Murcko scaffold
Ring system with 3 rings and 20 atoms
334 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 20
- Chemicals
- 334
- With full pages
- 20
Scaffold SMILES
O=C(Nc1cc(-c2ccccc2)cs1)c1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 334 chemicals
Ethyl 2-benzamido-4-phenylthiophene-3-carboxylate
CAS 43088-49-9C20H17NO3S
Ethyl 2-(benzoyl(4-ethoxy-4-oxobutyl)amino)-4-phenyl-3-thiophenecarboxylate
CAS 54805-47-9C26H27NO5S
Ethyl 2-(benzoylamino)-4-(3,4,5-trimethoxyphenyl)-3-thiophenecarboxylate
CAS 54805-43-5C23H23NO6S
2-(4-Methylbenzamido)-4-phenylthiophene-3-carboxylic acid
CAS 449192-51-2C19H15NO3S
2-(4-Fluoro-benzoylamino)-4-phenyl-thiophene-3-carboxylic acid
CAS 374549-27-6C18H12FNO3S
2-(2-Fluoro-benzoylamino)-4-phenyl-thiophene-3-carboxylic acid
CAS 5897-48-3C18H12FNO3S
![Ethyl 4-(4-chlorophenyl)-2-[(2-methoxybenzoyl)amino]thiophene-3-carboxylate chemical structure, C21H18ClNO4S, CAS 374546-66-4](/s/KGSGJMRKSXPOJP-UHFFFAOYSA-N.svg)
Ethyl 4-(4-chlorophenyl)-2-[(2-methoxybenzoyl)amino]thiophene-3-carboxylate
CAS 374546-66-4C21H18ClNO4S
Ethyl 4-phenyl-2-(3,4,5-trimethoxybenzamido)thiophene-3-carboxylate
CAS 300567-18-4C23H23NO6S
![Methyl 4-(3,4-dimethoxyphenyl)-2-[(3-ethoxybenzoyl)amino]-3-thiophenecarboxylate chemical structure, C23H23NO6S, CAS 438531-44-3](/s/BJISBLPTWCWYRU-UHFFFAOYSA-N.svg)
Methyl 4-(3,4-dimethoxyphenyl)-2-[(3-ethoxybenzoyl)amino]-3-thiophenecarboxylate
CAS 438531-44-3C23H23NO6S
![Methyl 2-[(4-methoxybenzoyl)amino]-4-(4-propan-2-ylphenyl)thiophene-3-carboxylate chemical structure, C23H23NO4S, CAS 445029-56-1](/s/FGLZZFHTFRBDND-UHFFFAOYSA-N.svg)
Methyl 2-[(4-methoxybenzoyl)amino]-4-(4-propan-2-ylphenyl)thiophene-3-carboxylate
CAS 445029-56-1C23H23NO4S
![Propan-2-yl 2-[(4-methoxybenzoyl)amino]-4-(4-methoxyphenyl)-5-methylthiophene-3-carboxylate chemical structure, C24H25NO5S, CAS 445029-76-5](/s/BHHREMDDDBGQQU-UHFFFAOYSA-N.svg)
Propan-2-yl 2-[(4-methoxybenzoyl)amino]-4-(4-methoxyphenyl)-5-methylthiophene-3-carboxylate
CAS 445029-76-5C24H25NO5S
![Ethyl 2-[(4-methoxybenzoyl)amino]-4-(3-methylphenyl)-3-thiophenecarboxylate chemical structure, C22H21NO4S, CAS 445231-20-9](/s/QNHOWBRDDYACRX-UHFFFAOYSA-N.svg)
Ethyl 2-[(4-methoxybenzoyl)amino]-4-(3-methylphenyl)-3-thiophenecarboxylate
CAS 445231-20-9C22H21NO4S
