Murcko scaffold
Ring system with 3 rings and 22 atoms
60 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 22
- Chemicals
- 60
- With full pages
- 11
Scaffold SMILES
O=C(NC=Cc1ccc(-c2ccccc2)o1)c1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 60 chemicals
![N-[(1Z)-1-[5-(3,4-Dichlorophenyl)furan-2-yl]-3-oxo-3-(propan-2-ylamino)prop-1-en-2-yl]-4-methoxybenzamide chemical structure, C24H22Cl2N2O4, CAS 500271-84-1](/s/YKSKJGKISMOBEC-BKUYFWCQSA-N.svg)
N-[(1Z)-1-[5-(3,4-Dichlorophenyl)furan-2-yl]-3-oxo-3-(propan-2-ylamino)prop-1-en-2-yl]-4-methoxybenzamide
CAS 500271-84-1C24H22Cl2N2O4
![N-{2-[5-(4-Bromophenyl)-2-furyl]-1-[(tert-butylamino)carbonyl]vinyl}benzamide chemical structure, C24H23BrN2O3, CAS 312607-16-2](/s/VKEPMZHJFJPIFV-HKWRFOASSA-N.svg)
N-{2-[5-(4-Bromophenyl)-2-furyl]-1-[(tert-butylamino)carbonyl]vinyl}benzamide
CAS 312607-16-2C24H23BrN2O3
![N-{2-[5-(4-Bromo-phenyl)-furan-2-yl]-1-methylcarbamoyl-vinyl}-benzamide chemical structure, C21H17BrN2O3, CAS 302821-40-5](/s/JFEMWNKCBBOTBF-AQTBWJFISA-N.svg)
N-{2-[5-(4-Bromo-phenyl)-furan-2-yl]-1-methylcarbamoyl-vinyl}-benzamide
CAS 302821-40-5C21H17BrN2O3
![N-[(1Z)-1-[5-(4-Bromophenyl)furan-2-yl]-3-(butylamino)-3-oxoprop-1-en-2-yl]-4-methoxybenzamide chemical structure, C25H25BrN2O4, CAS 385388-57-8](/s/LLLQIZNOIIFAOO-JWGURIENSA-N.svg)
N-[(1Z)-1-[5-(4-Bromophenyl)furan-2-yl]-3-(butylamino)-3-oxoprop-1-en-2-yl]-4-methoxybenzamide
CAS 385388-57-8C25H25BrN2O4
![(2Z)-3-[5-(2-Chlorophenyl)(2-furyl)]-N-(methylethyl)-2-(phenylcarbonylamino)pr op-2-enamide chemical structure, C23H21ClN2O3, CAS 324561-67-3](/s/YXIDWHJRNFPGMM-ZHZULCJRSA-N.svg)
(2Z)-3-[5-(2-Chlorophenyl)(2-furyl)]-N-(methylethyl)-2-(phenylcarbonylamino)pr op-2-enamide
CAS 324561-67-3C23H21ClN2O3
![N-[(Z)-1-[5-(2,4-Dichlorophenyl)furan-2-yl]-3-oxo-3-(propan-2-ylamino)prop-1-en-2-yl]benzamide chemical structure, C23H20Cl2N2O3, CAS 324561-70-8](/s/LUTHIAFIZSYXCV-MOSHPQCFSA-N.svg)
N-[(Z)-1-[5-(2,4-Dichlorophenyl)furan-2-yl]-3-oxo-3-(propan-2-ylamino)prop-1-en-2-yl]benzamide
CAS 324561-70-8C23H20Cl2N2O3
![N-[(Z)-3-(Butylamino)-1-[5-(3-nitrophenyl)furan-2-yl]-3-oxoprop-1-en-2-yl]-4-methoxybenzamide chemical structure, C25H25N3O6, CAS 374104-71-9](/s/NHECPZFKDZGKQT-JWGURIENSA-N.svg)
