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Murcko scaffold

Ring system with 3 rings and 19 atoms

49 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
49
With full pages
5
Scaffold SMILES

O=C1C=C(c2ccccc2)CC(c2ccccc2)C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1C=C(c2ccccc2)CC(c2ccccc2)C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 49 chemicals

Ethyl 2~5~-oxo-2~2~,2~3~,2~4~,2~5~-tetrahydro(1~1~,2~1~:2~3~,3~1~-terphenyl)-2~4~-carboxylate chemical structure, C21H20O3, CAS 6287-66-7
Ethyl 2~5~-oxo-2~2~,2~3~,2~4~,2~5~-tetrahydro(1~1~,2~1~:2~3~,3~1~-terphenyl)-2~4~-carboxylate
CAS 6287-66-7C21H20O3
3-Cyclohexene-1-carboxylicacid, 1-ethyl-2-oxo-4,6-diphenyl-, ethyl ester chemical structure, C23H24O3, CAS 10346-10-8
3-Cyclohexene-1-carboxylicacid, 1-ethyl-2-oxo-4,6-diphenyl-, ethyl ester
CAS 10346-10-8C23H24O3
Ethyl 1-methyl-2-oxo-4,6-diphenylcyclohex-3-ene-1-carboxylate chemical structure, C22H22O3, CAS 14164-75-1
Ethyl 1-methyl-2-oxo-4,6-diphenylcyclohex-3-ene-1-carboxylate
CAS 14164-75-1C22H22O3
6-Ethyl-3,5-diphenylcyclohex-2-en-1-one chemical structure, C20H20O, CAS 10346-11-9
6-Ethyl-3,5-diphenylcyclohex-2-en-1-one
CAS 10346-11-9C20H20O
Ethyl (1S,6S)-2-oxo-4,6-diphenylcyclohex-3-ene-1-carboxylate chemical structure, C21H20O3, CAS 113737-81-8
Ethyl (1S,6S)-2-oxo-4,6-diphenylcyclohex-3-ene-1-carboxylate
CAS 113737-81-8C21H20O3
Ethyl 1~4~-methoxy-2~5~-oxo-2~2~,2~3~,2~4~,2~5~-tetrahydro(1~1~,2~1~:2~3~,3~1~-terphenyl)-2~4~-carboxylate chemical structure, C22H22O4, CAS 25960-25-2
Ethyl 1~4~-methoxy-2~5~-oxo-2~2~,2~3~,2~4~,2~5~-tetrahydro(1~1~,2~1~:2~3~,3~1~-terphenyl)-2~4~-carboxylate
CAS 25960-25-2C22H22O4
Ethyl 4,6-bis(4-chlorophenyl)-2-oxo-3-cyclohexene-1-carboxylate chemical structure, C21H18Cl2O3, CAS 26379-96-4
Ethyl 4,6-bis(4-chlorophenyl)-2-oxo-3-cyclohexene-1-carboxylate
CAS 26379-96-4C21H18Cl2O3
3-(4-Methoxyphenyl)-5-phenyl-2-cyclohexen-1-one chemical structure, C19H18O2, CAS 25960-26-3
3-(4-Methoxyphenyl)-5-phenyl-2-cyclohexen-1-one
CAS 25960-26-3C19H18O2
Ethyl 6-(2-ethoxyphenyl)-4-[3-(methanesulfonamido)phenyl]-2-oxocyclohex-3-ene-1-carboxylate chemical structure, C24H27NO6S, CAS 867042-25-9
Ethyl 6-(2-ethoxyphenyl)-4-[3-(methanesulfonamido)phenyl]-2-oxocyclohex-3-ene-1-carboxylate
CAS 867042-25-9C24H27NO6S
Ethyl 4-[3-(methanesulfonamido)phenyl]-6-(4-methylphenyl)-2-oxocyclohex-3-ene-1-carboxylate chemical structure, C23H25NO5S, CAS 867042-27-1
Ethyl 4-[3-(methanesulfonamido)phenyl]-6-(4-methylphenyl)-2-oxocyclohex-3-ene-1-carboxylate
CAS 867042-27-1C23H25NO5S
6-Acetyl-3,5-diphenylcyclohex-2-en-1-one chemical structure, C20H18O2, CAS 51522-42-0
6-Acetyl-3,5-diphenylcyclohex-2-en-1-one
CAS 51522-42-0C20H18O2
Ethyl 6-(2,5-dimethoxyphenyl)-4-(4-methoxyphenyl)-2-oxocyclohex-3-ene-1-carboxylate chemical structure, C24H26O6, CAS 851715-62-3
Ethyl 6-(2,5-dimethoxyphenyl)-4-(4-methoxyphenyl)-2-oxocyclohex-3-ene-1-carboxylate
