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Murcko scaffold

1,2,3,4-Tetrahydro-1,8-naphthyridine scaffold

257 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
10
Chemicals
257
With full pages
38
Scaffold SMILES

c1cnc2c(c1)CCCN2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1,2,3,4-Tetrahydro-1,8-naphthyridine page
Murcko scaffold c1cnc2c(c1)CCCN2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 96 of 257 chemicals

tert-Butyl 7-(aminomethyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate chemical structure, C14H21N3O2, CAS 886362-43-2
tert-Butyl 7-(aminomethyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate
CAS 886362-43-2C14H21N3O2
8-N-Boc-5,6,7,8-tetrahydro-1,8-naphthyridin-2-propylamine chemical structure, C16H25N3O2, CAS 886362-44-3
8-N-Boc-5,6,7,8-tetrahydro-1,8-naphthyridin-2-propylamine
CAS 886362-44-3C16H25N3O2
8-N-Boc-5,6,7,8-Tetrahydro-1,8-naphthyridin-2-propionic acid chemical structure, C16H22N2O4, CAS 886362-45-4
8-N-Boc-5,6,7,8-Tetrahydro-1,8-naphthyridin-2-propionic acid
CAS 886362-45-4C16H22N2O4
tert-Butyl 7-(2-methoxy-2-oxoethyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate chemical structure, C16H22N2O4, CAS 925889-81-2
tert-Butyl 7-(2-methoxy-2-oxoethyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate
CAS 925889-81-2C16H22N2O4
Methyl 3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propanoate chemical structure, C12H16N2O2, CAS 886367-99-3
Methyl 3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propanoate
CAS 886367-99-3C12H16N2O2
5,6,7,8-Tetrahydro-1,8-naphthyridine-3-carboxylic acid chemical structure, C9H10N2O2, CAS 1023813-84-4
5,6,7,8-Tetrahydro-1,8-naphthyridine-3-carboxylic acid
CAS 1023813-84-4C9H10N2O2
6-Bromo-5-methyl-1,2,3,4-tetrahydro-1,8-naphthyridine chemical structure, C9H11BrN2, CAS 1150617-50-7
6-Bromo-5-methyl-1,2,3,4-tetrahydro-1,8-naphthyridine
CAS 1150617-50-7C9H11BrN2
Methyl 2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)acetate hydrochloride chemical structure, C11H15ClN2O2, CAS 1159823-05-8
Methyl 2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)acetate hydrochloride
CAS 1159823-05-8C11H15ClN2O2
6-Bromo-3-methyl-1,2,3,4-tetrahydro-1,8-naphthyridine chemical structure, C9H11BrN2, CAS 1204297-57-3
6-Bromo-3-methyl-1,2,3,4-tetrahydro-1,8-naphthyridine
CAS 1204297-57-3C9H11BrN2
6-Methyl-1,2,3,4-tetrahydro-1,8-naphthyridine chemical structure, C9H12N2, CAS 1204297-42-6
6-Methyl-1,2,3,4-tetrahydro-1,8-naphthyridine
CAS 1204297-42-6C9H12N2
5,6,7,8-Tetrahydro-1,8-naphthyridine-3-carbonitrile chemical structure, C9H9N3, CAS 1219022-89-5
5,6,7,8-Tetrahydro-1,8-naphthyridine-3-carbonitrile
CAS 1219022-89-5C9H9N3
1-(6-Fluoro-3,4-dihydro-1,8-naphthyridin-1(2H)-yl)-2,2-dimethylpropan-1-one chemical structure, C13H17FN2O, CAS 1222533-74-5
1-(6-Fluoro-3,4-dihydro-1,8-naphthyridin-1(2H)-yl)-2,2-dimethylpropan-1-one
CAS 1222533-74-5C13H17FN2O
8-Pivaloyl-5,6,7,8-tetrahydro-1,8-naphthyridine-3-carbonitrile chemical structure, C14H17N3O, CAS 1222533-78-9
8-Pivaloyl-5,6,7,8-tetrahydro-1,8-naphthyridine-3-carbonitrile
CAS 1222533-78-9C14H17N3O
2,2-Dimethyl-1-(6-((trimethylsilyl)ethynyl)-3,4-dihydro-1,8-naphthyridin-1(2H)-yl)propan-1-one chemical structure, C18H26N2OSi, CAS 1222533-79-0
2,2-Dimethyl-1-(6-((trimethylsilyl)ethynyl)-3,4-dihydro-1,8-naphthyridin-1(2H)-yl)propan-1-one
CAS 1222533-79-0C18H26N2OSi
1-(6-(3-Hydroxypropyl)-3,4-dihydro-1,8-naphthyridin-1(2H)-yl)-2,2-dimethylpropan-1-one chemical structure, C16H24N2O2, CAS 1222533-80-3
1-(6-(3-Hydroxypropyl)-3,4-dihydro-1,8-naphthyridin-1(2H)-yl)-2,2-dimethylpropan-1-one
CAS 1222533-80-3C16H24N2O2
(E)-Methyl 3-(8-pivaloyl-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylate chemical structure, C17H22N2O3, CAS 1222533-81-4
(E)-Methyl 3-(8-pivaloyl-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylate
CAS 1222533-81-4C17H22N2O3
5,6,7,8-Tetrahydro-1,8-naphthyridine-2-carboxylic acid chemical structure, C9H10N2O2, CAS 885278-22-8
5,6,7,8-Tetrahydro-1,8-naphthyridine-2-carboxylic acid
CAS 885278-22-8C9H10N2O2
5,6,7,8-Tetrahydro-1,8-naphthyridin-2-ethylamine hydrochloride chemical structure, C10H16ClN3, CAS 1319804-31-3
5,6,7,8-Tetrahydro-1,8-naphthyridin-2-ethylamine hydrochloride
CAS 1319804-31-3C10H16ClN3
8-[(tert-Butoxy)carbonyl]-5,6,7,8-tetrahydro-1,8-naphthyridine-2-carboxylic acid chemical structure, C14H18N2O4, CAS 1265894-40-3
8-[(tert-Butoxy)carbonyl]-5,6,7,8-tetrahydro-1,8-naphthyridine-2-carboxylic acid
CAS 1265894-40-3C14H18N2O4
tert-Butyl 7-(hydroxymethyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate chemical structure, C14H20N2O3, CAS 1265896-84-1
tert-Butyl 7-(hydroxymethyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate
CAS 1265896-84-1C14H20N2O3
Ethyl 2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)acetate chemical structure, C12H16N2O2, CAS 721920-80-5
Ethyl 2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)acetate
CAS 721920-80-5C12H16N2O2
tert-Butyl (2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)carbamate chemical structure, C15H23N3O2, CAS 227751-78-2
tert-Butyl (2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)carbamate
CAS 227751-78-2C15H23N3O2
7-Methyl-1,2,3,4-tetrahydro-1,8-naphthyridine-2-carboxylic acid chemical structure, C10H12N2O2, CAS 1246548-23-1
7-Methyl-1,2,3,4-tetrahydro-1,8-naphthyridine-2-carboxylic acid
CAS 1246548-23-1C10H12N2O2
5,6,7,8-Tetrahydro-1,8-naphthyridin-2-ylhydrazine chemical structure, C8H12N4, CAS 1260828-29-2
5,6,7,8-Tetrahydro-1,8-naphthyridin-2-ylhydrazine
CAS 1260828-29-2C8H12N4