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Murcko scaffold

Ring system with 3 rings and 22 atoms

376 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
376
With full pages
5
Scaffold SMILES

O=C(Nc1ccccc1)C1=CNC(=S)NC1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccc1)C1=CNC(=S)NC1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 289 to 336 of 376 chemicals

N-(2,3-Dimethylphenyl)-4-(4-fluorophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C20H20FN3OS, CAS 373611-15-5
N-(2,3-Dimethylphenyl)-4-(4-fluorophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 373611-15-5C20H20FN3OS
N-(2,3-Dimethylphenyl)-4-(2-fluorophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C20H20FN3OS, CAS 370853-14-8
N-(2,3-Dimethylphenyl)-4-(2-fluorophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 370853-14-8C20H20FN3OS
4-(2-Bromophenyl)-N-(2-ethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C20H20BrN3O2S, CAS 372508-32-2
4-(2-Bromophenyl)-N-(2-ethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 372508-32-2C20H20BrN3O2S
N-(2-Ethoxyphenyl)-4-(2-methoxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C21H23N3O3S, CAS 364620-86-0
N-(2-Ethoxyphenyl)-4-(2-methoxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 364620-86-0C21H23N3O3S
N-(2,5-Dimethylphenyl)-6-methyl-2-thioxo-4-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C23H27N3O4S, CAS 537680-03-8
N-(2,5-Dimethylphenyl)-6-methyl-2-thioxo-4-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 537680-03-8C23H27N3O4S
4-(3-Chlorophenyl)-N-(2,3-dimethylphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C20H20ClN3OS, CAS 373370-53-7
4-(3-Chlorophenyl)-N-(2,3-dimethylphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 373370-53-7C20H20ClN3OS
N-(4-Fluorophenyl)-4-(4-hydroxyphenyl)-6-methyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C18H16FN3O2S, CAS 455927-66-9
N-(4-Fluorophenyl)-4-(4-hydroxyphenyl)-6-methyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 455927-66-9C18H16FN3O2S
6-(3-Bromo-4-ethoxyphenyl)-4-methyl-N-(4-methylphenyl)-2-sulfanyl-1,6-dihydro-5-pyrimidinecarboxamide chemical structure, C21H22BrN3O2S, CAS 591764-72-6
6-(3-Bromo-4-ethoxyphenyl)-4-methyl-N-(4-methylphenyl)-2-sulfanyl-1,6-dihydro-5-pyrimidinecarboxamide
CAS 591764-72-6C21H22BrN3O2S
4-(3,4-Dimethoxyphenyl)-N-(3,5-dimethylphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C22H25N3O3S, CAS 537679-42-8
4-(3,4-Dimethoxyphenyl)-N-(3,5-dimethylphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 537679-42-8C22H25N3O3S
N-(3,4-Dimethylphenyl)-4-(2-fluorophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C20H20FN3OS, CAS 406690-34-4
N-(3,4-Dimethylphenyl)-4-(2-fluorophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 406690-34-4C20H20FN3OS
4-(3-Bromophenyl)-N-(2-ethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C20H20BrN3O2S, CAS 397863-26-2
4-(3-Bromophenyl)-N-(2-ethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 397863-26-2C20H20BrN3O2S
4-(3,4-Dimethoxyphenyl)-N-(2,5-dimethylphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C22H25N3O3S, CAS 537679-99-5
4-(3,4-Dimethoxyphenyl)-N-(2,5-dimethylphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 537679-99-5C22H25N3O3S
4-(3-Bromophenyl)-N-(2,3-dimethylphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C20H20BrN3OS, CAS 374602-22-9
4-(3-Bromophenyl)-N-(2,3-dimethylphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 374602-22-9C20H20BrN3OS
N-(2,3-Dimethylphenyl)-6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C20H21N3OS, CAS 372975-08-1
N-(2,3-Dimethylphenyl)-6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 372975-08-1C20H21N3OS
N-(3,5-Dimethylphenyl)-4-(3-ethoxy-4-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C22H25N3O3S, CAS 537679-75-7
N-(3,5-Dimethylphenyl)-4-(3-ethoxy-4-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 537679-75-7C22H25N3O3S
4-(2,3-Dimethoxyphenyl)-N-(2,3-dimethylphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C22H25N3O3S, CAS 372497-96-6
4-(2,3-Dimethoxyphenyl)-N-(2,3-dimethylphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 372497-96-6C22H25N3O3S
4-(3-Chlorophenyl)-N-(2-ethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C20H20ClN3O2S, CAS 397882-39-2
4-(3-Chlorophenyl)-N-(2-ethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 397882-39-2C20H20ClN3O2S
N-(2-Ethoxyphenyl)-6-methyl-4-phenyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C20H21N3O2S, CAS 372971-31-8
N-(2-Ethoxyphenyl)-6-methyl-4-phenyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 372971-31-8C20H21N3O2S
4-(2-(Hexyloxy)phenyl)-6-methyl-N-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C24H29N3O2S, CAS 439135-68-9
4-(2-(Hexyloxy)phenyl)-6-methyl-N-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 439135-68-9C24H29N3O2S
N-(2,5-Dimethylphenyl)-4-(3-ethoxy-4-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C22H25N3O3S, CAS 537680-33-4
N-(2,5-Dimethylphenyl)-4-(3-ethoxy-4-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 537680-33-4C22H25N3O3S
N-(2,3-Dimethylphenyl)-6-methyl-2-thioxo-4-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C21H23N3OS, CAS 374615-65-3
N-(2,3-Dimethylphenyl)-6-methyl-2-thioxo-4-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 374615-65-3C21H23N3OS
N-(3,4-Dimethylphenyl)-4-(4-ethoxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C22H25N3O2S, CAS 731828-98-1
N-(3,4-Dimethylphenyl)-4-(4-ethoxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 731828-98-1C22H25N3O2S
N-(4-Fluorophenyl)-4-(2-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C19H18FN3O2S, CAS 537679-14-4
N-(4-Fluorophenyl)-4-(2-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 537679-14-4C19H18FN3O2S
4-[4-(Dimethylamino)phenyl]-N-(3,5-dimethylphenyl)-6-methyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C22H26N4OS, CAS 537679-58-6
4-[4-(Dimethylamino)phenyl]-N-(3,5-dimethylphenyl)-6-methyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 537679-58-6C22H26N4OS