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Murcko scaffold

4-Phenyl-2-(piperazin-1-yl)quinazoline scaffold

34 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
34
With full pages
12
Scaffold SMILES

c1ccc(-c2nc(N3CCNCC3)nc3ccccc23)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 4-Phenyl-2-(piperazin-1-yl)quinazoline page
Murcko scaffold c1ccc(-c2nc(N3CCNCC3)nc3ccccc23)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 34 of 34 chemicals

6-Chloro-4-phenyl-2-(piperazin-1-yl)quinazoline chemical structure, C18H17ClN4, CAS 313398-51-5
6-Chloro-4-phenyl-2-(piperazin-1-yl)quinazoline
CAS 313398-51-5C18H17ClN4
2-[4-(6-Chloro-4-phenylquinazolin-2-yl)piperazin-1-yl]ethanol chemical structure, C20H21ClN4O, CAS 497078-51-0
2-[4-(6-Chloro-4-phenylquinazolin-2-yl)piperazin-1-yl]ethanol
CAS 497078-51-0C20H21ClN4O
1-[4-(4-Phenylquinazolin-2-yl)piperazin-1-yl]ethanone chemical structure, C20H20N4O, CAS 333749-38-5
1-[4-(4-Phenylquinazolin-2-yl)piperazin-1-yl]ethanone
CAS 333749-38-5C20H20N4O
4-(6-Methyl-4-phenylquinazolin-2-yl)piperazine-1-carbaldehyde chemical structure, C20H20N4O, CAS 332102-15-5
4-(6-Methyl-4-phenylquinazolin-2-yl)piperazine-1-carbaldehyde
CAS 332102-15-5C20H20N4O
2-(4-(6-Methyl-4-phenylquinazolin-2-yl)piperazin-1-yl)ethanol chemical structure, C21H24N4O, CAS 385417-69-6
2-(4-(6-Methyl-4-phenylquinazolin-2-yl)piperazin-1-yl)ethanol
CAS 385417-69-6C21H24N4O
4-[4-(6-Methyl-4-phenylquinazolin-2-yl)piperazin-1-yl]-4-oxobutanoic acid chemical structure, C23H24N4O3, CAS 412919-97-2
4-[4-(6-Methyl-4-phenylquinazolin-2-yl)piperazin-1-yl]-4-oxobutanoic acid
CAS 412919-97-2C23H24N4O3
1-(4-(6-Bromo-4-phenylquinazolin-2-yl)piperazin-1-yl)ethanone chemical structure, C20H19BrN4O, CAS 313398-52-6
1-(4-(6-Bromo-4-phenylquinazolin-2-yl)piperazin-1-yl)ethanone
CAS 313398-52-6C20H19BrN4O
4-(6-Chloro-4-phenylquinazolin-2-yl)piperazine-1-carbaldehyde chemical structure, C19H17ClN4O, CAS 5960-46-3
4-(6-Chloro-4-phenylquinazolin-2-yl)piperazine-1-carbaldehyde
CAS 5960-46-3C19H17ClN4O
4-Oxo-4-[4-(4-phenylquinazolin-2-yl)piperazin-1-yl]butanoic acid chemical structure, C22H22N4O3, CAS 333749-35-2
4-Oxo-4-[4-(4-phenylquinazolin-2-yl)piperazin-1-yl]butanoic acid
CAS 333749-35-2C22H22N4O3
2-[4-(6-Bromo-4-phenylquinazolin-2-yl)piperazin-1-yl]ethanol chemical structure, C20H21BrN4O, CAS 385388-80-7
2-[4-(6-Bromo-4-phenylquinazolin-2-yl)piperazin-1-yl]ethanol
CAS 385388-80-7C20H21BrN4O
1-[4-[6-Bromo-4-(2-chlorophenyl)quinazolin-2-yl]piperazin-1-yl]ethanone chemical structure, C20H18BrClN4O, CAS 421566-10-1
1-[4-[6-Bromo-4-(2-chlorophenyl)quinazolin-2-yl]piperazin-1-yl]ethanone
CAS 421566-10-1C20H18BrClN4O
