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Murcko scaffold

Ring system with 3 rings and 19 atoms

59 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
59
With full pages
7
Scaffold SMILES

O=C1N=C(N2CCOCC2)SC1=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1N=C(N2CCOCC2)SC1=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 59 chemicals

(5Z)-5-[1-(4-Chlorophenyl)ethylidene]-2-morpholin-4-yl-1,3-thiazol-4-one chemical structure, C15H15ClN2O2S, CAS 1164542-31-7
(5Z)-5-[1-(4-Chlorophenyl)ethylidene]-2-morpholin-4-yl-1,3-thiazol-4-one
CAS 1164542-31-7C15H15ClN2O2S
(5E)-5-[(4-Hydroxyphenyl)methylidene]-2-(morpholin-4-yl)-4,5-dihydro-1,3-thiazol-4-one chemical structure, C14H14N2O3S, CAS 81154-07-6
(5E)-5-[(4-Hydroxyphenyl)methylidene]-2-(morpholin-4-yl)-4,5-dihydro-1,3-thiazol-4-one
CAS 81154-07-6C14H14N2O3S
(E)-5-(4-(Dimethylamino)benzylidene)-2-morpholinothiazol-4(5H)-one chemical structure, C16H19N3O2S, CAS 36937-49-2
(E)-5-(4-(Dimethylamino)benzylidene)-2-morpholinothiazol-4(5H)-one
CAS 36937-49-2C16H19N3O2S
2-Morpholino-5-[(Z)-4-fluorobenzylidene]-4,5-dihydrothiazole-4-one chemical structure, C14H13FN2O2S, CAS 851429-31-7
2-Morpholino-5-[(Z)-4-fluorobenzylidene]-4,5-dihydrothiazole-4-one
CAS 851429-31-7C14H13FN2O2S
(5Z)-2-(Morpholin-4-yl)-5-[4-(propan-2-yl)benzylidene]-1,3-thiazol-4(5H)-one chemical structure, C17H20N2O2S, CAS 311332-66-8
(5Z)-2-(Morpholin-4-yl)-5-[4-(propan-2-yl)benzylidene]-1,3-thiazol-4(5H)-one
CAS 311332-66-8C17H20N2O2S
5-{3-Nitrobenzylidene}-2-(4-morpholinyl)-1,3-thiazol-4(5H)-one chemical structure, C14H13N3O4S, CAS 16781-69-4
5-{3-Nitrobenzylidene}-2-(4-morpholinyl)-1,3-thiazol-4(5H)-one
CAS 16781-69-4C14H13N3O4S
(E)-5-(4-(Diethylamino)benzylidene)-2-morpholinothiazol-4(5H)-one chemical structure, C18H23N3O2S, CAS 5404-72-8
(E)-5-(4-(Diethylamino)benzylidene)-2-morpholinothiazol-4(5H)-one
CAS 5404-72-8C18H23N3O2S
(5Z)-5-(4-Methylbenzylidene)-2-morpholin-4-yl-1,3-thiazol-4(5H)-one chemical structure, C15H16N2O2S, CAS 1351285-84-1
(5Z)-5-(4-Methylbenzylidene)-2-morpholin-4-yl-1,3-thiazol-4(5H)-one
CAS 1351285-84-1C15H16N2O2S
(5Z)-5-[(4-tert-Butylphenyl)methylidene]-2-morpholin-4-yl-1,3-thiazol-4-one chemical structure, C18H22N2O2S, CAS 312317-70-7
(5Z)-5-[(4-tert-Butylphenyl)methylidene]-2-morpholin-4-yl-1,3-thiazol-4-one
CAS 312317-70-7C18H22N2O2S
2-Morpholino-5-(3-methoxy-4-hydroxybenzylidene)-2-thiazoline-4-one chemical structure, C15H16N2O4S, CAS 101113-19-3
2-Morpholino-5-(3-methoxy-4-hydroxybenzylidene)-2-thiazoline-4-one
CAS 101113-19-3C15H16N2O4S
(5Z)-5-[(3-Hydroxyphenyl)methylidene]-2-morpholin-4-yl-1,3-thiazol-4-one chemical structure, C14H14N2O3S, CAS 5562-53-8
(5Z)-5-[(3-Hydroxyphenyl)methylidene]-2-morpholin-4-yl-1,3-thiazol-4-one
CAS 5562-53-8C14H14N2O3S