N-[(Z)-3-(Butylamino)-1-[5-(3-nitrophenyl)furan-2-yl]-3-oxoprop-1-en-2-yl]-4-methoxybenzamide
CAS 374104-71-9C25H25N3O6
![N-[(1Z)-3-(Dimethylamino)-3-oxo-1-{5-[3-(trifluoromethyl)phenyl]furan-2-yl}prop-1-en-2-yl]-4-methoxybenzamide chemical structure, C24H21F3N2O4, CAS 384359-63-1](/s/YXOHBHPGZKHRIE-ZHZULCJRSA-N.svg)
N-[(1Z)-3-(Dimethylamino)-3-oxo-1-{5-[3-(trifluoromethyl)phenyl]furan-2-yl}prop-1-en-2-yl]-4-methoxybenzamide
CAS 384359-63-1C24H21F3N2O4
![(2Z)-2-[(4-Methoxyphenyl)carbonylamino]-N-methyl-3-{5-[3-(trifluoromethyl)phen yl](2-furyl)}prop-2-enamide chemical structure, C23H19F3N2O4, CAS 383900-29-6](/s/FHEOHQRLXQEWHL-UYRXBGFRSA-N.svg)
(2Z)-2-[(4-Methoxyphenyl)carbonylamino]-N-methyl-3-{5-[3-(trifluoromethyl)phen yl](2-furyl)}prop-2-enamide
CAS 383900-29-6C23H19F3N2O4
![N-{(1Z)-1-[5-(2,5-dichlorophenyl)furan-2-yl]-3-[(2-methoxyethyl)amino]-3-oxoprop-1-en-2-yl}-4-methoxybenzamide chemical structure, C24H22Cl2N2O5, CAS 384795-26-0](/s/LEWHIDLKCVRBRE-STZFKDTASA-N.svg)
N-{(1Z)-1-[5-(2,5-dichlorophenyl)furan-2-yl]-3-[(2-methoxyethyl)amino]-3-oxoprop-1-en-2-yl}-4-methoxybenzamide
CAS 384795-26-0C24H22Cl2N2O5
![N-[(Z)-1-[5-(4-Chlorophenyl)furan-2-yl]-3-[3-(dimethylamino)propylamino]-3-oxoprop-1-en-2-yl]-4-methylbenzamide chemical structure, C26H28ClN3O3, CAS 303227-91-0](/s/MXXPOBMGINPDNZ-QJOMJCCJSA-N.svg)
N-[(Z)-1-[5-(4-Chlorophenyl)furan-2-yl]-3-[3-(dimethylamino)propylamino]-3-oxoprop-1-en-2-yl]-4-methylbenzamide
CAS 303227-91-0C26H28ClN3O3
![N-[(1Z)-3-Oxo-3-(propan-2-ylamino)-1-{5-[3-(trifluoromethyl)phenyl]furan-2-yl}prop-1-en-2-yl]benzamide chemical structure, C24H21F3N2O3, CAS 384802-20-4](/s/CMYGPQTTYWWSHO-ZHZULCJRSA-N.svg)
N-[(1Z)-3-Oxo-3-(propan-2-ylamino)-1-{5-[3-(trifluoromethyl)phenyl]furan-2-yl}prop-1-en-2-yl]benzamide
CAS 384802-20-4C24H21F3N2O3
![N-[(1Z)-1-[5-(3-Chlorophenyl)furan-2-yl]-3-(dimethylamino)-3-oxoprop-1-en-2-yl]-4-methoxybenzamide chemical structure, C23H21ClN2O4, CAS 384803-05-8](/s/ZCNPYYFMWAGWAA-ZHZULCJRSA-N.svg)
N-[(1Z)-1-[5-(3-Chlorophenyl)furan-2-yl]-3-(dimethylamino)-3-oxoprop-1-en-2-yl]-4-methoxybenzamide
CAS 384803-05-8C23H21ClN2O4