CAS 851715-62-3C24H26O6
Ethyl 6-(2-chloro-6-fluorophenyl)-4-(3,4-dimethoxyphenyl)-2-oxocyclohex-3-ene-1-carboxylate chemical structure, C23H22ClFO5, CAS 851716-21-7
Ethyl 6-(2-chloro-6-fluorophenyl)-4-(3,4-dimethoxyphenyl)-2-oxocyclohex-3-ene-1-carboxylate
CAS 851716-21-7C23H22ClFO5
Ethyl 6-(2,3-dimethoxyphenyl)-4-(3,4-dimethoxyphenyl)-2-oxocyclohex-3-ene-1-carboxylate chemical structure, C25H28O7, CAS 851716-28-4
Ethyl 6-(2,3-dimethoxyphenyl)-4-(3,4-dimethoxyphenyl)-2-oxocyclohex-3-ene-1-carboxylate
CAS 851716-28-4C25H28O7
Ethyl 4-(3,4-dimethoxyphenyl)-6-(4-ethoxyphenyl)-2-oxocyclohex-3-ene-1-carboxylate chemical structure, C25H28O6, CAS 851716-16-0
Ethyl 4-(3,4-dimethoxyphenyl)-6-(4-ethoxyphenyl)-2-oxocyclohex-3-ene-1-carboxylate
CAS 851716-16-0C25H28O6
Ethyl 4-[3-(methanesulfonamido)phenyl]-6-(2-methylphenyl)-2-oxocyclohex-3-ene-1-carboxylate chemical structure, C23H25NO5S, CAS 867042-23-7
Ethyl 4-[3-(methanesulfonamido)phenyl]-6-(2-methylphenyl)-2-oxocyclohex-3-ene-1-carboxylate
CAS 867042-23-7C23H25NO5S
Ethyl 4,6-bis(4-methoxyphenyl)-2-oxocyclohex-3-ene-1-carboxylate chemical structure, C23H24O5, CAS 102657-36-3
Ethyl 4,6-bis(4-methoxyphenyl)-2-oxocyclohex-3-ene-1-carboxylate
CAS 102657-36-3C23H24O5
Ethyl 4-(4-fluorophenyl)-6-(4-methoxyphenyl)-2-oxocyclohex-3-ene-1-carboxylate chemical structure, C22H21FO4, CAS 851715-67-8
Ethyl 4-(4-fluorophenyl)-6-(4-methoxyphenyl)-2-oxocyclohex-3-ene-1-carboxylate
CAS 851715-67-8C22H21FO4
Ethyl 6-[4-(dimethylamino)phenyl]-4-(4-fluorophenyl)-2-oxocyclohex-3-ene-1-carboxylate chemical structure, C23H24FNO3, CAS 851715-64-5
Ethyl 6-[4-(dimethylamino)phenyl]-4-(4-fluorophenyl)-2-oxocyclohex-3-ene-1-carboxylate
CAS 851715-64-5C23H24FNO3
Ethyl 4-(4-methoxyphenyl)-6-(4-nitrophenyl)-2-oxocyclohex-3-ene-1-carboxylate chemical structure, C22H21NO6, CAS 851715-59-8
Ethyl 4-(4-methoxyphenyl)-6-(4-nitrophenyl)-2-oxocyclohex-3-ene-1-carboxylate
CAS 851715-59-8C22H21NO6
Ethyl 6-(2-fluorophenyl)-4-(3-methanesulfonamidophenyl)-2-oxocyclohex-3-ene-1-carboxylate chemical structure, C22H22FNO5S, CAS 867042-24-8
Ethyl 6-(2-fluorophenyl)-4-(3-methanesulfonamidophenyl)-2-oxocyclohex-3-ene-1-carboxylate
CAS 867042-24-8C22H22FNO5S
Ethyl 4-[3-(methanesulfonamido)phenyl]-6-(4-methoxyphenyl)-2-oxocyclohex-3-ene-1-carboxylate chemical structure, C23H25NO6S, CAS 867042-26-0
Ethyl 4-[3-(methanesulfonamido)phenyl]-6-(4-methoxyphenyl)-2-oxocyclohex-3-ene-1-carboxylate
CAS 867042-26-0C23H25NO6S
Ethyl 4-(4-methylphenyl)-2-oxo-6-(4-propan-2-ylphenyl)cyclohex-3-ene-1-carboxylate chemical structure, C25H28O3, CAS 851716-37-5
Ethyl 4-(4-methylphenyl)-2-oxo-6-(4-propan-2-ylphenyl)cyclohex-3-ene-1-carboxylate
CAS 851716-37-5C25H28O3
Ethyl 4,6-bis(4-fluorophenyl)-2-oxocyclohex-3-ene-1-carboxylate chemical structure, C21H18F2O3, CAS 851715-70-3
Ethyl 4,6-bis(4-fluorophenyl)-2-oxocyclohex-3-ene-1-carboxylate
CAS 851715-70-3C21H18F2O3