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Murcko scaffold

Ring system with 2 rings and 16 atoms

67 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
16
Chemicals
67
With full pages
3
Scaffold SMILES

O=C(CSc1nccs1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nccs1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 67 chemicals

2-[(4-tert-Butyl-1,3-thiazol-2-yl)sulfanyl]-N-(4-methoxyphenyl)acetamide chemical structure, C16H20N2O2S2, CAS 825656-47-1
2-[(4-tert-Butyl-1,3-thiazol-2-yl)sulfanyl]-N-(4-methoxyphenyl)acetamide
CAS 825656-47-1C16H20N2O2S2
N-(4-Iodophenyl)-2-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]acetamide chemical structure, C12H11IN2OS2, CAS 826997-44-8
N-(4-Iodophenyl)-2-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]acetamide
CAS 826997-44-8C12H11IN2OS2
2-[(4-Methyl-1,3-thiazol-2-yl)sulfanyl]-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C13H11F3N2OS2, CAS 827011-67-6
2-[(4-Methyl-1,3-thiazol-2-yl)sulfanyl]-N-[3-(trifluoromethyl)phenyl]acetamide
CAS 827011-67-6C13H11F3N2OS2
N-(2-Ethoxyphenyl)-2-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]acetamide chemical structure, C14H16N2O2S2, CAS 892062-28-1
N-(2-Ethoxyphenyl)-2-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]acetamide
CAS 892062-28-1C14H16N2O2S2
N-(2,5-Dimethylphenyl)-2-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]acetamide chemical structure, C14H16N2OS2, CAS 847930-99-8
N-(2,5-Dimethylphenyl)-2-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]acetamide
CAS 847930-99-8C14H16N2OS2
5-[[2-[(4-Methyl-1,3-thiazol-2-yl)sulfanyl]acetyl]amino]benzene-1,3-dicarboxamide chemical structure, C14H14N4O3S2, CAS 852132-12-8
5-[[2-[(4-Methyl-1,3-thiazol-2-yl)sulfanyl]acetyl]amino]benzene-1,3-dicarboxamide
CAS 852132-12-8C14H14N4O3S2
N-(4-Methoxy-2-nitrophenyl)-2-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]acetamide chemical structure, C13H13N3O4S2, CAS 854352-63-9
N-(4-Methoxy-2-nitrophenyl)-2-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]acetamide
CAS 854352-63-9C13H13N3O4S2
N-(2-Chloro-4-fluorophenyl)-2-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]propanamide chemical structure, C13H12ClFN2OS2, CAS 746613-45-6
N-(2-Chloro-4-fluorophenyl)-2-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]propanamide
CAS 746613-45-6C13H12ClFN2OS2
Ethyl 2-(2-((2-((4-ethylphenyl)amino)-2-oxoethyl)thio)thiazol-4-yl)acetate chemical structure, C17H20N2O3S2, CAS 1172547-32-8
Ethyl 2-(2-((2-((4-ethylphenyl)amino)-2-oxoethyl)thio)thiazol-4-yl)acetate
CAS 1172547-32-8C17H20N2O3S2
N-(3-Acetamidophenyl)-2-((4-(2-(ethylamino)-2-oxoethyl)thiazol-2-yl)thio)acetamide chemical structure, C17H20N4O3S2, CAS 954039-50-0
N-(3-Acetamidophenyl)-2-((4-(2-(ethylamino)-2-oxoethyl)thiazol-2-yl)thio)acetamide
CAS 954039-50-0C17H20N4O3S2
N-(3-Acetamidophenyl)-2-((4-(2-oxo-2-(propylamino)ethyl)thiazol-2-yl)thio)acetamide chemical structure, C18H22N4O3S2, CAS 954094-26-9
N-(3-Acetamidophenyl)-2-((4-(2-oxo-2-(propylamino)ethyl)thiazol-2-yl)thio)acetamide
CAS 954094-26-9C18H22N4O3S2
N-(3-Acetamidophenyl)-2-((4-(2-(butylamino)-2-oxoethyl)thiazol-2-yl)thio)acetamide chemical structure, C19H24N4O3S2, CAS 954039-54-4
