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Murcko scaffold

2-[(2,5-Dioxo-1-phenylpyrrolidin-3-yl)sulfanyl]-N-phenylacetamide scaffold

49 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
24
Chemicals
49
With full pages
11
Scaffold SMILES

O=C(CSC1CC(=O)N(c2ccccc2)C1=O)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-[(2,5-Dioxo-1-phenylpyrrolidin-3-yl)sulfanyl]-N-phenylacetamide page
Murcko scaffold O=C(CSC1CC(=O)N(c2ccccc2)C1=O)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 49 chemicals

N-(4-Chlorophenyl)-2-[1-(3-chlorophenyl)-2,5-dioxopyrrolidin-3-yl]sulfanylacetamide chemical structure, C18H14Cl2N2O3S, CAS 300690-39-5
N-(4-Chlorophenyl)-2-[1-(3-chlorophenyl)-2,5-dioxopyrrolidin-3-yl]sulfanylacetamide
CAS 300690-39-5C18H14Cl2N2O3S
N-(3,5-Bis(trifluoromethyl)phenyl)-2-((1-(4-methyl-3-nitrophenyl)-2,5-dioxopyrrolidin-3-yl)thio)acetamide chemical structure, C21H15F6N3O5S, CAS 217317-54-9
N-(3,5-Bis(trifluoromethyl)phenyl)-2-((1-(4-methyl-3-nitrophenyl)-2,5-dioxopyrrolidin-3-yl)thio)acetamide
CAS 217317-54-9C21H15F6N3O5S
N-(4-Bromophenyl)-2-[1-(4-chlorophenyl)-2,5-dioxopyrrolidin-3-yl]sulfanylacetamide chemical structure, C18H14BrClN2O3S, CAS 332125-98-1
N-(4-Bromophenyl)-2-[1-(4-chlorophenyl)-2,5-dioxopyrrolidin-3-yl]sulfanylacetamide
CAS 332125-98-1C18H14BrClN2O3S
N-(4-Bromophenyl)-2-[1-(3-chlorophenyl)-2,5-dioxopyrrolidin-3-yl]sulfanylacetamide chemical structure, C18H14BrClN2O3S, CAS 332125-94-7
N-(4-Bromophenyl)-2-[1-(3-chlorophenyl)-2,5-dioxopyrrolidin-3-yl]sulfanylacetamide
CAS 332125-94-7C18H14BrClN2O3S
N-(4-Chlorophenyl)-2-[1-(3-methylphenyl)-2,5-dioxopyrrolidin-3-yl]sulfanylacetamide chemical structure, C19H17ClN2O3S, CAS 301654-61-5
N-(4-Chlorophenyl)-2-[1-(3-methylphenyl)-2,5-dioxopyrrolidin-3-yl]sulfanylacetamide
CAS 301654-61-5C19H17ClN2O3S
N-(4-Chlorophenyl)-2-(2,5-dioxo-1-phenylpyrrolidin-3-yl)sulfanylacetamide chemical structure, C18H15ClN2O3S, CAS 300690-38-4
N-(4-Chlorophenyl)-2-(2,5-dioxo-1-phenylpyrrolidin-3-yl)sulfanylacetamide
CAS 300690-38-4C18H15ClN2O3S
N-(4-Chlorophenyl)-2-[1-(4-ethoxyphenyl)-2,5-dioxopyrrolidin-3-yl]sulfanylacetamide chemical structure, C20H19ClN2O4S, CAS 331966-10-0
N-(4-Chlorophenyl)-2-[1-(4-ethoxyphenyl)-2,5-dioxopyrrolidin-3-yl]sulfanylacetamide
CAS 331966-10-0C20H19ClN2O4S
N-(4-Bromophenyl)-2-[(2,5-dioxo-1-phenylpyrrolidin-3-yl)sulfanyl]acetamide chemical structure, C18H15BrN2O3S, CAS 301654-76-2
N-(4-Bromophenyl)-2-[(2,5-dioxo-1-phenylpyrrolidin-3-yl)sulfanyl]acetamide
CAS 301654-76-2C18H15BrN2O3S
N-(3-Fluorophenyl)-2-[1-(4-methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]sulfanylacetamide chemical structure, C19H17FN2O4S, CAS 313378-85-7
N-(3-Fluorophenyl)-2-[1-(4-methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]sulfanylacetamide
CAS 313378-85-7C19H17FN2O4S
2-(2,5-Dioxo-1-phenylpyrrolidin-3-yl)sulfanyl-N-(3-fluorophenyl)acetamide chemical structure, C18H15FN2O3S, CAS 331966-15-5
2-(2,5-Dioxo-1-phenylpyrrolidin-3-yl)sulfanyl-N-(3-fluorophenyl)acetamide
CAS 331966-15-5C18H15FN2O3S
N-(4-Bromophenyl)-2-[1-(3,4-dichlorophenyl)-2,5-dioxopyrrolidin-3-yl]sulfanylacetamide chemical structure, C18H13BrCl2N2O3S, CAS 332126-01-9
N-(4-Bromophenyl)-2-[1-(3,4-dichlorophenyl)-2,5-dioxopyrrolidin-3-yl]sulfanylacetamide
CAS 332126-01-9C18H13BrCl2N2O3S
N-(4-Chlorophenyl)-2-[1-(2,4-dichlorophenyl)-2,5-dioxopyrrolidin-3-yl]sulfanylacetamide chemical structure, C18H13Cl3N2O3S, CAS 331245-18-2