![4-(2,4-Dichlorophenyl)-2-[(4-methoxybenzoyl)amino]-3-thiophenecarboxamide chemical structure, C19H14Cl2N2O3S, CAS 522598-47-6](/s/BZNANUVIOHHQKB-UHFFFAOYSA-N.svg)
4-(2,4-Dichlorophenyl)-2-[(4-methoxybenzoyl)amino]-3-thiophenecarboxamide
CAS 522598-47-6C19H14Cl2N2O3S
![Ethyl 2-[(4-methoxybenzoyl)amino]-4-phenyl-3-thiophenecarboxylate chemical structure, C21H19NO4S, CAS 441315-58-8](/s/DQLKSRCUKBQYAS-UHFFFAOYSA-N.svg)
Ethyl 2-[(4-methoxybenzoyl)amino]-4-phenyl-3-thiophenecarboxylate
CAS 441315-58-8C21H19NO4S
![Methyl 4-(3-chlorophenyl)-2-[(2,6-difluorobenzoyl)amino]-5-methylthiophene-3-carboxylate chemical structure, C20H14ClF2NO3S, CAS 444906-77-8](/s/LSZVBCZIJGUNLP-UHFFFAOYSA-N.svg)
Methyl 4-(3-chlorophenyl)-2-[(2,6-difluorobenzoyl)amino]-5-methylthiophene-3-carboxylate
CAS 444906-77-8C20H14ClF2NO3S
![Ethyl 2-{[4-(difluoromethoxy)-3-methoxybenzoyl]amino}-4-(4-methoxyphenyl)-3-thiophenecarboxylate chemical structure, C23H21F2NO6S, CAS 723254-33-9](/s/YZXFNCUUIWPJBB-UHFFFAOYSA-N.svg)
Ethyl 2-{[4-(difluoromethoxy)-3-methoxybenzoyl]amino}-4-(4-methoxyphenyl)-3-thiophenecarboxylate
CAS 723254-33-9C23H21F2NO6S
![Methyl 2-[(4-ethoxybenzoyl)amino]-4-(4-fluorophenyl)thiophene-3-carboxylate chemical structure, C21H18FNO4S, CAS 545429-76-3](/s/QXBUKBRVOCWPHF-UHFFFAOYSA-N.svg)
Methyl 2-[(4-ethoxybenzoyl)amino]-4-(4-fluorophenyl)thiophene-3-carboxylate
CAS 545429-76-3C21H18FNO4S
![Methyl 4-(4-chlorophenyl)-2-[(2-fluorobenzoyl)amino]-3-thiophenecarboxylate chemical structure, C19H13ClFNO3S, CAS 545440-46-8](/s/VIFZFUWNUDPPMK-UHFFFAOYSA-N.svg)
Methyl 4-(4-chlorophenyl)-2-[(2-fluorobenzoyl)amino]-3-thiophenecarboxylate
CAS 545440-46-8C19H13ClFNO3S
![Ethyl 2-[(2-fluorobenzoyl)amino]-4-(4-fluorophenyl)-3-thiophenecarboxylate chemical structure, C20H15F2NO3S, CAS 546106-11-0](/s/ZXDMTIGIQFTKTG-UHFFFAOYSA-N.svg)
Ethyl 2-[(2-fluorobenzoyl)amino]-4-(4-fluorophenyl)-3-thiophenecarboxylate
CAS 546106-11-0C20H15F2NO3S
![Methyl 2-[(3,5-dimethoxybenzoyl)amino]-4-(4-methylphenyl)-3-thiophenecarboxylate chemical structure, C22H21NO5S, CAS 546083-03-8](/s/XZPLPYPGERMPAT-UHFFFAOYSA-N.svg)
Methyl 2-[(3,5-dimethoxybenzoyl)amino]-4-(4-methylphenyl)-3-thiophenecarboxylate
CAS 546083-03-8C22H21NO5S
Methyl 2-({2-chloro-5-nitrobenzoyl}amino)-4-(4-fluorophenyl)-3-thiophenecarboxylate
