Murcko scaffold
1-Phenyl-3-(thiophene-2-carbonyl)-thiourea scaffold
77 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 17
- Chemicals
- 77
- With full pages
- 8
Scaffold SMILES
O=C(NC(=S)Nc1ccccc1)c1cccs1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 77 chemicals
![N-[Methyl(phenyl)carbamothioyl]thiophene-2-carboxamide chemical structure, C13H12N2OS2, CAS 111752-86-4](/s/WLITZBLBCAJIQI-UHFFFAOYSA-N.svg)
N-[Methyl(phenyl)carbamothioyl]thiophene-2-carboxamide
CAS 111752-86-4C13H12N2OS2
N-((4-(Difluoromethoxy)phenyl)carbamothioyl)thiophene-2-carboxamide
CAS 302552-73-4C13H10F2N2O2S2
![N-[[4-(Difluoromethylsulfanyl)phenyl]carbamothioyl]thiophene-2-carboxamide chemical structure, C13H10F2N2OS3, CAS 305373-07-3](/s/SHFJLDPXHQDEAL-UHFFFAOYSA-N.svg)
N-[[4-(Difluoromethylsulfanyl)phenyl]carbamothioyl]thiophene-2-carboxamide
CAS 305373-07-3C13H10F2N2OS3
![N-[(2-Hydroxyphenyl)carbamothioyl]thiophene-2-carboxamide chemical structure, C12H10N2O2S2, CAS 381171-05-7](/s/DLQJCCWCQOZSHB-UHFFFAOYSA-N.svg)
N-[(2-Hydroxyphenyl)carbamothioyl]thiophene-2-carboxamide
CAS 381171-05-7C12H10N2O2S2
N-(4-Fluorophenyl)-N'-(2-thienylcarbonyl)thiourea
CAS 347309-90-4C12H9FN2OS2
![N-[(4-Ethylphenyl)carbamothioyl]thiophene-2-carboxamide chemical structure, C14H14N2OS2, CAS 380155-10-2](/s/FPCJEGNWGNMKLY-UHFFFAOYSA-N.svg)
N-[(4-Ethylphenyl)carbamothioyl]thiophene-2-carboxamide
CAS 380155-10-2C14H14N2OS2
![N-[(2-Chlorophenyl)carbamothioyl]thiophene-2-carboxamide chemical structure, C12H9ClN2OS2, CAS 6317-09-5](/s/HYMSRPADMFPZQW-UHFFFAOYSA-N.svg)
N-[(2-Chlorophenyl)carbamothioyl]thiophene-2-carboxamide
CAS 6317-09-5C12H9ClN2OS2
![N-[(3-Chlorophenyl)carbamothioyl]thiophene-2-carboxamide chemical structure, C12H9ClN2OS2, CAS 439137-64-1](/s/FKEXMGWFUCXXGC-UHFFFAOYSA-N.svg)
N-[(3-Chlorophenyl)carbamothioyl]thiophene-2-carboxamide
CAS 439137-64-1C12H9ClN2OS2
![N-[(4-Chlorophenyl)carbamothioyl]thiophene-2-carboxamide chemical structure, C12H9ClN2OS2, CAS 425660-27-1](/s/CWBOMJABCYVOMK-UHFFFAOYSA-N.svg)
N-[(4-Chlorophenyl)carbamothioyl]thiophene-2-carboxamide
CAS 425660-27-1C12H9ClN2OS2
![N-[(3-Nitrophenyl)carbamothioyl]thiophene-2-carboxamide chemical structure, C12H9N3O3S2, CAS 424813-53-6](/s/GNCCAPYMWBZDRO-UHFFFAOYSA-N.svg)
N-[(3-Nitrophenyl)carbamothioyl]thiophene-2-carboxamide
CAS 424813-53-6C12H9N3O3S2
![N-[(3-Chloro-2-methylphenyl)carbamothioyl]thiophene-2-carboxamide chemical structure, C13H11ClN2OS2, CAS 378765-23-2](/s/IQJVHUMELDKVOX-UHFFFAOYSA-N.svg)
N-[(3-Chloro-2-methylphenyl)carbamothioyl]thiophene-2-carboxamide
CAS 378765-23-2C13H11ClN2OS2
![N-[(2,5-Dimethoxyphenyl)carbamothioyl]thiophene-2-carboxamide chemical structure, C14H14N2O3S2, CAS 425662-85-7](/s/UABGFSRMMHCOQR-UHFFFAOYSA-N.svg)
