Murcko scaffold
Ring system with 2 rings and 16 atoms
139 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 16
- Chemicals
- 139
- With full pages
- 8
Scaffold SMILES
O=C(C=Cc1ccccc1)Nc1cccs1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 139 chemicals
![Methyl 4-ethyl-2-[[(E)-3-(4-fluorophenyl)prop-2-enoyl]amino]-5-methylthiophene-3-carboxylate chemical structure, C18H18FNO3S, CAS 329078-00-4](/s/OFFPKTLYRLCUQD-JXMROGBWSA-N.svg)
Methyl 4-ethyl-2-[[(E)-3-(4-fluorophenyl)prop-2-enoyl]amino]-5-methylthiophene-3-carboxylate
CAS 329078-00-4C18H18FNO3S
![5-Ethyl-2-{[3-(4-methoxyphenyl)acryloyl]amino}-3-thiophenecarboxylic acid chemical structure, C17H17NO4S, CAS 312584-60-4](/s/OURUQWHDCYXNFZ-RMKNXTFCSA-N.svg)
5-Ethyl-2-{[3-(4-methoxyphenyl)acryloyl]amino}-3-thiophenecarboxylic acid
CAS 312584-60-4C17H17NO4S
![Ethyl 5-methyl-2-[[(E)-3-phenylprop-2-enoyl]amino]thiophene-3-carboxylate chemical structure, C17H17NO3S, CAS 472996-76-2](/s/LYIRNWGXRAMBGN-MDZDMXLPSA-N.svg)
Ethyl 5-methyl-2-[[(E)-3-phenylprop-2-enoyl]amino]thiophene-3-carboxylate
CAS 472996-76-2C17H17NO3S
![2-[[(E)-3-(4-Chlorophenyl)prop-2-enoyl]amino]-4,5-dimethylthiophene-3-carboxamide chemical structure, C16H15ClN2O2S, CAS 544669-94-5](/s/CCHKNWTYLMVUMB-VMPITWQZSA-N.svg)
2-[[(E)-3-(4-Chlorophenyl)prop-2-enoyl]amino]-4,5-dimethylthiophene-3-carboxamide
CAS 544669-94-5C16H15ClN2O2S
![2-[[(E)-3-(4-Chlorophenyl)prop-2-enoyl]amino]-4-ethyl-5-methylthiophene-3-carboxamide chemical structure, C17H17ClN2O2S, CAS 419560-12-6](/s/CNYLBGGVFLLAPE-RMKNXTFCSA-N.svg)
2-[[(E)-3-(4-Chlorophenyl)prop-2-enoyl]amino]-4-ethyl-5-methylthiophene-3-carboxamide
CAS 419560-12-6C17H17ClN2O2S
![2-[[(E)-3-(3-Chlorophenyl)prop-2-enoyl]amino]-4,5-dimethylthiophene-3-carboxamide chemical structure, C16H15ClN2O2S, CAS 419560-86-4](/s/RNLHRKWIHSATBT-VOTSOKGWSA-N.svg)
2-[[(E)-3-(3-Chlorophenyl)prop-2-enoyl]amino]-4,5-dimethylthiophene-3-carboxamide
CAS 419560-86-4C16H15ClN2O2S
![2-[[(E)-3-(3-Chlorophenyl)prop-2-enoyl]amino]-4-ethyl-5-methylthiophene-3-carboxamide chemical structure, C17H17ClN2O2S, CAS 420093-87-4](/s/IRGKELAKRQQJOJ-BQYQJAHWSA-N.svg)
2-[[(E)-3-(3-Chlorophenyl)prop-2-enoyl]amino]-4-ethyl-5-methylthiophene-3-carboxamide
CAS 420093-87-4C17H17ClN2O2S
Methyl 2-((2E)-3-phenylprop-2-enoylamino)-4,5-dimethylthiophene-3-carboxylate
CAS 420094-71-9C17H17NO3S
![4-Ethyl-2-[[(E)-3-(4-fluorophenyl)prop-2-enoyl]amino]-5-methylthiophene-3-carboxamide chemical structure, C17H17FN2O2S, CAS 550354-41-1](/s/KZHZXTVEBBXKMC-RMKNXTFCSA-N.svg)
4-Ethyl-2-[[(E)-3-(4-fluorophenyl)prop-2-enoyl]amino]-5-methylthiophene-3-carboxamide
CAS 550354-41-1C17H17FN2O2S
