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Murcko scaffold

Ring system with 4 rings and 22 atoms

21 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
21
With full pages
6
Scaffold SMILES

c1ccc(-c2nc(N3CCNCC3)c3ccccc3n2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2nc(N3CCNCC3)c3ccccc3n2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 21 of 21 chemicals

4-(4-Methyl-1-piperazinyl)-2-phenylquinazoline chemical structure, C19H20N4, CAS 143871-26-5
4-(4-Methyl-1-piperazinyl)-2-phenylquinazoline
CAS 143871-26-5C19H20N4
2-(4-Chlorophenyl)-4-(4-methylpiperazin-1-yl)quinazoline chemical structure, C19H19ClN4, CAS 5996-13-4
2-(4-Chlorophenyl)-4-(4-methylpiperazin-1-yl)quinazoline
CAS 5996-13-4C19H19ClN4
4-(4-Ethylpiperazin-1-yl)-2-phenylquinazoline chemical structure, C20H22N4, CAS 385419-24-9
4-(4-Ethylpiperazin-1-yl)-2-phenylquinazoline
CAS 385419-24-9C20H22N4
2-(2-Fluorophenyl)-4-(4-methylpiperazin-1-yl)quinazoline chemical structure, C19H19FN4, CAS 510738-17-7
2-(2-Fluorophenyl)-4-(4-methylpiperazin-1-yl)quinazoline
CAS 510738-17-7C19H19FN4
2-[4-(4-Ethylpiperazin-4-ium-1-yl)quinazolin-2-yl]phenolate chemical structure, C20H22N4O, CAS 433953-35-6
2-[4-(4-Ethylpiperazin-4-ium-1-yl)quinazolin-2-yl]phenolate
CAS 433953-35-6C20H22N4O
4-(4-Methylpiperazin-1-yl)-2-(4-nitrophenyl)quinazoline chemical structure, C19H19N5O2, CAS 442151-97-5
4-(4-Methylpiperazin-1-yl)-2-(4-nitrophenyl)quinazoline
CAS 442151-97-5C19H19N5O2
2-(4-(4-Methylpiperazin-1-yl)quinazolin-2-yl)phenol chemical structure, C19H20N4O, CAS 354993-42-3
2-(4-(4-Methylpiperazin-1-yl)quinazolin-2-yl)phenol
CAS 354993-42-3C19H20N4O
4-(4-Methylpiperazin-1-yl)-2-(3-nitrophenyl)quinazoline chemical structure, C19H19N5O2, CAS 370847-09-9
4-(4-Methylpiperazin-1-yl)-2-(3-nitrophenyl)quinazoline
CAS 370847-09-9C19H19N5O2
2-(4-Chlorophenyl)-4-(4-ethylpiperazin-1-yl)quinazoline chemical structure, C20H21ClN4, CAS 6369-26-2
2-(4-Chlorophenyl)-4-(4-ethylpiperazin-1-yl)quinazoline
CAS 6369-26-2C20H21ClN4
2-(3,4-Dichlorophenyl)-4-(4-methylpiperazin-1-yl)quinazoline chemical structure, C19H18Cl2N4, CAS 354992-36-2
2-(3,4-Dichlorophenyl)-4-(4-methylpiperazin-1-yl)quinazoline
CAS 354992-36-2C19H18Cl2N4
2-[4-(4-Ethyl-piperazin-1-yl)-quinazolin-2-yl]-6-methoxy-phenol chemical structure, C21H24N4O2, CAS 799810-01-8
2-[4-(4-Ethyl-piperazin-1-yl)-quinazolin-2-yl]-6-methoxy-phenol
CAS 799810-01-8C21H24N4O2
4-(4-Methylpiperazin-1-yl)-2-(4-propoxyphenyl)quinazoline chemical structure, C22H26N4O, CAS 381190-29-0
4-(4-Methylpiperazin-1-yl)-2-(4-propoxyphenyl)quinazoline
CAS 381190-29-0C22H26N4O
2-(2-Chlorophenyl)-4-piperazin-1-ylquinazoline chemical structure, C18H17ClN4, CAS 959491-09-9
2-(2-Chlorophenyl)-4-piperazin-1-ylquinazoline
CAS 959491-09-9C18H17ClN4
Bvdv-IN-1 chemical structure, C20H22N4O, CAS 345651-04-9
Bvdv-IN-1
CAS 345651-04-9C20H22N4O
2-(4-(Piperazin-1-yl)quinazolin-2-yl)phenol chemical structure, C18H18N4O, CAS 757983-22-5
2-(4-(Piperazin-1-yl)quinazolin-2-yl)phenol
CAS 757983-22-5C18H18N4O
2-[4-(2-Hydroxymethyl-piperazin-1-yl)-7-methyl-quinazolin-2-yl]-phenol chemical structure, C20H22N4O2, CAS 879274-91-6
2-[4-(2-Hydroxymethyl-piperazin-1-yl)-7-methyl-quinazolin-2-yl]-phenol
CAS 879274-91-6C20H22N4O2
3-Fluoro-2-(7-methyl-4-(piperazin-1-yl)quinazolin-2-yl)phenol chemical structure, C19H19FN4O, CAS 879274-81-4
3-Fluoro-2-(7-methyl-4-(piperazin-1-yl)quinazolin-2-yl)phenol
CAS 879274-81-4C19H19FN4O
2-(6-Fluoro-4-(piperazin-1-yl)quinazolin-2-yl)phenol chemical structure, C18H17FN4O, CAS 879274-76-7
2-(6-Fluoro-4-(piperazin-1-yl)quinazolin-2-yl)phenol
CAS 879274-76-7C18H17FN4O
6-[7-Methyl-4-(1-piperazinyl)-1H-quinazolin-2-ylidene]-1-cyclohexa-2,4-dienone chemical structure, C19H20N4O, CAS 879274-64-3
6-[7-Methyl-4-(1-piperazinyl)-1H-quinazolin-2-ylidene]-1-cyclohexa-2,4-dienone
CAS 879274-64-3C19H20N4O
Hdac-IN-36 chemical structure, C29H39N5O5, CAS 2482992-54-9
Hdac-IN-36
CAS 2482992-54-9C29H39N5O5
mTOR/HDAC6-IN-1 chemical structure, C20H20ClN5O2, CAS 2986747-52-6
mTOR/HDAC6-IN-1
CAS 2986747-52-6C20H20ClN5O2