5-[4-(6-Methyl-4-phenylquinazolin-2-yl)piperazin-1-yl]-5-oxopentanoic acid chemical structure, C24H26N4O3, CAS 412919-98-3
5-[4-(6-Methyl-4-phenylquinazolin-2-yl)piperazin-1-yl]-5-oxopentanoic acid
CAS 412919-98-3C24H26N4O3
6-Bromo-4-(2-chloro-phenyl)-2-piperazin-1-yl-quinazoline chemical structure, C18H16BrClN4, CAS 488704-92-3
6-Bromo-4-(2-chloro-phenyl)-2-piperazin-1-yl-quinazoline
CAS 488704-92-3C18H16BrClN4
5-{4-[6-Bromo-4-(2-chlorophenyl)quinazolin-2-yl]piperazin-1-yl}-5-oxopentanoic acid chemical structure, C23H22BrClN4O3, CAS 421566-08-7
5-{4-[6-Bromo-4-(2-chlorophenyl)quinazolin-2-yl]piperazin-1-yl}-5-oxopentanoic acid
CAS 421566-08-7C23H22BrClN4O3
(2Z)-4-[4-(6-Bromo-4-phenylquinazolin-2-yl)piperazin-1-yl]-4-oxobut-2-enoic acid chemical structure, C22H19BrN4O3, CAS 412920-04-8
(2Z)-4-[4-(6-Bromo-4-phenylquinazolin-2-yl)piperazin-1-yl]-4-oxobut-2-enoic acid
CAS 412920-04-8C22H19BrN4O3
6-Methyl-2-(4-pentylpiperazin-1-yl)-4-phenylquinazoline chemical structure, C24H30N4, CAS 300703-96-2
6-Methyl-2-(4-pentylpiperazin-1-yl)-4-phenylquinazoline
CAS 300703-96-2C24H30N4
2-(4-Butylpiperazin-1-yl)-6-methyl-4-phenylquinazoline chemical structure, C23H28N4, CAS 5689-50-9
2-(4-Butylpiperazin-1-yl)-6-methyl-4-phenylquinazoline
CAS 5689-50-9C23H28N4
Ethyl 4-(6-methyl-4-phenylquinazolin-2-yl)piperazine-1-carboxylate chemical structure, C22H24N4O2, CAS 421565-99-3
Ethyl 4-(6-methyl-4-phenylquinazolin-2-yl)piperazine-1-carboxylate
CAS 421565-99-3C22H24N4O2
Quinazoline, 4-(2-chlorophenyl)-2-(4-methyl-1-piperazinyl)-6-nitro- chemical structure, C19H18ClN5O2, CAS 88422-37-1
Quinazoline, 4-(2-chlorophenyl)-2-(4-methyl-1-piperazinyl)-6-nitro-
CAS 88422-37-1C19H18ClN5O2
Quinazoline, 6-chloro-4-(2-chlorophenyl)-2-(4-methyl-1-piperazinyl)-, hydrochloride chemical structure, C19H19Cl3N4, CAS 88422-41-7
Quinazoline, 6-chloro-4-(2-chlorophenyl)-2-(4-methyl-1-piperazinyl)-, hydrochloride
CAS 88422-41-7C19H19Cl3N4
Quinazoline, 6-chloro-4-(2-chlorophenyl)-2-(4-methyl-1-piperazinyl)- chemical structure, C19H18Cl2N4, CAS 88422-46-2
Quinazoline, 6-chloro-4-(2-chlorophenyl)-2-(4-methyl-1-piperazinyl)-
CAS 88422-46-2C19H18Cl2N4
Quinazoline, 6-chloro-4-(2-fluorophenyl)-2-(4-methyl-1-piperazinyl)- chemical structure, C19H18ClFN4, CAS 88422-42-8
Quinazoline, 6-chloro-4-(2-fluorophenyl)-2-(4-methyl-1-piperazinyl)-
CAS 88422-42-8C19H18ClFN4
Quinazoline, 6-chloro-4-(2-fluorophenyl)-2-(1-piperazinyl)-, hydrochloride chemical structure, C18H17Cl2FN4, CAS 88422-44-0
Quinazoline, 6-chloro-4-(2-fluorophenyl)-2-(1-piperazinyl)-, hydrochloride
CAS 88422-44-0C18H17Cl2FN4
Quinazoline, 6-chloro-4-(2-fluorophenyl)-2-(1-piperazinyl)- chemical structure, C18H16ClFN4, CAS 88422-47-3
Quinazoline, 6-chloro-4-(2-fluorophenyl)-2-(1-piperazinyl)-
CAS 88422-47-3C18H16ClFN4