CAS 546096-76-8C19H12ClFN2O5S
![Methyl 2-[(4-fluorobenzoyl)amino]-4-(4-methylphenyl)-3-thiophenecarboxylate chemical structure, C20H16FNO3S, CAS 546067-94-1](/s/UYZJQCWVOPFZOO-UHFFFAOYSA-N.svg)
Methyl 2-[(4-fluorobenzoyl)amino]-4-(4-methylphenyl)-3-thiophenecarboxylate
CAS 546067-94-1C20H16FNO3S
Ethyl 4-(4-fluorophenyl)-2-({3-nitro-2-methylbenzoyl}amino)-3-thiophenecarboxylate
CAS 547703-90-2C21H17FN2O5S
![Ethyl 2-[(2,4-dimethoxybenzoyl)amino]-4-(4-fluorophenyl)thiophene-3-carboxylate chemical structure, C22H20FNO5S, CAS 546092-31-3](/s/MRQQCRXNZLAYKT-UHFFFAOYSA-N.svg)
Ethyl 2-[(2,4-dimethoxybenzoyl)amino]-4-(4-fluorophenyl)thiophene-3-carboxylate
CAS 546092-31-3C22H20FNO5S
- Methyl 4-(3-chlorophenyl)-2-({2-nitrobenzoyl}amino)-5-methylthiophene-3-carboxylate444997-95-9C20H15ClN2O5S
- Methyl 4-(4-chlorophenyl)-2-[(3,4-dimethoxybenzoyl)amino]thiophene-3-carboxylate444998-23-6C21H18ClNO5S
- Methyl 2-({3-nitro-2-methylbenzoyl}amino)-4-(4-methylphenyl)thiophene-3-carboxylate444998-93-0C21H18N2O5S
- Methyl 4-(2,5-dimethylphenyl)-2-({3-nitro-4-methoxybenzoyl}amino)-3-thiophenecarboxylate495382-93-9C22H20N2O6S
- Methyl 2-({2-chloro-5-nitrobenzoyl}amino)-4-(4-fluorophenyl)-5-methylthiophene-3-carboxylate444999-38-6C20H14ClFN2O5S
- Methyl 4-(3-chlorophenyl)-2-({4-nitrobenzoyl}amino)-5-methylthiophene-3-carboxylate444999-59-1C20H15ClN2O5S
- Isopropyl 5-methyl-4-phenyl-2-[(3,4,5-trimethoxybenzoyl)amino]-3-thiophenecarboxylate445000-60-2C25H27NO6S
- Isopropyl 4-(3,4-dimethoxyphenyl)-2-[(2-methoxybenzoyl)amino]-3-thiophenecarboxylate445000-67-9C24H25NO6S
- Isopropyl 2-({3-nitrobenzoyl}amino)-4-phenylthiophene-3-carboxylate445001-30-9C21H18N2O5S
- Methyl 4-(3-bromophenyl)-2-({3-nitrobenzoyl}amino)thiophene-3-carboxylate445001-34-3C19H13BrN2O5S
- Ethyl 5-methyl-4-(4-methylphenyl)-2-[(3,4,5-trimethoxybenzoyl)amino]-3-thiophenecarboxylate445001-50-3C25H27NO6S
- Methyl 2-[(2,3-dimethoxybenzoyl)amino]-4-(4-fluorophenyl)-5-methylthiophene-3-carboxylate495383-51-2C22H20FNO5S
- Isopropyl 4-(4-fluorophenyl)-2-({3-nitro-4-methoxybenzoyl}amino)-5-methyl-3-thiophenecarboxylate445002-03-9C23H21FN2O6S
- Methyl 4-(4-fluorophenyl)-2-({4-nitrobenzoyl}amino)-5-methylthiophene-3-carboxylate445002-12-0C20H15FN2O5S
