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Murcko scaffold

Ring system with 3 rings and 20 atoms

123 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
123
With full pages
5
Scaffold SMILES

O=C1SC(=Cc2ccccc2)C(=O)N1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1SC(=Cc2ccccc2)C(=O)N1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 123 chemicals

5-(4-Hydroxy-3-methoxybenzylidene)-3-(4-hydroxyphenyl)-1,3-thiazolidine-2,4-dione chemical structure, C17H13NO5S, CAS 25745-34-0
5-(4-Hydroxy-3-methoxybenzylidene)-3-(4-hydroxyphenyl)-1,3-thiazolidine-2,4-dione
CAS 25745-34-0C17H13NO5S
Methyl 4-{[3-(4-chlorophenyl)-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl}benzoate chemical structure, C18H12ClNO4S, CAS 429625-21-8
Methyl 4-{[3-(4-chlorophenyl)-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl}benzoate
CAS 429625-21-8C18H12ClNO4S
5-(5-Bromo-2,4-dimethoxybenzylidene)-3-(3-chlorophenyl)-1,3-thiazolidine-2,4-dione chemical structure, C18H13BrClNO4S, CAS 428828-11-9
5-(5-Bromo-2,4-dimethoxybenzylidene)-3-(3-chlorophenyl)-1,3-thiazolidine-2,4-dione
CAS 428828-11-9C18H13BrClNO4S
(5Z)-5-[(3-Bromo-4-methoxyphenyl)methylidene]-3-(3-chlorophenyl)-1,3-thiazolidine-2,4-dione chemical structure, C17H11BrClNO3S, CAS 428835-42-1
(5Z)-5-[(3-Bromo-4-methoxyphenyl)methylidene]-3-(3-chlorophenyl)-1,3-thiazolidine-2,4-dione
CAS 428835-42-1C17H11BrClNO3S
3-(3-Chlorophenyl)-5-(2-methoxybenzylidene)-1,3-thiazolidine-2,4-dione chemical structure, C17H12ClNO3S, CAS 428824-08-2
3-(3-Chlorophenyl)-5-(2-methoxybenzylidene)-1,3-thiazolidine-2,4-dione
CAS 428824-08-2C17H12ClNO3S
3-(3-Chlorophenyl)-5-(4-hydroxy-3-iodo-5-methoxybenzylidene)-1,3-thiazolidine-2,4-dione chemical structure, C17H11ClINO4S, CAS 428848-62-8
3-(3-Chlorophenyl)-5-(4-hydroxy-3-iodo-5-methoxybenzylidene)-1,3-thiazolidine-2,4-dione
CAS 428848-62-8C17H11ClINO4S
3-(3-Chlorophenyl)-5-(4-hydroxy-3-methoxy-5-nitrobenzylidene)-1,3-thiazolidine-2,4-dione chemical structure, C17H11ClN2O6S, CAS 428838-70-4
3-(3-Chlorophenyl)-5-(4-hydroxy-3-methoxy-5-nitrobenzylidene)-1,3-thiazolidine-2,4-dione
CAS 428838-70-4C17H11ClN2O6S
(5Z)-3-(3-Chlorophenyl)-5-[(4,5-dimethoxy-2-nitrophenyl)methylidene]-1,3-thiazolidine-2,4-dione chemical structure, C18H13ClN2O6S, CAS 428830-63-1
(5Z)-3-(3-Chlorophenyl)-5-[(4,5-dimethoxy-2-nitrophenyl)methylidene]-1,3-thiazolidine-2,4-dione
CAS 428830-63-1C18H13ClN2O6S
Methyl 4-{[3-(3-chlorophenyl)-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl}benzoate chemical structure, C18H12ClNO4S, CAS 428848-51-5
Methyl 4-{[3-(3-chlorophenyl)-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl}benzoate
CAS 428848-51-5C18H12ClNO4S
5-(3-Bromo-4,5-dimethoxybenzylidene)-3-(3-chlorophenyl)-1,3-thiazolidine-2,4-dione chemical structure, C18H13BrClNO4S, CAS 428838-75-9
5-(3-Bromo-4,5-dimethoxybenzylidene)-3-(3-chlorophenyl)-1,3-thiazolidine-2,4-dione
CAS 428838-75-9C18H13BrClNO4S
3-(3-Chlorophenyl)-5-(2,4-diethoxybenzylidene)-1,3-thiazolidine-2,4-dione chemical structure, C20H18ClNO4S, CAS 428830-21-1
3-(3-Chlorophenyl)-5-(2,4-diethoxybenzylidene)-1,3-thiazolidine-2,4-dione
CAS 428830-21-1C20H18ClNO4S
5-(3-Chloro-5-ethoxy-4-hydroxybenzylidene)-3-(3-chlorophenyl)-1,3-thiazolidine-2,4-dione chemical structure, C18H13Cl2NO4S, CAS 428842-91-5
