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Murcko scaffold

Ring system with 2 rings and 16 atoms

135 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
16
Chemicals
135
With full pages
15
Scaffold SMILES

O=C(C=Cc1cccs1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C=Cc1cccs1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 135 chemicals

(Z)-2-Cyano-N-(4-fluorophenyl)-3-thiophen-2-ylprop-2-enamide chemical structure, C14H9FN2OS, CAS 340229-35-8
(Z)-2-Cyano-N-(4-fluorophenyl)-3-thiophen-2-ylprop-2-enamide
CAS 340229-35-8C14H9FN2OS
(2E)-N-(2,5-Dichlorophenyl)-3-(2-thienyl)prop-2-enamide chemical structure, C13H9Cl2NOS, CAS 96460-09-2
(2E)-N-(2,5-Dichlorophenyl)-3-(2-thienyl)prop-2-enamide
CAS 96460-09-2C13H9Cl2NOS
(E)-Ethyl 2-(2-cyano-3-(thiophen-2-yl)acrylamido)benzoate chemical structure, C17H14N2O3S, CAS 367279-03-6
(E)-Ethyl 2-(2-cyano-3-(thiophen-2-yl)acrylamido)benzoate
CAS 367279-03-6C17H14N2O3S
(2E)-N-[4-(Acetylamino)phenyl]-2-cyano-3-(thiophen-2-yl)prop-2-enamide chemical structure, C16H13N3O2S, CAS 469873-02-7
(2E)-N-[4-(Acetylamino)phenyl]-2-cyano-3-(thiophen-2-yl)prop-2-enamide
CAS 469873-02-7C16H13N3O2S
N-(4-Bromo-2-fluorophenyl)-3-(2-thienyl)acrylamide chemical structure, C13H9BrFNOS, CAS 544688-09-7
N-(4-Bromo-2-fluorophenyl)-3-(2-thienyl)acrylamide
CAS 544688-09-7C13H9BrFNOS
N-(2-Ethyl-6-methylphenyl)-3-(2-thienyl)acrylamide chemical structure, C16H17NOS, CAS 544683-89-8
N-(2-Ethyl-6-methylphenyl)-3-(2-thienyl)acrylamide
CAS 544683-89-8C16H17NOS
N-(2-Ethoxyphenyl)-3-(2-thienyl)acrylamide chemical structure, C15H15NO2S, CAS 853348-55-7
N-(2-Ethoxyphenyl)-3-(2-thienyl)acrylamide
CAS 853348-55-7C15H15NO2S
(E)-N-(4-Chloro-2-fluorophenyl)-3-thiophen-2-ylprop-2-enamide chemical structure, C13H9ClFNOS, CAS 546069-66-3
(E)-N-(4-Chloro-2-fluorophenyl)-3-thiophen-2-ylprop-2-enamide
CAS 546069-66-3C13H9ClFNOS
(E)-N-(3-Chloro-4-fluorophenyl)-3-thiophen-2-ylprop-2-enamide chemical structure, C13H9ClFNOS, CAS 419559-91-4
(E)-N-(3-Chloro-4-fluorophenyl)-3-thiophen-2-ylprop-2-enamide
CAS 419559-91-4C13H9ClFNOS
(E)-N-(2,3-Dimethylphenyl)-3-thiophen-2-ylprop-2-enamide chemical structure, C15H15NOS, CAS 419560-41-1
(E)-N-(2,3-Dimethylphenyl)-3-thiophen-2-ylprop-2-enamide
CAS 419560-41-1C15H15NOS
(2E)-N-(2-Bromo-4-methylphenyl)-3-(2-thienyl)prop-2-enamide chemical structure, C14H12BrNOS, CAS 420092-55-3
(2E)-N-(2-Bromo-4-methylphenyl)-3-(2-thienyl)prop-2-enamide
CAS 420092-55-3C14H12BrNOS
