Murcko scaffold
Ring system with 3 rings and 23 atoms
138 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 23
- Chemicals
- 138
- With full pages
- 4
Scaffold SMILES
O=C(Nc1ccc(C(=O)Nc2ccccc2)s1)c1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 138 chemicals
![Ethyl 2-[(4-chlorobenzoyl)amino]-5-[(4-ethoxycarbonylphenyl)carbamoyl]-4-methylthiophene-3-carboxylate chemical structure, C25H23ClN2O6S, CAS 312586-18-8](/s/SPIBWHWXUWPDOZ-UHFFFAOYSA-N.svg)
Ethyl 2-[(4-chlorobenzoyl)amino]-5-[(4-ethoxycarbonylphenyl)carbamoyl]-4-methylthiophene-3-carboxylate
CAS 312586-18-8C25H23ClN2O6S
![Ethyl 5-[(4-ethoxycarbonylphenyl)carbamoyl]-2-[(2-fluorobenzoyl)amino]-4-methylthiophene-3-carboxylate chemical structure, C25H23FN2O6S, CAS 312586-25-7](/s/JKZMQJLYLANAQT-UHFFFAOYSA-N.svg)
Ethyl 5-[(4-ethoxycarbonylphenyl)carbamoyl]-2-[(2-fluorobenzoyl)amino]-4-methylthiophene-3-carboxylate
CAS 312586-25-7C25H23FN2O6S
![Ethyl 2-[(3-chlorobenzoyl)amino]-4-methyl-5-(2-toluidinocarbonyl)-3-thiophenecarboxylate chemical structure, C23H21ClN2O4S, CAS 312587-33-0](/s/JVWOWSCVJIUAJU-UHFFFAOYSA-N.svg)
Ethyl 2-[(3-chlorobenzoyl)amino]-4-methyl-5-(2-toluidinocarbonyl)-3-thiophenecarboxylate
CAS 312587-33-0C23H21ClN2O4S
![Isopropyl 2-[(3-fluorobenzoyl)amino]-5-[(2-methoxyanilino)carbonyl]-4-methyl-3-thiophenecarboxylate chemical structure, C24H23FN2O5S, CAS 445029-50-5](/s/KXRSUSBZAHQBBV-UHFFFAOYSA-N.svg)
Isopropyl 2-[(3-fluorobenzoyl)amino]-5-[(2-methoxyanilino)carbonyl]-4-methyl-3-thiophenecarboxylate
CAS 445029-50-5C24H23FN2O5S
![Ethyl 2-[(2-methoxybenzoyl)amino]-4-methyl-5-[(2-methylphenyl)carbamoyl]thiophene-3-carboxylate chemical structure, C24H24N2O5S, CAS 445029-81-2](/s/OHMFTXFAOVHEEF-UHFFFAOYSA-N.svg)
Ethyl 2-[(2-methoxybenzoyl)amino]-4-methyl-5-[(2-methylphenyl)carbamoyl]thiophene-3-carboxylate
CAS 445029-81-2C24H24N2O5S
Ethyl 2-(benzoylamino)-4-methyl-5-(4-toluidinocarbonyl)-3-thiophenecarboxylate
CAS 303141-28-8C23H22N2O4S
![Ethyl 2-{[(2-chlorophenyl)carbonyl]amino}-4-methyl-5-(phenylcarbamoyl)thiophene-3-carboxylate chemical structure, C22H19ClN2O4S, CAS 296244-50-3](/s/VDFYYVKLJQXMLM-UHFFFAOYSA-N.svg)
Ethyl 2-{[(2-chlorophenyl)carbonyl]amino}-4-methyl-5-(phenylcarbamoyl)thiophene-3-carboxylate
CAS 296244-50-3C22H19ClN2O4S
Methyl 2-benzamido-4-methyl-5-(phenylcarbamoyl)thiophene-3-carboxylate
CAS 444998-17-8C21H18N2O4S
![Methyl 5-[(4-methoxyphenyl)carbamoyl]-4-methyl-2-[(2-methylbenzoyl)amino]thiophene-3-carboxylate chemical structure, C23H22N2O5S, CAS 444998-68-9](/s/OBXRGBDOJZVQHK-UHFFFAOYSA-N.svg)
Methyl 5-[(4-methoxyphenyl)carbamoyl]-4-methyl-2-[(2-methylbenzoyl)amino]thiophene-3-carboxylate
