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Murcko scaffold

2,4-Diphenylpyridine scaffold

274 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
274
With full pages
24
Scaffold SMILES

c1ccc(-c2ccnc(-c3ccccc3)c2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2,4-Diphenylpyridine page
Murcko scaffold c1ccc(-c2ccnc(-c3ccccc3)c2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 97 to 144 of 274 chemicals

4,6-Bis(4-methoxyphenyl)-2-prop-2-enylsulfanylpyridine-3-carbonitrile chemical structure, C23H20N2O2S, CAS 312758-22-8
4,6-Bis(4-methoxyphenyl)-2-prop-2-enylsulfanylpyridine-3-carbonitrile
CAS 312758-22-8C23H20N2O2S
4,6-Diphenyl-2-(2-propen-1-ylthio)-3-pyridinecarbonitrile chemical structure, C21H16N2S, CAS 123413-87-6
4,6-Diphenyl-2-(2-propen-1-ylthio)-3-pyridinecarbonitrile
CAS 123413-87-6C21H16N2S
4-(4-Methylphenyl)-6-phenylpyridin-2-amine chemical structure, C18H16N2, CAS 743442-08-2
4-(4-Methylphenyl)-6-phenylpyridin-2-amine
CAS 743442-08-2C18H16N2
2-Chloro-4-(2,4-dichlorophenyl)-6-(4-methylphenyl)nicotinonitrile chemical structure, C19H11Cl3N2, CAS 860609-63-8
2-Chloro-4-(2,4-dichlorophenyl)-6-(4-methylphenyl)nicotinonitrile
CAS 860609-63-8C19H11Cl3N2
4-(2,4-Dichlorophenyl)-2-(isopropylamino)-6-[3-(trifluoromethyl)phenyl]nicotinonitrile chemical structure, C22H16Cl2F3N3, CAS 341964-96-3
4-(2,4-Dichlorophenyl)-2-(isopropylamino)-6-[3-(trifluoromethyl)phenyl]nicotinonitrile
CAS 341964-96-3C22H16Cl2F3N3
2-Chloro-4-(4-chlorophenyl)-6-[3-(trifluoromethyl)phenyl]nicotinonitrile chemical structure, C19H9Cl2F3N2, CAS 860649-59-8
2-Chloro-4-(4-chlorophenyl)-6-[3-(trifluoromethyl)phenyl]nicotinonitrile
CAS 860649-59-8C19H9Cl2F3N2
2-Methyl-4,6-diphenyl-1-propylpyridinium tetrafluoroborate chemical structure, C21H22BF4N, CAS 828940-80-3
2-Methyl-4,6-diphenyl-1-propylpyridinium tetrafluoroborate
CAS 828940-80-3C21H22BF4N
Ethyl 2-(3-cyano-4,6-diphenyl-2-pyridyloxy)acetate chemical structure, C22H18N2O3, CAS 118666-03-8
Ethyl 2-(3-cyano-4,6-diphenyl-2-pyridyloxy)acetate
CAS 118666-03-8C22H18N2O3
2-Amino-5-butyl-4-(4-methoxyphenyl)-6-phenylnicotinonitrile chemical structure, C23H23N3O, CAS 331979-93-2
2-Amino-5-butyl-4-(4-methoxyphenyl)-6-phenylnicotinonitrile
CAS 331979-93-2C23H23N3O
2-Amino-5-butyl-4-(3,4-dimethoxyphenyl)-6-phenylnicotinonitrile chemical structure, C24H25N3O2, CAS 331980-19-9
2-Amino-5-butyl-4-(3,4-dimethoxyphenyl)-6-phenylnicotinonitrile
CAS 331980-19-9C24H25N3O2
2-Amino-5-butyl-4-(4-hydroxy-3-methoxyphenyl)-6-phenylnicotinonitrile chemical structure, C23H23N3O2, CAS 332040-24-1
2-Amino-5-butyl-4-(4-hydroxy-3-methoxyphenyl)-6-phenylnicotinonitrile
CAS 332040-24-1C23H23N3O2