(E)-2-(3-(4-Methoxyphenyl)acrylamido)-4,5-dimethylthiophene-3-carboxamide
CAS 525580-64-7C17H18N2O3S
![4-(2-Methylpropyl)-2-[[(E)-3-phenylprop-2-enoyl]amino]thiophene-3-carboxylic acid chemical structure, C18H19NO3S, CAS 325740-82-7](/s/LZBMIDTVNHHAQK-CMDGGOBGSA-N.svg)
4-(2-Methylpropyl)-2-[[(E)-3-phenylprop-2-enoyl]amino]thiophene-3-carboxylic acid
CAS 325740-82-7C18H19NO3S
2-Cinnamamido-4,5-dimethylthiophene-3-carboxylic acid
CAS 472989-97-2C16H15NO3S
![Ethyl 5-(aminocarbonyl)-2-{[3-(3-chlorophenyl)acryloyl]amino}-4-methyl-3-thiophenecarboxylate chemical structure, C18H17ClN2O4S, CAS 303134-00-1](/s/ZWIPYYTWNYIICA-BQYQJAHWSA-N.svg)
Ethyl 5-(aminocarbonyl)-2-{[3-(3-chlorophenyl)acryloyl]amino}-4-methyl-3-thiophenecarboxylate
CAS 303134-00-1C18H17ClN2O4S
![Methyl 4-ethyl-2-[(3-{4-nitrophenyl}acryloyl)amino]-5-methyl-3-thiophenecarboxylate chemical structure, C18H18N2O5S, CAS 560075-96-9](/s/QGVVBZPCMAMXHK-JXMROGBWSA-N.svg)
Methyl 4-ethyl-2-[(3-{4-nitrophenyl}acryloyl)amino]-5-methyl-3-thiophenecarboxylate
CAS 560075-96-9C18H18N2O5S
![Isopropyl 5-[(diethylamino)carbonyl]-2-{[3-(4-methoxyphenyl)acryloyl]amino}-4-methyl-3-thiophenecarboxylate chemical structure, C24H30N2O5S, CAS 545347-84-0](/s/INYRAXOOEGQUPN-SDNWHVSQSA-N.svg)
Isopropyl 5-[(diethylamino)carbonyl]-2-{[3-(4-methoxyphenyl)acryloyl]amino}-4-methyl-3-thiophenecarboxylate
CAS 545347-84-0C24H30N2O5S
![Methyl 5-(diethylcarbamoyl)-2-[[(E)-3-(4-fluorophenyl)prop-2-enoyl]amino]-4-methylthiophene-3-carboxylate chemical structure, C21H23FN2O4S, CAS 560105-77-3](/s/SYBFEENRLUZUQN-FMIVXFBMSA-N.svg)
Methyl 5-(diethylcarbamoyl)-2-[[(E)-3-(4-fluorophenyl)prop-2-enoyl]amino]-4-methylthiophene-3-carboxylate
CAS 560105-77-3C21H23FN2O4S
![Ethyl 5-carbamoyl-2-[[(E)-3-(2-chlorophenyl)prop-2-enoyl]amino]-4-methylthiophene-3-carboxylate chemical structure, C18H17ClN2O4S, CAS 544690-15-5](/s/UZVBFADEYCDVOY-CMDGGOBGSA-N.svg)
Ethyl 5-carbamoyl-2-[[(E)-3-(2-chlorophenyl)prop-2-enoyl]amino]-4-methylthiophene-3-carboxylate
CAS 544690-15-5C18H17ClN2O4S
![2-[[(E)-3-(4-tert-Butylphenyl)prop-2-enoyl]amino]-4-ethyl-5-methylthiophene-3-carboxamide chemical structure, C21H26N2O2S, CAS 560092-10-6](/s/GAILXKVVYGEICX-FMIVXFBMSA-N.svg)
2-[[(E)-3-(4-tert-Butylphenyl)prop-2-enoyl]amino]-4-ethyl-5-methylthiophene-3-carboxamide
CAS 560092-10-6C21H26N2O2S
![Methyl 5-[(dimethylamino)carbonyl]-2-[(3-{3-nitrophenyl}acryloyl)amino]-4-methyl-3-thiophenecarboxylate chemical structure, C19H19N3O6S, CAS 547696-91-3](/s/CWHAIZFYHLYHCM-CMDGGOBGSA-N.svg)
Methyl 5-[(dimethylamino)carbonyl]-2-[(3-{3-nitrophenyl}acryloyl)amino]-4-methyl-3-thiophenecarboxylate
CAS 547696-91-3C19H19N3O6S
