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Murcko scaffold

2-(1H-Pyrazol-3-yl)pyrazine scaffold

323 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
11
Chemicals
323
With full pages
4
Scaffold SMILES

c1cnc(-c2ccn[nH]2)cn1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-(1H-Pyrazol-3-yl)pyrazine page
Murcko scaffold c1cnc(-c2ccn[nH]2)cn1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 97 to 144 of 323 chemicals

1-(Cyanomethyl)-3-(pyrazin-2-yl)-1H-pyrazole-5-carboxamide chemical structure, C10H8N6O, CAS 2098005-44-6
1-(Cyanomethyl)-3-(pyrazin-2-yl)-1H-pyrazole-5-carboxamide
CAS 2098005-44-6C10H8N6O
1-(Difluoromethyl)-3-(pyrazin-2-yl)-1H-pyrazole-5-carboxamide chemical structure, C9H7F2N5O, CAS 2097958-25-1
1-(Difluoromethyl)-3-(pyrazin-2-yl)-1H-pyrazole-5-carboxamide
CAS 2097958-25-1C9H7F2N5O
1-Methyl-3-(pyrazin-2-yl)-1H-pyrazole-5-carbonitrile chemical structure, C9H7N5, CAS 2098069-92-0
1-Methyl-3-(pyrazin-2-yl)-1H-pyrazole-5-carbonitrile
CAS 2098069-92-0C9H7N5
1-Ethyl-3-(pyrazin-2-yl)-1H-pyrazole-5-carbonitrile chemical structure, C10H9N5, CAS 2097958-31-9
1-Ethyl-3-(pyrazin-2-yl)-1H-pyrazole-5-carbonitrile
CAS 2097958-31-9C10H9N5
1-Isopropyl-3-(pyrazin-2-yl)-1H-pyrazole-5-carbonitrile chemical structure, C11H11N5, CAS 2098104-18-6
1-Isopropyl-3-(pyrazin-2-yl)-1H-pyrazole-5-carbonitrile
CAS 2098104-18-6C11H11N5
1-Isobutyl-3-(pyrazin-2-yl)-1H-pyrazole-5-carbonitrile chemical structure, C12H13N5, CAS 2098104-24-4
1-Isobutyl-3-(pyrazin-2-yl)-1H-pyrazole-5-carbonitrile
CAS 2098104-24-4C12H13N5
1-(2-Fluoroethyl)-3-(pyrazin-2-yl)-1H-pyrazole-5-carbonitrile chemical structure, C10H8FN5, CAS 2098128-22-2
1-(2-Fluoroethyl)-3-(pyrazin-2-yl)-1H-pyrazole-5-carbonitrile
CAS 2098128-22-2C10H8FN5
1-(Prop-2-yn-1-yl)-3-(pyrazin-2-yl)-1H-pyrazole-5-carbonitrile chemical structure, C11H7N5, CAS 2098104-29-9
1-(Prop-2-yn-1-yl)-3-(pyrazin-2-yl)-1H-pyrazole-5-carbonitrile
CAS 2098104-29-9C11H7N5
1-(Difluoromethyl)-3-(pyrazin-2-yl)-1H-pyrazole-5-carbonitrile chemical structure, C9H5F2N5, CAS 2098104-44-8
1-(Difluoromethyl)-3-(pyrazin-2-yl)-1H-pyrazole-5-carbonitrile
CAS 2098104-44-8C9H5F2N5
1-Methyl-3-(pyrazin-2-yl)-1H-pyrazole-5-carboximidamide chemical structure, C9H10N6, CAS 2098069-93-1
1-Methyl-3-(pyrazin-2-yl)-1H-pyrazole-5-carboximidamide
CAS 2098069-93-1C9H10N6
1-Ethyl-3-(pyrazin-2-yl)-1H-pyrazole-5-carboximidamide chemical structure, C10H12N6, CAS 2098134-41-7
1-Ethyl-3-(pyrazin-2-yl)-1H-pyrazole-5-carboximidamide
CAS 2098134-41-7C10H12N6
