Murcko scaffold
Ring system with 3 rings and 22 atoms
60 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 22
- Chemicals
- 60
- With full pages
- 7
Scaffold SMILES
O=C(COc1ccccc1)Nc1cc(-c2ccccc2)cs1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 60 chemicals
Ethyl 2-(2-phenoxyacetamido)-4-phenylthiophene-3-carboxylate
CAS 324073-87-2C21H19NO4S
![Ethyl 4-(4-chlorophenyl)-2-{[(2-methoxyphenoxy)acetyl]amino}thiophene-3-carboxylate chemical structure, C22H20ClNO5S, CAS 372970-14-4](/s/WIFPORRBZCUHDH-UHFFFAOYSA-N.svg)
Ethyl 4-(4-chlorophenyl)-2-{[(2-methoxyphenoxy)acetyl]amino}thiophene-3-carboxylate
CAS 372970-14-4C22H20ClNO5S
ET 2-(((2-Methylphenoxy)acetyl)amino)-4-(4-methylphenyl)-3-thiophenecarboxylate
CAS 303092-57-1C23H23NO4S
Ethyl 2-(((2-methylphenoxy)acetyl)amino)-4-phenyl-3-thiophenecarboxylate
CAS 303092-58-2C22H21NO4S
![2-[[2-(2-Chlorophenoxy)acetyl]amino]-4-(2,4-dichlorophenyl)thiophene-3-carboxamide chemical structure, C19H13Cl3N2O3S, CAS 445231-99-2](/s/LCYQAUFWTGFPJC-UHFFFAOYSA-N.svg)
2-[[2-(2-Chlorophenoxy)acetyl]amino]-4-(2,4-dichlorophenyl)thiophene-3-carboxamide
CAS 445231-99-2C19H13Cl3N2O3S
![Methyl 2-{[(2-chlorophenoxy)acetyl]amino}-4-(4-methoxyphenyl)-5-methyl-3-thiophenecarboxylate chemical structure, C22H20ClNO5S, CAS 444905-81-1](/s/HKIZUMKLFAMXTJ-UHFFFAOYSA-N.svg)
Methyl 2-{[(2-chlorophenoxy)acetyl]amino}-4-(4-methoxyphenyl)-5-methyl-3-thiophenecarboxylate
CAS 444905-81-1C22H20ClNO5S
![Methyl 4-(4-bromophenyl)-2-[(phenoxyacetyl)amino]-3-thiophenecarboxylate chemical structure, C20H16BrNO4S, CAS 546120-49-4](/s/UNVDUBUUMRPYRF-UHFFFAOYSA-N.svg)
Methyl 4-(4-bromophenyl)-2-[(phenoxyacetyl)amino]-3-thiophenecarboxylate
CAS 546120-49-4C20H16BrNO4S
![Ethyl 4-(3,4-dimethylphenyl)-2-[(phenoxyacetyl)amino]thiophene-3-carboxylate chemical structure, C23H23NO4S, CAS 444940-20-9](/s/OWLCKPHVAKHUEK-UHFFFAOYSA-N.svg)
Ethyl 4-(3,4-dimethylphenyl)-2-[(phenoxyacetyl)amino]thiophene-3-carboxylate
CAS 444940-20-9C23H23NO4S
![Ethyl 4-(2,4-dimethylphenyl)-2-[(phenoxyacetyl)amino]thiophene-3-carboxylate chemical structure, C23H23NO4S, CAS 445000-24-8](/s/YWSSYOAEEDTMCZ-UHFFFAOYSA-N.svg)
Ethyl 4-(2,4-dimethylphenyl)-2-[(phenoxyacetyl)amino]thiophene-3-carboxylate
CAS 445000-24-8C23H23NO4S
![Methyl 4-(4-methoxyphenyl)-5-methyl-2-[(phenoxyacetyl)amino]thiophene-3-carboxylate chemical structure, C22H21NO5S, CAS 445002-93-7](/s/COUKBLVPBDFJCT-UHFFFAOYSA-N.svg)
Methyl 4-(4-methoxyphenyl)-5-methyl-2-[(phenoxyacetyl)amino]thiophene-3-carboxylate
CAS 445002-93-7C22H21NO5S
![Methyl 2-[({4-nitrophenoxy}acetyl)amino]-4-phenylthiophene-3-carboxylate chemical structure, C20H16N2O6S, CAS 445006-80-4](/s/QTPUCXQFGKJVFN-UHFFFAOYSA-N.svg)
Methyl 2-[({4-nitrophenoxy}acetyl)amino]-4-phenylthiophene-3-carboxylate
CAS 445006-80-4C20H16N2O6S
![Propan-2-yl 4-(4-fluorophenyl)-2-[[2-(4-nitrophenoxy)acetyl]amino]thiophene-3-carboxylate chemical structure, C22H19FN2O6S, CAS 445007-52-3](/s/OOCKUPJQQQVKEJ-UHFFFAOYSA-N.svg)
Propan-2-yl 4-(4-fluorophenyl)-2-[[2-(4-nitrophenoxy)acetyl]amino]thiophene-3-carboxylate
CAS 445007-52-3C22H19FN2O6S
