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Murcko scaffold

2-Benzyl-3,4-dihydro-1H-isoquinoline scaffold

146 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
17
Chemicals
146
With full pages
17
Scaffold SMILES

c1ccc(CN2CCc3ccccc3C2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-Benzyl-3,4-dihydro-1H-isoquinoline page
Murcko scaffold c1ccc(CN2CCc3ccccc3C2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 97 to 144 of 146 chemicals

N-(2-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-(4-(dimethylamino)phenyl)ethyl)-3-methylbutanamide chemical structure, C24H33N3O, CAS 946365-76-0
N-(2-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-(4-(dimethylamino)phenyl)ethyl)-3-methylbutanamide
CAS 946365-76-0C24H33N3O
N-(2-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-(4-(dimethylamino)phenyl)ethyl)pivalamide chemical structure, C24H33N3O, CAS 946244-21-9
N-(2-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-(4-(dimethylamino)phenyl)ethyl)pivalamide
CAS 946244-21-9C24H33N3O
N-(2-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-(4-(dimethylamino)phenyl)ethyl)propionamide chemical structure, C22H29N3O, CAS 946287-53-2
N-(2-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-(4-(dimethylamino)phenyl)ethyl)propionamide
CAS 946287-53-2C22H29N3O
3-Chloro-N-(2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-(4-(dimethylamino)phenyl)ethyl)-2,2-dimethylpropanamide chemical structure, C24H32ClN3O, CAS 946316-43-4
3-Chloro-N-(2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-(4-(dimethylamino)phenyl)ethyl)-2,2-dimethylpropanamide
CAS 946316-43-4C24H32ClN3O
N-(2-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-(4-(dimethylamino)phenyl)ethyl)methanesulfonamide chemical structure, C20H27N3O2S, CAS 946317-27-7
N-(2-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-(4-(dimethylamino)phenyl)ethyl)methanesulfonamide
CAS 946317-27-7C20H27N3O2S
2-Benzyl-3-aminomethyl-1,2,3,4-tetrahydro-isoquinoline chemical structure, C17H20N2, CAS 54329-56-5
2-Benzyl-3-aminomethyl-1,2,3,4-tetrahydro-isoquinoline
CAS 54329-56-5C17H20N2
6,7-Dimethoxy-2-(1-phenylethyl)-1,2,3,4-tetrahydroisoquinoline chemical structure, C19H23NO2, CAS 1239865-64-5
6,7-Dimethoxy-2-(1-phenylethyl)-1,2,3,4-tetrahydroisoquinoline
CAS 1239865-64-5C19H23NO2
2-Benzyl-1,2,3,4-tetrahydroisoquinoline-3-carbohydrazide chemical structure, C17H19N3O, CAS 1251924-04-5
2-Benzyl-1,2,3,4-tetrahydroisoquinoline-3-carbohydrazide
CAS 1251924-04-5C17H19N3O
7-Ethyl-1,2,3,4-tetrahydro-2-((3,4,5-trimethoxyphenyl)methyl)-6-isoquinolinyl sulfamate chemical structure, C21H28N2O6S, CAS 1228996-85-7
7-Ethyl-1,2,3,4-tetrahydro-2-((3,4,5-trimethoxyphenyl)methyl)-6-isoquinolinyl sulfamate
CAS 1228996-85-7C21H28N2O6S
3-[(3,4-Dihydroisoquinolin-2(1H)-yl)methyl]phenyl acetate--hydrogen chloride (1/1) chemical structure, C18H20ClNO2, CAS 5468-10-0
3-[(3,4-Dihydroisoquinolin-2(1H)-yl)methyl]phenyl acetate--hydrogen chloride (1/1)