5-(3-Chloro-5-ethoxy-4-hydroxybenzylidene)-3-(3-chlorophenyl)-1,3-thiazolidine-2,4-dione
CAS 428842-91-5C18H13Cl2NO4S
5-(2-Bromo-4,5-dimethoxybenzylidene)-3-(3-chlorophenyl)-1,3-thiazolidine-2,4-dione chemical structure, C18H13BrClNO4S, CAS 428827-22-9
5-(2-Bromo-4,5-dimethoxybenzylidene)-3-(3-chlorophenyl)-1,3-thiazolidine-2,4-dione
CAS 428827-22-9C18H13BrClNO4S
5-(5-Bromo-3-ethoxy-2-hydroxybenzylidene)-3-(3-chlorophenyl)-1,3-thiazolidine-2,4-dione chemical structure, C18H13BrClNO4S, CAS 428839-39-8
5-(5-Bromo-3-ethoxy-2-hydroxybenzylidene)-3-(3-chlorophenyl)-1,3-thiazolidine-2,4-dione
CAS 428839-39-8C18H13BrClNO4S
5-(3-Chloro-4-methoxybenzylidene)-3-(3-chlorophenyl)-1,3-thiazolidine-2,4-dione chemical structure, C17H11Cl2NO3S, CAS 428845-63-0
5-(3-Chloro-4-methoxybenzylidene)-3-(3-chlorophenyl)-1,3-thiazolidine-2,4-dione
CAS 428845-63-0C17H11Cl2NO3S
5-(5-Bromo-2-methoxybenzylidene)-3-(3-chlorophenyl)-1,3-thiazolidine-2,4-dione chemical structure, C17H11BrClNO3S, CAS 429624-01-1
5-(5-Bromo-2-methoxybenzylidene)-3-(3-chlorophenyl)-1,3-thiazolidine-2,4-dione
CAS 429624-01-1C17H11BrClNO3S
(5-Bromo-4-{[3-(4-chlorophenyl)-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl}-2-methoxyphenoxy)acetic acid chemical structure, C19H13BrClNO6S, CAS 428849-49-4
(5-Bromo-4-{[3-(4-chlorophenyl)-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl}-2-methoxyphenoxy)acetic acid
CAS 428849-49-4C19H13BrClNO6S
5-(5-Bromo-2,4-dimethoxybenzylidene)-3-(4-chlorophenyl)-1,3-thiazolidine-2,4-dione chemical structure, C18H13BrClNO4S, CAS 428823-82-9
5-(5-Bromo-2,4-dimethoxybenzylidene)-3-(4-chlorophenyl)-1,3-thiazolidine-2,4-dione
CAS 428823-82-9C18H13BrClNO4S
3-(4-Chlorophenyl)-5-(3,4,5-trimethoxybenzylidene)-1,3-thiazolidine-2,4-dione chemical structure, C19H16ClNO5S, CAS 428831-55-4
3-(4-Chlorophenyl)-5-(3,4,5-trimethoxybenzylidene)-1,3-thiazolidine-2,4-dione
CAS 428831-55-4C19H16ClNO5S
(5Z)-3-(4-Chlorophenyl)-5-(4,5-dimethoxy-2-nitrobenzylidene)-1,3-thiazolidine-2,4-dione chemical structure, C18H13ClN2O6S, CAS 428505-24-2
(5Z)-3-(4-Chlorophenyl)-5-(4,5-dimethoxy-2-nitrobenzylidene)-1,3-thiazolidine-2,4-dione
CAS 428505-24-2C18H13ClN2O6S
5-(3-Chloro-5-ethoxy-4-hydroxybenzylidene)-3-(4-chlorophenyl)-1,3-thiazolidine-2,4-dione chemical structure, C18H13Cl2NO4S, CAS 428836-87-7
5-(3-Chloro-5-ethoxy-4-hydroxybenzylidene)-3-(4-chlorophenyl)-1,3-thiazolidine-2,4-dione
CAS 428836-87-7C18H13Cl2NO4S
(2-Chloro-4-{(Z)-[3-(4-chlorophenyl)-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl}-6-methoxyphenoxy)acetic acid chemical structure, C19H13Cl2NO6S, CAS 428849-22-3
(2-Chloro-4-{(Z)-[3-(4-chlorophenyl)-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl}-6-methoxyphenoxy)acetic acid
CAS 428849-22-3C19H13Cl2NO6S
5-(5-Bromo-3-ethoxy-2-hydroxybenzylidene)-3-(4-chlorophenyl)-1,3-thiazolidine-2,4-dione chemical structure, C18H13BrClNO4S, CAS 428830-17-5
5-(5-Bromo-3-ethoxy-2-hydroxybenzylidene)-3-(4-chlorophenyl)-1,3-thiazolidine-2,4-dione
CAS 428830-17-5C18H13BrClNO4S
Ethyl (2-chloro-4-{[3-(4-chlorophenyl)-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl}phenoxy)acetate chemical structure, C20H15Cl2NO5S, CAS 428829-34-9
Ethyl (2-chloro-4-{[3-(4-chlorophenyl)-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl}phenoxy)acetate
CAS 428829-34-9C20H15Cl2NO5S