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Murcko scaffold

Ring system with 3 rings and 22 atoms

65 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
65
With full pages
5
Scaffold SMILES

O=C(Nc1ccc(Sc2ccccc2)cc1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccc(Sc2ccccc2)cc1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 65 chemicals

3-(2,2-Dimethylpropanoylamino)-N-[4-(4-nitrophenyl)sulfanylphenyl]benzamide chemical structure, C24H23N3O4S, CAS 352217-43-7
3-(2,2-Dimethylpropanoylamino)-N-[4-(4-nitrophenyl)sulfanylphenyl]benzamide
CAS 352217-43-7C24H23N3O4S
N-[3-Cyano-4-(phenylsulfanyl)phenyl]-3-(trifluoromethyl)benzenecarboxamide chemical structure, C21H13F3N2OS, CAS 303147-77-5
N-[3-Cyano-4-(phenylsulfanyl)phenyl]-3-(trifluoromethyl)benzenecarboxamide
CAS 303147-77-5C21H13F3N2OS
4-Chloro-N-[3-cyano-4-(phenylthio)phenyl]benzamide chemical structure, C20H13ClN2OS, CAS 303147-79-7
4-Chloro-N-[3-cyano-4-(phenylthio)phenyl]benzamide
CAS 303147-79-7C20H13ClN2OS
2-Chloro-N-{4-[(4-fluorophenyl)sulfanyl]phenyl}-4-(methylsulfonyl)benzenecarboxamide chemical structure, C20H15ClFNO3S2, CAS 339011-57-3
2-Chloro-N-{4-[(4-fluorophenyl)sulfanyl]phenyl}-4-(methylsulfonyl)benzenecarboxamide
CAS 339011-57-3C20H15ClFNO3S2
2-Chloro-N-{4-[(4-methylphenyl)sulfanyl]phenyl}-4-(methylsulfonyl)benzenecarboxamide chemical structure, C21H18ClNO3S2, CAS 339096-18-3
2-Chloro-N-{4-[(4-methylphenyl)sulfanyl]phenyl}-4-(methylsulfonyl)benzenecarboxamide
CAS 339096-18-3C21H18ClNO3S2
4-Fluoro-N-{4-[(4-methylphenyl)sulfanyl]phenyl}benzenecarboxamide chemical structure, C20H16FNOS, CAS 339096-22-9
4-Fluoro-N-{4-[(4-methylphenyl)sulfanyl]phenyl}benzenecarboxamide
CAS 339096-22-9C20H16FNOS
3-Methoxy-N-[4-(4-methylphenyl)sulfanylphenyl]benzamide chemical structure, C21H19NO2S, CAS 339096-28-5
3-Methoxy-N-[4-(4-methylphenyl)sulfanylphenyl]benzamide
CAS 339096-28-5C21H19NO2S
4-Fluoro-N-{4-[(4-fluorophenyl)sulfanyl]phenyl}benzenecarboxamide chemical structure, C19H13F2NOS, CAS 339096-35-4
4-Fluoro-N-{4-[(4-fluorophenyl)sulfanyl]phenyl}benzenecarboxamide
CAS 339096-35-4C19H13F2NOS
N-{4-[(4-Chlorophenyl)sulfanyl]phenyl}-4-methylbenzamide chemical structure, C20H16ClNOS, CAS 521295-64-7
N-{4-[(4-Chlorophenyl)sulfanyl]phenyl}-4-methylbenzamide
CAS 521295-64-7C20H16ClNOS
N-{4-[(2-Chlorophenyl)sulfanyl]phenyl}-3-methylbenzenecarboxamide chemical structure, C20H16ClNOS, CAS 251096-72-7
N-{4-[(2-Chlorophenyl)sulfanyl]phenyl}-3-methylbenzenecarboxamide
CAS 251096-72-7C20H16ClNOS
3,4-Dichloro-N-[3-cyano-4-(phenylsulfanyl)phenyl]benzenecarboxamide chemical structure, C20H12Cl2N2OS, CAS 303147-70-8
3,4-Dichloro-N-[3-cyano-4-(phenylsulfanyl)phenyl]benzenecarboxamide
CAS 303147-70-8C20H12Cl2N2OS
3,5-Dichloro-N-[3-cyano-4-(phenylsulfanyl)phenyl]benzenecarboxamide chemical structure, C20H12Cl2N2OS, CAS 306980-37-0
