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Murcko scaffold

Ring system with 3 rings and 19 atoms

88 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
88
With full pages
6
Scaffold SMILES

O=C1OC(c2ccccc2)=CC1=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1OC(c2ccccc2)=CC1=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 88 chemicals

3-[(2,4-Dihydroxyphenyl)methylidene]-5-(4-methoxyphenyl)furan-2-one chemical structure, C18H14O5
3-[(2,4-Dihydroxyphenyl)methylidene]-5-(4-methoxyphenyl)furan-2-one
C18H14O5
3-[(4-Chlorophenyl)methylidene]-5-phenylfuran-2-one chemical structure, C17H11ClO2
3-[(4-Chlorophenyl)methylidene]-5-phenylfuran-2-one
C17H11ClO2
3-[(4-Methoxyphenyl)methylidene]-5-phenyl-furan-2-one chemical structure, C18H14O3
3-[(4-Methoxyphenyl)methylidene]-5-phenyl-furan-2-one
C18H14O3
3-[(4-Nitrophenyl)methylidene]-5-phenylfuran-2-one chemical structure, C17H11NO4
3-[(4-Nitrophenyl)methylidene]-5-phenylfuran-2-one
C17H11NO4
3-[N-(2-Cyanoethyl)-4-[[5-(2,4-dimethylphenyl)-2-oxofuran-3-ylidene]methyl]anilino]propanenitrile chemical structure, C25H23N3O2
3-[N-(2-Cyanoethyl)-4-[[5-(2,4-dimethylphenyl)-2-oxofuran-3-ylidene]methyl]anilino]propanenitrile
C25H23N3O2
(3E)-5-(4-Chlorophenyl)-3-[(4-methoxy-3-methylphenyl)methylidene]furan-2-one chemical structure, C19H15ClO3, CAS 340306-27-6
(3E)-5-(4-Chlorophenyl)-3-[(4-methoxy-3-methylphenyl)methylidene]furan-2-one
CAS 340306-27-6C19H15ClO3
Methyl 4-{(E)-[5-(4-chlorophenyl)-2-oxofuran-3(2H)-ylidene]methyl}benzoate chemical structure, C19H13ClO4, CAS 340308-81-8
Methyl 4-{(E)-[5-(4-chlorophenyl)-2-oxofuran-3(2H)-ylidene]methyl}benzoate
CAS 340308-81-8C19H13ClO4
(3E)-5-(4-Chlorophenyl)-3-(2-methoxybenzylidene)furan-2(3H)-one chemical structure, C18H13ClO3, CAS 340225-77-6
(3E)-5-(4-Chlorophenyl)-3-(2-methoxybenzylidene)furan-2(3H)-one
CAS 340225-77-6C18H13ClO3
(3E)-5-(4-Chlorophenyl)-3-[(3,4-dimethoxyphenyl)methylidene]furan-2-one chemical structure, C19H15ClO4, CAS 1160787-46-1
(3E)-5-(4-Chlorophenyl)-3-[(3,4-dimethoxyphenyl)methylidene]furan-2-one
CAS 1160787-46-1C19H15ClO4
(3E)-5-(4-Chlorophenyl)-3-[(4-fluorophenyl)methylidene]furan-2-one chemical structure, C17H10ClFO2, CAS 1160787-45-0
(3E)-5-(4-Chlorophenyl)-3-[(4-fluorophenyl)methylidene]furan-2-one
CAS 1160787-45-0C17H10ClFO2
(3Z)-3-Benzylidene-5-(4-chlorophenyl)furan-2-one chemical structure, C17H11ClO2, CAS 6295-78-9
(3Z)-3-Benzylidene-5-(4-chlorophenyl)furan-2-one
CAS 6295-78-9C17H11ClO2
(3E)-5-Phenyl-3-(phenylmethylene)-2(3H)-furanone chemical structure, C17H12O2, CAS 53949-11-4