![Ethyl 5-[(diethylamino)carbonyl]-2-{[3-(4-fluorophenyl)acryloyl]amino}-4-methyl-3-thiophenecarboxylate chemical structure, C22H25FN2O4S, CAS 560075-86-7](/s/QMLJKPTXRLMTEB-JLHYYAGUSA-N.svg)
Ethyl 5-[(diethylamino)carbonyl]-2-{[3-(4-fluorophenyl)acryloyl]amino}-4-methyl-3-thiophenecarboxylate
CAS 560075-86-7C22H25FN2O4S
![Methyl 2-{[3-(4-isopropylphenyl)acryloyl]amino}-4,5-dimethyl-3-thiophenecarboxylate chemical structure, C20H23NO3S, CAS 544698-69-3](/s/MOMSYPWFERHGNO-DHZHZOJOSA-N.svg)
Methyl 2-{[3-(4-isopropylphenyl)acryloyl]amino}-4,5-dimethyl-3-thiophenecarboxylate
CAS 544698-69-3C20H23NO3S
![Ethyl 2-{[3-(4-tert-butylphenyl)acryloyl]amino}-5-[(dimethylamino)carbonyl]-4-methyl-3-thiophenecarboxylate chemical structure, C24H30N2O4S, CAS 547705-00-0](/s/ZDKAJJFWMYTLPH-SDNWHVSQSA-N.svg)
Ethyl 2-{[3-(4-tert-butylphenyl)acryloyl]amino}-5-[(dimethylamino)carbonyl]-4-methyl-3-thiophenecarboxylate
CAS 547705-00-0C24H30N2O4S
![Ethyl 5-(dimethylcarbamoyl)-4-methyl-2-[[(E)-3-(4-propan-2-ylphenyl)prop-2-enoyl]amino]thiophene-3-carboxylate chemical structure, C23H28N2O4S, CAS 546088-57-7](/s/PPMVAVAVZJKOEX-JLHYYAGUSA-N.svg)
Ethyl 5-(dimethylcarbamoyl)-4-methyl-2-[[(E)-3-(4-propan-2-ylphenyl)prop-2-enoyl]amino]thiophene-3-carboxylate
CAS 546088-57-7C23H28N2O4S
![Ethyl 4-ethyl-5-methyl-2-[[(E)-3-(3-nitrophenyl)prop-2-enoyl]amino]thiophene-3-carboxylate chemical structure, C19H20N2O5S, CAS 540801-61-4](/s/OJZGYIBQSMZCOW-MDZDMXLPSA-N.svg)
Ethyl 4-ethyl-5-methyl-2-[[(E)-3-(3-nitrophenyl)prop-2-enoyl]amino]thiophene-3-carboxylate
CAS 540801-61-4C19H20N2O5S
- 2-[[(E)-3-(2,6-Dichlorophenyl)prop-2-enoyl]amino]-4,5-dimethylthiophene-3-carboxamide543684-00-0C16H14Cl2N2O2S
- Methyl 2-{[3-(3,4-dimethoxyphenyl)acryloyl]amino}-5-[(dimethylamino)carbonyl]-4-methyl-3-thiophenecarboxylate444935-12-0C21H24N2O6S
- Ethyl 5-(aminocarbonyl)-2-{[3-(4-methoxyphenyl)acryloyl]amino}-4-methyl-3-thiophenecarboxylate354545-75-8C19H20N2O5S
- (E)-Diethyl 5-(3-(3,4-dimethoxyphenyl)acrylamido)-3-methylthiophene-2,4-dicarboxylate301305-65-7C22H25NO7S
- (E)-Diethyl 5-(3-(4-methoxyphenyl)acrylamido)-3-methylthiophene-2,4-dicarboxylate301305-66-8C21H23NO6S
- (E)-Ethyl 5-acetyl-2-(3-(4-methoxyphenyl)acrylamido)-4-methylthiophene-3-carboxylate301305-68-0C20H21NO5S
- (E)-Diethyl 5-(3-(4-fluorophenyl)acrylamido)-3-methylthiophene-2,4-dicarboxylate325850-89-3C20H20FNO5S
- Ethyl 2-{[3-(4-methoxyphenyl)acryloyl]amino}-4,5-dimethyl-3-thiophenecarboxylate324044-72-6C19H21NO4S
- Diethyl 3-methyl-5-{[(2E)-3-phenylprop-2-enoyl]amino}thiophene-2,4-dicarboxylate290835-18-6C20H21NO5S
