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Murcko scaffold

2,4-Diphenylpyridine scaffold

274 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
274
With full pages
24
Scaffold SMILES

c1ccc(-c2ccnc(-c3ccccc3)c2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2,4-Diphenylpyridine page
Murcko scaffold c1ccc(-c2ccnc(-c3ccccc3)c2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 96 of 274 chemicals

Ethyl {[3-cyano-4-(2-methoxyphenyl)-6-phenylpyridin-2-yl]sulfanyl}acetate chemical structure, C23H20N2O3S, CAS 312758-13-7
Ethyl {[3-cyano-4-(2-methoxyphenyl)-6-phenylpyridin-2-yl]sulfanyl}acetate
CAS 312758-13-7C23H20N2O3S
Ethyl 2-{[3-cyano-4-(4-methoxyphenyl)-6-phenylpyridin-2-yl]sulfanyl}acetate chemical structure, C23H20N2O3S, CAS 94360-74-4
Ethyl 2-{[3-cyano-4-(4-methoxyphenyl)-6-phenylpyridin-2-yl]sulfanyl}acetate
CAS 94360-74-4C23H20N2O3S
2-Amino-6-(3,4-dichlorophenyl)-4-(4-methoxyphenyl)nicotinonitrile chemical structure, C19H13Cl2N3O, CAS 106043-97-4
2-Amino-6-(3,4-dichlorophenyl)-4-(4-methoxyphenyl)nicotinonitrile
CAS 106043-97-4C19H13Cl2N3O
2-Amino-6-(2,4-dichlorophenyl)-4-(4-hydroxy-3-methoxyphenyl)nicotinonitrile chemical structure, C19H13Cl2N3O2, CAS 331980-00-8
2-Amino-6-(2,4-dichlorophenyl)-4-(4-hydroxy-3-methoxyphenyl)nicotinonitrile
CAS 331980-00-8C19H13Cl2N3O2
2-Amino-6-(4-bromophenyl)-4-(3,4-dimethoxyphenyl)nicotinonitrile chemical structure, C20H16BrN3O2, CAS 331981-00-1
2-Amino-6-(4-bromophenyl)-4-(3,4-dimethoxyphenyl)nicotinonitrile
CAS 331981-00-1C20H16BrN3O2
2-Amino-6-(4-bromophenyl)-4-(3-ethoxy-4-hydroxyphenyl)nicotinonitrile chemical structure, C20H16BrN3O2, CAS 333341-54-1
2-Amino-6-(4-bromophenyl)-4-(3-ethoxy-4-hydroxyphenyl)nicotinonitrile
CAS 333341-54-1C20H16BrN3O2
2-Amino-6-(4-bromophenyl)-4-(2-methoxyphenyl)nicotinonitrile chemical structure, C19H14BrN3O, CAS 332018-29-8
2-Amino-6-(4-bromophenyl)-4-(2-methoxyphenyl)nicotinonitrile
CAS 332018-29-8C19H14BrN3O
(3-Cyano-4,6-diphenyl-pyridin-2-ylsulfanyl)-acetic acid methyl ester chemical structure, C21H16N2O2S, CAS 78564-30-4
(3-Cyano-4,6-diphenyl-pyridin-2-ylsulfanyl)-acetic acid methyl ester
CAS 78564-30-4C21H16N2O2S
2-Amino-6-(4-chlorophenyl)-4-(3-ethoxy-4-hydroxyphenyl)nicotinonitrile chemical structure, C20H16ClN3O2, CAS 332127-22-7
2-Amino-6-(4-chlorophenyl)-4-(3-ethoxy-4-hydroxyphenyl)nicotinonitrile
CAS 332127-22-7C20H16ClN3O2
2-Amino-6-(4-chlorophenyl)-4-(3,4-dimethoxyphenyl)nicotinonitrile chemical structure, C20H16ClN3O2, CAS 160729-10-2
2-Amino-6-(4-chlorophenyl)-4-(3,4-dimethoxyphenyl)nicotinonitrile
CAS 160729-10-2C20H16ClN3O2
3-(3-Cyano-4,6-diphenyl-pyridin-2-ylsulfanyl)-propionic acid chemical structure, C21H16N2O2S, CAS 332040-72-9
3-(3-Cyano-4,6-diphenyl-pyridin-2-ylsulfanyl)-propionic acid