N-[(2,5-Dimethoxyphenyl)carbamothioyl]thiophene-2-carboxamide
CAS 425662-85-7C14H14N2O3S2
![N-[[3-(Trifluoromethyl)phenyl]carbamothioyl]thiophene-2-carboxamide chemical structure, C13H9F3N2OS2, CAS 443292-45-3](/s/MREDBSJEHVADCZ-UHFFFAOYSA-N.svg)
N-[[3-(Trifluoromethyl)phenyl]carbamothioyl]thiophene-2-carboxamide
CAS 443292-45-3C13H9F3N2OS2
![Ethyl 4-{[(thiophen-2-ylcarbonyl)carbamothioyl]amino}benzoate chemical structure, C15H14N2O3S2, CAS 426246-61-9](/s/BLWWVDLHIFAVHH-UHFFFAOYSA-N.svg)
Ethyl 4-{[(thiophen-2-ylcarbonyl)carbamothioyl]amino}benzoate
CAS 426246-61-9C15H14N2O3S2
![N-[(4-Bromophenyl)carbamothioyl]thiophene-2-carboxamide chemical structure, C12H9BrN2OS2, CAS 6351-24-2](/s/ZHECYDFMBXSMGR-UHFFFAOYSA-N.svg)
N-[(4-Bromophenyl)carbamothioyl]thiophene-2-carboxamide
CAS 6351-24-2C12H9BrN2OS2
![N-[(4-Chloro-3-nitrophenyl)carbamothioyl]thiophene-2-carboxamide chemical structure, C12H8ClN3O3S2, CAS 426243-75-6](/s/HOJVLMABVGRNCA-UHFFFAOYSA-N.svg)
N-[(4-Chloro-3-nitrophenyl)carbamothioyl]thiophene-2-carboxamide
CAS 426243-75-6C12H8ClN3O3S2
Methyl 2-(thiophene-2-carbonylcarbamothioylamino)benzoate
CAS 355821-97-5C14H12N2O3S2
1-(4-Methoxyphenyl)-3-(thiophene-2-carbonyl)thiourea
CAS 352348-63-1C13H12N2O2S2
![N-[(2-Propan-2-ylphenyl)carbamothioyl]thiophene-2-carboxamide chemical structure, C15H16N2OS2, CAS 433245-56-8](/s/WIDLCUDXLHFUAP-UHFFFAOYSA-N.svg)
N-[(2-Propan-2-ylphenyl)carbamothioyl]thiophene-2-carboxamide
CAS 433245-56-8C15H16N2OS2
![4-{[(Thiophen-2-ylcarbonyl)carbamothioyl]amino}benzoic acid chemical structure, C13H10N2O3S2, CAS 370574-94-0](/s/RXTCQBFKYAOSBD-UHFFFAOYSA-N.svg)
4-{[(Thiophen-2-ylcarbonyl)carbamothioyl]amino}benzoic acid
CAS 370574-94-0C13H10N2O3S2
1-Phenyl-3-(thiophene-2-carbonyl)-thiourea
CAS 83790-79-8C12H10N2OS2
![N-[(2-Methoxyphenyl)carbamothioyl]thiophene-2-carboxamide chemical structure, C13H12N2O2S2, CAS 333415-04-6](/s/UGSZANBDAOJZNX-UHFFFAOYSA-N.svg)
N-[(2-Methoxyphenyl)carbamothioyl]thiophene-2-carboxamide
CAS 333415-04-6C13H12N2O2S2
![N-[(3,4-Dimethoxyphenyl)carbamothioyl]thiophene-2-carboxamide chemical structure, C14H14N2O3S2, CAS 347309-97-1](/s/BOLFFAOAEXGKGJ-UHFFFAOYSA-N.svg)
N-[(3,4-Dimethoxyphenyl)carbamothioyl]thiophene-2-carboxamide
CAS 347309-97-1C14H14N2O3S2
![N-[[4-(Diethylamino)phenyl]carbamothioyl]thiophene-2-carboxamide chemical structure, C16H19N3OS2, CAS 352348-72-2](/s/YLAKAILXHFFTNE-UHFFFAOYSA-N.svg)
N-[[4-(Diethylamino)phenyl]carbamothioyl]thiophene-2-carboxamide
CAS 352348-72-2C16H19N3OS2
- N-[(3-Acetylphenyl)carbamothioyl]thiophene-2-carboxamide335209-05-7C14H12N2O2S2
- N-[[2-(Trifluoromethyl)phenyl]carbamothioyl]thiophene-2-carboxamide333415-06-8C13H9F3N2OS2
- N-[4-(Dimethylamino)phenyl]-N'-(thien-2-ylcarbonyl)thiourea335209-04-6C14H15N3OS2