![4-(4-tert-Butylphenyl)-5-methyl-2-[(phenoxyacetyl)amino]thiophene-3-carboxamide chemical structure, C24H26N2O3S, CAS 445008-29-7](/s/MVHFBUHAABZBKM-UHFFFAOYSA-N.svg)
4-(4-tert-Butylphenyl)-5-methyl-2-[(phenoxyacetyl)amino]thiophene-3-carboxamide
CAS 445008-29-7C24H26N2O3S
![Methyl 2-[({4-nitrophenoxy}acetyl)amino]-4-(4-isopropylphenyl)thiophene-3-carboxylate chemical structure, C23H22N2O6S, CAS 445013-70-7](/s/YZIXZPZIFBOQSW-UHFFFAOYSA-N.svg)
Methyl 2-[({4-nitrophenoxy}acetyl)amino]-4-(4-isopropylphenyl)thiophene-3-carboxylate
CAS 445013-70-7C23H22N2O6S
ET 2-(((2-Fluorophenoxy)acetyl)amino)-4-(4-methylphenyl)-3-thiophenecarboxylate
CAS 373375-70-3C22H20FNO4S
N-(3-Cyano-5-methyl-4-phenylthiophen-2-yl)-2-(3-methylphenoxy)acetamide
CAS 445022-30-0C21H18N2O2S
![Ethyl 2-{[(4-methylphenoxy)acetyl]amino}-4-(4-methylphenyl)thiophene-3-carboxylate chemical structure, C23H23NO4S, CAS 372976-62-0](/s/ILQURDQKMQVVHO-UHFFFAOYSA-N.svg)
Ethyl 2-{[(4-methylphenoxy)acetyl]amino}-4-(4-methylphenyl)thiophene-3-carboxylate
CAS 372976-62-0C23H23NO4S
![Ethyl 4-(4-methylphenyl)-2-[[2-(4-nitrophenoxy)acetyl]amino]thiophene-3-carboxylate chemical structure, C22H20N2O6S, CAS 374084-10-3](/s/VEWSTYYLACKIFH-UHFFFAOYSA-N.svg)
Ethyl 4-(4-methylphenyl)-2-[[2-(4-nitrophenoxy)acetyl]amino]thiophene-3-carboxylate
CAS 374084-10-3C22H20N2O6S
![Ethyl 4-(4-chlorophenyl)-2-[[2-(4-nitrophenoxy)acetyl]amino]thiophene-3-carboxylate chemical structure, C21H17ClN2O6S, CAS 374598-53-5](/s/ZWNOHPAQJOHCFB-UHFFFAOYSA-N.svg)
Ethyl 4-(4-chlorophenyl)-2-[[2-(4-nitrophenoxy)acetyl]amino]thiophene-3-carboxylate
CAS 374598-53-5C21H17ClN2O6S
Ethyl 4-(4-methoxyphenyl)-2-(2-phenoxyacetamido)thiophene-3-carboxylate
CAS 373369-36-9C22H21NO5S
ET 2-(((4-Bromophenoxy)acetyl)amino)-4-(4-chlorophenyl)-3-thiophenecarboxylate
CAS 374086-71-2C21H17BrClNO4S
![Ethyl 4-(4-bromophenyl)-2-[(phenoxyacetyl)amino]-3-thiophenecarboxylate chemical structure, C21H18BrNO4S, CAS 545441-36-9](/s/FFJWXMLMBTYNEH-UHFFFAOYSA-N.svg)
Ethyl 4-(4-bromophenyl)-2-[(phenoxyacetyl)amino]-3-thiophenecarboxylate
CAS 545441-36-9C21H18BrNO4S
ET 2-(((4-Bromophenoxy)acetyl)amino)-4-(4-methylphenyl)-3-thiophenecarboxylate
CAS 374085-59-3C22H20BrNO4S
![Ethyl 4-(4-bromophenyl)-2-[[2-(2-methylphenoxy)acetyl]amino]thiophene-3-carboxylate chemical structure, C22H20BrNO4S, CAS 325729-96-2](/s/YOJVVHBYSREIOG-UHFFFAOYSA-N.svg)
Ethyl 4-(4-bromophenyl)-2-[[2-(2-methylphenoxy)acetyl]amino]thiophene-3-carboxylate
CAS 325729-96-2C22H20BrNO4S
- Ethyl 2-[[2-(2,5-dimethylphenoxy)acetyl]amino]-4-(4-ethoxyphenyl)thiophene-3-carboxylate6876-63-7C25H27NO5S
- Isopropyl 2-{[2-(4-chlorophenoxy)-2-methylpropanoyl]amino}-4-phenyl-3-thiophenecarboxylate438537-88-3C24H24ClNO4S
- 1-Methylethyl 2-((2-(4-chlorophenoxy)-2-methyl-1-oxopropyl)amino)-4-(4-ethoxyphenyl)-3-thiophenecarboxylate444905-38-8C26H28ClNO5S
- Methyl 2-[[2-(4-chlorophenoxy)-2-methylpropanoyl]amino]-4-(4-chlorophenyl)thiophene-3-carboxylate444906-01-8C22H19Cl2NO4S
- Ethyl 2-{[(2-chlorophenoxy)acetyl]amino}-4-(4-methoxyphenyl)-5-methylthiophene-3-carboxylate444998-84-9C23H22ClNO5S