CAS 332040-72-9C21H16N2O2S
2-Amino-6-(4-bromophenyl)-4-(4-methoxyphenyl)nicotinonitrile chemical structure, C19H14BrN3O, CAS 126202-92-4
2-Amino-6-(4-bromophenyl)-4-(4-methoxyphenyl)nicotinonitrile
CAS 126202-92-4C19H14BrN3O
2-Amino-4-(3-methoxyphenyl)-6-phenylnicotinonitrile chemical structure, C19H15N3O, CAS 642016-80-6
2-Amino-4-(3-methoxyphenyl)-6-phenylnicotinonitrile
CAS 642016-80-6C19H15N3O
2,4-Bis(3-chloro-4-methoxyphenyl)-6-methylpyridine chemical structure, C20H17Cl2NO2, CAS 372180-93-3
2,4-Bis(3-chloro-4-methoxyphenyl)-6-methylpyridine
CAS 372180-93-3C20H17Cl2NO2
2-[3-Cyano-4-(3,4-dimethoxyphenyl)-6-phenylpyridin-2-yl]sulfanylacetamide chemical structure, C22H19N3O3S, CAS 690961-89-8
2-[3-Cyano-4-(3,4-dimethoxyphenyl)-6-phenylpyridin-2-yl]sulfanylacetamide
CAS 690961-89-8C22H19N3O3S
2-(2-Ethylsulfinylethylsulfanyl)-6-(4-methoxyphenyl)-4-phenylpyridine-3-carbonitrile chemical structure, C23H22N2O2S2, CAS 459153-85-6
2-(2-Ethylsulfinylethylsulfanyl)-6-(4-methoxyphenyl)-4-phenylpyridine-3-carbonitrile
CAS 459153-85-6C23H22N2O2S2
Methyl {[3-cyano-4-(2-methoxyphenyl)-6-phenylpyridin-2-yl]sulfanyl}acetate chemical structure, C22H18N2O3S, CAS 312758-11-5
Methyl {[3-cyano-4-(2-methoxyphenyl)-6-phenylpyridin-2-yl]sulfanyl}acetate
CAS 312758-11-5C22H18N2O3S
2-Methyl-6-(4-methylphenyl)-4-(3,4,5-trimethoxyphenyl)pyridine-3-carbonitrile chemical structure, C23H22N2O3, CAS 865658-16-8
2-Methyl-6-(4-methylphenyl)-4-(3,4,5-trimethoxyphenyl)pyridine-3-carbonitrile
CAS 865658-16-8C23H22N2O3
2-Methyl-6-(4-methylphenyl)-4-(3,4,5-trimethoxyphenyl)pyridine-3-carboxamide chemical structure, C23H24N2O4, CAS 866018-29-3
2-Methyl-6-(4-methylphenyl)-4-(3,4,5-trimethoxyphenyl)pyridine-3-carboxamide
CAS 866018-29-3C23H24N2O4
2-Amino-6-(4-chlorophenyl)-5-methyl-4-phenylnicotinonitrile chemical structure, C19H14ClN3, CAS 344263-60-1
2-Amino-6-(4-chlorophenyl)-5-methyl-4-phenylnicotinonitrile
CAS 344263-60-1C19H14ClN3
2-Amino-4-(2-chlorophenyl)-6-(4-chlorophenyl)-5-methylnicotinonitrile chemical structure, C19H13Cl2N3, CAS 344264-24-0
2-Amino-4-(2-chlorophenyl)-6-(4-chlorophenyl)-5-methylnicotinonitrile
CAS 344264-24-0C19H13Cl2N3
Isopropyl 4-{[3-cyano-6-(4-fluorophenyl)-4-phenyl-2-pyridinyl]sulfanyl}-3-oxobutanoate chemical structure, C25H21FN2O3S, CAS 340817-53-0
Isopropyl 4-{[3-cyano-6-(4-fluorophenyl)-4-phenyl-2-pyridinyl]sulfanyl}-3-oxobutanoate
CAS 340817-53-0C25H21FN2O3S
2-[(Cyanomethyl)sulfanyl]-4,6-diphenylnicotinonitrile chemical structure, C20H13N3S, CAS 78564-27-9
2-[(Cyanomethyl)sulfanyl]-4,6-diphenylnicotinonitrile
CAS 78564-27-9C20H13N3S
2-(4-Bromophenyl)-6-tert-butyl-4-phenylpyridine chemical structure, C21H20BrN, CAS 150648-26-3
2-(4-Bromophenyl)-6-tert-butyl-4-phenylpyridine
CAS 150648-26-3C21H20BrN