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Murcko scaffold

N-Phenyl-4-pyrimidin-2-ylpiperazine-1-carbothioamide scaffold

23 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
23
With full pages
9
Scaffold SMILES

S=C(Nc1ccccc1)N1CCN(c2ncccn2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the N-Phenyl-4-pyrimidin-2-ylpiperazine-1-carbothioamide page
Murcko scaffold S=C(Nc1ccccc1)N1CCN(c2ncccn2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 23 of 23 chemicals

N-(4-Fluorophenyl)-4-pyrimidin-2-ylpiperazine-1-carbothioamide chemical structure, C15H16FN5S, CAS 313381-13-4
N-(4-Fluorophenyl)-4-pyrimidin-2-ylpiperazine-1-carbothioamide
CAS 313381-13-4C15H16FN5S
N-Phenyl-4-pyrimidin-2-ylpiperazine-1-carbothioamide chemical structure, C15H17N5S, CAS 313381-02-1
N-Phenyl-4-pyrimidin-2-ylpiperazine-1-carbothioamide
CAS 313381-02-1C15H17N5S
N-(3,5-Dimethylphenyl)-4-(2-pyrimidinyl)-1-piperazinecarbothioamide chemical structure, C17H21N5S, CAS 454193-16-9
N-(3,5-Dimethylphenyl)-4-(2-pyrimidinyl)-1-piperazinecarbothioamide
CAS 454193-16-9C17H21N5S
N-(3-Chloro-2-methylphenyl)-4-(pyrimidin-2-yl)piperazine-1-carbothioamide chemical structure, C16H18ClN5S, CAS 516460-31-4
N-(3-Chloro-2-methylphenyl)-4-(pyrimidin-2-yl)piperazine-1-carbothioamide
CAS 516460-31-4C16H18ClN5S
N-(4-Chloro-2-methylphenyl)-4-pyrimidin-2-ylpiperazine-1-carbothioamide chemical structure, C16H18ClN5S, CAS 516460-33-6
N-(4-Chloro-2-methylphenyl)-4-pyrimidin-2-ylpiperazine-1-carbothioamide
CAS 516460-33-6C16H18ClN5S
N-(2,4-Dimethylphenyl)-4-pyrimidin-2-ylpiperazine-1-carbothioamide chemical structure, C17H21N5S, CAS 485363-83-5
N-(2,4-Dimethylphenyl)-4-pyrimidin-2-ylpiperazine-1-carbothioamide
CAS 485363-83-5C17H21N5S
N-(2-Methoxyphenyl)-4-pyrimidin-2-ylpiperazine-1-carbothioamide chemical structure, C16H19N5OS, CAS 455313-21-0
N-(2-Methoxyphenyl)-4-pyrimidin-2-ylpiperazine-1-carbothioamide
CAS 455313-21-0C16H19N5OS
N-(3-Acetylphenyl)-4-pyrimidin-2-ylpiperazine-1-carbothioamide chemical structure, C17H19N5OS, CAS 701940-13-8
N-(3-Acetylphenyl)-4-pyrimidin-2-ylpiperazine-1-carbothioamide
CAS 701940-13-8C17H19N5OS
N-(2-Methoxy-5-methylphenyl)-4-pyrimidin-2-ylpiperazine-1-carbothioamide chemical structure, C17H21N5OS, CAS 706772-04-5
N-(2-Methoxy-5-methylphenyl)-4-pyrimidin-2-ylpiperazine-1-carbothioamide
CAS 706772-04-5C17H21N5OS
N-(3,4-Dimethylphenyl)-4-pyrimidin-2-ylpiperazine-1-carbothioamide chemical structure, C17H21N5S, CAS 482329-35-1
N-(3,4-Dimethylphenyl)-4-pyrimidin-2-ylpiperazine-1-carbothioamide
CAS 482329-35-1C17H21N5S
N-(3,5-Dimethoxyphenyl)-4-pyrimidin-2-ylpiperazine-1-carbothioamide chemical structure, C17H21N5O2S, CAS 516460-40-5
N-(3,5-Dimethoxyphenyl)-4-pyrimidin-2-ylpiperazine-1-carbothioamide
