, C11H11NO2S, CAS 2229418-37-3](/s/TUSDXLIWTNOKKH-UHFFFAOYSA-N.svg)
2-[1-(5-Cyanothiophen-2-yl)cyclobutyl]acetic acid
CAS 2229418-37-3C11H11NO2S
3-Hydroxy-1-(5-propylthiophen-2-yl)cyclobutane-1-carboxylic acid
CAS 2228140-23-4C12H16O3S
![Methyl 5-[1-(2-aminoethyl)cyclobutyl]thiophene-3-carboxylate chemical structure, C12H17NO2S, CAS 2229180-62-3](/s/RWUQQUJUIBKCGH-UHFFFAOYSA-N.svg)
Methyl 5-[1-(2-aminoethyl)cyclobutyl]thiophene-3-carboxylate
CAS 2229180-62-3C12H17NO2S
![Methyl 5-[1-(aminomethyl)cyclobutyl]thiophene-3-carboxylate chemical structure, C11H15NO2S, CAS 2228599-03-7](/s/RPOBKNAJSFIODB-UHFFFAOYSA-N.svg)
Methyl 5-[1-(aminomethyl)cyclobutyl]thiophene-3-carboxylate
CAS 2228599-03-7C11H15NO2S
5-(1-Aminocyclobutyl)thiophene-2-carbonitrile
CAS 2228776-92-7C9H10N2S
![2-[1-(3-Ethylthiophen-2-yl)cyclobutyl]ethan-1-amine chemical structure, C12H19NS, CAS 2229430-15-1](/s/GPRCJBCZDOUFPJ-UHFFFAOYSA-N.svg)
2-[1-(3-Ethylthiophen-2-yl)cyclobutyl]ethan-1-amine
CAS 2229430-15-1C12H19NS
![2-[1-(5-Propylthiophen-2-yl)cyclobutyl]ethan-1-amine chemical structure, C13H21NS, CAS 2228881-23-8](/s/RVTAEPAMARTRDN-UHFFFAOYSA-N.svg)
2-[1-(5-Propylthiophen-2-yl)cyclobutyl]ethan-1-amine
CAS 2228881-23-8C13H21NS
5-(1-Aminocyclobutyl)thiophene-3-carbonitrile
CAS 2228676-60-4C9H10N2S
1-(4-Cyanothiophen-2-yl)cyclobutane-1-carboxylic acid
CAS 2228409-33-2C10H9NO2S
3-(Aminomethyl)-3-(5-methylthiophen-2-yl)cyclobutan-1-ol
CAS 2229196-60-3C10H15NOS
![2-[1-(5-Methylthiophen-2-yl)cyclobutyl]ethan-1-amine chemical structure, C11H17NS, CAS 2229276-63-3](/s/GDAJCXFADXSXLC-UHFFFAOYSA-N.svg)
2-[1-(5-Methylthiophen-2-yl)cyclobutyl]ethan-1-amine
CAS 2229276-63-3C11H17NS
![2-[1-(4-Methylthiophen-2-yl)cyclobutyl]ethan-1-amine chemical structure, C11H17NS, CAS 2228821-33-6](/s/GJLGGKYWXNFAEI-UHFFFAOYSA-N.svg)
2-[1-(4-Methylthiophen-2-yl)cyclobutyl]ethan-1-amine
CAS 2228821-33-6C11H17NS
![2-[1-(4-Methylthiophen-2-yl)cyclobutyl]acetic acid chemical structure, C11H14O2S, CAS 2229501-76-0](/s/KEFRAOCWQSQNOK-UHFFFAOYSA-N.svg)
2-[1-(4-Methylthiophen-2-yl)cyclobutyl]acetic acid
CAS 2229501-76-0C11H14O2S
![[1-(4-Methylthiophen-2-yl)cyclobutyl]methanol chemical structure, C10H14OS, CAS 2228598-30-7](/s/HICKAZORLZZLLW-UHFFFAOYSA-N.svg)
[1-(4-Methylthiophen-2-yl)cyclobutyl]methanol
CAS 2228598-30-7C10H14OS
1-(4-Methylthiophen-2-yl)cyclobutane-1-carbonitrile
CAS 2228822-53-3C10H11NS
3,3-Difluoro-1-(5-methylthiophen-2-yl)cyclobutan-1-amine
CAS 2229518-39-0C9H11F2NS
![1-[5-(Trifluoromethyl)thiophen-2-yl]cyclobutane-1-carbonitrile chemical structure, C10H8F3NS, CAS 2229408-42-6](/s/IQHIMIIMNNGKQU-UHFFFAOYSA-N.svg)
1-[5-(Trifluoromethyl)thiophen-2-yl]cyclobutane-1-carbonitrile
CAS 2229408-42-6C10H8F3NS
5-(1-Amino-3,3-difluorocyclobutyl)thiophene-2-carbonitrile
CAS 2228732-76-9C9H8F2N2S
1-(4-Chlorothiophen-2-yl)-3,3-difluorocyclobutan-1-amine
CAS 2229522-90-9C8H8ClF2NS
![1-[1-(4-Chlorothiophen-2-yl)-3,3-difluorocyclobutyl]methanamine chemical structure, C9H10ClF2NS, CAS 2228804-47-3](/s/TZUDXFFNYUCGJM-UHFFFAOYSA-N.svg)
1-[1-(4-Chlorothiophen-2-yl)-3,3-difluorocyclobutyl]methanamine
CAS 2228804-47-3C9H10ClF2NS
![[3,3-Difluoro-1-(5-propylthiophen-2-yl)cyclobutyl]methanamine chemical structure, C12H17F2NS, CAS 2228396-47-0](/s/XHWXGEJWTRIDEH-UHFFFAOYSA-N.svg)
