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Murcko scaffold

Ring system with 2 rings and 16 atoms

109 chemicals on CompoundList share this ring system.

Rings: 2
Scaffold atoms: 16
Chemicals: 109
With full pages: 15

Scaffold SMILES

O=C(C=Cc1ccccc1)Nc1nccs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(C=Cc1ccccc1)Nc1nccs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 109 chemicals

(2E)-3-Phenyl-N-(1,3-thiazol-2-yl)prop-2-enamide chemical structure, C12H10N2OS, CAS 300829-00-9

(2E)-3-Phenyl-N-(1,3-thiazol-2-yl)prop-2-enamide

CAS 300829-00-9C₁₂H₁₀N₂OS

Ethyl 2-((2E)-3-phenylprop-2-enoylamino)-4-methyl-1,3-thiazole-5-carboxylate chemical structure, C16H16N2O3S, CAS 1164534-54-6

Ethyl 2-((2E)-3-phenylprop-2-enoylamino)-4-methyl-1,3-thiazole-5-carboxylate

CAS 1164534-54-6C₁₆H₁₆N₂O₃S

(E)-3-(2-Chlorophenyl)-N-(1,3-thiazol-2-yl)prop-2-enamide chemical structure, C12H9ClN2OS, CAS 300825-49-4

(E)-3-(2-Chlorophenyl)-N-(1,3-thiazol-2-yl)prop-2-enamide

CAS 300825-49-4C₁₂H₉ClN₂OS

{2-[3-(4-Methoxy-phenyl)-acryloylamino]-thiazol-4-yl}-acetic acid ethyl ester chemical structure, C17H18N2O4S, CAS 301678-27-3

{2-[3-(4-Methoxy-phenyl)-acryloylamino]-thiazol-4-yl}-acetic acid ethyl ester

CAS 301678-27-3C₁₇H₁₈N₂O₄S

(2E)-2-Cyano-3-(4-methoxyphenyl)-N-(1,3-thiazol-2-yl)prop-2-enamide chemical structure, C14H11N3O2S, CAS 307539-21-5

(2E)-2-Cyano-3-(4-methoxyphenyl)-N-(1,3-thiazol-2-yl)prop-2-enamide

CAS 307539-21-5C₁₄H₁₁N₃O₂S

(2E)-2-Cyano-3-phenyl-N-2-thiazolyl-2-propenamide chemical structure, C13H9N3OS, CAS 1006694-45-6

(2E)-2-Cyano-3-phenyl-N-2-thiazolyl-2-propenamide

CAS 1006694-45-6C₁₃H₉N₃OS

Ethyl (2-{[(2E)-3-phenyl-2-propenoyl]amino}-1,3-thiazol-4-yl)acetate chemical structure, C16H16N2O3S

Ethyl (2-{[(2E)-3-phenyl-2-propenoyl]amino}-1,3-thiazol-4-yl)acetate

C₁₆H₁₆N₂O₃S

(E)-N-(4,5-Dimethylthiazol-2-yl)-3-(2-methoxyphenyl)acrylamide chemical structure, C15H16N2O2S, CAS 685851-27-8

(E)-N-(4,5-Dimethylthiazol-2-yl)-3-(2-methoxyphenyl)acrylamide

CAS 685851-27-8C₁₅H₁₆N₂O₂S

(E)-3-(3,4-Dimethoxyphenyl)-N-(4,5-dimethyl-1,3-thiazol-2-yl)prop-2-enamide chemical structure, C16H18N2O3S, CAS 361159-99-1

(E)-3-(3,4-Dimethoxyphenyl)-N-(4,5-dimethyl-1,3-thiazol-2-yl)prop-2-enamide

CAS 361159-99-1C₁₆H₁₈N₂O₃S

Methyl 2-{[(2E)-3-(4-chlorophenyl)prop-2-enoyl]amino}-4-methyl-1,3-thiazole-5-carboxylate chemical structure, C15H13ClN2O3S, CAS 431886-26-9

Methyl 2-{[(2E)-3-(4-chlorophenyl)prop-2-enoyl]amino}-4-methyl-1,3-thiazole-5-carboxylate

CAS 431886-26-9C₁₅H₁₃ClN₂O₃S

3-(4-tert-Butylphenyl)-N-(4,5-dimethyl-1,3-thiazol-2-yl)acrylamide chemical structure, C18H22N2OS, CAS 544656-85-1

3-(4-tert-Butylphenyl)-N-(4,5-dimethyl-1,3-thiazol-2-yl)acrylamide

CAS 544656-85-1C₁₈H₂₂N₂OS

2-(Cinnamoylamino)-N,N,4-trimethyl-1,3-thiazole-5-carboxamide chemical structure, C16H17N3O2S, CAS 1164564-02-6