CAS 516460-40-5C17H21N5O2S
Methyl 4,5-dimethoxy-2-(4-(pyrimidin-2-yl)piperazine-1-carbothioamido)benzoate chemical structure, C19H23N5O4S, CAS 717830-15-4
Methyl 4,5-dimethoxy-2-(4-(pyrimidin-2-yl)piperazine-1-carbothioamido)benzoate
CAS 717830-15-4C19H23N5O4S
Methyl 4-(methoxycarbonyl)-3-{[(4-pyrimidin-2-ylpiperazinyl)thioxomethyl]amino}benzoate chemical structure, C19H21N5O4S, CAS 895993-92-7
Methyl 4-(methoxycarbonyl)-3-{[(4-pyrimidin-2-ylpiperazinyl)thioxomethyl]amino}benzoate
CAS 895993-92-7C19H21N5O4S
N-(4-Butylphenyl)-4-(2-pyrimidinyl)-1-piperazinecarbothioamide chemical structure, C19H25N5S, CAS 516466-31-2
N-(4-Butylphenyl)-4-(2-pyrimidinyl)-1-piperazinecarbothioamide
CAS 516466-31-2C19H25N5S
Ethyl 4-{[(4-pyrimidin-2-ylpiperazinyl)thioxomethyl]amino}benzoate chemical structure, C18H21N5O2S, CAS 475423-40-6
Ethyl 4-{[(4-pyrimidin-2-ylpiperazinyl)thioxomethyl]amino}benzoate
CAS 475423-40-6C18H21N5O2S
N-(4-Chloro-2,5-dimethoxyphenyl)-4-(pyrimidin-2-yl)piperazine-1-carbothioamide chemical structure, C17H20ClN5O2S, CAS 516466-34-5
N-(4-Chloro-2,5-dimethoxyphenyl)-4-(pyrimidin-2-yl)piperazine-1-carbothioamide
CAS 516466-34-5C17H20ClN5O2S
Methyl [4-({[4-(pyrimidin-2-yl)piperazin-1-yl]carbonothioyl}amino)phenyl]acetate chemical structure, C18H21N5O2S, CAS 516458-89-2
Methyl [4-({[4-(pyrimidin-2-yl)piperazin-1-yl]carbonothioyl}amino)phenyl]acetate
CAS 516458-89-2C18H21N5O2S
N-(3,4-Dimethoxyphenyl)-4-pyrimidin-2-ylpiperazine-1-carbothioamide chemical structure, C17H21N5O2S, CAS 701972-39-6
N-(3,4-Dimethoxyphenyl)-4-pyrimidin-2-ylpiperazine-1-carbothioamide
CAS 701972-39-6C17H21N5O2S
(4-Pyrimidin-2-ylpiperazinyl)[(3,4,5-trimethoxyphenyl)amino]methane-1-thione chemical structure, C18H23N5O3S, CAS 879761-22-5
(4-Pyrimidin-2-ylpiperazinyl)[(3,4,5-trimethoxyphenyl)amino]methane-1-thione
CAS 879761-22-5C18H23N5O3S
N-(3,5-Difluorophenyl)-4-pyrimidin-2-ylpiperazine-1-carbothioamide chemical structure, C15H15F2N5S, CAS 838901-98-7
N-(3,5-Difluorophenyl)-4-pyrimidin-2-ylpiperazine-1-carbothioamide
CAS 838901-98-7C15H15F2N5S
N-(2,4-Dimethoxyphenyl)-4-(pyrimidin-2-yl)piperazine-1-carbothioamide chemical structure, C17H21N5O2S, CAS 516460-36-9
N-(2,4-Dimethoxyphenyl)-4-(pyrimidin-2-yl)piperazine-1-carbothioamide
CAS 516460-36-9C17H21N5O2S
N-(2,5-Dimethoxyphenyl)-4-(pyrimidin-2-yl)piperazine-1-carbothioamide chemical structure, C17H21N5O2S, CAS 516460-38-1
N-(2,5-Dimethoxyphenyl)-4-(pyrimidin-2-yl)piperazine-1-carbothioamide
CAS 516460-38-1C17H21N5O2S
N-(4-Acetylphenyl)-4-pyrimidin-2-ylpiperazine-1-carbothioamide chemical structure, C17H19N5OS, CAS 879475-32-8
N-(4-Acetylphenyl)-4-pyrimidin-2-ylpiperazine-1-carbothioamide
CAS 879475-32-8C17H19N5OS