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Murcko scaffold

Ring system with 3 rings and 27 atoms

25 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 27
Chemicals: 25
With full pages: 5

Scaffold SMILES

O=C(C=Cc1ccccc1)Nc1ccc(S(=O)(=O)Nc2ncccn2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(C=Cc1ccccc1)Nc1ccc(S(=O)(=O)Nc2ncccn2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 25 of 25 chemicals

(E)-3-(4-Fluorophenyl)-N-[4-[(4-methylpyrimidin-2-yl)sulfamoyl]phenyl]prop-2-enamide chemical structure, C20H17FN4O3S, CAS 331983-08-5

(E)-3-(4-Fluorophenyl)-N-[4-[(4-methylpyrimidin-2-yl)sulfamoyl]phenyl]prop-2-enamide

CAS 331983-08-5C₂₀H₁₇FN₄O₃S

(2E)-3-(2-Chlorophenyl)-N-{4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl}prop-2-enamide chemical structure, C21H19ClN4O3S, CAS 332414-46-7

(2E)-3-(2-Chlorophenyl)-N-{4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl}prop-2-enamide

CAS 332414-46-7C₂₁H₁₉ClN₄O₃S

(E)-3-(2-Chlorophenyl)-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]prop-2-enamide chemical structure, C19H15ClN4O3S, CAS 873307-13-2

(E)-3-(2-Chlorophenyl)-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]prop-2-enamide

CAS 873307-13-2C₁₉H₁₅ClN₄O₃S

(2E)-N-{4-[(4,6-Dimethylpyrimidin-2-yl)sulfamoyl]phenyl}-3-phenylprop-2-enamide chemical structure, C21H20N4O3S, CAS 113569-91-8

(2E)-N-{4-[(4,6-Dimethylpyrimidin-2-yl)sulfamoyl]phenyl}-3-phenylprop-2-enamide

CAS 113569-91-8C₂₁H₂₀N₄O₃S

3-(4-Chlorophenyl)-N-(4-((2-pyrimidinylamino)sulfonyl)phenyl)acrylamide chemical structure, C19H15ClN4O3S, CAS 303792-42-9

3-(4-Chlorophenyl)-N-(4-((2-pyrimidinylamino)sulfonyl)phenyl)acrylamide

CAS 303792-42-9C₁₉H₁₅ClN₄O₃S

3-(4-Methylphenyl)-N-{4-[(pyrimidin-2-yl)sulfamoyl]phenyl}prop-2-enamide chemical structure, C20H18N4O3S, CAS 324562-68-7

3-(4-Methylphenyl)-N-{4-[(pyrimidin-2-yl)sulfamoyl]phenyl}prop-2-enamide

CAS 324562-68-7C₂₀H₁₈N₄O₃S

(2E)-N-{4-[(4,6-Dimethylpyrimidin-2-yl)sulfamoyl]phenyl}-3-(4-methylphenyl)prop-2-enamide chemical structure, C22H22N4O3S, CAS 873307-22-3

(2E)-N-{4-[(4,6-Dimethylpyrimidin-2-yl)sulfamoyl]phenyl}-3-(4-methylphenyl)prop-2-enamide

CAS 873307-22-3C₂₂H₂₂N₄O₃S

(2E)-3-(4-Ethoxyphenyl)-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]prop-2-enamide chemical structure, C21H20N4O4S, CAS 384368-66-5

(2E)-3-(4-Ethoxyphenyl)-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]prop-2-enamide

CAS 384368-66-5C₂₁H₂₀N₄O₄S

(2E)-N-{4-[(4,6-Dimethylpyrimidin-2-yl)sulfamoyl]phenyl}-3-(4-ethoxyphenyl)prop-2-enamide chemical structure, C23H24N4O4S, CAS 369392-51-8

(2E)-N-{4-[(4,6-Dimethylpyrimidin-2-yl)sulfamoyl]phenyl}-3-(4-ethoxyphenyl)prop-2-enamide

CAS 369392-51-8C₂₃H₂₄N₄O₄S

(2E)-N-{4-[(4,6-Dimethylpyrimidin-2-yl)sulfamoyl]phenyl}-3-(4-methoxyphenyl)prop-2-enamide chemical structure, C22H22N4O4S, CAS 496032-86-1

(2E)-N-{4-[(4,6-Dimethylpyrimidin-2-yl)sulfamoyl]phenyl}-3-(4-methoxyphenyl)prop-2-enamide

CAS 496032-86-1C₂₂H₂₂N₄O₄S

(E)-3-(4-tert-Butylphenyl)-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]prop-2-enamide chemical structure, C23H24N4O3S, CAS 378773-56-9

(E)-3-(4-tert-Butylphenyl)-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]prop-2-enamide

CAS 378773-56-9C₂₃H₂₄N₄O₃S

(E)-3-(4-tert-Butylphenyl)-N-[4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl]prop-2-enamide chemical structure, C25H28N4O3S, CAS 380592-61-0

(E)-3-(4-tert-Butylphenyl)-N-[4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl]prop-2-enamide