![N-[(1Z)-1-[5-(4-Bromophenyl)furan-2-yl]-3-(butylamino)-3-oxoprop-1-en-2-yl]-4-methylbenzamide chemical structure, C25H25BrN2O3, CAS 302603-23-2](/s/AHZKHDBIFXGHRO-JWGURIENSA-N.svg)
N-[(1Z)-1-[5-(4-Bromophenyl)furan-2-yl]-3-(butylamino)-3-oxoprop-1-en-2-yl]-4-methylbenzamide
CAS 302603-23-2C25H25BrN2O3
![N-[(1Z)-1-[5-(3,4-Dichlorophenyl)furan-2-yl]-3-(dimethylamino)-3-oxoprop-1-en-2-yl]-4-methoxybenzamide chemical structure, C23H20Cl2N2O4, CAS 384366-12-5](/s/XASQJTCTRVUNFX-MOSHPQCFSA-N.svg)
N-[(1Z)-1-[5-(3,4-Dichlorophenyl)furan-2-yl]-3-(dimethylamino)-3-oxoprop-1-en-2-yl]-4-methoxybenzamide
CAS 384366-12-5C23H20Cl2N2O4
![N-{(1Z)-3-(tert-butylamino)-1-[5-(3,4-dichlorophenyl)furan-2-yl]-3-oxoprop-1-en-2-yl}-4-methoxybenzamide chemical structure, C25H24Cl2N2O4, CAS 384373-46-0](/s/GGTOFEYIPXSZFS-STZFKDTASA-N.svg)
N-{(1Z)-3-(tert-butylamino)-1-[5-(3,4-dichlorophenyl)furan-2-yl]-3-oxoprop-1-en-2-yl}-4-methoxybenzamide
CAS 384373-46-0C25H24Cl2N2O4
![N-[(1Z)-1-[5-(3,4-Dichlorophenyl)furan-2-yl]-3-(ethylamino)-3-oxoprop-1-en-2-yl]-4-methoxybenzamide chemical structure, C23H20Cl2N2O4, CAS 384376-24-3](/s/NNEZBUBFSDJKMB-MOSHPQCFSA-N.svg)
N-[(1Z)-1-[5-(3,4-Dichlorophenyl)furan-2-yl]-3-(ethylamino)-3-oxoprop-1-en-2-yl]-4-methoxybenzamide
CAS 384376-24-3C23H20Cl2N2O4
![4-Methoxy-N-[(1Z)-3-oxo-3-(propan-2-ylamino)-1-{5-[3-(trifluoromethyl)phenyl]furan-2-yl}prop-1-en-2-yl]benzamide chemical structure, C25H23F3N2O4, CAS 385386-28-7](/s/APXYJXNMXCCQKT-STZFKDTASA-N.svg)
4-Methoxy-N-[(1Z)-3-oxo-3-(propan-2-ylamino)-1-{5-[3-(trifluoromethyl)phenyl]furan-2-yl}prop-1-en-2-yl]benzamide
CAS 385386-28-7C25H23F3N2O4
![N-[(1Z)-3-(Ethylamino)-3-oxo-1-{5-[3-(trifluoromethyl)phenyl]furan-2-yl}prop-1-en-2-yl]-4-methoxybenzamide chemical structure, C24H21F3N2O4, CAS 385387-44-0](/s/ZNWNGYJPAUKLJU-ZHZULCJRSA-N.svg)
N-[(1Z)-3-(Ethylamino)-3-oxo-1-{5-[3-(trifluoromethyl)phenyl]furan-2-yl}prop-1-en-2-yl]-4-methoxybenzamide
CAS 385387-44-0C24H21F3N2O4
![N-{(1Z)-3-(tert-butylamino)-1-[5-(4-chlorophenyl)furan-2-yl]-3-oxoprop-1-en-2-yl}-4-chlorobenzamide chemical structure, C24H22Cl2N2O3, CAS 385394-16-1](/s/ZTADPNDVYTYYLH-ZHZULCJRSA-N.svg)
N-{(1Z)-3-(tert-butylamino)-1-[5-(4-chlorophenyl)furan-2-yl]-3-oxoprop-1-en-2-yl}-4-chlorobenzamide
CAS 385394-16-1C24H22Cl2N2O3