- Methyl 2-[(4-methoxy-3-nitrobenzoyl)amino]-4-(4-methoxyphenyl)-5-methylthiophene-3-carboxylate445002-34-6C22H20N2O7S
- Propan-2-yl 2-[(4-methoxy-3-nitrobenzoyl)amino]-5-methyl-4-phenylthiophene-3-carboxylate495386-04-4C23H22N2O6S
- Methyl 4-(3-bromophenyl)-2-[(2-fluorobenzoyl)amino]thiophene-3-carboxylate445002-84-6C19H13BrFNO3S
- 5-Chloro-N-(3-cyano-5-methyl-4-phenylthiophen-2-yl)-2-methoxybenzamide445003-12-3C20H15ClN2O2S
- 4-Chloro-N-(3-cyano-5-methyl-4-phenylthien-2-yl)-3-nitrobenzamide445003-19-0C19H12ClN3O3S
- 1-Methylethyl 2-(benzoylamino)-4-(4-methoxyphenyl)-3-thiophenecarboxylate445003-38-3C22H21NO4S
- Methyl 2-({4-chloro-3-nitrobenzoyl}amino)-4-(4-methoxyphenyl)-5-methylthiophene-3-carboxylate445003-60-1C21H17ClN2O6S
- 3-Thiophenecarboxylic acid, 2-(benzoylamino)-4-phenyl-, 2-(dimethylamino)ethyl ester, monohydrochloride78033-92-8C22H23ClN2O3S
- 3-Thiophenecarboxylic acid, 2-(benzoylamino)-4-phenyl-, 2-(diethylamino)ethyl ester78033-93-9C24H26N2O3S
- 3-Thiophenecarboxylic acid, 2-(benzoylamino)-4-phenyl-, 2-(diethylamino)ethyl ester, monohydrochloride78033-94-0C24H27ClN2O3S
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold c1ccc(CSc2nnc(-c3ccccc3)[nH]2)cc1](/scaffold/CBPCFMMAXNCEHC-UHFFFAOYSA-N/structure.svg)
c1ccc(CSc2nnc(-c3ccccc3)[nH]2)cc169 chemicals
O=C(Nc1ccccc1)c1ccc(-c2ccccc2)o166 chemicals
O=C1C(N=Nc2ccccc2)C=NN1c1ccccc163 chemicals
O=C(Nc1ccccc1)C1CC(=O)N(c2ccccc2)C149 chemicals
c1ccc(N=Nc2cnn(-c3ccccc3)c2)cc140 chemicals![Scaffold c1ccc(CSc2nnc(-c3ccccn3)[nH]2)cc1](/scaffold/DBVANQGRXKUFCH-UHFFFAOYSA-N/structure.svg)
c1ccc(CSc2nnc(-c3ccccn3)[nH]2)cc139 chemicals![Scaffold c1ccc(CSc2nnc(-c3ccncc3)[nH]2)cc1](/scaffold/JTTNDRXETJGQKP-UHFFFAOYSA-N/structure.svg)
c1ccc(CSc2nnc(-c3ccncc3)[nH]2)cc135 chemicals
O=C(Nc1nc(-c2ccccc2)cs1)c1ccccc131 chemicals![Scaffold O=c1c(NS(=O)(=O)c2ccccc2)c[nH]n1-c1ccccc1](/scaffold/XHWZVQUKSBVLDH-UHFFFAOYSA-N/structure.svg)
O=c1c(NS(=O)(=O)c2ccccc2)c[nH]n1-c1ccccc130 chemicals![Scaffold O=c1c(N=Cc2ccccc2)c[nH]n1-c1ccccc1](/scaffold/ARHCMYOKQKXAGO-UHFFFAOYSA-N/structure.svg)
O=c1c(N=Cc2ccccc2)c[nH]n1-c1ccccc127 chemicals![Scaffold c1ccc(CSc2nnc(-c3cccnc3)[nH]2)cc1](/scaffold/OUELDRTWHCTFGU-UHFFFAOYSA-N/structure.svg)
c1ccc(CSc2nnc(-c3cccnc3)[nH]2)cc125 chemicals
O=C1CC(NCc2ccccc2)C(=O)N1c1ccccc125 chemicals