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Murcko scaffold

Ring system with 4 rings and 25 atoms

275 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
275
With full pages
26
Scaffold SMILES

O=c1c2ccccc2nc(C=Cc2ccccc2)n1-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1c2ccccc2nc(C=Cc2ccccc2)n1-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 96 of 275 chemicals

2-(4-Isopropylstyryl)-3-(2-methoxyphenyl)quinazolin-4(3H)-one chemical structure, C26H24N2O2, CAS 488813-23-6
2-(4-Isopropylstyryl)-3-(2-methoxyphenyl)quinazolin-4(3H)-one
CAS 488813-23-6C26H24N2O2
3-(2-Chlorophenyl)-2-(2-hydroxystyryl)-6-iodoquinazolin-4(3H)-one chemical structure, C22H14ClIN2O2, CAS 799820-95-4
3-(2-Chlorophenyl)-2-(2-hydroxystyryl)-6-iodoquinazolin-4(3H)-one
CAS 799820-95-4C22H14ClIN2O2
4-(2-[2-(4-Hydroxy-3-methoxy-phenyl)-vinyl]-4-oxo-4H-quinazolin-3-yl)-benzoic acid chemical structure, C24H18N2O5
4-(2-[2-(4-Hydroxy-3-methoxy-phenyl)-vinyl]-4-oxo-4H-quinazolin-3-yl)-benzoic acid
C24H18N2O5
2-(5-Bromo-2-hydroxystyryl)-3-(2,5-dibromophenyl)quinazolin-4(3H)-one chemical structure, C22H13Br3N2O2, CAS 488130-25-2
2-(5-Bromo-2-hydroxystyryl)-3-(2,5-dibromophenyl)quinazolin-4(3H)-one
CAS 488130-25-2C22H13Br3N2O2
2-(2-Hydroxystyryl)-6-iodo-3-(2-methoxyphenyl)quinazolin-4(3H)-one chemical structure, C23H17IN2O3, CAS 799811-23-7
2-(2-Hydroxystyryl)-6-iodo-3-(2-methoxyphenyl)quinazolin-4(3H)-one
CAS 799811-23-7C23H17IN2O3
3-(4-Bromophenyl)-2-(4-hydroxystyryl)-6-iodoquinazolin-4(3H)-one chemical structure, C22H14BrIN2O2, CAS 499210-33-2
3-(4-Bromophenyl)-2-(4-hydroxystyryl)-6-iodoquinazolin-4(3H)-one
CAS 499210-33-2C22H14BrIN2O2
3-(4-Chlorophenyl)-2-{(E)-2-[4-(dimethylamino)phenyl]ethenyl}-6-iodoquinazolin-4(3H)-one chemical structure, C24H19ClIN3O, CAS 96911-46-5
3-(4-Chlorophenyl)-2-{(E)-2-[4-(dimethylamino)phenyl]ethenyl}-6-iodoquinazolin-4(3H)-one
CAS 96911-46-5C24H19ClIN3O
2-[(E)-2-(4-Bromophenyl)ethenyl]-3-(4-nitrophenyl)quinazolin-4-one chemical structure, C22H14BrN3O3, CAS 302601-94-1
2-[(E)-2-(4-Bromophenyl)ethenyl]-3-(4-nitrophenyl)quinazolin-4-one
CAS 302601-94-1C22H14BrN3O3
RefChem:381591 chemical structure, C23H17BrN2O, CAS 5130-75-6
RefChem:381591
CAS 5130-75-6C23H17BrN2O
3-(3-Methylphenyl)-2-[(E)-2-(4-nitrophenyl)ethenyl]quinazolin-4-one chemical structure, C23H17N3O3, CAS 300806-01-3
3-(3-Methylphenyl)-2-[(E)-2-(4-nitrophenyl)ethenyl]quinazolin-4-one
CAS 300806-01-3C23H17N3O3
2-(3-Bromostyryl)-3-phenyl-4(3H)-quinazolinone chemical structure, C22H15BrN2O, CAS 327099-73-0
2-(3-Bromostyryl)-3-phenyl-4(3H)-quinazolinone
CAS 327099-73-0C22H15BrN2O
2-[(E)-2-(2-Fluorophenyl)ethenyl]-3-phenylquinazolin-4(3H)-one chemical structure, C22H15FN2O, CAS 5705-41-9