(3E)-5-Phenyl-3-(phenylmethylene)-2(3H)-furanone
CAS 53949-11-4C17H12O2
2(3H)-Furanone, 3-benzylidene-5-phenyl- chemical structure, C17H12O2, CAS 4361-96-0
2(3H)-Furanone, 3-benzylidene-5-phenyl-
CAS 4361-96-0C17H12O2
3-(3,4-Dimethoxy-benzylidene)-5-phenyl-3H-furan-2-one chemical structure, C19H16O4, CAS 84023-76-7
3-(3,4-Dimethoxy-benzylidene)-5-phenyl-3H-furan-2-one
CAS 84023-76-7C19H16O4
5-(4-Methylphenyl)-3-[(3-nitrophenyl)methylidene]furan-2-one chemical structure, C18H13NO4, CAS 419545-79-2
5-(4-Methylphenyl)-3-[(3-nitrophenyl)methylidene]furan-2-one
CAS 419545-79-2C18H13NO4
4-{(E)-[5-(4-Chlorophenyl)-2-oxofuran-3(2H)-ylidene]methyl}phenyl acetate chemical structure, C19H13ClO4, CAS 347375-36-4
4-{(E)-[5-(4-Chlorophenyl)-2-oxofuran-3(2H)-ylidene]methyl}phenyl acetate
CAS 347375-36-4C19H13ClO4
3-(3-Methoxy-4-methylbenzylidene)-5-phenyl-2(3H)-furanone chemical structure, C19H16O3, CAS 6370-11-2
3-(3-Methoxy-4-methylbenzylidene)-5-phenyl-2(3H)-furanone
CAS 6370-11-2C19H16O3
2-[(E)-(2-Oxo-5-phenylfuran-3(2H)-ylidene)methyl]phenyl acetate chemical structure, C19H14O4, CAS 296243-38-4
2-[(E)-(2-Oxo-5-phenylfuran-3(2H)-ylidene)methyl]phenyl acetate
CAS 296243-38-4C19H14O4
2(3H)-Furanone, 5-(3,4-dimethylphenyl)-3-(phenylmethylene)- chemical structure, C19H16O2, CAS 54543-72-5
2(3H)-Furanone, 5-(3,4-dimethylphenyl)-3-(phenylmethylene)-
CAS 54543-72-5C19H16O2
3-(3,4-Dimethoxy-benzylidene)-5-(3,4-dimethoxy-phenyl)-3H-furan-2-one chemical structure, C21H20O6, CAS 102474-18-0
3-(3,4-Dimethoxy-benzylidene)-5-(3,4-dimethoxy-phenyl)-3H-furan-2-one
CAS 102474-18-0C21H20O6
(3Z)-5-(3,4-Dimethoxyphenyl)-3-[(3,4-dimethoxyphenyl)methylidene]furan-2-one chemical structure, C21H20O6, CAS 155787-77-2
(3Z)-5-(3,4-Dimethoxyphenyl)-3-[(3,4-dimethoxyphenyl)methylidene]furan-2-one
CAS 155787-77-2C21H20O6
(3E)-5-(4-Bromophenyl)-3-[(4,5-dimethoxy-2-nitrophenyl)methylidene]furan-2-one chemical structure, C19H14BrNO6, CAS 6019-78-9
(3E)-5-(4-Bromophenyl)-3-[(4,5-dimethoxy-2-nitrophenyl)methylidene]furan-2-one
CAS 6019-78-9C19H14BrNO6
2-Ethoxy-4-{(E)-[5-(4-methylphenyl)-2-oxofuran-3(2H)-ylidene]methyl}phenyl acetate chemical structure, C22H20O5, CAS 1187050-80-1
2-Ethoxy-4-{(E)-[5-(4-methylphenyl)-2-oxofuran-3(2H)-ylidene]methyl}phenyl acetate
CAS 1187050-80-1C22H20O5
2-{(E)-[5-(4-Bromophenyl)-2-oxofuran-3(2H)-ylidene]methyl}phenyl acetate chemical structure, C19H13BrO4, CAS 347375-45-5
2-{(E)-[5-(4-Bromophenyl)-2-oxofuran-3(2H)-ylidene]methyl}phenyl acetate
CAS 347375-45-5C19H13BrO4