1-Isopropyl-3-(pyrazin-2-yl)-1H-pyrazole-5-carboximidamide chemical structure, C11H14N6, CAS 2097958-37-5
1-Isopropyl-3-(pyrazin-2-yl)-1H-pyrazole-5-carboximidamide
CAS 2097958-37-5C11H14N6
1-(2-Fluoroethyl)-3-(pyrazin-2-yl)-1H-pyrazole-5-carboximidamide chemical structure, C10H11FN6, CAS 2097983-18-9
1-(2-Fluoroethyl)-3-(pyrazin-2-yl)-1H-pyrazole-5-carboximidamide
CAS 2097983-18-9C10H11FN6
1-(Prop-2-yn-1-yl)-3-(pyrazin-2-yl)-1H-pyrazole-5-carboximidamide chemical structure, C11H10N6, CAS 2098128-27-7
1-(Prop-2-yn-1-yl)-3-(pyrazin-2-yl)-1H-pyrazole-5-carboximidamide
CAS 2098128-27-7C11H10N6
1-(Difluoromethyl)-3-(pyrazin-2-yl)-1H-pyrazole-5-carboximidamide chemical structure, C9H8F2N6, CAS 2097958-39-7
1-(Difluoromethyl)-3-(pyrazin-2-yl)-1H-pyrazole-5-carboximidamide
CAS 2097958-39-7C9H8F2N6
Methyl 1-methyl-3-(pyrazin-2-yl)-1H-pyrazole-5-carbimidate chemical structure, C10H11N5O, CAS 2098051-19-3
Methyl 1-methyl-3-(pyrazin-2-yl)-1H-pyrazole-5-carbimidate
CAS 2098051-19-3C10H11N5O
Methyl 1-ethyl-3-(pyrazin-2-yl)-1H-pyrazole-5-carbimidate chemical structure, C11H13N5O, CAS 2098069-96-4
Methyl 1-ethyl-3-(pyrazin-2-yl)-1H-pyrazole-5-carbimidate
CAS 2098069-96-4C11H13N5O
(1-Ethyl-3-(pyrazin-2-yl)-1H-pyrazol-5-yl)methanamine chemical structure, C10H13N5, CAS 2090293-89-1
(1-Ethyl-3-(pyrazin-2-yl)-1H-pyrazol-5-yl)methanamine
CAS 2090293-89-1C10H13N5
(1-Isopropyl-3-(pyrazin-2-yl)-1H-pyrazol-5-yl)methanamine chemical structure, C11H15N5, CAS 2092489-33-1
(1-Isopropyl-3-(pyrazin-2-yl)-1H-pyrazol-5-yl)methanamine
CAS 2092489-33-1C11H15N5
(1-Isobutyl-3-(pyrazin-2-yl)-1H-pyrazol-5-yl)methanamine chemical structure, C12H17N5, CAS 2097958-46-6
(1-Isobutyl-3-(pyrazin-2-yl)-1H-pyrazol-5-yl)methanamine
CAS 2097958-46-6C12H17N5
(1-(2-Fluoroethyl)-3-(pyrazin-2-yl)-1H-pyrazol-5-yl)methanamine chemical structure, C10H12FN5, CAS 2098104-49-3
(1-(2-Fluoroethyl)-3-(pyrazin-2-yl)-1H-pyrazol-5-yl)methanamine
CAS 2098104-49-3C10H12FN5
(1-(Prop-2-yn-1-yl)-3-(pyrazin-2-yl)-1H-pyrazol-5-yl)methanamine chemical structure, C11H11N5, CAS 2090959-18-3
(1-(Prop-2-yn-1-yl)-3-(pyrazin-2-yl)-1H-pyrazol-5-yl)methanamine
CAS 2090959-18-3C11H11N5
2-(5-(Aminomethyl)-3-(pyrazin-2-yl)-1H-pyrazol-1-yl)ethan-1-ol chemical structure, C10H13N5O, CAS 2098069-94-2
2-(5-(Aminomethyl)-3-(pyrazin-2-yl)-1H-pyrazol-1-yl)ethan-1-ol
CAS 2098069-94-2C10H13N5O
(1-(Difluoromethyl)-3-(pyrazin-2-yl)-1H-pyrazol-5-yl)methanamine chemical structure, C9H9F2N5, CAS 2090595-07-4
(1-(Difluoromethyl)-3-(pyrazin-2-yl)-1H-pyrazol-5-yl)methanamine
CAS 2090595-07-4C9H9F2N5