(E)-3-Thiophen-2-yl-N-[2-(trifluoromethyl)phenyl]prop-2-enamide chemical structure, C14H10F3NOS, CAS 420093-27-2
(E)-3-Thiophen-2-yl-N-[2-(trifluoromethyl)phenyl]prop-2-enamide
CAS 420093-27-2C14H10F3NOS
Methyl 5-((2E)-3-(2-thienyl)prop-2-enoylamino)-3-(methoxycarbonyl)benzoate chemical structure, C17H15NO5S, CAS 420093-49-8
Methyl 5-((2E)-3-(2-thienyl)prop-2-enoylamino)-3-(methoxycarbonyl)benzoate
CAS 420093-49-8C17H15NO5S
(E)-N-(2-Propan-2-ylphenyl)-3-thiophen-2-ylprop-2-enamide chemical structure, C16H17NOS, CAS 424807-12-5
(E)-N-(2-Propan-2-ylphenyl)-3-thiophen-2-ylprop-2-enamide
CAS 424807-12-5C16H17NOS
(2E)-3-(4-Bromothiophen-2-yl)-N-(2-methoxyphenyl)prop-2-enamide chemical structure, C14H12BrNO2S, CAS 300813-88-1
(2E)-3-(4-Bromothiophen-2-yl)-N-(2-methoxyphenyl)prop-2-enamide
CAS 300813-88-1C14H12BrNO2S
(E)-3-(4-Bromothiophen-2-yl)-N-phenylprop-2-enamide chemical structure, C13H10BrNOS, CAS 300813-86-9
(E)-3-(4-Bromothiophen-2-yl)-N-phenylprop-2-enamide
CAS 300813-86-9C13H10BrNOS
(2E)-3-(4-Bromothiophen-2-yl)-N-(3-methylphenyl)prop-2-enamide chemical structure, C14H12BrNOS, CAS 300813-87-0
(2E)-3-(4-Bromothiophen-2-yl)-N-(3-methylphenyl)prop-2-enamide
CAS 300813-87-0C14H12BrNOS
(E)-Ethyl 4-(3-(5-nitrothiophen-2-yl)acrylamido)benzoate chemical structure, C16H14N2O5S, CAS 93014-56-3
(E)-Ethyl 4-(3-(5-nitrothiophen-2-yl)acrylamido)benzoate
CAS 93014-56-3C16H14N2O5S
(2E)-N-(2-Methoxy-5-nitrophenyl)-3-(thiophen-2-yl)prop-2-enamide chemical structure, C14H12N2O4S, CAS 476308-28-8
(2E)-N-(2-Methoxy-5-nitrophenyl)-3-(thiophen-2-yl)prop-2-enamide
CAS 476308-28-8C14H12N2O4S
2-Propenamide, N-(4-chlorophenyl)-3-(2-thienyl)- chemical structure, C13H10ClNOS, CAS 64741-20-4
2-Propenamide, N-(4-chlorophenyl)-3-(2-thienyl)-
CAS 64741-20-4C13H10ClNOS
(E)-N-(3,4-Dimethylphenyl)-3-thiophen-2-ylprop-2-enamide chemical structure, C15H15NOS, CAS 545350-06-9
(E)-N-(3,4-Dimethylphenyl)-3-thiophen-2-ylprop-2-enamide
CAS 545350-06-9C15H15NOS
Dimethyl 2-[[(E)-3-thiophen-2-ylprop-2-enoyl]amino]benzene-1,4-dicarboxylate chemical structure, C17H15NO5S, CAS 540798-10-5
Dimethyl 2-[[(E)-3-thiophen-2-ylprop-2-enoyl]amino]benzene-1,4-dicarboxylate
CAS 540798-10-5C17H15NO5S
(E)-N-(2,5-Dimethoxyphenyl)-3-thiophen-2-ylprop-2-enamide chemical structure, C15H15NO3S, CAS 560093-27-8
(E)-N-(2,5-Dimethoxyphenyl)-3-thiophen-2-ylprop-2-enamide
CAS 560093-27-8C15H15NO3S
(2E)-N-(3,5-Dimethylphenyl)-3-(thiophen-2-yl)prop-2-enamide chemical structure, C15H15NOS, CAS 551908-56-6
(2E)-N-(3,5-Dimethylphenyl)-3-(thiophen-2-yl)prop-2-enamide
CAS 551908-56-6C15H15NOS