N-(3-Acetamidophenyl)-2-((4-(2-(butylamino)-2-oxoethyl)thiazol-2-yl)thio)acetamide
CAS 954039-54-4C19H24N4O3S2
N-(3-Acetamidophenyl)-2-((4-(2-(isopropylamino)-2-oxoethyl)thiazol-2-yl)thio)acetamide chemical structure, C18H22N4O3S2, CAS 953983-10-3
N-(3-Acetamidophenyl)-2-((4-(2-(isopropylamino)-2-oxoethyl)thiazol-2-yl)thio)acetamide
CAS 953983-10-3C18H22N4O3S2
N-(3-Acetamidophenyl)-2-((4-(2-(isobutylamino)-2-oxoethyl)thiazol-2-yl)thio)acetamide chemical structure, C19H24N4O3S2, CAS 954094-32-7
N-(3-Acetamidophenyl)-2-((4-(2-(isobutylamino)-2-oxoethyl)thiazol-2-yl)thio)acetamide
CAS 954094-32-7C19H24N4O3S2
N-(3-Acetamidophenyl)-2-((4-(2-(sec-butylamino)-2-oxoethyl)thiazol-2-yl)thio)acetamide chemical structure, C19H24N4O3S2, CAS 954039-58-8
N-(3-Acetamidophenyl)-2-((4-(2-(sec-butylamino)-2-oxoethyl)thiazol-2-yl)thio)acetamide
CAS 954039-58-8C19H24N4O3S2
N-(3-Acetamidophenyl)-2-((4-(2-(allylamino)-2-oxoethyl)thiazol-2-yl)thio)acetamide chemical structure, C18H20N4O3S2, CAS 953983-18-1
N-(3-Acetamidophenyl)-2-((4-(2-(allylamino)-2-oxoethyl)thiazol-2-yl)thio)acetamide
CAS 953983-18-1C18H20N4O3S2
N-(3-Acetamidophenyl)-2-((4-(2-(isopentylamino)-2-oxoethyl)thiazol-2-yl)thio)acetamide chemical structure, C20H26N4O3S2, CAS 953926-10-8
N-(3-Acetamidophenyl)-2-((4-(2-(isopentylamino)-2-oxoethyl)thiazol-2-yl)thio)acetamide
CAS 953926-10-8C20H26N4O3S2
N-(3-Acetamidophenyl)-2-((4-(2-((2-methoxyethyl)amino)-2-oxoethyl)thiazol-2-yl)thio)acetamide chemical structure, C18H22N4O4S2, CAS 954094-38-3
N-(3-Acetamidophenyl)-2-((4-(2-((2-methoxyethyl)amino)-2-oxoethyl)thiazol-2-yl)thio)acetamide
CAS 954094-38-3C18H22N4O4S2
N-(4-Acetamidophenyl)-2-((4-(2-oxo-2-(propylamino)ethyl)thiazol-2-yl)thio)acetamide chemical structure, C18H22N4O3S2, CAS 941960-83-4
N-(4-Acetamidophenyl)-2-((4-(2-oxo-2-(propylamino)ethyl)thiazol-2-yl)thio)acetamide
CAS 941960-83-4C18H22N4O3S2
N-(4-Acetamidophenyl)-2-((4-(2-(butylamino)-2-oxoethyl)thiazol-2-yl)thio)acetamide chemical structure, C19H24N4O3S2, CAS 941997-20-2
N-(4-Acetamidophenyl)-2-((4-(2-(butylamino)-2-oxoethyl)thiazol-2-yl)thio)acetamide
CAS 941997-20-2C19H24N4O3S2
N-(4-Acetamidophenyl)-2-((4-(2-(isopropylamino)-2-oxoethyl)thiazol-2-yl)thio)acetamide chemical structure, C18H22N4O3S2, CAS 941891-75-4
N-(4-Acetamidophenyl)-2-((4-(2-(isopropylamino)-2-oxoethyl)thiazol-2-yl)thio)acetamide
CAS 941891-75-4C18H22N4O3S2
N-(4-Acetamidophenyl)-2-((4-(2-(isobutylamino)-2-oxoethyl)thiazol-2-yl)thio)acetamide chemical structure, C19H24N4O3S2, CAS 941937-14-0
N-(4-Acetamidophenyl)-2-((4-(2-(isobutylamino)-2-oxoethyl)thiazol-2-yl)thio)acetamide
CAS 941937-14-0C19H24N4O3S2
N-(4-Acetamidophenyl)-2-((4-(2-(sec-butylamino)-2-oxoethyl)thiazol-2-yl)thio)acetamide chemical structure, C19H24N4O3S2, CAS 941960-86-7
N-(4-Acetamidophenyl)-2-((4-(2-(sec-butylamino)-2-oxoethyl)thiazol-2-yl)thio)acetamide
CAS 941960-86-7C19H24N4O3S2
N-(4-Acetamidophenyl)-2-((4-(2-(allylamino)-2-oxoethyl)thiazol-2-yl)thio)acetamide chemical structure, C18H20N4O3S2, CAS 941997-23-5
N-(4-Acetamidophenyl)-2-((4-(2-(allylamino)-2-oxoethyl)thiazol-2-yl)thio)acetamide
CAS 941997-23-5C18H20N4O3S2