2-[(E)-2-(2-Fluorophenyl)ethenyl]-3-phenylquinazolin-4(3H)-one
CAS 5705-41-9C22H15FN2O
3-(4-Methoxyphenyl)-2-[(E)-2-phenylethenyl]quinazolin-4-one chemical structure, C23H18N2O2, CAS 115781-70-9
3-(4-Methoxyphenyl)-2-[(E)-2-phenylethenyl]quinazolin-4-one
CAS 115781-70-9C23H18N2O2
2-[(E)-2-(3-Bromophenyl)ethenyl]-3-(4-methoxyphenyl)quinazolin-4-one chemical structure, C23H17BrN2O2, CAS 369602-98-2
2-[(E)-2-(3-Bromophenyl)ethenyl]-3-(4-methoxyphenyl)quinazolin-4-one
CAS 369602-98-2C23H17BrN2O2
3-(3-Methylphenyl)-2-[(E)-2-phenylethenyl]quinazolin-4(3H)-one chemical structure, C23H18N2O, CAS 304872-16-0
3-(3-Methylphenyl)-2-[(E)-2-phenylethenyl]quinazolin-4(3H)-one
CAS 304872-16-0C23H18N2O
2-[(E)-2-(3-Bromophenyl)ethenyl]-3-(3-methylphenyl)quinazolin-4-one chemical structure, C23H17BrN2O, CAS 370074-82-1
2-[(E)-2-(3-Bromophenyl)ethenyl]-3-(3-methylphenyl)quinazolin-4-one
CAS 370074-82-1C23H17BrN2O
2-[(E)-2-(4-Chlorophenyl)ethenyl]-3-(4-methylphenyl)quinazolin-4-one chemical structure, C23H17ClN2O, CAS 1047648-00-9
2-[(E)-2-(4-Chlorophenyl)ethenyl]-3-(4-methylphenyl)quinazolin-4-one
CAS 1047648-00-9C23H17ClN2O
(E)-2-(4-(Dimethylamino)styryl)-3-(p-tolyl)quinazolin-4(3H)-one chemical structure, C25H23N3O, CAS 74115-95-0
(E)-2-(4-(Dimethylamino)styryl)-3-(p-tolyl)quinazolin-4(3H)-one
CAS 74115-95-0C25H23N3O
2-[(E)-2-(4-Bromophenyl)ethenyl]-3-(4-methoxyphenyl)quinazolin-4-one chemical structure, C23H17BrN2O2, CAS 368840-39-5
2-[(E)-2-(4-Bromophenyl)ethenyl]-3-(4-methoxyphenyl)quinazolin-4-one
CAS 368840-39-5C23H17BrN2O2
2-[(E)-2-(4-Chlorophenyl)ethenyl]-3-(4-methoxyphenyl)quinazolin-4-one chemical structure, C23H17ClN2O2, CAS 41466-19-7
2-[(E)-2-(4-Chlorophenyl)ethenyl]-3-(4-methoxyphenyl)quinazolin-4-one
CAS 41466-19-7C23H17ClN2O2
2-{(E)-2-[4-(Dimethylamino)phenyl]ethenyl}-3-(4-methoxyphenyl)quinazolin-4(3H)-one chemical structure, C25H23N3O2, CAS 304877-66-5
2-{(E)-2-[4-(Dimethylamino)phenyl]ethenyl}-3-(4-methoxyphenyl)quinazolin-4(3H)-one
CAS 304877-66-5C25H23N3O2
3-(2-Methylphenyl)-2-[(E)-2-(3-nitrophenyl)ethenyl]quinazolin-4-one chemical structure, C23H17N3O3, CAS 1769-27-3
3-(2-Methylphenyl)-2-[(E)-2-(3-nitrophenyl)ethenyl]quinazolin-4-one
CAS 1769-27-3C23H17N3O3
2-[(E)-2-(3-Bromophenyl)ethenyl]-3-(2-methylphenyl)quinazolin-4-one chemical structure, C23H17BrN2O, CAS 305864-28-2
2-[(E)-2-(3-Bromophenyl)ethenyl]-3-(2-methylphenyl)quinazolin-4-one
CAS 305864-28-2C23H17BrN2O
3-(4-Methylphenyl)-2-[(E)-2-(2-nitrophenyl)ethenyl]quinazolin-4-one chemical structure, C23H17N3O3, CAS 334505-70-3
3-(4-Methylphenyl)-2-[(E)-2-(2-nitrophenyl)ethenyl]quinazolin-4-one
CAS 334505-70-3C23H17N3O3