- Isopropyl 4-(4-methylphenyl)-2-[(phenoxyacetyl)amino]thiophene-3-carboxylate444999-39-7C23H23NO4S
- Methyl 4-(3,4-dimethylphenyl)-5-methyl-2-[(2-phenoxyacetyl)amino]thiophene-3-carboxylate515148-91-1C23H23NO4S
- Propyl 2-{[(3,4-dimethylphenoxy)acetyl]amino}-4-(4-ethylphenyl)-3-thiophenecarboxylate438197-55-8C26H29NO4S
- 2-[[2-(3,4-Dimethylphenoxy)acetyl]amino]-5-methyl-4-(4-propan-2-ylphenyl)thiophene-3-carboxamide438197-87-6C25H28N2O3S
- Propyl 4-(4-chlorophenyl)-2-{[(3,4-dimethylphenoxy)acetyl]amino}-3-thiophenecarboxylate438198-04-0C24H24ClNO4S
- Ethyl 2-[[2-(4-chlorophenoxy)-2-methylpropanoyl]amino]-4-(4-ethoxyphenyl)thiophene-3-carboxylate438199-35-0C25H26ClNO5S
- 2-[[2-(2,5-Dichlorophenoxy)acetyl]amino]-5-methyl-4-(4-propan-2-ylphenyl)thiophene-3-carboxamide438211-14-4C23H22Cl2N2O3S
- Methyl 4-(2,4-dichlorophenyl)-2-{[(3,4-dimethylphenoxy)acetyl]amino}-3-thiophenecarboxylate438211-41-7C22H19Cl2NO4S
- Methyl 2-[[2-(4-chlorophenoxy)-2-methylpropanoyl]amino]-4-(2,4-dimethylphenyl)-5-methylthiophene-3-carboxylate438212-01-2C25H26ClNO4S
- Ethyl 2-[[2-(4-chlorophenoxy)-2-methylpropanoyl]amino]-4-(4-ethylphenyl)thiophene-3-carboxylate438214-32-5C25H26ClNO4S
- Ethyl 4-(4-tert-butylphenyl)-2-{[(2,4-dichlorophenoxy)acetyl]amino}-3-thiophenecarboxylate445037-61-6C25H25Cl2NO4S
- Methyl 2-{[2-(4-chlorophenoxy)-2-methylpropanoyl]amino}-4-(4-fluorophenyl)-3-thiophenecarboxylate380568-89-8C22H19ClFNO4S
- Ethyl 4-(2,4-dimethylphenyl)-2-[[2-(2-methylphenoxy)acetyl]amino]thiophene-3-carboxylate514818-30-5C24H25NO4S
- Ethyl 4-(4-chlorophenyl)-2-{[(4-methoxyphenoxy)acetyl]amino}thiophene-3-carboxylate374099-77-1C22H20ClNO5S
- Ethyl 4-(4-chlorophenyl)-2-{[(4-fluorophenoxy)acetyl]amino}thiophene-3-carboxylate374546-46-0C21H17ClFNO4S
- Propyl 2-{[(2-chlorophenoxy)acetyl]amino}-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate524925-20-0C24H24ClNO6S
- Methyl 2-{[(2,4-dichlorophenoxy)acetyl]amino}-4-(4-fluorophenyl)-3-thiophenecarboxylate546068-69-3C20H14Cl2FNO4S
- Ethyl 4-(4-chlorophenyl)-2-[(2-phenoxyacetyl)amino]thiophene-3-carboxylate374087-38-4C21H18ClNO4S
- Ethyl 2-{[(4-chlorophenoxy)acetyl]amino}-4-phenyl-3-thiophenecarboxylate327025-67-2C21H18ClNO4S
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=C(CSc1nnc(-c2ccccn2)[nH]1)Nc1ccccc1](/scaffold/RPGQONZTKJZFKA-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnc(-c2ccccn2)[nH]1)Nc1ccccc1111 chemicals![Scaffold O=C(NN=Cc1ccccc1)c1cc(-c2ccccc2)n[nH]1](/scaffold/HSDVCEWEQSYSJL-UHFFFAOYSA-N/structure.svg)
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O=C(CSc1nnc(-c2ccccc2)[nH]1)Nc1ccccc185 chemicals![Scaffold O=C(CSc1nnc(-c2cccnc2)[nH]1)Nc1ccccc1](/scaffold/HPEIJTCNFVAYEW-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnc(-c2cccnc2)[nH]1)Nc1ccccc179 chemicals![Scaffold O=C(CSc1nnc(-c2ccncc2)[nH]1)Nc1ccccc1](/scaffold/PBHQJIGZLPAKKZ-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnc(-c2ccncc2)[nH]1)Nc1ccccc178 chemicals![Scaffold O=C(CSc1nnc(-c2cnccn2)[nH]1)Nc1ccccc1](/scaffold/HZSLYHSAMJCXQO-UHFFFAOYSA-N/structure.svg)
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