CAS 380592-61-0C₂₅H₂₈N₄O₃S

(2E)-3-(3-Methoxy-4-propoxyphenyl)-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]prop-2-enamide chemical structure, C23H24N4O5S, CAS 6153-67-9

(2E)-3-(3-Methoxy-4-propoxyphenyl)-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]prop-2-enamide

CAS 6153-67-9C₂₃H₂₄N₄O₅S

(2E)-3-(4-Propoxyphenyl)-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]prop-2-enamide chemical structure, C22H22N4O4S, CAS 433956-40-2

(2E)-3-(4-Propoxyphenyl)-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]prop-2-enamide

CAS 433956-40-2C₂₂H₂₂N₄O₄S

(2E)-N-{4-[(4,6-Dimethylpyrimidin-2-yl)sulfamoyl]phenyl}-3-(4-propoxyphenyl)prop-2-enamide chemical structure, C24H26N4O4S, CAS 433694-19-0

(2E)-N-{4-[(4,6-Dimethylpyrimidin-2-yl)sulfamoyl]phenyl}-3-(4-propoxyphenyl)prop-2-enamide

CAS 433694-19-0C₂₄H₂₆N₄O₄S

(E)-N-(4-(N-(4-Methylpyrimidin-2-yl)sulfamoyl)phenyl)-3-(3-nitrophenyl)acrylamide chemical structure, C20H17N5O5S, CAS 349434-24-8

(E)-N-(4-(N-(4-Methylpyrimidin-2-yl)sulfamoyl)phenyl)-3-(3-nitrophenyl)acrylamide

CAS 349434-24-8C₂₀H₁₇N₅O₅S

(2E)-N-{4-[(4-Methylpyrimidin-2-yl)sulfamoyl]phenyl}-3-phenylprop-2-enamide chemical structure, C20H18N4O3S, CAS 109649-40-3

(2E)-N-{4-[(4-Methylpyrimidin-2-yl)sulfamoyl]phenyl}-3-phenylprop-2-enamide

CAS 109649-40-3C₂₀H₁₈N₄O₃S

(E)-3-(4-Chlorophenyl)-2-cyano-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]prop-2-enamide chemical structure, C20H14ClN5O3S, CAS 464196-28-9

(E)-3-(4-Chlorophenyl)-2-cyano-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]prop-2-enamide

CAS 464196-28-9C₂₀H₁₄ClN₅O₃S

(E)-3-(4-Bromophenyl)-N-[4-[(4-methylpyrimidin-2-yl)sulfamoyl]phenyl]prop-2-enamide chemical structure, C20H17BrN4O3S, CAS 543703-87-3

(E)-3-(4-Bromophenyl)-N-[4-[(4-methylpyrimidin-2-yl)sulfamoyl]phenyl]prop-2-enamide

CAS 543703-87-3C₂₀H₁₇BrN₄O₃S

(E)-3-(2-Nitrophenyl)-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]prop-2-enamide chemical structure, C19H15N5O5S, CAS 600123-94-2

(E)-3-(2-Nitrophenyl)-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]prop-2-enamide

CAS 600123-94-2C₁₉H₁₅N₅O₅S

(E)-N-[4-[(4-Methylpyrimidin-2-yl)sulfamoyl]phenyl]-3-(2-nitrophenyl)prop-2-enamide chemical structure, C20H17N5O5S, CAS 600123-76-0

(E)-N-[4-[(4-Methylpyrimidin-2-yl)sulfamoyl]phenyl]-3-(2-nitrophenyl)prop-2-enamide

CAS 600123-76-0C₂₀H₁₇N₅O₅S

(E)-2-Cyano-3-[4-(difluoromethoxy)phenyl]-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]prop-2-enamide chemical structure, C21H15F2N5O4S, CAS 326178-05-6

(E)-2-Cyano-3-[4-(difluoromethoxy)phenyl]-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]prop-2-enamide

CAS 326178-05-6C₂₁H₁₅F₂N₅O₄S

(E)-3-(2,4-Dichlorophenyl)-N-[4-[(4-methylpyrimidin-2-yl)sulfamoyl]phenyl]prop-2-enamide chemical structure, C20H16Cl2N4O3S, CAS 560089-11-4

(E)-3-(2,4-Dichlorophenyl)-N-[4-[(4-methylpyrimidin-2-yl)sulfamoyl]phenyl]prop-2-enamide

CAS 560089-11-4C₂₀H₁₆Cl₂N₄O₃S

(2E)-N-{4-[(4-Methylpyrimidin-2-yl)sulfamoyl]phenyl}-3-(4-nitrophenyl)prop-2-enamide chemical structure, C20H17N5O5S, CAS 476274-58-5

(2E)-N-{4-[(4-Methylpyrimidin-2-yl)sulfamoyl]phenyl}-3-(4-nitrophenyl)prop-2-enamide

CAS 476274-58-5C₂₀H₁₇N₅O₅S

(Z)-2-Cyano-3-phenyl-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]prop-2-enamide
875302-54-8C₂₀H₁₅N₅O₃S