2-(Cinnamoylamino)-N,N,4-trimethyl-1,3-thiazole-5-carboxamide

CAS 1164564-02-6C₁₆H₁₇N₃O₂S

2-{[3-(4-Fluorophenyl)acryloyl]amino}-N,N,4-trimethyl-1,3-thiazole-5-carboxamide chemical structure, C16H16FN3O2S, CAS 1164504-60-2

2-{[3-(4-Fluorophenyl)acryloyl]amino}-N,N,4-trimethyl-1,3-thiazole-5-carboxamide

CAS 1164504-60-2C₁₆H₁₆FN₃O₂S

(E)-3-(4-tert-Butylphenyl)-N-(4-methyl-1,3-thiazol-2-yl)prop-2-enamide chemical structure, C17H20N2OS, CAS 545339-49-9

(E)-3-(4-tert-Butylphenyl)-N-(4-methyl-1,3-thiazol-2-yl)prop-2-enamide

CAS 545339-49-9C₁₇H₂₀N₂OS

(E)-3-(2,4-Dichlorophenyl)-N-(4-methyl-1,3-thiazol-2-yl)prop-2-enamide chemical structure, C13H10Cl2N2OS, CAS 353476-15-0

(E)-3-(2,4-Dichlorophenyl)-N-(4-methyl-1,3-thiazol-2-yl)prop-2-enamide

CAS 353476-15-0C₁₃H₁₀Cl₂N₂OS

(E)-3-(4-tert-Butylphenyl)-N-(1,3-thiazol-2-yl)prop-2-enamide chemical structure, C16H18N2OS, CAS 321533-28-2

(E)-3-(4-tert-Butylphenyl)-N-(1,3-thiazol-2-yl)prop-2-enamide

CAS 321533-28-2C₁₆H₁₈N₂OS

(E)-3-(2-Nitrophenyl)-N-(1,3-thiazol-2-yl)prop-2-enamide chemical structure, C12H9N3O3S, CAS 600122-73-4

(E)-3-(2-Nitrophenyl)-N-(1,3-thiazol-2-yl)prop-2-enamide

CAS 600122-73-4C₁₂H₉N₃O₃S

(E)-N-(4-Methyl-1,3-thiazol-2-yl)-3-(2-nitrophenyl)prop-2-enamide chemical structure, C13H11N3O3S, CAS 600124-04-7

(E)-N-(4-Methyl-1,3-thiazol-2-yl)-3-(2-nitrophenyl)prop-2-enamide

CAS 600124-04-7C₁₃H₁₁N₃O₃S

(E)-N-(4,5-Dimethyl-1,3-thiazol-2-yl)-3-(4-methoxyphenyl)prop-2-enamide chemical structure, C15H16N2O2S, CAS 550354-72-8

(E)-N-(4,5-Dimethyl-1,3-thiazol-2-yl)-3-(4-methoxyphenyl)prop-2-enamide

CAS 550354-72-8C₁₅H₁₆N₂O₂S

Ethyl 2-[[(E)-3-(4-fluorophenyl)prop-2-enoyl]amino]-4-methyl-1,3-thiazole-5-carboxylate chemical structure, C16H15FN2O3S, CAS 464910-08-5

Ethyl 2-[[(E)-3-(4-fluorophenyl)prop-2-enoyl]amino]-4-methyl-1,3-thiazole-5-carboxylate

CAS 464910-08-5C₁₆H₁₅FN₂O₃S

2-{[3-(4-Methoxyphenyl)acryloyl]amino}-N,N,4-trimethyl-1,3-thiazole-5-carboxamide chemical structure, C17H19N3O3S, CAS 1164528-79-3

2-{[3-(4-Methoxyphenyl)acryloyl]amino}-N,N,4-trimethyl-1,3-thiazole-5-carboxamide

CAS 1164528-79-3C₁₇H₁₉N₃O₃S

(E)-3-(2,6-Dichlorophenyl)-N-(4,5-dimethyl-1,3-thiazol-2-yl)prop-2-enamide chemical structure, C14H12Cl2N2OS, CAS 550312-53-3

(E)-3-(2,6-Dichlorophenyl)-N-(4,5-dimethyl-1,3-thiazol-2-yl)prop-2-enamide

CAS 550312-53-3C₁₄H₁₂Cl₂N₂OS

SphK1&2-IN-1 chemical structure, C14H14N2O3S, CAS 1415662-57-5

CAS 1415662-57-5C₁₄H₁₄N₂O₃S

(E)-N-(4,5-Dimethyl-1,3-thiazol-2-yl)-3-(4-methylphenyl)prop-2-enamide chemical structure, C15H16N2OS, CAS 560102-52-5

(E)-N-(4,5-Dimethyl-1,3-thiazol-2-yl)-3-(4-methylphenyl)prop-2-enamide

CAS 560102-52-5C₁₅H₁₆N₂OS