![N-[(1Z)-3-[(3-Methoxypropyl)amino]-3-oxo-1-{5-[3-(trifluoromethyl)phenyl]furan-2-yl}prop-1-en-2-yl]benzamide chemical structure, C25H23F3N2O4, CAS 385418-19-9](/s/IZYVNLMXBCBOIT-PGMHBOJBSA-N.svg)
N-[(1Z)-3-[(3-Methoxypropyl)amino]-3-oxo-1-{5-[3-(trifluoromethyl)phenyl]furan-2-yl}prop-1-en-2-yl]benzamide
CAS 385418-19-9C25H23F3N2O4
![(2Z)-3-[5-(4-Bromophenyl)furan-2-yl]-N-butyl-2-(phenylformamido)prop-2-enamide chemical structure, C24H23BrN2O3, CAS 302821-41-6](/s/JGELFXFFAXCPKT-PGMHBOJBSA-N.svg)
(2Z)-3-[5-(4-Bromophenyl)furan-2-yl]-N-butyl-2-(phenylformamido)prop-2-enamide
CAS 302821-41-6C24H23BrN2O3
![4-Methoxy-N-[(1Z)-3-oxo-3-(propylamino)-1-{5-[3-(trifluoromethyl)phenyl]furan-2-yl}prop-1-en-2-yl]benzamide chemical structure, C25H23F3N2O4, CAS 487037-83-2](/s/QTVDOBXGFJAHIP-QNGOZBTKSA-N.svg)
4-Methoxy-N-[(1Z)-3-oxo-3-(propylamino)-1-{5-[3-(trifluoromethyl)phenyl]furan-2-yl}prop-1-en-2-yl]benzamide
CAS 487037-83-2C25H23F3N2O4
![4-Methoxy-N-[(1Z)-3-[(2-methylpropyl)amino]-3-oxo-1-{5-[3-(trifluoromethyl)phenyl]furan-2-yl}prop-1-en-2-yl]benzamide chemical structure, C26H25F3N2O4, CAS 488108-84-5](/s/QSHXWNIGTHOERM-HMAPJEAMSA-N.svg)
4-Methoxy-N-[(1Z)-3-[(2-methylpropyl)amino]-3-oxo-1-{5-[3-(trifluoromethyl)phenyl]furan-2-yl}prop-1-en-2-yl]benzamide
CAS 488108-84-5C26H25F3N2O4
- (2Z)-N-(2-Methoxyethyl)-2-(phenylcarbonylamino)-3-{5-[3-(trifluoromethyl)pheny l](2-furyl)}prop-2-enamide498537-82-9C24H21F3N2O4
- N-{(1Z)-1-[5-(3-chlorophenyl)furan-2-yl]-3-[(3-methoxypropyl)amino]-3-oxoprop-1-en-2-yl}-4-methoxybenzamide500273-66-5C25H25ClN2O5
- N-[(Z)-1-[5-(2-Nitrophenyl)furan-2-yl]-3-oxo-3-(propylamino)prop-1-en-2-yl]benzamide432014-69-2C23H21N3O5
- N-{1-({[2-(Dimethylamino)ethyl]amino}carbonyl)-2-[5-(3-nitrophenyl)-2-furyl]vinyl}benzamide1164551-17-0C24H24N4O5
- N-[(Z)-3-[3-(Dimethylamino)propylamino]-1-[5-(3-nitrophenyl)furan-2-yl]-3-oxoprop-1-en-2-yl]-4-methylbenzamide324566-35-0C26H28N4O5
- N-[(Z)-3-[3-(Dimethylamino)propylamino]-1-[5-(2-nitrophenyl)furan-2-yl]-3-oxoprop-1-en-2-yl]-4-methylbenzamide384369-45-3C26H28N4O5
- N-[(Z)-1-[5-(4-Bromophenyl)furan-2-yl]-3-[3-(dimethylamino)propylamino]-3-oxoprop-1-en-2-yl]-4-methylbenzamide302821-45-0C26H28BrN3O3
