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Murcko scaffold

Ring system with 3 rings and 20 atoms

108 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
108
With full pages
16
Scaffold SMILES

O=C1OC(C(=O)Nc2ccccc2)Cc2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1OC(C(=O)Nc2ccccc2)Cc2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 108 chemicals

(S)-N-(3,4-Dimethylphenyl)-1-oxoisochromane-3-carboxamide chemical structure, C18H17NO3, CAS 1351474-93-5
(S)-N-(3,4-Dimethylphenyl)-1-oxoisochromane-3-carboxamide
CAS 1351474-93-5C18H17NO3
1-Oxo-N-[3-(trifluoromethyl)phenyl]-3,4-dihydroisochromene-3-carboxamide chemical structure, C17H12F3NO3, CAS 618392-49-7
1-Oxo-N-[3-(trifluoromethyl)phenyl]-3,4-dihydroisochromene-3-carboxamide
CAS 618392-49-7C17H12F3NO3
1-Oxo-N-(4-propan-2-ylphenyl)-3,4-dihydroisochromene-3-carboxamide chemical structure, C19H19NO3, CAS 618392-71-5
1-Oxo-N-(4-propan-2-ylphenyl)-3,4-dihydroisochromene-3-carboxamide
CAS 618392-71-5C19H19NO3
N-(4-Methoxyphenyl)-1-oxo-3,4-dihydroisochromene-3-carboxamide chemical structure, C17H15NO4, CAS 618392-63-5
N-(4-Methoxyphenyl)-1-oxo-3,4-dihydroisochromene-3-carboxamide
CAS 618392-63-5C17H15NO4
N-[2-Chloro-5-(trifluoromethyl)phenyl]-1-oxo-3,4-dihydroisochromene-3-carboxamide chemical structure, C17H11ClF3NO3, CAS 618392-54-4
N-[2-Chloro-5-(trifluoromethyl)phenyl]-1-oxo-3,4-dihydroisochromene-3-carboxamide
CAS 618392-54-4C17H11ClF3NO3
N-(4-Butylphenyl)-1-oxo-3,4-dihydro-1H-isochromene-3-carboxamide chemical structure, C20H21NO3, CAS 618392-74-8
N-(4-Butylphenyl)-1-oxo-3,4-dihydro-1H-isochromene-3-carboxamide
CAS 618392-74-8C20H21NO3
N-(3-Methoxyphenyl)-1-oxo-3,4-dihydroisochromene-3-carboxamide chemical structure, C17H15NO4, CAS 618392-60-2
N-(3-Methoxyphenyl)-1-oxo-3,4-dihydroisochromene-3-carboxamide
CAS 618392-60-2C17H15NO4
1-Oxo-isochroman-3-carboxylic acid (2-methoxy-phenyl)-amide chemical structure, C17H15NO4, CAS 627889-89-8
1-Oxo-isochroman-3-carboxylic acid (2-methoxy-phenyl)-amide
CAS 627889-89-8C17H15NO4
1-Oxo-N-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-isochromene-3-carboxamide chemical structure, C17H12F3NO3, CAS 627889-86-5
1-Oxo-N-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-isochromene-3-carboxamide
CAS 627889-86-5C17H12F3NO3
1-Oxo-N-(2,4,6-trimethylphenyl)-3,4-dihydroisochromene-3-carboxamide chemical structure, C19H19NO3, CAS 627889-90-1
1-Oxo-N-(2,4,6-trimethylphenyl)-3,4-dihydroisochromene-3-carboxamide
CAS 627889-90-1C19H19NO3
N-(2-Iodophenyl)-1-oxo-3,4-dihydroisochromene-3-carboxamide chemical structure, C16H12INO3, CAS 627889-94-5
N-(2-Iodophenyl)-1-oxo-3,4-dihydroisochromene-3-carboxamide
CAS 627889-94-5C16H12INO3