5-(2-Hydroxybenzylidene)-2-(4-morpholinyl)-1,3-thiazol-4(5H)-one chemical structure, C14H14N2O3S, CAS 81154-06-5
5-(2-Hydroxybenzylidene)-2-(4-morpholinyl)-1,3-thiazol-4(5H)-one
CAS 81154-06-5C14H14N2O3S
(5Z)-5-[(2,5-Dimethoxyphenyl)methylidene]-2-morpholin-4-yl-1,3-thiazol-4-one chemical structure, C16H18N2O4S, CAS 346444-79-9
(5Z)-5-[(2,5-Dimethoxyphenyl)methylidene]-2-morpholin-4-yl-1,3-thiazol-4-one
CAS 346444-79-9C16H18N2O4S
5-(2,6-Dichloro-benzylidene)-2-morpholin-4-yl-thiazol-4-one chemical structure, C14H12Cl2N2O2S, CAS 302549-00-4
5-(2,6-Dichloro-benzylidene)-2-morpholin-4-yl-thiazol-4-one
CAS 302549-00-4C14H12Cl2N2O2S
2-(4-Morpholinyl)-5-(4-nitrobenzylidene)-1,3-thiazol-4(5H)-one chemical structure, C14H13N3O4S, CAS 145802-13-7
2-(4-Morpholinyl)-5-(4-nitrobenzylidene)-1,3-thiazol-4(5H)-one
CAS 145802-13-7C14H13N3O4S
5-(2,4-Dichlorobenzylidene)-2-(4-morpholinyl)-1,3-thiazol-4(5H)-one chemical structure, C14H12Cl2N2O2S, CAS 300560-09-2
5-(2,4-Dichlorobenzylidene)-2-(4-morpholinyl)-1,3-thiazol-4(5H)-one
CAS 300560-09-2C14H12Cl2N2O2S
(2-{(E)-[2-(Morpholin-4-yl)-4-oxo-1,3-thiazol-5(4H)-ylidene]methyl}phenoxy)acetic acid chemical structure, C16H16N2O5S, CAS 431923-82-9
(2-{(E)-[2-(Morpholin-4-yl)-4-oxo-1,3-thiazol-5(4H)-ylidene]methyl}phenoxy)acetic acid
CAS 431923-82-9C16H16N2O5S
(E)-5-(2-Ethoxybenzylidene)-2-morpholinothiazol-4(5H)-one chemical structure, C16H18N2O3S, CAS 405920-43-6
(E)-5-(2-Ethoxybenzylidene)-2-morpholinothiazol-4(5H)-one
CAS 405920-43-6C16H18N2O3S
(5Z)-5-[(2-Fluorophenyl)methylidene]-2-morpholin-4-yl-1,3-thiazol-4-one chemical structure, C14H13FN2O2S, CAS 333393-73-0
(5Z)-5-[(2-Fluorophenyl)methylidene]-2-morpholin-4-yl-1,3-thiazol-4-one
CAS 333393-73-0C14H13FN2O2S
5-[(4-Ethoxy-3-methoxyphenyl)methylene]-2-(4-morpholinyl)-4(5H)-thiazolone chemical structure, C17H20N2O4S, CAS 6297-18-3
5-[(4-Ethoxy-3-methoxyphenyl)methylene]-2-(4-morpholinyl)-4(5H)-thiazolone
CAS 6297-18-3C17H20N2O4S
(5Z)-5-[(2-Hydroxy-3-methoxyphenyl)methylidene]-2-morpholin-4-yl-1,3-thiazol-4-one chemical structure, C15H16N2O4S, CAS 312317-65-0
(5Z)-5-[(2-Hydroxy-3-methoxyphenyl)methylidene]-2-morpholin-4-yl-1,3-thiazol-4-one
CAS 312317-65-0C15H16N2O4S
(E)-5-(4-Isopropoxybenzylidene)-2-morpholinothiazol-4(5H)-one chemical structure, C17H20N2O3S, CAS 370848-87-6
(E)-5-(4-Isopropoxybenzylidene)-2-morpholinothiazol-4(5H)-one
CAS 370848-87-6C17H20N2O3S
(E)-5-(4-Hydroxy-3-nitrobenzylidene)-2-morpholinothiazol-4(5H)-one chemical structure, C14H13N3O5S, CAS 371129-53-2
(E)-5-(4-Hydroxy-3-nitrobenzylidene)-2-morpholinothiazol-4(5H)-one
CAS 371129-53-2C14H13N3O5S
(5E)-5-[[3-Bromo-4-(dimethylamino)phenyl]methylidene]-2-morpholin-4-yl-1,3-thiazol-4-one chemical structure, C16H18BrN3O2S, CAS 667913-89-5
(5E)-5-[[3-Bromo-4-(dimethylamino)phenyl]methylidene]-2-morpholin-4-yl-1,3-thiazol-4-one
CAS 667913-89-5C16H18BrN3O2S