3,5-Dichloro-N-[3-cyano-4-(phenylsulfanyl)phenyl]benzenecarboxamide
CAS 306980-37-0C20H12Cl2N2OS
N-{4-[(4-Chlorophenyl)sulfanyl]-3-cyanophenyl}-3-(trifluoromethyl)benzenecarboxamide chemical structure, C21H12ClF3N2OS, CAS 306980-38-1
N-{4-[(4-Chlorophenyl)sulfanyl]-3-cyanophenyl}-3-(trifluoromethyl)benzenecarboxamide
CAS 306980-38-1C21H12ClF3N2OS
3,4-Dichloro-N-{4-[(4-chlorophenyl)sulfanyl]-3-cyanophenyl}benzenecarboxamide chemical structure, C20H11Cl3N2OS, CAS 306980-39-2
3,4-Dichloro-N-{4-[(4-chlorophenyl)sulfanyl]-3-cyanophenyl}benzenecarboxamide
CAS 306980-39-2C20H11Cl3N2OS
N-[3-Cyano-4-[(4-methylphenyl)thio]phenyl]-4-fluorobenzamide chemical structure, C21H15FN2OS, CAS 306980-42-7
N-[3-Cyano-4-[(4-methylphenyl)thio]phenyl]-4-fluorobenzamide
CAS 306980-42-7C21H15FN2OS
N-{3-Cyano-4-[(4-methylphenyl)sulfanyl]phenyl}-2-methylbenzenecarboxamide chemical structure, C22H18N2OS, CAS 306980-43-8
N-{3-Cyano-4-[(4-methylphenyl)sulfanyl]phenyl}-2-methylbenzenecarboxamide
CAS 306980-43-8C22H18N2OS
3,4-Dichloro-N-{3-cyano-4-[(4-methylphenyl)sulfanyl]phenyl}benzenecarboxamide chemical structure, C21H14Cl2N2OS, CAS 306980-44-9
3,4-Dichloro-N-{3-cyano-4-[(4-methylphenyl)sulfanyl]phenyl}benzenecarboxamide
CAS 306980-44-9C21H14Cl2N2OS
N-{3-Cyano-4-[(4-methylphenyl)sulfanyl]phenyl}-3-(trifluoromethyl)benzenecarboxamide chemical structure, C22H15F3N2OS, CAS 306980-45-0
N-{3-Cyano-4-[(4-methylphenyl)sulfanyl]phenyl}-3-(trifluoromethyl)benzenecarboxamide
CAS 306980-45-0C22H15F3N2OS
2-Chloro-N-{3-cyano-4-[(4-methylphenyl)sulfanyl]phenyl}benzenecarboxamide chemical structure, C21H15ClN2OS, CAS 306980-46-1
2-Chloro-N-{3-cyano-4-[(4-methylphenyl)sulfanyl]phenyl}benzenecarboxamide
CAS 306980-46-1C21H15ClN2OS
N-{4-[(4-Chlorophenyl)sulfanyl]-3-cyanophenyl}-4-fluorobenzenecarboxamide chemical structure, C20H12ClFN2OS, CAS 306980-47-2
N-{4-[(4-Chlorophenyl)sulfanyl]-3-cyanophenyl}-4-fluorobenzenecarboxamide
CAS 306980-47-2C20H12ClFN2OS
3,5-Dichloro-N-{3-cyano-4-[(4-methylphenyl)sulfanyl]phenyl}benzenecarboxamide chemical structure, C21H14Cl2N2OS, CAS 306980-63-2
3,5-Dichloro-N-{3-cyano-4-[(4-methylphenyl)sulfanyl]phenyl}benzenecarboxamide
CAS 306980-63-2C21H14Cl2N2OS
N-{3-Cyano-4-[(2-methylphenyl)sulfanyl]phenyl}-2-methylbenzenecarboxamide chemical structure, C22H18N2OS, CAS 860784-75-4
N-{3-Cyano-4-[(2-methylphenyl)sulfanyl]phenyl}-2-methylbenzenecarboxamide
CAS 860784-75-4C22H18N2OS
N-{3-Cyano-4-[(2-methylphenyl)sulfanyl]phenyl}-4-fluorobenzenecarboxamide chemical structure, C21H15FN2OS, CAS 306980-73-4
N-{3-Cyano-4-[(2-methylphenyl)sulfanyl]phenyl}-4-fluorobenzenecarboxamide
CAS 306980-73-4C21H15FN2OS
2-Chloro-N-{3-cyano-4-[(2-methylphenyl)sulfanyl]phenyl}benzenecarboxamide chemical structure, C21H15ClN2OS, CAS 306980-74-5
2-Chloro-N-{3-cyano-4-[(2-methylphenyl)sulfanyl]phenyl}benzenecarboxamide
CAS 306980-74-5C21H15ClN2OS