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Murcko scaffold

Ring system with 3 rings and 23 atoms

137 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
23
Chemicals
137
With full pages
3
Scaffold SMILES

O=S(=O)(NCCc1cnc(-c2ccccc2)s1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=S(=O)(NCCc1cnc(-c2ccccc2)s1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 137 chemicals

N-[2-[2-(3,4-Dimethoxyphenyl)-4-methyl-1,3-thiazol-5-yl]ethyl]-2,5-dimethoxybenzenesulfonamide chemical structure, C22H26N2O6S2, CAS 873010-68-5
N-[2-[2-(3,4-Dimethoxyphenyl)-4-methyl-1,3-thiazol-5-yl]ethyl]-2,5-dimethoxybenzenesulfonamide
CAS 873010-68-5C22H26N2O6S2
4-Fluoro-N-[2-[4-methyl-2-(3-methylphenyl)-1,3-thiazol-5-yl]ethyl]-3-(trifluoromethyl)benzenesulfonamide chemical structure, C20H18F4N2O2S2, CAS 873010-41-4
4-Fluoro-N-[2-[4-methyl-2-(3-methylphenyl)-1,3-thiazol-5-yl]ethyl]-3-(trifluoromethyl)benzenesulfonamide
CAS 873010-41-4C20H18F4N2O2S2
4-Fluoro-N-(2-(4-methyl-2-(m-tolyl)thiazol-5-yl)ethyl)benzenesulfonamide chemical structure, C19H19FN2O2S2, CAS 869069-96-5
4-Fluoro-N-(2-(4-methyl-2-(m-tolyl)thiazol-5-yl)ethyl)benzenesulfonamide
CAS 869069-96-5C19H19FN2O2S2
N-[2-[2-(4-Methoxyphenyl)-4-methyl-1,3-thiazol-5-yl]ethyl]-3,4-dimethylbenzenesulfonamide chemical structure, C21H24N2O3S2, CAS 869069-85-2
N-[2-[2-(4-Methoxyphenyl)-4-methyl-1,3-thiazol-5-yl]ethyl]-3,4-dimethylbenzenesulfonamide
CAS 869069-85-2C21H24N2O3S2
4-Fluoro-N-[2-[2-(4-methoxyphenyl)-4-methyl-1,3-thiazol-5-yl]ethyl]benzenesulfonamide chemical structure, C19H19FN2O3S2, CAS 869069-88-5
4-Fluoro-N-[2-[2-(4-methoxyphenyl)-4-methyl-1,3-thiazol-5-yl]ethyl]benzenesulfonamide
CAS 869069-88-5C19H19FN2O3S2
2-Fluoro-N-[2-[2-(4-methoxyphenyl)-4-methyl-1,3-thiazol-5-yl]ethyl]benzenesulfonamide chemical structure, C19H19FN2O3S2, CAS 869069-92-1
2-Fluoro-N-[2-[2-(4-methoxyphenyl)-4-methyl-1,3-thiazol-5-yl]ethyl]benzenesulfonamide
CAS 869069-92-1C19H19FN2O3S2
N-[2-[4-Methyl-2-(3-methylphenyl)-1,3-thiazol-5-yl]ethyl]-3-nitrobenzenesulfonamide chemical structure, C19H19N3O4S2, CAS 869069-94-3
N-[2-[4-Methyl-2-(3-methylphenyl)-1,3-thiazol-5-yl]ethyl]-3-nitrobenzenesulfonamide
CAS 869069-94-3C19H19N3O4S2
3-Fluoro-4-methoxy-N-[2-[4-methyl-2-(4-methylphenyl)-1,3-thiazol-5-yl]ethyl]benzenesulfonamide chemical structure, C20H21FN2O3S2, CAS 893349-29-6
3-Fluoro-4-methoxy-N-[2-[4-methyl-2-(4-methylphenyl)-1,3-thiazol-5-yl]ethyl]benzenesulfonamide
CAS 893349-29-6C20H21FN2O3S2
4-Methoxy-N-[2-[4-methyl-2-(4-methylphenyl)-1,3-thiazol-5-yl]ethyl]benzenesulfonamide chemical structure, C20H22N2O3S2, CAS 893349-60-5
4-Methoxy-N-[2-[4-methyl-2-(4-methylphenyl)-1,3-thiazol-5-yl]ethyl]benzenesulfonamide
CAS 893349-60-5C20H22N2O3S2
2,5-Difluoro-N-[2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]benzenesulfonamide chemical structure, C18H16F2N2O2S2, CAS 894014-84-7
2,5-Difluoro-N-[2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]benzenesulfonamide
CAS 894014-84-7C18H16F2N2O2S2
3,4-Dimethyl-N-[2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]benzenesulfonamide chemical structure, C20H22N2O2S2, CAS 894014-91-6
3,4-Dimethyl-N-[2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]benzenesulfonamide
CAS 894014-91-6C20H22N2O2S2
