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Murcko scaffold

3,6-Dibenzyl-2,5-dioxopiperazine scaffold

15 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
15
With full pages
5
Scaffold SMILES

O=C1NC(Cc2ccccc2)C(=O)NC1Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 3,6-Dibenzyl-2,5-dioxopiperazine page
Murcko scaffold O=C1NC(Cc2ccccc2)C(=O)NC1Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 15 of 15 chemicals

3,6-Dibenzyl-2,5-dioxopiperazine chemical structure, C18H18N2O2, CAS 2308-61-4
3,6-Dibenzyl-2,5-dioxopiperazine
CAS 2308-61-4C18H18N2O2
Cyclo(phenylalanylphenylalanine) chemical structure, C18H18N2O2, CAS 2862-51-3
Cyclo(phenylalanylphenylalanine)
CAS 2862-51-3C18H18N2O2
3,6-Bis((4-hydroxyphenyl)methyl)-2,5-piperazinedione chemical structure, C18H18N2O4, CAS 5625-40-1
3,6-Bis((4-hydroxyphenyl)methyl)-2,5-piperazinedione
CAS 5625-40-1C18H18N2O4
(3R,6R)-3,6-Dibenzylpiperazine-2,5-dione chemical structure, C18H18N2O2, CAS 1021171-64-1
(3R,6R)-3,6-Dibenzylpiperazine-2,5-dione
CAS 1021171-64-1C18H18N2O2
(3R,6S)-3,6-Dibenzylpiperazine-2,5-dione chemical structure, C18H18N2O2, CAS 15136-18-2
(3R,6S)-3,6-Dibenzylpiperazine-2,5-dione
CAS 15136-18-2C18H18N2O2
(3R,6S)-1,4-Diacetyl-3,6-dibenzylpiperazine-2,5-dione chemical structure, C22H22N2O4, CAS 94514-47-3
(3R,6S)-1,4-Diacetyl-3,6-dibenzylpiperazine-2,5-dione
CAS 94514-47-3C22H22N2O4
1,4-Diacetyl-3,6-dibenzylpiperazine-2,5-dione chemical structure, C22H22N2O4, CAS 59552-68-0
1,4-Diacetyl-3,6-dibenzylpiperazine-2,5-dione
CAS 59552-68-0C22H22N2O4
Cyclobis(N-methylphenylalanine) chemical structure, C20H22N2O2, CAS 61125-52-8
Cyclobis(N-methylphenylalanine)
CAS 61125-52-8C20H22N2O2
(3S,6S)-3,6-Bis(4-hydroxybenzyl)piperazine-2,5-dione chemical structure, C18H18N2O4, CAS 10125-11-8
(3S,6S)-3,6-Bis(4-hydroxybenzyl)piperazine-2,5-dione
CAS 10125-11-8C18H18N2O4
(3R,6S)-3,6-Dibenzyl-1,4-dimethylpiperazine-2,5-dione chemical structure, C20H22N2O2, CAS 61139-44-4
(3R,6S)-3,6-Dibenzyl-1,4-dimethylpiperazine-2,5-dione
CAS 61139-44-4C20H22N2O2
3-Benzyl-6-((4-hydroxyphenyl)methyl)piperazine-2,5-dione chemical structure, C18H18N2O3, CAS 5147-17-1
3-Benzyl-6-((4-hydroxyphenyl)methyl)piperazine-2,5-dione
CAS 5147-17-1C18H18N2O3
(3R,6R)-3,6-Bis(4-hydroxybenzyl)piperazine-2,5-dione chemical structure, C18H18N2O4, CAS 1445324-30-0
(3R,6R)-3,6-Bis(4-hydroxybenzyl)piperazine-2,5-dione
CAS 1445324-30-0C18H18N2O4
(3R,6S)-3,6-Bis[(4-hydroxyphenyl)methyl]piperazine-2,5-dione chemical structure, C18H18N2O4, CAS 1445324-27-5
(3R,6S)-3,6-Bis[(4-hydroxyphenyl)methyl]piperazine-2,5-dione
CAS 1445324-27-5C18H18N2O4
3,6-Bis[(4-aminophenyl)methyl]piperazine-2,5-dione chemical structure, C18H20N4O2, CAS 63808-86-6
3,6-Bis[(4-aminophenyl)methyl]piperazine-2,5-dione
CAS 63808-86-6C18H20N4O2
3,6-Bis[(2-chlorophenyl)methyl]piperazine-2,5-dione chemical structure, C18H16Cl2N2O2, CAS 7763-25-9
3,6-Bis[(2-chlorophenyl)methyl]piperazine-2,5-dione
CAS 7763-25-9C18H16Cl2N2O2