N-(4-Chlorophenyl)-2-[1-(2,4-dichlorophenyl)-2,5-dioxopyrrolidin-3-yl]sulfanylacetamide
CAS 331245-18-2C18H13Cl3N2O3S
2-[1-(3-Chlorophenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl-N-(3,4-dichlorophenyl)acetamide chemical structure, C18H13Cl3N2O3S, CAS 301325-81-5
2-[1-(3-Chlorophenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl-N-(3,4-dichlorophenyl)acetamide
CAS 301325-81-5C18H13Cl3N2O3S
2-{[1-(3-Bromophenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}-N-(4-chlorophenyl)acetamide chemical structure, C18H14BrClN2O3S, CAS 331966-20-2
2-{[1-(3-Bromophenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}-N-(4-chlorophenyl)acetamide
CAS 331966-20-2C18H14BrClN2O3S
2-{[1-(3-Chlorophenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}-N-(4-fluorophenyl)acetamide chemical structure, C18H14ClFN2O3S, CAS 311766-75-3
2-{[1-(3-Chlorophenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}-N-(4-fluorophenyl)acetamide
CAS 311766-75-3C18H14ClFN2O3S
N-(4-Fluorophenyl)-2-{[1-(4-methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}acetamide chemical structure, C19H17FN2O4S, CAS 301325-79-1
N-(4-Fluorophenyl)-2-{[1-(4-methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}acetamide
CAS 301325-79-1C19H17FN2O4S
4-[3-[2-(4-Fluoroanilino)-2-oxoethyl]sulfanyl-2,5-dioxopyrrolidin-1-yl]benzoic acid chemical structure, C19H15FN2O5S, CAS 299949-56-7
4-[3-[2-(4-Fluoroanilino)-2-oxoethyl]sulfanyl-2,5-dioxopyrrolidin-1-yl]benzoic acid
CAS 299949-56-7C19H15FN2O5S
N-(4-Chlorophenyl)-2-[2,5-dioxo-1-(4-propoxyphenyl)pyrrolidin-3-yl]sulfanylacetamide chemical structure, C21H21ClN2O4S, CAS 329928-92-9
N-(4-Chlorophenyl)-2-[2,5-dioxo-1-(4-propoxyphenyl)pyrrolidin-3-yl]sulfanylacetamide
CAS 329928-92-9C21H21ClN2O4S
4-[3-[2-(4-Chloroanilino)-2-oxoethyl]sulfanyl-2,5-dioxopyrrolidin-1-yl]benzoic acid chemical structure, C19H15ClN2O5S, CAS 313378-86-8
4-[3-[2-(4-Chloroanilino)-2-oxoethyl]sulfanyl-2,5-dioxopyrrolidin-1-yl]benzoic acid
CAS 313378-86-8C19H15ClN2O5S
N-(4-Bromophenyl)-2-[1-(3-methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]sulfanylacetamide chemical structure, C19H17BrN2O4S, CAS 333398-45-1
N-(4-Bromophenyl)-2-[1-(3-methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]sulfanylacetamide
CAS 333398-45-1C19H17BrN2O4S
N-(4-Chlorophenyl)-2-[1-(3-methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]sulfanylacetamide chemical structure, C19H17ClN2O4S, CAS 331966-24-6
N-(4-Chlorophenyl)-2-[1-(3-methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]sulfanylacetamide
CAS 331966-24-6C19H17ClN2O4S
2-[1-(4-Bromophenyl)-2,5-dioxoazolidin-3-ylthio]-N-phenylacetamide chemical structure, C18H15BrN2O3S, CAS 5668-71-3
2-[1-(4-Bromophenyl)-2,5-dioxoazolidin-3-ylthio]-N-phenylacetamide
CAS 5668-71-3C18H15BrN2O3S
N-(4-Chlorophenyl)-2-{[1-(4-chlorophenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}acetamide chemical structure, C18H14Cl2N2O3S, CAS 301325-83-7
N-(4-Chlorophenyl)-2-{[1-(4-chlorophenyl)-2,5-dioxopyrrolidin-3-yl]sulfanyl}acetamide
CAS 301325-83-7C18H14Cl2N2O3S
N-(3-Chlorophenyl)-2-[1-(2-fluorophenyl)-2,5-dioxopyrrolidin-3-yl]sulfanylacetamide chemical structure, C18H14ClFN2O3S, CAS 312266-46-9
N-(3-Chlorophenyl)-2-[1-(2-fluorophenyl)-2,5-dioxopyrrolidin-3-yl]sulfanylacetamide
CAS 312266-46-9C18H14ClFN2O3S