- N-[2-[5-(2,4-Dichlorophenyl)-2-furyl]-1-({[2-(dimethylamino)ethyl]amino}carbonyl)vinyl]benzamide1164551-08-9C24H23Cl2N3O3
- N-[(Z)-3-(3-Hydroxypropylamino)-1-[5-(3-nitrophenyl)furan-2-yl]-3-oxoprop-1-en-2-yl]benzamide374614-98-9C23H21N3O6
- N-{(1Z)-1-[5-(2,5-dichlorophenyl)furan-2-yl]-3-[(2-methoxyethyl)amino]-3-oxoprop-1-en-2-yl}-4-methylbenzamide935550-87-1C24H22Cl2N2O4
- N-{1-Butylcarbamoyl-2-[5-(4-nitro-phenyl)-furan-2--yl]-vinyl}-4-methyl-benzamide302603-24-3C25H25N3O5
- N-[(Z)-1-[5-(2,5-Dichlorophenyl)furan-2-yl]-3-(methylamino)-3-oxoprop-1-en-2-yl]-4-methylbenzamide935550-89-3C22H18Cl2N2O3
- N-[2-[5-(3-Chlorophenyl)-2-furyl]-1-({[2-(dimethylamino)ethyl]amino}carbonyl)vinyl]benzamide1164483-66-2C24H24ClN3O3
- N-{1-({[2-(Dimethylamino)ethyl]amino}carbonyl)-2-[5-(2-nitrophenyl)-2-furyl]vinyl}-4-methylbenzamide432006-32-1C25H26N4O5
- N-[(Z)-3-(2-Methoxyethylamino)-1-[5-(2-nitrophenyl)furan-2-yl]-3-oxoprop-1-en-2-yl]-4-methylbenzamide384801-53-0C24H23N3O6
- N-{(1Z)-1-[5-(3,4-dichlorophenyl)furan-2-yl]-3-[(2-hydroxyethyl)amino]-3-oxoprop-1-en-2-yl}-4-methoxybenzamide384798-65-6C23H20Cl2N2O5
- N-[(Z)-3-(2-Methoxyethylamino)-1-[5-(3-nitrophenyl)furan-2-yl]-3-oxoprop-1-en-2-yl]-4-methylbenzamide500275-26-3C24H23N3O6
- N-[(Z)-3-(3-Methoxypropylamino)-1-[5-(3-nitrophenyl)furan-2-yl]-3-oxoprop-1-en-2-yl]-4-methylbenzamide488744-85-0C25H25N3O6
- N-[(Z)-1-[5-(4-Bromophenyl)furan-2-yl]-3-(methylamino)-3-oxoprop-1-en-2-yl]-4-methylbenzamide302603-21-0C22H19BrN2O3
- N-[(E)-3-(Butylamino)-1-[5-(4-nitrophenyl)furan-2-yl]-3-oxoprop-1-en-2-yl]benzamide302603-22-1C24H23N3O5
- N-[(1Z)-1-[5-(4-Bromophenyl)furan-2-yl]-3-(dimethylamino)-3-oxoprop-1-en-2-yl]-4-methylbenzamide305863-94-9C23H21BrN2O3
- N-[(1Z)-1-[5-(4-Bromophenyl)furan-2-yl]-3-oxo-3-(prop-2-en-1-ylamino)prop-1-en-2-yl]-4-methylbenzamide302821-39-2C24H21BrN2O3
- N(2-(5-(3,4-DI-CL-PH)-2-Furyl)-1-((isopropylamino)carbonyl)vinyl)-4-ME-benzamide307974-03-4C24H22Cl2N2O3
- N-((E)-2-(5-(3,4-Dichlorophenyl)-2-furyl)-1-(((2-methoxyethyl)amino)carbonyl)ethenyl)-4-methylbenzamide307974-08-9C24H22Cl2N2O4
Related scaffolds
Same ring framework with different atoms or bond orders
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