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Murcko scaffold

Ring system with 3 rings and 22 atoms

51 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
51
With full pages
5
Scaffold SMILES

O=C(CSc1nnc(-c2ccccc2)[nH]1)NC1CCCCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nnc(-c2ccccc2)[nH]1)NC1CCCCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 51 chemicals

N-Cyclohexyl-2-[[4-methyl-5-(3-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide chemical structure, C18H24N4OS, CAS 626203-65-4
N-Cyclohexyl-2-[[4-methyl-5-(3-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide
CAS 626203-65-4C18H24N4OS
N-Cyclohexyl-2-{[5-(2,4-dichlorophenyl)-4-ethyl-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C18H22Cl2N4OS, CAS 591761-82-9
N-Cyclohexyl-2-{[5-(2,4-dichlorophenyl)-4-ethyl-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 591761-82-9C18H22Cl2N4OS
2-{[5-(4-Bromophenyl)-4-ethyl-4H-1,2,4-triazol-3-yl]sulfanyl}-N-cyclohexylacetamide chemical structure, C18H23BrN4OS, CAS 693236-02-1
2-{[5-(4-Bromophenyl)-4-ethyl-4H-1,2,4-triazol-3-yl]sulfanyl}-N-cyclohexylacetamide
CAS 693236-02-1C18H23BrN4OS
2-[[4-Amino-5-(2-chlorophenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-cyclohexylacetamide chemical structure, C16H20ClN5OS, CAS 665017-48-1
2-[[4-Amino-5-(2-chlorophenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-cyclohexylacetamide
CAS 665017-48-1C16H20ClN5OS
N-Cyclohexyl-2-{[5-(4-methoxyphenyl)-4-methyl-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C18H24N4O2S, CAS 484646-74-4
N-Cyclohexyl-2-{[5-(4-methoxyphenyl)-4-methyl-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 484646-74-4C18H24N4O2S
2-[[5-(3-Aminophenyl)-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-N-cyclohexylacetamide chemical structure, C18H25N5OS, CAS 701244-62-4
2-[[5-(3-Aminophenyl)-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-N-cyclohexylacetamide
CAS 701244-62-4C18H25N5OS
N-Cyclohexyl-2-[[5-(4-methoxyphenyl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]acetamide chemical structure, C20H26N4O2S, CAS 339339-32-1
N-Cyclohexyl-2-[[5-(4-methoxyphenyl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]acetamide
CAS 339339-32-1C20H26N4O2S
N-Cyclohexyl-2-[[4-ethyl-5-(4-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide chemical structure, C19H26N4OS, CAS 591760-91-7
N-Cyclohexyl-2-[[4-ethyl-5-(4-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide
CAS 591760-91-7C19H26N4OS
2-[[5-(4-Aminophenyl)-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-N-cyclohexylacetamide chemical structure, C18H25N5OS, CAS 500266-10-4
2-[[5-(4-Aminophenyl)-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-N-cyclohexylacetamide
CAS 500266-10-4C18H25N5OS
2-{[4-Amino-5-(4-chlorophenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-cyclohexylacetamide chemical structure, C16H20ClN5OS, CAS 540498-91-7
2-{[4-Amino-5-(4-chlorophenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-cyclohexylacetamide
CAS 540498-91-7C16H20ClN5OS
N-[4-(5-{[2-(Cyclohexylamino)-2-oxoethyl]sulfanyl}-4-methyl-4H-1,2,4-triazol-3-yl)phenyl]propanamide chemical structure, C20H27N5O2S, CAS 500266-49-9
N-[4-(5-{[2-(Cyclohexylamino)-2-oxoethyl]sulfanyl}-4-methyl-4H-1,2,4-triazol-3-yl)phenyl]propanamide
CAS 500266-49-9C20H27N5O2S
N-Cyclohexyl-2-[[4-methyl-5-(4-nitrophenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide chemical structure, C17H21N5O3S, CAS 693228-44-3
N-Cyclohexyl-2-[[4-methyl-5-(4-nitrophenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide
CAS 693228-44-3C17H21N5O3S
2-[[5-(4-Acetamidophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-cyclohexylacetamide chemical structure, C19H25N5O2S, CAS 693236-85-0
2-[[5-(4-Acetamidophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-cyclohexylacetamide
CAS 693236-85-0C19H25N5O2S
N-Cyclohexyl-2-[[4-ethyl-5-(4-nitrophenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide chemical structure, C18H23N5O3S, CAS 639004-05-0
N-Cyclohexyl-2-[[4-ethyl-5-(4-nitrophenyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide
CAS 639004-05-0C18H23N5O3S
2-[[5-(2-Chloro-4-methylphenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-cyclohexylacetamide chemical structure, C18H23ClN4OS, CAS 824971-73-5
2-[[5-(2-Chloro-4-methylphenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-cyclohexylacetamide
CAS 824971-73-5C18H23ClN4OS
N-Cyclohexyl-2-[[5-(4-fluorophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]acetamide chemical structure, C17H21FN4OS, CAS 561293-80-9
N-Cyclohexyl-2-[[5-(4-fluorophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]acetamide
CAS 561293-80-9C17H21FN4OS
2-[[4-Amino-5-(4-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-cyclohexylacetamide chemical structure, C17H23N5O2S, CAS 879187-69-6
2-[[4-Amino-5-(4-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-cyclohexylacetamide
CAS 879187-69-6C17H23N5O2S
N-(1-Cyanocyclohexyl)-2-((4-ethyl-5-(2-methoxyphenyl)-4H-1,2,4-triazol-3-yl)thio)acetamide chemical structure, C20H25N5O2S, CAS 851871-04-0
N-(1-Cyanocyclohexyl)-2-((4-ethyl-5-(2-methoxyphenyl)-4H-1,2,4-triazol-3-yl)thio)acetamide
CAS 851871-04-0C20H25N5O2S
2-[(4-Amino-5-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(1-cyanocyclohexyl)acetamide chemical structure, C17H20N6OS, CAS 852295-38-6
2-[(4-Amino-5-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(1-cyanocyclohexyl)acetamide
CAS 852295-38-6C17H20N6OS
2-{[4-Ethyl-5-(4-methylphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(2-methylcyclohexyl)acetamide chemical structure, C20H28N4OS, CAS 591760-89-3
2-{[4-Ethyl-5-(4-methylphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(2-methylcyclohexyl)acetamide
CAS 591760-89-3C20H28N4OS
2-[[5-(4-Bromophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-(2-methylcyclohexyl)acetamide chemical structure, C18H23BrN4OS, CAS 692775-02-3
2-[[5-(4-Bromophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-(2-methylcyclohexyl)acetamide
CAS 692775-02-3C18H23BrN4OS
N-Cyclohexyl-2-[[5-(4-nitrophenyl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]acetamide chemical structure, C19H23N5O3S, CAS 693232-96-1
N-Cyclohexyl-2-[[5-(4-nitrophenyl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]acetamide
CAS 693232-96-1C19H23N5O3S
2-[[4-Amino-5-(4-chlorophenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(2-methylcyclohexyl)acetamide chemical structure, C17H22ClN5OS, CAS 694460-38-3
2-[[4-Amino-5-(4-chlorophenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(2-methylcyclohexyl)acetamide
CAS 694460-38-3C17H22ClN5OS
2-[[5-(4-Chlorophenyl)-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-N-(2-methylcyclohexyl)acetamide chemical structure, C19H25ClN4OS, CAS 694462-31-2
2-[[5-(4-Chlorophenyl)-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-N-(2-methylcyclohexyl)acetamide
CAS 694462-31-2C19H25ClN4OS