CAS 444998-68-9C23H22N2O5S
![Ethyl 5-[(3-chloroanilino)carbonyl]-2-[(2-fluorobenzoyl)amino]-4-methyl-3-thiophenecarboxylate chemical structure, C22H18ClFN2O4S, CAS 314025-54-2](/s/XHYNKEHIBPJYBW-UHFFFAOYSA-N.svg)
Ethyl 5-[(3-chloroanilino)carbonyl]-2-[(2-fluorobenzoyl)amino]-4-methyl-3-thiophenecarboxylate
CAS 314025-54-2C22H18ClFN2O4S
Methyl 2-((5-chloro-2-methoxybenzoyl)amino)-5-(((2-methoxyphenyl)amino)carbonyl)-4-methyl-3-thiophenecarboxylate
CAS 444999-99-9C23H21ClN2O6S
![Methyl 2-[(2-methoxybenzoyl)amino]-5-[(4-methoxyphenyl)carbamoyl]-4-methylthiophene-3-carboxylate chemical structure, C23H22N2O6S, CAS 445000-63-5](/s/WHUZWFAIKGXHNF-UHFFFAOYSA-N.svg)
Methyl 2-[(2-methoxybenzoyl)amino]-5-[(4-methoxyphenyl)carbamoyl]-4-methylthiophene-3-carboxylate
CAS 445000-63-5C23H22N2O6S
![Ethyl 2-[(3,4-dimethoxybenzoyl)amino]-5-[(2,4-dimethylanilino)carbonyl]-4-methyl-3-thiophenecarboxylate chemical structure, C26H28N2O6S, CAS 347351-99-9](/s/WBGNELRJVDFVEO-UHFFFAOYSA-N.svg)
Ethyl 2-[(3,4-dimethoxybenzoyl)amino]-5-[(2,4-dimethylanilino)carbonyl]-4-methyl-3-thiophenecarboxylate
CAS 347351-99-9C26H28N2O6S
![Ethyl 5-[(2,4-dimethylanilino)carbonyl]-2-[(2-methoxybenzoyl)amino]-4-methyl-3-thiophenecarboxylate chemical structure, C25H26N2O5S, CAS 347352-39-0](/s/RQNLRZMGWCIPNH-UHFFFAOYSA-N.svg)
Ethyl 5-[(2,4-dimethylanilino)carbonyl]-2-[(2-methoxybenzoyl)amino]-4-methyl-3-thiophenecarboxylate
CAS 347352-39-0C25H26N2O5S
![Ethyl 5-[(2-fluoroanilino)carbonyl]-2-[(2-methoxybenzoyl)amino]-4-methyl-3-thiophenecarboxylate chemical structure, C23H21FN2O5S, CAS 347352-99-2](/s/YWSCAEPHLMXICH-UHFFFAOYSA-N.svg)
Ethyl 5-[(2-fluoroanilino)carbonyl]-2-[(2-methoxybenzoyl)amino]-4-methyl-3-thiophenecarboxylate
CAS 347352-99-2C23H21FN2O5S
![Ethyl 2-[(2-chlorobenzoyl)amino]-5-[(2-ethoxyanilino)carbonyl]-4-methylthiophene-3-carboxylate chemical structure, C24H23ClN2O5S, CAS 346714-33-8](/s/CUDXORYDFIFKAL-UHFFFAOYSA-N.svg)
Ethyl 2-[(2-chlorobenzoyl)amino]-5-[(2-ethoxyanilino)carbonyl]-4-methylthiophene-3-carboxylate
CAS 346714-33-8C24H23ClN2O5S
![Ethyl 5-(anilinocarbonyl)-2-[(4-bromobenzoyl)amino]-4-methyl-3-thiophenecarboxylate chemical structure, C22H19BrN2O4S, CAS 303139-45-9](/s/SDQRZWPRYPPWSB-UHFFFAOYSA-N.svg)
Ethyl 5-(anilinocarbonyl)-2-[(4-bromobenzoyl)amino]-4-methyl-3-thiophenecarboxylate
CAS 303139-45-9C22H19BrN2O4S
![Methyl 2-[(4-fluorobenzoyl)amino]-5-[(2-methoxyphenyl)carbamoyl]-4-methylthiophene-3-carboxylate chemical structure, C22H19FN2O5S, CAS 333308-70-6](/s/GWYBZSRZSNIJRV-UHFFFAOYSA-N.svg)
Methyl 2-[(4-fluorobenzoyl)amino]-5-[(2-methoxyphenyl)carbamoyl]-4-methylthiophene-3-carboxylate
CAS 333308-70-6C22H19FN2O5S
