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Murcko scaffold

1-Phenylpiperazine scaffold

6,403 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
6,403
With full pages
595
Scaffold SMILES

c1ccc(N2CCNCC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenylpiperazine page
Murcko scaffold c1ccc(N2CCNCC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1,633 to 1,680 of 6,403 chemicals

tert-Butyl 4-(2-bromophenyl)piperazine-1-carboxylate chemical structure, C15H21BrN2O2, CAS 494773-35-2
tert-Butyl 4-(2-bromophenyl)piperazine-1-carboxylate
CAS 494773-35-2C15H21BrN2O2
2-[4-(4-Amino-phenyl)-piperazin-1-yl]-ethanol dihydrochloride chemical structure, C12H21Cl2N3O, CAS 1052550-29-4
2-[4-(4-Amino-phenyl)-piperazin-1-yl]-ethanol dihydrochloride
CAS 1052550-29-4C12H21Cl2N3O
1-Piperazinepropanoic acid, 4-(4-nitrophenyl)- chemical structure, C13H17N3O4, CAS 108911-74-6
1-Piperazinepropanoic acid, 4-(4-nitrophenyl)-
CAS 108911-74-6C13H17N3O4
4-(2-Methoxyphenyl)piperazine-1-carboximidamide chemical structure, C12H18N4O, CAS 77723-23-0
4-(2-Methoxyphenyl)piperazine-1-carboximidamide
CAS 77723-23-0C12H18N4O
Dimethyl 2-(4-(4-fluorophenyl)piperazin-1-yl)succinate chemical structure, C16H21FN2O4, CAS 893762-43-1
Dimethyl 2-(4-(4-fluorophenyl)piperazin-1-yl)succinate
CAS 893762-43-1C16H21FN2O4
[3-Chloro-2-(4-propionylpiperazin-1-yl)phenyl]amine chemical structure, C13H18ClN3O, CAS 905809-80-5
[3-Chloro-2-(4-propionylpiperazin-1-yl)phenyl]amine
CAS 905809-80-5C13H18ClN3O
Ethyl 4-(4-acetylpiperazin-1-yl)-3-aminobenzoate chemical structure, C15H21N3O3, CAS 889946-58-1
Ethyl 4-(4-acetylpiperazin-1-yl)-3-aminobenzoate
CAS 889946-58-1C15H21N3O3
2-Chloro-1-(4-(4-fluorophenyl)piperazin-1-yl)propan-1-one chemical structure, C13H16ClFN2O, CAS 928707-61-3
2-Chloro-1-(4-(4-fluorophenyl)piperazin-1-yl)propan-1-one
CAS 928707-61-3C13H16ClFN2O
1-(2-Chloropropanoyl)-4-(2-fluorophenyl)piperazine chemical structure, C13H16ClFN2O, CAS 928707-62-4
1-(2-Chloropropanoyl)-4-(2-fluorophenyl)piperazine
CAS 928707-62-4C13H16ClFN2O
4-(4-Fluorophenyl)piperazine-1-carboximidamide chemical structure, C11H15FN4, CAS 77723-19-4
4-(4-Fluorophenyl)piperazine-1-carboximidamide
CAS 77723-19-4C11H15FN4
4-(3-Methoxyphenyl)piperazine-1-carboximidamide chemical structure, C12H18N4O, CAS 893759-74-5
4-(3-Methoxyphenyl)piperazine-1-carboximidamide
CAS 893759-74-5C12H18N4O
1-(m-Trifluoromethylphenyl) piperazine (hydrochloride) chemical structure, C11H15Cl2F3N2, CAS 76835-14-8
1-(m-Trifluoromethylphenyl) piperazine (hydrochloride)
CAS 76835-14-8C11H15Cl2F3N2
2-(4-Phenylpiperazin-1-yl)propan-1-amine chemical structure, C13H21N3, CAS 889941-00-8
2-(4-Phenylpiperazin-1-yl)propan-1-amine
CAS 889941-00-8C13H21N3
4-(3-Chlorophenyl)-N-methylpiperazine-1-carboxamide chemical structure, C12H16ClN3O, CAS 925174-08-9
4-(3-Chlorophenyl)-N-methylpiperazine-1-carboxamide
CAS 925174-08-9C12H16ClN3O
4-(5-Chloro-2-methylphenyl)-N-methylpiperazine-1-carboxamide chemical structure, C13H18ClN3O, CAS 925627-25-4
4-(5-Chloro-2-methylphenyl)-N-methylpiperazine-1-carboxamide
CAS 925627-25-4C13H18ClN3O
1-Piperazinecarboxamide, N-methyl-4-phenyl- chemical structure, C12H17N3O, CAS 21492-36-4
1-Piperazinecarboxamide, N-methyl-4-phenyl-
CAS 21492-36-4C12H17N3O
4-(4-Fluorophenyl)-N-methylpiperazine-1-carboxamide chemical structure, C12H16FN3O, CAS 925116-22-9
4-(4-Fluorophenyl)-N-methylpiperazine-1-carboxamide
CAS 925116-22-9C12H16FN3O
4-(4-Methoxyphenyl)-N-methylpiperazine-1-carboxamide chemical structure, C13H19N3O2, CAS 925200-10-8
4-(4-Methoxyphenyl)-N-methylpiperazine-1-carboxamide
CAS 925200-10-8C13H19N3O2
4-(3-Chlorophenyl)-N-(2-methoxyethyl)piperazine-1-carboxamide chemical structure, C14H20ClN3O2, CAS 925046-82-8
4-(3-Chlorophenyl)-N-(2-methoxyethyl)piperazine-1-carboxamide
CAS 925046-82-8C14H20ClN3O2
4-(5-Chloro-2-methylphenyl)-N-(2-methoxyethyl)piperazine-1-carboxamide chemical structure, C15H22ClN3O2, CAS 925174-23-8
4-(5-Chloro-2-methylphenyl)-N-(2-methoxyethyl)piperazine-1-carboxamide
CAS 925174-23-8C15H22ClN3O2
N-(2-Methoxyethyl)-4-phenylpiperazine-1-carboxamide chemical structure, C14H21N3O2, CAS 925082-57-1
N-(2-Methoxyethyl)-4-phenylpiperazine-1-carboxamide
CAS 925082-57-1C14H21N3O2
2-(3-Methylpiperazin-1-yl)-3-nitrobenzoic acid chemical structure, C12H15N3O4, CAS 893611-87-5
2-(3-Methylpiperazin-1-yl)-3-nitrobenzoic acid
CAS 893611-87-5C12H15N3O4
1-(2,3-Dichlorophenyl)piperazine dihydrochloride chemical structure, C10H14Cl4N2, CAS 864512-47-0
1-(2,3-Dichlorophenyl)piperazine dihydrochloride
CAS 864512-47-0C10H14Cl4N2
1-(3,5-Dichlorophenyl)piperazine dihydrochloride chemical structure, C10H14Cl4N2, CAS 76835-16-0
1-(3,5-Dichlorophenyl)piperazine dihydrochloride
CAS 76835-16-0C10H14Cl4N2