CAS 5468-10-0C18H20ClNO2
2-Benzyl-6-nitro-1,2,3,4-tetrahydroisoquinoline hydrochloride chemical structure, C16H17ClN2O2, CAS 1256483-34-7
2-Benzyl-6-nitro-1,2,3,4-tetrahydroisoquinoline hydrochloride
CAS 1256483-34-7C16H17ClN2O2
2-Benzyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide chemical structure, C17H18N2O, CAS 54329-49-6
2-Benzyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
CAS 54329-49-6C17H18N2O
2-(4-Chlorobenzyl)-1,2,3,4-tetrahydroisoquinoline-8-carboxylic acid chemical structure, C17H16ClNO2, CAS 1196047-61-6
2-(4-Chlorobenzyl)-1,2,3,4-tetrahydroisoquinoline-8-carboxylic acid
CAS 1196047-61-6C17H16ClNO2
Ethyl 2-benzyl-1,2,3,4-tetrahydroisoquinoline-1-carboxylate chemical structure, C19H21NO2, CAS 1085539-18-9
Ethyl 2-benzyl-1,2,3,4-tetrahydroisoquinoline-1-carboxylate
CAS 1085539-18-9C19H21NO2
(4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)phenyl)methanol chemical structure, C17H19NO, CAS 888070-03-9
(4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)phenyl)methanol
CAS 888070-03-9C17H19NO
2-[1-(5-Amino-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]-1,4-benzenediol chemical structure, C17H20N2O2, CAS 1179221-23-8
2-[1-(5-Amino-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]-1,4-benzenediol
CAS 1179221-23-8C17H20N2O2
(4-((3,4-Dihydroisoquinolin-2(1H)-yl)methyl)phenyl)boronic acid chemical structure, C16H18BNO2, CAS 1313742-04-9
(4-((3,4-Dihydroisoquinolin-2(1H)-yl)methyl)phenyl)boronic acid
CAS 1313742-04-9C16H18BNO2
1,2,3,4-Tetrahydro-N-methyl-2-(phenylmethyl)-3-isoquinolinemethanamine chemical structure, C18H22N2, CAS 54329-63-4
1,2,3,4-Tetrahydro-N-methyl-2-(phenylmethyl)-3-isoquinolinemethanamine
CAS 54329-63-4C18H22N2
Methyl({2-[(2-methylphenyl)methyl]-1,2,3,4-tetrahydroisoquinolin-3-yl}methyl)amine chemical structure, C19H24N2, CAS 1457531-32-6
Methyl({2-[(2-methylphenyl)methyl]-1,2,3,4-tetrahydroisoquinolin-3-yl}methyl)amine
CAS 1457531-32-6C19H24N2
Methyl 2-Benzyl-1,2,3,4-tetrahydroisoquinoline-6-carboxylate chemical structure, C18H19NO2, CAS 1144523-92-1
Methyl 2-Benzyl-1,2,3,4-tetrahydroisoquinoline-6-carboxylate
CAS 1144523-92-1C18H19NO2
2-(2-Benzyl-1,2,3,4-tetrahydro-6-isoquinolyl)-2-propanol chemical structure, C19H23NO, CAS 1144523-95-4
2-(2-Benzyl-1,2,3,4-tetrahydro-6-isoquinolyl)-2-propanol
CAS 1144523-95-4C19H23NO
2-Benzyl-6-isopropyl-1,2,3,4-tetrahydroisoquinoline chemical structure, C19H23N, CAS 1144523-96-5
2-Benzyl-6-isopropyl-1,2,3,4-tetrahydroisoquinoline
CAS 1144523-96-5C19H23N
4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)benzoic acid ethyl ester chemical structure, C19H21NO2, CAS 1186634-31-0
4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)benzoic acid ethyl ester
CAS 1186634-31-0C19H21NO2
2-[(3,5-Difluorophenyl)methyl]-1,2,3,4-tetrahydroisoquinolin-8-ol chemical structure, C16H15F2NO, CAS 827310-56-5
2-[(3,5-Difluorophenyl)methyl]-1,2,3,4-tetrahydroisoquinolin-8-ol
CAS 827310-56-5C16H15F2NO