4-Chloro-N-[2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]benzenesulfonamide chemical structure, C18H17ClN2O2S2, CAS 894014-98-3
4-Chloro-N-[2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]benzenesulfonamide
CAS 894014-98-3C18H17ClN2O2S2
4-Fluoro-N-(2-(4-methyl-2-phenylthiazol-5-yl)ethyl)benzenesulfonamide chemical structure, C18H17FN2O2S2, CAS 894015-05-5
4-Fluoro-N-(2-(4-methyl-2-phenylthiazol-5-yl)ethyl)benzenesulfonamide
CAS 894015-05-5C18H17FN2O2S2
2,4,6-Trimethyl-N-[2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]benzenesulfonamide chemical structure, C21H24N2O2S2, CAS 894015-11-3
2,4,6-Trimethyl-N-[2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]benzenesulfonamide
CAS 894015-11-3C21H24N2O2S2
4-Methyl-N-[2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]benzenesulfonamide chemical structure, C19H20N2O2S2, CAS 894015-23-7
4-Methyl-N-[2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]benzenesulfonamide
CAS 894015-23-7C19H20N2O2S2
4-Ethoxy-N-(2-(4-methyl-2-phenylthiazol-5-yl)ethyl)benzenesulfonamide chemical structure, C20H22N2O3S2, CAS 894015-36-2
4-Ethoxy-N-(2-(4-methyl-2-phenylthiazol-5-yl)ethyl)benzenesulfonamide
CAS 894015-36-2C20H22N2O3S2
4-Methoxy-3-methyl-N-[2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]benzenesulfonamide chemical structure, C20H22N2O3S2, CAS 894015-42-0
4-Methoxy-3-methyl-N-[2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]benzenesulfonamide
CAS 894015-42-0C20H22N2O3S2
2-Fluoro-N-[2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]benzenesulfonamide chemical structure, C18H17FN2O2S2, CAS 894015-48-6
2-Fluoro-N-[2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)ethyl]benzenesulfonamide
CAS 894015-48-6C18H17FN2O2S2
4-Methoxy-N-[2-[2-(4-methoxyphenyl)-4-methyl-1,3-thiazol-5-yl]ethyl]benzenesulfonamide chemical structure, C20H22N2O4S2, CAS 873010-15-2
4-Methoxy-N-[2-[2-(4-methoxyphenyl)-4-methyl-1,3-thiazol-5-yl]ethyl]benzenesulfonamide
CAS 873010-15-2C20H22N2O4S2
N-[2-[2-(4-Methoxyphenyl)-4-methyl-1,3-thiazol-5-yl]ethyl]-4-methylbenzenesulfonamide chemical structure, C20H22N2O3S2, CAS 873010-19-6
N-[2-[2-(4-Methoxyphenyl)-4-methyl-1,3-thiazol-5-yl]ethyl]-4-methylbenzenesulfonamide
CAS 873010-19-6C20H22N2O3S2
4-Ethyl-N-[2-[2-(4-methoxyphenyl)-4-methyl-1,3-thiazol-5-yl]ethyl]benzenesulfonamide chemical structure, C21H24N2O3S2, CAS 873010-25-4
4-Ethyl-N-[2-[2-(4-methoxyphenyl)-4-methyl-1,3-thiazol-5-yl]ethyl]benzenesulfonamide
CAS 873010-25-4C21H24N2O3S2
2,5-Difluoro-N-[2-[4-methyl-2-(3-methylphenyl)-1,3-thiazol-5-yl]ethyl]benzenesulfonamide chemical structure, C19H18F2N2O2S2, CAS 873010-29-8
2,5-Difluoro-N-[2-[4-methyl-2-(3-methylphenyl)-1,3-thiazol-5-yl]ethyl]benzenesulfonamide
CAS 873010-29-8C19H18F2N2O2S2
3-Fluoro-4-methoxy-N-[2-[4-methyl-2-(3-methylphenyl)-1,3-thiazol-5-yl]ethyl]benzenesulfonamide chemical structure, C20H21FN2O3S2, CAS 873010-30-1
3-Fluoro-4-methoxy-N-[2-[4-methyl-2-(3-methylphenyl)-1,3-thiazol-5-yl]ethyl]benzenesulfonamide
CAS 873010-30-1C20H21FN2O3S2
2,4,5-Trimethyl-N-[2-[4-methyl-2-(3-methylphenyl)-1,3-thiazol-5-yl]ethyl]benzenesulfonamide chemical structure, C22H26N2O2S2, CAS 873010-32-3
2,4,5-Trimethyl-N-[2-[4-methyl-2-(3-methylphenyl)-1,3-thiazol-5-yl]ethyl]benzenesulfonamide
CAS 873010-32-3C22H26N2O2S2