2-[(3-Cyano-4,6-diphenyl-2-pyridinyl)thio]-3-methylbutanoic acid chemical structure, C23H20N2O2S, CAS 332040-74-1
2-[(3-Cyano-4,6-diphenyl-2-pyridinyl)thio]-3-methylbutanoic acid
CAS 332040-74-1C23H20N2O2S
2-(3-Cyano-4,6-diphenyl-pyridin-2-ylsulfanyl)-malonic acid diethyl ester chemical structure, C25H22N2O4S, CAS 174074-02-3
2-(3-Cyano-4,6-diphenyl-pyridin-2-ylsulfanyl)-malonic acid diethyl ester
CAS 174074-02-3C25H22N2O4S
Ethyl 2-[(3-cyano-4,6-diphenylpyridin-2-yl)sulfanyl]propanoate chemical structure, C23H20N2O2S, CAS 336180-45-1
Ethyl 2-[(3-cyano-4,6-diphenylpyridin-2-yl)sulfanyl]propanoate
CAS 336180-45-1C23H20N2O2S
Diethyl 2-((3-cyano-6-(4-ethoxyphenyl)-4-phenylpyridin-2-yl)thio)malonate chemical structure, C27H26N2O5S, CAS 332101-12-9
Diethyl 2-((3-cyano-6-(4-ethoxyphenyl)-4-phenylpyridin-2-yl)thio)malonate
CAS 332101-12-9C27H26N2O5S
Ethyl 2-((3-cyano-6-(4-ethoxyphenyl)-4-phenylpyridin-2-yl)thio)butanoate chemical structure, C26H26N2O3S, CAS 332375-88-9
Ethyl 2-((3-cyano-6-(4-ethoxyphenyl)-4-phenylpyridin-2-yl)thio)butanoate
CAS 332375-88-9C26H26N2O3S
Methyl 2-((4,6-bis(4-chlorophenyl)-3-cyanopyridin-2-yl)thio)acetate chemical structure, C21H14Cl2N2O2S, CAS 332385-72-5
Methyl 2-((4,6-bis(4-chlorophenyl)-3-cyanopyridin-2-yl)thio)acetate
CAS 332385-72-5C21H14Cl2N2O2S
Isopropyl 2-((4,6-bis(4-chlorophenyl)-3-cyanopyridin-2-yl)thio)acetate chemical structure, C23H18Cl2N2O2S, CAS 332385-73-6
Isopropyl 2-((4,6-bis(4-chlorophenyl)-3-cyanopyridin-2-yl)thio)acetate
CAS 332385-73-6C23H18Cl2N2O2S
Isopropyl 2-((4-(4-chlorophenyl)-3-cyano-6-(p-tolyl)pyridin-2-yl)thio)acetate chemical structure, C24H21ClN2O2S, CAS 444153-80-4
Isopropyl 2-((4-(4-chlorophenyl)-3-cyano-6-(p-tolyl)pyridin-2-yl)thio)acetate
CAS 444153-80-4C24H21ClN2O2S
4-(4-Chlorophenyl)-2-(isopropylthio)-6-(p-tolyl)nicotinonitrile chemical structure, C22H19ClN2S, CAS 444154-03-4
4-(4-Chlorophenyl)-2-(isopropylthio)-6-(p-tolyl)nicotinonitrile
CAS 444154-03-4C22H19ClN2S
2-(Butylthio)-4-(4-chlorophenyl)-6-(p-tolyl)nicotinonitrile chemical structure, C23H21ClN2S, CAS 339199-79-0
2-(Butylthio)-4-(4-chlorophenyl)-6-(p-tolyl)nicotinonitrile
CAS 339199-79-0C23H21ClN2S
2-Amino-4-(4-methoxyphenyl)-5-methyl-6-phenylnicotinonitrile chemical structure, C20H17N3O, CAS 338793-75-2
2-Amino-4-(4-methoxyphenyl)-5-methyl-6-phenylnicotinonitrile
CAS 338793-75-2C20H17N3O
2-Amino-4-(3-chlorophenyl)-6-phenylpyridine-3-carbonitrile chemical structure, C18H12ClN3, CAS 126202-89-9
2-Amino-4-(3-chlorophenyl)-6-phenylpyridine-3-carbonitrile
CAS 126202-89-9C18H12ClN3
2-Amino-4-(4-bromophenyl)-6-(4-chlorophenyl)pyridine-3-carbonitrile chemical structure, C18H11BrClN3, CAS 642028-71-5
2-Amino-4-(4-bromophenyl)-6-(4-chlorophenyl)pyridine-3-carbonitrile
CAS 642028-71-5C18H11BrClN3