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Murcko scaffold

2-Benzyl-3,4-dihydro-1H-isoquinoline scaffold

146 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
17
Chemicals
146
With full pages
17
Scaffold SMILES

c1ccc(CN2CCc3ccccc3C2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-Benzyl-3,4-dihydro-1H-isoquinoline page
Murcko scaffold c1ccc(CN2CCc3ccccc3C2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 96 of 146 chemicals

2-[(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)methyl]aniline chemical structure, C18H22N2O2, CAS 114688-61-8
2-[(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)methyl]aniline
CAS 114688-61-8C18H22N2O2
2-((3,4-Dihydroisoquinolin-2(1H)-yl)methyl)aniline chemical structure, C16H18N2, CAS 133528-08-2
2-((3,4-Dihydroisoquinolin-2(1H)-yl)methyl)aniline
CAS 133528-08-2C16H18N2
2-Benzyl-5-nitro-1,2,3,4-tetrahydroisoquinoline chemical structure, C16H16N2O2, CAS 915126-46-4
2-Benzyl-5-nitro-1,2,3,4-tetrahydroisoquinoline
CAS 915126-46-4C16H16N2O2
2-Benzyl-1,2,3,4-tetrahydroisoquinolin-4-ol chemical structure, C16H17NO, CAS 70273-41-5
2-Benzyl-1,2,3,4-tetrahydroisoquinolin-4-ol
CAS 70273-41-5C16H17NO
2-Benzyl-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile chemical structure, C17H16N2, CAS 37039-47-7
2-Benzyl-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile
CAS 37039-47-7C17H16N2
(2-Benzyl-1,2,3,4-tetrahydroisoquinolin-1-yl)methanamine chemical structure, C17H20N2, CAS 40615-06-3
(2-Benzyl-1,2,3,4-tetrahydroisoquinolin-1-yl)methanamine
CAS 40615-06-3C17H20N2
2-Benzyl-1,2,3,4-tetrahydroisoquinolin-4-amine chemical structure, C16H18N2, CAS 53667-22-4
2-Benzyl-1,2,3,4-tetrahydroisoquinolin-4-amine
CAS 53667-22-4C16H18N2
1,2,3,4-Tetrahydro-6-methoxy-2-(phenylmethyl)-3-isoquinolinecarboxylicacid chemical structure, C18H19NO3, CAS 86804-60-6
1,2,3,4-Tetrahydro-6-methoxy-2-(phenylmethyl)-3-isoquinolinecarboxylicacid
CAS 86804-60-6C18H19NO3
2-Benzyl-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium iodide chemical structure, C17H20IN, CAS 87993-10-0
2-Benzyl-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium iodide
CAS 87993-10-0C17H20IN
4-Ethoxy-1,2,3,4-tetrahydro-2-(phenylmethyl)isoquinoline chemical structure, C18H21NO, CAS 106889-85-4
4-Ethoxy-1,2,3,4-tetrahydro-2-(phenylmethyl)isoquinoline
CAS 106889-85-4C18H21NO
2-Benzyl-1,2,3,4-tetrahydroisoquinolin-6-amine chemical structure, C16H18N2, CAS 208589-96-2
2-Benzyl-1,2,3,4-tetrahydroisoquinolin-6-amine
CAS 208589-96-2C16H18N2
2-Benzyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid chemical structure, C17H17NO2, CAS 54329-48-5
2-Benzyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
CAS 54329-48-5C17H17NO2
3-Isoquinolinecarboxylic acid, 2-[(4-chlorophenyl)methyl]-1,2,3,4-tetrahydro- chemical structure, C17H16ClNO2, CAS 1025495-98-0
3-Isoquinolinecarboxylic acid, 2-[(4-chlorophenyl)methyl]-1,2,3,4-tetrahydro-
CAS 1025495-98-0C17H16ClNO2
3-Isoquinolinecarboxylic acid, 2-[(4-fluorophenyl)methyl]-1,2,3,4-tetrahydro- chemical structure, C17H16FNO2, CAS 1025496-01-8
3-Isoquinolinecarboxylic acid, 2-[(4-fluorophenyl)methyl]-1,2,3,4-tetrahydro-
CAS 1025496-01-8C17H16FNO2
3-Isoquinolinecarboxylic acid, 7-chloro-2-[(4-chlorophenyl)methyl]-1,2,3,4-tetrahydro- chemical structure, C17H15Cl2NO2, CAS 1032335-18-4
3-Isoquinolinecarboxylic acid, 7-chloro-2-[(4-chlorophenyl)methyl]-1,2,3,4-tetrahydro-
CAS 1032335-18-4C17H15Cl2NO2
3-Isoquinolinecarboxylic acid, 7-chloro-2-[(4-fluorophenyl)methyl]-1,2,3,4-tetrahydro- chemical structure, C17H15ClFNO2, CAS 1025736-14-4
3-Isoquinolinecarboxylic acid, 7-chloro-2-[(4-fluorophenyl)methyl]-1,2,3,4-tetrahydro-
CAS 1025736-14-4C17H15ClFNO2
3-Isoquinolinecarboxylic acid, 2-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro- chemical structure, C17H15ClFNO2, CAS 1025736-22-4
3-Isoquinolinecarboxylic acid, 2-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-
CAS 1025736-22-4C17H15ClFNO2
3-Isoquinolinecarboxylic acid, 2-[(3-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro- chemical structure, C17H15ClFNO2, CAS 1045893-30-8
3-Isoquinolinecarboxylic acid, 2-[(3-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-
CAS 1045893-30-8C17H15ClFNO2
3-Isoquinolinecarboxylic acid, 7-fluoro-2-[(4-fluorophenyl)methyl]-1,2,3,4-tetrahydro- chemical structure, C17H15F2NO2, CAS 1045893-32-0
3-Isoquinolinecarboxylic acid, 7-fluoro-2-[(4-fluorophenyl)methyl]-1,2,3,4-tetrahydro-
CAS 1045893-32-0C17H15F2NO2
(4-[2-Amino-1-(3,4-dihydroisoquinolin-2(1H)-YL)ethyl]phenyl)dimethylamine chemical structure, C19H25N3, CAS 954578-77-9
(4-[2-Amino-1-(3,4-dihydroisoquinolin-2(1H)-YL)ethyl]phenyl)dimethylamine
CAS 954578-77-9C19H25N3
N1-(2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-(4-(dimethylamino)phenyl)ethyl)-N2-(2-methoxyethyl)oxalamide chemical structure, C24H32N4O3, CAS 941995-73-9
N1-(2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-(4-(dimethylamino)phenyl)ethyl)-N2-(2-methoxyethyl)oxalamide
CAS 941995-73-9C24H32N4O3
2-[(4-Cyanophenyl)methyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide chemical structure, C18H17N3O, CAS 1104637-66-2
2-[(4-Cyanophenyl)methyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide
CAS 1104637-66-2C18H17N3O
N1-(2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-(4-(dimethylamino)phenyl)ethyl)-N2-propyloxalamide chemical structure, C24H32N4O2, CAS 941995-70-6
N1-(2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-(4-(dimethylamino)phenyl)ethyl)-N2-propyloxalamide
CAS 941995-70-6C24H32N4O2
N1-allyl-N2-(2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-(4-(dimethylamino)phenyl)ethyl)oxalamide chemical structure, C24H30N4O2, CAS 941869-89-2
N1-allyl-N2-(2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-(4-(dimethylamino)phenyl)ethyl)oxalamide
CAS 941869-89-2C24H30N4O2