N-(2-Methylphenyl)-1-oxo-3,4-dihydroisochromene-3-carboxamide chemical structure, C17H15NO3, CAS 627889-91-2
N-(2-Methylphenyl)-1-oxo-3,4-dihydroisochromene-3-carboxamide
CAS 627889-91-2C17H15NO3
N-(3-Bromophenyl)-1-oxo-3,4-dihydro-1H-isochromene-3-carboxamide chemical structure, C16H12BrNO3, CAS 627889-95-6
N-(3-Bromophenyl)-1-oxo-3,4-dihydro-1H-isochromene-3-carboxamide
CAS 627889-95-6C16H12BrNO3
N-(4-Ethylphenyl)-3-methyl-1-oxo-3,4-dihydro-1H-isochromene-3-carboxamide chemical structure, C19H19NO3, CAS 708252-45-3
N-(4-Ethylphenyl)-3-methyl-1-oxo-3,4-dihydro-1H-isochromene-3-carboxamide
CAS 708252-45-3C19H19NO3
N-(3-Bromophenyl)-3-methyl-1-oxoisochroman-3-carboxamide chemical structure, C17H14BrNO3, CAS 708279-22-5
N-(3-Bromophenyl)-3-methyl-1-oxoisochroman-3-carboxamide
CAS 708279-22-5C17H14BrNO3
2-[(3-Methyl-1-oxo-isochroman-3-carbonyl)-amino]-benzoic acid methyl ester chemical structure, C19H17NO5, CAS 708283-88-9
2-[(3-Methyl-1-oxo-isochroman-3-carbonyl)-amino]-benzoic acid methyl ester
CAS 708283-88-9C19H17NO5
N-(3-Fluorophenyl)-3-methyl-1-oxo-3,4-dihydro-1H-isochromene-3-carboxamide chemical structure, C17H14FNO3, CAS 720671-68-1
N-(3-Fluorophenyl)-3-methyl-1-oxo-3,4-dihydro-1H-isochromene-3-carboxamide
CAS 720671-68-1C17H14FNO3
N-(3-Methoxyphenyl)-3-methyl-1-oxo-3,4-dihydro-1H-isochromene-3-carboxamide chemical structure, C18H17NO4, CAS 824944-28-7
N-(3-Methoxyphenyl)-3-methyl-1-oxo-3,4-dihydro-1H-isochromene-3-carboxamide
CAS 824944-28-7C18H17NO4
N-(2-Ethoxyphenyl)-3-methyl-1-oxo-3,4-dihydro-1H-isochromene-3-carboxamide chemical structure, C19H19NO4, CAS 824944-31-2
N-(2-Ethoxyphenyl)-3-methyl-1-oxo-3,4-dihydro-1H-isochromene-3-carboxamide
CAS 824944-31-2C19H19NO4
3-Methyl-N-(3-methylphenyl)-1-oxo-4H-isochromene-3-carboxamide chemical structure, C18H17NO3, CAS 708991-79-1
3-Methyl-N-(3-methylphenyl)-1-oxo-4H-isochromene-3-carboxamide
CAS 708991-79-1C18H17NO3
N-(3,5-Dichlorophenyl)-3-methyl-1-oxo-3,4-dihydro-1H-isochromene-3-carboxamide chemical structure, C17H13Cl2NO3, CAS 708993-66-2
N-(3,5-Dichlorophenyl)-3-methyl-1-oxo-3,4-dihydro-1H-isochromene-3-carboxamide
CAS 708993-66-2C17H13Cl2NO3
3-Methyl-N-(4-nitrophenyl)-1-oxo-4H-isochromene-3-carboxamide chemical structure, C17H14N2O5, CAS 824944-98-1
3-Methyl-N-(4-nitrophenyl)-1-oxo-4H-isochromene-3-carboxamide
CAS 824944-98-1C17H14N2O5
N-(4-Ethoxyphenyl)-3-methyl-1-oxo-3,4-dihydro-1H-isochromene-3-carboxamide chemical structure, C19H19NO4, CAS 824945-09-7
N-(4-Ethoxyphenyl)-3-methyl-1-oxo-3,4-dihydro-1H-isochromene-3-carboxamide
CAS 824945-09-7C19H19NO4
N-(4-Bromophenyl)-3-methyl-1-oxoisochroman-3-carboxamide chemical structure, C17H14BrNO3, CAS 709000-35-1
N-(4-Bromophenyl)-3-methyl-1-oxoisochroman-3-carboxamide
CAS 709000-35-1C17H14BrNO3