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Murcko scaffold

Ring system with 3 rings and 22 atoms

376 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 22
Chemicals: 376
With full pages: 5

Scaffold SMILES

O=C(Nc1ccccc1)C1=CNC(=S)NC1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(Nc1ccccc1)C1=CNC(=S)NC1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 241 to 288 of 376 chemicals

4-(3-Bromo-2-chloro-5-ethoxy-4-hydroxyphenyl)-6-methyl-N-phenyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxamide chemical structure, C20H19BrClN3O3S, CAS 666207-19-8

4-(3-Bromo-2-chloro-5-ethoxy-4-hydroxyphenyl)-6-methyl-N-phenyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxamide

CAS 666207-19-8C₂₀H₁₉BrClN₃O₃S

N-(2-Fluorophenyl)-6-methyl-4-(4-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C18H15FN4O3S, CAS 694463-19-9

N-(2-Fluorophenyl)-6-methyl-4-(4-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

CAS 694463-19-9C₁₈H₁₅FN₄O₃S

4-(3-Bromophenyl)-N-(2-fluorophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C18H15BrFN3OS, CAS 694463-85-9

4-(3-Bromophenyl)-N-(2-fluorophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide

CAS 694463-85-9C₁₈H₁₅BrFN₃OS

N-(2-Fluorophenyl)-6-methyl-4-(3-nitrophenyl)-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C18H15FN4O3S, CAS 694465-69-5

N-(2-Fluorophenyl)-6-methyl-4-(3-nitrophenyl)-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide

CAS 694465-69-5C₁₈H₁₅FN₄O₃S

4-(3,4-Dimethoxyphenyl)-N-(2-fluorophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C20H20FN3O3S, CAS 694466-10-9

4-(3,4-Dimethoxyphenyl)-N-(2-fluorophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide

CAS 694466-10-9C₂₀H₂₀FN₃O₃S

N-(2-Fluorophenyl)-4-(2-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C19H18FN3O2S, CAS 694467-13-5

N-(2-Fluorophenyl)-4-(2-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

CAS 694467-13-5C₁₉H₁₈FN₃O₂S

4-(2,5-Dimethoxyphenyl)-N-(2-fluorophenyl)-6-methyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C20H20FN3O3S, CAS 713096-25-4

4-(2,5-Dimethoxyphenyl)-N-(2-fluorophenyl)-6-methyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxamide

CAS 713096-25-4C₂₀H₂₀FN₃O₃S

4-(2-Bromophenyl)-N-(2-fluorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C18H15BrFN3OS, CAS 694472-73-6

4-(2-Bromophenyl)-N-(2-fluorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

CAS 694472-73-6C₁₈H₁₅BrFN₃OS

4-(4-Ethoxyphenyl)-N-(2-fluorophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C20H20FN3O2S, CAS 694476-71-6

4-(4-Ethoxyphenyl)-N-(2-fluorophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide

CAS 694476-71-6C₂₀H₂₀FN₃O₂S

4-(4-Chlorophenyl)-N-(3,5-dimethylphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C20H20ClN3OS, CAS 459199-16-7

4-(4-Chlorophenyl)-N-(3,5-dimethylphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

CAS 459199-16-7C₂₀H₂₀ClN₃OS

N-(3,5-Dimethylphenyl)-4-(4-ethoxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C22H25N3O2S, CAS 537679-90-6

N-(3,5-Dimethylphenyl)-4-(4-ethoxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide

CAS 537679-90-6C₂₂H₂₅N₃O₂S

4-(2-Bromophenyl)-N-(4-fluorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C18H15BrFN3OS, CAS 537679-02-0

4-(2-Bromophenyl)-N-(4-fluorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

CAS 537679-02-0C₁₈H₁₅BrFN₃OS

N-(3,5-Dimethylphenyl)-6-methyl-4-(3-nitrophenyl)-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C20H20N4O3S, CAS 537679-44-0

N-(3,5-Dimethylphenyl)-6-methyl-4-(3-nitrophenyl)-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide

CAS 537679-44-0C₂₀H₂₀N₄O₃S

N-(3,5-Dimethylphenyl)-4-(2-methoxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C21H23N3O2S, CAS 537679-70-2

N-(3,5-Dimethylphenyl)-4-(2-methoxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide

CAS 537679-70-2C₂₁H₂₃N₃O₂S

4-(4-Bromophenyl)-N-(3,5-dimethylphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C20H20BrN3OS, CAS 537679-66-6

4-(4-Bromophenyl)-N-(3,5-dimethylphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide

CAS 537679-66-6C₂₀H₂₀BrN₃OS

4-(3-Ethoxy-4-hydroxyphenyl)-N-(4-fluorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C20H20FN3O3S, CAS 537679-21-3

4-(3-Ethoxy-4-hydroxyphenyl)-N-(4-fluorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

CAS 537679-21-3C₂₀H₂₀FN₃O₃S

N-(3,5-Dimethylphenyl)-4-(2-fluorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C20H20FN3OS, CAS 537679-54-2

N-(3,5-Dimethylphenyl)-4-(2-fluorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

CAS 537679-54-2C₂₀H₂₀FN₃OS

4-(2-Bromophenyl)-N-(3,5-dimethylphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C20H20BrN3OS, CAS 537679-62-2

4-(2-Bromophenyl)-N-(3,5-dimethylphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

CAS 537679-62-2C₂₀H₂₀BrN₃OS

N-(3,5-Dimethylphenyl)-6-methyl-4-(4-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C20H20N4O3S, CAS 537679-50-8

N-(3,5-Dimethylphenyl)-6-methyl-4-(4-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

CAS 537679-50-8C₂₀H₂₀N₄O₃S

4-(4-Acetamidophenyl)-N-(3,4-dimethylphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C22H24N4O2S, CAS 713104-08-6

4-(4-Acetamidophenyl)-N-(3,4-dimethylphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide

CAS 713104-08-6C₂₂H₂₄N₄O₂S

N-(2,4-Dimethylphenyl)-4-(3-fluorophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C20H20FN3OS, CAS 695198-05-1

N-(2,4-Dimethylphenyl)-4-(3-fluorophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide

CAS 695198-05-1C₂₀H₂₀FN₃OS

N-(4-Bromophenyl)-6-methyl-4-phenyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C18H16BrN3OS, CAS 331272-69-6

N-(4-Bromophenyl)-6-methyl-4-phenyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide

CAS 331272-69-6C₁₈H₁₆BrN₃OS

4-(3,4-Dimethoxyphenyl)-6-methyl-N-(3-methylphenyl)-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C21H23N3O3S, CAS 331676-26-7

4-(3,4-Dimethoxyphenyl)-6-methyl-N-(3-methylphenyl)-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide

CAS 331676-26-7C₂₁H₂₃N₃O₃S

4-(3,4-Dimethoxyphenyl)-6-methyl-2-thioxo-N-(o-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C21H23N3O3S, CAS 313970-22-8

4-(3,4-Dimethoxyphenyl)-6-methyl-2-thioxo-N-(o-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide

CAS 313970-22-8C₂₁H₂₃N₃O₃S