- N-[(3-Cyanophenyl)carbamothioyl]thiophene-2-carboxamide501111-68-8C13H9N3OS2
- N-[(2-Ethoxyphenyl)carbamothioyl]thiophene-2-carboxamide433253-25-9C14H14N2O2S2
- N-[(2-Fluorophenyl)carbamothioyl]thiophene-2-carboxamide364628-29-5C12H9FN2OS2
- Ethyl 3-(3-(thiophene-2-carbonyl)thioureido)benzoate370573-25-4C15H14N2O3S2
- N-[[4-(Propanoylamino)phenyl]carbamothioyl]thiophene-2-carboxamide425659-31-0C15H15N3O2S2
- N-[(4-Methylphenyl)carbamothioyl]thiophene-2-carboxamide425660-73-7C13H12N2OS2
- N-[(3,4-Dichlorophenyl)carbamothioyl]thiophene-2-carboxamide425661-80-9C12H8Cl2N2OS2
- N-[(2,3-Dichlorophenyl)carbamothioyl]thiophene-2-carboxamide347327-25-7C12H8Cl2N2OS2
- N-[(3-Methylphenyl)carbamothioyl]thiophene-2-carboxamide425656-24-2C13H12N2OS2
- N-[[3-(Butanoylamino)phenyl]carbamothioyl]thiophene-2-carboxamide355419-17-9C16H17N3O2S2
- N-[[3-(Propanoylamino)phenyl]carbamothioyl]thiophene-2-carboxamide428835-24-9C15H15N3O2S2
- N-[(3-Chloro-4-methylphenyl)carbamothioyl]thiophene-2-carboxamide428837-41-6C13H11ClN2OS2
- N-[(3-Chloro-4-methoxyphenyl)carbamothioyl]thiophene-2-carboxamide428853-73-0C13H11ClN2O2S2
- N-[(2-Hydroxy-5-methylphenyl)carbamothioyl]thiophene-2-carboxamide364744-33-2C13H12N2O2S2
- N-[(2-Hydroxy-4,5-dimethylphenyl)carbamothioyl]thiophene-2-carboxamide364748-72-1C14H14N2O2S2
- N-[(2-Hydroxy-4-methylphenyl)carbamothioyl]thiophene-2-carboxamide428860-59-7C13H12N2O2S2
- N-[(3,5-Dimethylphenyl)carbamothioyl]thiophene-2-carboxamide364745-17-5C14H14N2OS2
- N-[(3-Chloro-4-fluorophenyl)carbamothioyl]thiophene-2-carboxamide431070-45-0C12H8ClFN2OS2
- 4-Chloro-3-{[(thiophen-2-ylcarbonyl)carbamothioyl]amino}benzoic acid531515-99-8C13H9ClN2O3S2
- N-[(2-Hydroxy-3-methylphenyl)carbamothioyl]thiophene-2-carboxamide532422-82-5C13H12N2O2S2
- N-[(2-Methyl-5-nitrophenyl)carbamothioyl]thiophene-2-carboxamide642956-71-6C13H11N3O3S2
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=C(CSc1nnc[nH]1)Nc1ccccc1](/scaffold/VJBDIQRNSVRUDP-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnc[nH]1)Nc1ccccc165 chemicals
O=C(COc1ccccc1)Nc1nccs143 chemicals
O=C(CCc1ccco1)Nc1ccccc134 chemicals
O=C(CSc1nncs1)Nc1ccccc134 chemicals![Scaffold O=C(NN=Cc1ccccc1)c1cc[nH]n1](/scaffold/UEBQXDJERRSAMF-UHFFFAOYSA-N/structure.svg)
O=C(NN=Cc1ccccc1)c1cc[nH]n129 chemicals
O=C(CCc1ccccc1)Nc1nncs125 chemicals
S=C(NCc1ccco1)Nc1ccccc124 chemicals![Scaffold O=C(CSc1nnn[nH]1)Nc1ccccc1](/scaffold/FDRBWKCIVMSABC-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnn[nH]1)Nc1ccccc122 chemicals![Scaffold O=C(CSc1ncc[nH]1)Nc1ccccc1](/scaffold/OMOYRSCPUXAYDW-UHFFFAOYSA-N/structure.svg)
O=C(CSc1ncc[nH]1)Nc1ccccc121 chemicals
O=C(NC(=S)Nc1ccccc1)c1ccco121 chemicals
O=C(CCN1CCCC1)Nc1ccccc120 chemicals
O=C(NN=Cc1ccco1)c1ccccc119 chemicals