- Ethyl 5-acetyl-2-{[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino}-4-methylthiophene-3-carboxylate290839-57-5C21H23NO6S
- Ethyl 5-acetyl-2-[[2-cyano-3-(4-methoxyphenyl)-1-oxo-2-propen-1-yl]amino]-4-methyl-3-thiophenecarboxylate307539-22-6C21H20N2O5S
- Diethyl 5-{[(2E)-3-(3-bromo-4-methoxyphenyl)-2-propenoyl]amino}-3-methyl-2,4-thiophenedicarboxylate307505-48-2C21H22BrNO6S
- Diethyl 5-{[(2E)-3-(4-ethoxyphenyl)prop-2-enoyl]amino}-3-methylthiophene-2,4-dicarboxylate431071-93-1C22H25NO6S
- 3-(4-Bromophenyl)-N-(3-cyano-4,5-dimethyl-2-thienyl)acrylamide354146-21-7C16H13BrN2OS
- 2-[[(E)-3-(4-Bromophenyl)prop-2-enoyl]amino]-4,5-dimethylthiophene-3-carboxamide353783-18-3C16H15BrN2O2S
- Ethyl 2-{[3-(4-bromophenyl)acryloyl]amino}-5-[(diethylamino)carbonyl]-4-methyl-3-thiophenecarboxylate313392-64-2C22H25BrN2O4S
- Methyl 5-(diethylcarbamoyl)-4-methyl-2-[[(E)-3-phenylprop-2-enoyl]amino]thiophene-3-carboxylate353786-68-2C21H24N2O4S
- Ethyl 5-carbamoyl-4-methyl-2-[[(E)-3-phenylprop-2-enoyl]amino]thiophene-3-carboxylate353470-19-6C18H18N2O4S
- Propan-2-yl 4-carbamoyl-5-[[(E)-3-(4-fluorophenyl)prop-2-enoyl]amino]-3-methylthiophene-2-carboxylate353470-73-2C19H19FN2O4S
- Methyl 5-[(diethylamino)carbonyl]-2-{[3-(4-methoxyphenyl)acryloyl]amino}-4-methyl-3-thiophenecarboxylate353470-98-1C22H26N2O5S
- 2-[[(E)-3-(4-tert-Butylphenyl)prop-2-enoyl]amino]-4,5-dimethylthiophene-3-carboxamide352679-38-0C20H24N2O2S
- Isopropyl 2-[(3-{4-nitrophenyl}acryloyl)amino]-4,5-dimethyl-3-thiophenecarboxylate524731-38-2C19H20N2O5S
- Propan-2-yl 5-[[(E)-3-(4-tert-butylphenyl)prop-2-enoyl]amino]-4-carbamoyl-3-methylthiophene-2-carboxylate5704-62-1C23H28N2O4S
- Methyl 2-[[(E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino]-4,5-dimethylthiophene-3-carboxylate354994-70-0C19H21NO5S
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=C(CSc1nnc[nH]1)Nc1ccccc1](/scaffold/VJBDIQRNSVRUDP-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnc[nH]1)Nc1ccccc165 chemicals
O=C(COc1ccccc1)Nc1nccs143 chemicals
O=C(CCc1ccco1)Nc1ccccc134 chemicals
O=C(CSc1nncs1)Nc1ccccc134 chemicals![Scaffold O=C(NN=Cc1ccccc1)c1cc[nH]n1](/scaffold/UEBQXDJERRSAMF-UHFFFAOYSA-N/structure.svg)
O=C(NN=Cc1ccccc1)c1cc[nH]n129 chemicals
O=C(CCc1ccccc1)Nc1nncs125 chemicals
S=C(NCc1ccco1)Nc1ccccc124 chemicals![Scaffold O=C(CSc1nnn[nH]1)Nc1ccccc1](/scaffold/FDRBWKCIVMSABC-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnn[nH]1)Nc1ccccc122 chemicals![Scaffold O=C(CSc1ncc[nH]1)Nc1ccccc1](/scaffold/OMOYRSCPUXAYDW-UHFFFAOYSA-N/structure.svg)
O=C(CSc1ncc[nH]1)Nc1ccccc121 chemicals
O=C(NC(=S)Nc1ccccc1)c1ccco121 chemicals
O=C(CCN1CCCC1)Nc1ccccc120 chemicals
O=C(NN=Cc1ccco1)c1ccccc119 chemicals