![Ethyl 5-[(3-chloroanilino)carbonyl]-4-methyl-2-[(4-methylbenzoyl)amino]-3-thiophenecarboxylate chemical structure, C23H21ClN2O4S, CAS 303137-19-1](/s/BQOZXCDTIQOVKR-UHFFFAOYSA-N.svg)
Ethyl 5-[(3-chloroanilino)carbonyl]-4-methyl-2-[(4-methylbenzoyl)amino]-3-thiophenecarboxylate
CAS 303137-19-1C23H21ClN2O4S
![Ethyl 2-{[(4-chlorophenyl)carbonyl]amino}-5-[(3-methoxyphenyl)carbamoyl]-4-methylthiophene-3-carboxylate chemical structure, C23H21ClN2O5S, CAS 312587-51-2](/s/XVBFHOMQZKOVBQ-UHFFFAOYSA-N.svg)
Ethyl 2-{[(4-chlorophenyl)carbonyl]amino}-5-[(3-methoxyphenyl)carbamoyl]-4-methylthiophene-3-carboxylate
CAS 312587-51-2C23H21ClN2O5S
![Ethyl 2-{[(4-fluorophenyl)carbonyl]amino}-5-[(3-methoxyphenyl)carbamoyl]-4-methylthiophene-3-carboxylate chemical structure, C23H21FN2O5S, CAS 346713-45-9](/s/LXKQNLFUZMNROG-UHFFFAOYSA-N.svg)
Ethyl 2-{[(4-fluorophenyl)carbonyl]amino}-5-[(3-methoxyphenyl)carbamoyl]-4-methylthiophene-3-carboxylate
CAS 346713-45-9C23H21FN2O5S
![Ethyl 2-{[(2-fluorophenyl)carbonyl]amino}-5-[(2-methoxyphenyl)carbamoyl]-4-methylthiophene-3-carboxylate chemical structure, C23H21FN2O5S, CAS 297158-17-9](/s/UPWLIWLJDCNKNT-UHFFFAOYSA-N.svg)
Ethyl 2-{[(2-fluorophenyl)carbonyl]amino}-5-[(2-methoxyphenyl)carbamoyl]-4-methylthiophene-3-carboxylate
CAS 297158-17-9C23H21FN2O5S
![Ethyl 4-methyl-5-(phenylcarbamoyl)-2-{[(3,4,5-trimethoxyphenyl)carbonyl]amino}thiophene-3-carboxylate chemical structure, C25H26N2O7S, CAS 333774-49-5](/s/OSHCEUPHUNNARL-UHFFFAOYSA-N.svg)
Ethyl 4-methyl-5-(phenylcarbamoyl)-2-{[(3,4,5-trimethoxyphenyl)carbonyl]amino}thiophene-3-carboxylate
CAS 333774-49-5C25H26N2O7S
AG-690/13774274
CAS 6044-39-9C23H21FN2O4S
- Ethyl 5-[(3-chloro-2-methylphenyl)carbamoyl]-2-[(4-methoxybenzoyl)amino]-4-methylthiophene-3-carboxylate6623-03-6C24H23ClN2O5S
- Ethyl 5-[(3-chloro-4-methylphenyl)carbamoyl]-4-methyl-2-{[(3,4,5-trimethoxyphenyl)carbonyl]amino}thiophene-3-carboxylate332905-54-1C26H27ClN2O7S
- Ethyl 5-[(2,4-dimethylphenyl)carbamoyl]-2-(3-fluorobenzamido)-4-methylthiophene-3-carboxylate332905-74-5C24H23FN2O4S
- Ethyl 5-[(2,5-dimethylphenyl)carbamoyl]-2-{[(3-fluorophenyl)carbonyl]amino}-4-methylthiophene-3-carboxylate332906-10-2C24H23FN2O4S
- Methyl 5-((3-chloro-4-methylphenyl)carbamoyl)-2-(3-methoxybenzamido)-4-methylthiophene-3-carboxylate332923-77-0C23H21ClN2O5S
- Methyl 2-benzamido-5-[(2,4-dimethylphenyl)carbamoyl]-4-methylthiophene-3-carboxylate332924-41-1C23H22N2O4S
- Methyl 5-((2-ethoxyphenyl)carbamoyl)-2-(4-methoxybenzamido)-4-methylthiophene-3-carboxylate335405-89-5C24H24N2O6S
- Methyl 5-((4-ethoxyphenyl)carbamoyl)-2-(4-fluorobenzamido)-4-methylthiophene-3-carboxylate335406-28-5C23H21FN2O5S