[3,3-Difluoro-1-(5-propylthiophen-2-yl)cyclobutyl]methanamine
CAS 2228396-47-0C12H17F2NS
![1-[1-(4-Chlorothiophen-2-yl)cyclobutyl]methanamine chemical structure, C9H12ClNS, CAS 2229539-19-7](/s/HKYQOXVQYQEUCS-UHFFFAOYSA-N.svg)
1-[1-(4-Chlorothiophen-2-yl)cyclobutyl]methanamine
CAS 2229539-19-7C9H12ClNS
![3-Amino-3-[5-(trifluoromethyl)thiophen-2-yl]cyclobutan-1-ol chemical structure, C9H10F3NOS, CAS 2228400-38-0](/s/CCSVDWSBCHZYBU-UHFFFAOYSA-N.svg)
3-Amino-3-[5-(trifluoromethyl)thiophen-2-yl]cyclobutan-1-ol
CAS 2228400-38-0C9H10F3NOS
- 3,3-Difluoro-1-[5-(trifluoromethyl)thiophen-2-yl]cyclobutan-1-amine2228748-82-9C9H8F5NS
- 1-(3-Chlorothiophen-2-yl)-3-hydroxycyclobutane-1-carboxylic acid2228746-06-1C9H9ClO3S
- 5-[1-(Aminomethyl)-3,3-difluorocyclobutyl]thiophene-3-carbonitrile2228755-43-7C10H10F2N2S
- 2-{1-[5-(Trifluoromethyl)thiophen-2-yl]cyclobutyl}acetic acid2228302-98-3C11H11F3O2S
- 3-(Aminomethyl)-3-(3-bromo-5-methylthiophen-2-yl)cyclobutan-1-ol2229310-47-6C10H14BrNOS
- Methyl 5-[1-(hydroxymethyl)cyclobutyl]thiophene-2-carboxylate2229135-48-0C11H14O3S
- 3-Amino-3-(3-chlorothiophen-2-yl)cyclobutan-1-ol2228825-37-2C8H10ClNOS
- 1-(3-Bromothiophen-2-yl)cyclobutane-1-carbonitrile2228315-44-2C9H8BrNS
- 3-Amino-3-(4-bromothiophen-2-yl)cyclobutan-1-ol2228691-82-3C8H10BrNOS
- 1-(3-Bromo-5-methylthiophen-2-yl)cyclobutan-1-amine2228837-95-2C9H12BrNS
- 1-[1-(3-Bromo-4-methylthiophen-2-yl)cyclobutyl]methanamine2228861-91-2C10H14BrNS
- 1-(4-Bromo-5-methoxythiophen-2-yl)cyclobutane-1-carbonitrile2229360-01-2C10H10BrNOS
- [1-(4-Bromo-5-methoxythiophen-2-yl)cyclobutyl]methanol2228863-67-8C10H13BrO2S
- 1-[1-(4-Bromo-5-methylthiophen-2-yl)cyclobutyl]methanamine2229361-00-4C10H14BrNS
- 2-[1-(4-Bromo-5-methylthiophen-2-yl)cyclobutyl]ethan-1-amine2228785-32-6C11H16BrNS
- 2-[1-(3-Bromo-5-methylthiophen-2-yl)cyclobutyl]acetic acid2228168-49-6C11H13BrO2S
- 1-(3-Bromo-4-methylthiophen-2-yl)cyclobutane-1-carboxylic acid2228203-40-3C10H11BrO2S
- 1-(3-Bromo-4-methylthiophen-2-yl)-3,3-difluorocyclobutan-1-amine2229368-65-2C9H10BrF2NS
- 1-[1-(3-Ethylthiophen-2-yl)-3,3-difluorocyclobutyl]methanamine2229592-67-8C11H15F2NS
- 1-(3-Ethylthiophen-2-yl)cyclobutane-1-carbonitrile2228579-96-0C11H13NS
- 5-[1-(Aminomethyl)cyclobutyl]thiophene-3-carbonitrile2228789-05-5C10H12N2S
- 1-(3-Bromothiophen-2-yl)-3-hydroxycyclobutane-1-carboxylic acid2229030-03-7C9H9BrO3S
- 5-[1-(Hydroxymethyl)cyclobutyl]thiophene-2-carbonitrile2229048-06-8C10H11NOS
- 3-(Aminomethyl)-3-(4-methylthiophen-2-yl)cyclobutan-1-ol2228431-25-0C10H15NOS
Related scaffolds
Same ring framework with different atoms or bond orders
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c1cnn(C2CNC2)c121 chemicals![Scaffold c1cc(C2CCC2)[nH]n1](/scaffold/HLPBQDVLMHJKRN-UHFFFAOYSA-N/structure.svg)
c1cc(C2CCC2)[nH]n117 chemicals
c1cc(C2CCC2)no117 chemicals
c1cc(C2CNC2)no112 chemicals
C1CCN(C2CNC2)C111 chemicals![Scaffold c1cc(C2CNC2)[nH]n1](/scaffold/CMLYUYXCLKBTDM-UHFFFAOYSA-N/structure.svg)
c1cc(C2CNC2)[nH]n19 chemicals
c1cn(C2CNC2)nn18 chemicals
c1csc(C2CCC2)n17 chemicals
C1CN(C2CCNC2)C17 chemicals![Scaffold c1n[nH]c(C2CCC2)n1](/scaffold/GUXDCSDPNPVZOS-UHFFFAOYSA-N/structure.svg)
c1n[nH]c(C2CCC2)n17 chemicals
c1coc(C2CCC2)n17 chemicals