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Murcko scaffold

Ring system with 3 rings and 20 atoms

12 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
12
With full pages
3
Scaffold SMILES

c1ccc(CCNc2cnc(-c3ccccc3)o2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(CCNc2cnc(-c3ccccc3)o2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

2-(4-Methoxyphenyl)-5-[(2-phenylethyl)amino]-1,3-oxazole-4-carbonitrile chemical structure, C19H17N3O2, CAS 521283-90-9
2-(4-Methoxyphenyl)-5-[(2-phenylethyl)amino]-1,3-oxazole-4-carbonitrile
CAS 521283-90-9C19H17N3O2
2-(2-Fluorophenyl)-5-[(2-phenylethyl)amino]-1,3-oxazole-4-carbonitrile chemical structure, C18H14FN3O, CAS 613651-94-8
2-(2-Fluorophenyl)-5-[(2-phenylethyl)amino]-1,3-oxazole-4-carbonitrile
CAS 613651-94-8C18H14FN3O
2-(2-Chlorophenyl)-5-[(2-phenylethyl)amino]-1,3-oxazole-4-carbonitrile chemical structure, C18H14ClN3O, CAS 613651-60-8
2-(2-Chlorophenyl)-5-[(2-phenylethyl)amino]-1,3-oxazole-4-carbonitrile
CAS 613651-60-8C18H14ClN3O
2-(3-Methylphenyl)-5-[(2-phenylethyl)amino]-1,3-oxazole-4-carbonitrile chemical structure, C19H17N3O, CAS 613651-07-3
2-(3-Methylphenyl)-5-[(2-phenylethyl)amino]-1,3-oxazole-4-carbonitrile
CAS 613651-07-3C19H17N3O
2-(2-Methylphenyl)-5-[(2-phenylethyl)amino]-1,3-oxazole-4-carbonitrile chemical structure, C19H17N3O, CAS 613650-73-0
2-(2-Methylphenyl)-5-[(2-phenylethyl)amino]-1,3-oxazole-4-carbonitrile
CAS 613650-73-0C19H17N3O
2-(4-Nitrophenyl)-5-(phenethylamino)oxazole-4-carbonitrile chemical structure, C18H14N4O3, CAS 613649-85-7
2-(4-Nitrophenyl)-5-(phenethylamino)oxazole-4-carbonitrile
CAS 613649-85-7C18H14N4O3
2-(3-Chlorophenyl)-5-[(2-phenylethyl)amino]-1,3-oxazole-4-carbonitrile chemical structure, C18H14ClN3O, CAS 825600-38-2
2-(3-Chlorophenyl)-5-[(2-phenylethyl)amino]-1,3-oxazole-4-carbonitrile
CAS 825600-38-2C18H14ClN3O
5-[2-(3,4-Dimethoxyphenyl)ethylamino]-2-(4-methylphenyl)-1,3-oxazole-4-carbonitrile chemical structure, C21H21N3O3, CAS 380594-29-6
5-[2-(3,4-Dimethoxyphenyl)ethylamino]-2-(4-methylphenyl)-1,3-oxazole-4-carbonitrile
CAS 380594-29-6C21H21N3O3
5-[2-(3,4-Dimethoxyphenyl)ethylamino]-2-(4-propoxyphenyl)-1,3-oxazole-4-carbonitrile chemical structure, C23H25N3O4, CAS 845653-55-6
5-[2-(3,4-Dimethoxyphenyl)ethylamino]-2-(4-propoxyphenyl)-1,3-oxazole-4-carbonitrile
CAS 845653-55-6C23H25N3O4
4-{4-Cyano-5-[(2-phenylethyl)amino]-1,3-oxazol-2-yl}-N,N-dimethylbenzenesulfonamide chemical structure, C20H20N4O3S, CAS 941240-49-9
4-{4-Cyano-5-[(2-phenylethyl)amino]-1,3-oxazol-2-yl}-N,N-dimethylbenzenesulfonamide
CAS 941240-49-9C20H20N4O3S
4-(4-Cyano-5-{[2-(4-methoxyphenyl)ethyl]amino}-1,3-oxazol-2-yl)-N,N-dimethylbenzenesulfonamide chemical structure, C21H22N4O4S, CAS 941265-20-9
4-(4-Cyano-5-{[2-(4-methoxyphenyl)ethyl]amino}-1,3-oxazol-2-yl)-N,N-dimethylbenzenesulfonamide
CAS 941265-20-9C21H22N4O4S
4-(4-Cyano-5-(phenethylamino)oxazol-2-yl)-N,N-diethylbenzenesulfonamide chemical structure, C22H24N4O3S, CAS 941243-07-8
4-(4-Cyano-5-(phenethylamino)oxazol-2-yl)-N,N-diethylbenzenesulfonamide
CAS 941243-07-8C22H24N4O3S