- Methyl 2-(3-chlorobenzamido)-5-((2-ethoxyphenyl)carbamoyl)-4-methylthiophene-3-carboxylate505095-53-4C23H21ClN2O5S
- Methyl 5-((2-ethoxyphenyl)carbamoyl)-2-(3-fluorobenzamido)-4-methylthiophene-3-carboxylate505095-59-0C23H21FN2O5S
- Methyl 5-((2-fluorophenyl)carbamoyl)-4-methyl-2-(3,4,5-trimethoxybenzamido)thiophene-3-carboxylate335407-15-3C24H23FN2O7S
- Methyl 5-((4-(ethoxycarbonyl)phenyl)carbamoyl)-4-methyl-2-(2-methylbenzamido)thiophene-3-carboxylate335407-53-9C25H24N2O6S
- Methyl 2-(2-chlorobenzamido)-5-((2,5-dimethylphenyl)carbamoyl)-4-methylthiophene-3-carboxylate335407-55-1C23H21ClN2O4S
- Methyl 2-(2,4-dichlorobenzamido)-5-((2-ethoxyphenyl)carbamoyl)-4-methylthiophene-3-carboxylate505095-81-8C23H20Cl2N2O5S
- Methyl 2-benzamido-5-((2-ethoxyphenyl)carbamoyl)-4-methylthiophene-3-carboxylate335408-24-7C23H22N2O5S
- Methyl 5-((3-methoxyphenyl)carbamoyl)-4-methyl-2-(3-methylbenzamido)thiophene-3-carboxylate335406-05-8C23H22N2O5S
- Methyl 2-(2,4-dichlorobenzamido)-5-((4-ethoxyphenyl)carbamoyl)-4-methylthiophene-3-carboxylate505095-97-6C23H20Cl2N2O5S
- Methyl 5-((3-chlorophenyl)carbamoyl)-4-methyl-2-(3,4,5-trimethoxybenzamido)thiophene-3-carboxylate335406-29-6C24H23ClN2O7S
- Methyl 2-(3-chlorobenzamido)-4-methyl-5-(m-tolylcarbamoyl)thiophene-3-carboxylate335406-72-9C22H19ClN2O4S
- Methyl 2-(2,4-dichlorobenzamido)-5-((3,5-dimethylphenyl)carbamoyl)-4-methylthiophene-3-carboxylate335407-12-0C23H20Cl2N2O4S
- Methyl 2-(4-chlorobenzamido)-5-((3-chlorophenyl)carbamoyl)-4-methylthiophene-3-carboxylate505096-13-9C21H16Cl2N2O4S
- Methyl 5-((2-chlorophenyl)carbamoyl)-4-methyl-2-(3-methylbenzamido)thiophene-3-carboxylate335407-75-5C22H19ClN2O4S
- Methyl 5-((2-ethoxyphenyl)carbamoyl)-2-(4-fluorobenzamido)-4-methylthiophene-3-carboxylate505096-33-3C23H21FN2O5S
- Methyl 2-(3-chlorobenzamido)-5-((3-chlorophenyl)carbamoyl)-4-methylthiophene-3-carboxylate335408-68-9C21H16Cl2N2O4S
Related scaffolds
Same ring framework with different atoms or bond orders
c1ccc(CSc2nnc(SCc3ccccc3)s2)cc122 chemicals
O=C(Nc1ccccc1)c1ccc(COc2ccccc2)o114 chemicals
O=C(Nc1ccccc1)c1ccc(CSc2ccccc2)o17 chemicals![Scaffold O=C(Nc1ccccc1)c1cc(C(=O)Nc2ccccc2)[nH]n1](/scaffold/DPLZIUVKOMQMDS-UHFFFAOYSA-N/structure.svg)
O=C(Nc1ccccc1)c1cc(C(=O)Nc2ccccc2)[nH]n14 chemicals
C(=Cc1nnc(SCc2ccccc2)o1)c1ccccc14 chemicals
O=C(Nc1nnc(SCc2ccccc2)s1)c1ccccc14 chemicals
O=C(Nc1ccccn1)c1ccc(COc2ccccc2)o14 chemicals
O=C(Nc1nnc(S(=O)(=O)Cc2ccccc2)s1)c1ccccc13 chemicals
c1ccc(CNc2cnc(COc3ccccc3)o2)cc13 chemicals
c1ccc(CSc2cc(SCc3ccccc3)sn2)cc13 chemicals
O=C(Nc1ccccc1)C1CC(=O)N(CCc2ccccc2)C13 chemicals
O=C(Nc1cccnc1)c1ccc(COc2ccccc2)o12 chemicals