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Murcko scaffold

Ring system with 3 rings and 21 atoms

12 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
12
With full pages
7
Scaffold SMILES

O=C(CSc1nnc(-c2ccccn2)[nH]1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nnc(-c2ccccn2)[nH]1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

1-(4-Fluorophenyl)-2-{[4-methyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}ethanone chemical structure, C16H13FN4OS, CAS 677024-40-7
1-(4-Fluorophenyl)-2-{[4-methyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}ethanone
CAS 677024-40-7C16H13FN4OS
1-(4-Chlorophenyl)-2-{[4-methyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}ethanone chemical structure, C16H13ClN4OS, CAS 578719-03-6
1-(4-Chlorophenyl)-2-{[4-methyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}ethanone
CAS 578719-03-6C16H13ClN4OS
2-(4-Methyl-5-pyridin-2-yl-4H-[1,2,4]triazol-3-ylsulfanyl)-1-phenyl-ethanone chemical structure, C16H14N4OS, CAS 578736-83-1
2-(4-Methyl-5-pyridin-2-yl-4H-[1,2,4]triazol-3-ylsulfanyl)-1-phenyl-ethanone
CAS 578736-83-1C16H14N4OS
1-(4-Chlorophenyl)-2-{[4-ethyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}ethanone chemical structure, C17H15ClN4OS, CAS 578749-68-5
1-(4-Chlorophenyl)-2-{[4-ethyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}ethanone
CAS 578749-68-5C17H15ClN4OS
1-(3,4-Dichlorophenyl)-2-{[4-methyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}ethanone chemical structure, C16H12Cl2N4OS, CAS 578760-45-9
1-(3,4-Dichlorophenyl)-2-{[4-methyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}ethanone
CAS 578760-45-9C16H12Cl2N4OS
2-{[4-Ethyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}-1-phenylethanone chemical structure, C17H16N4OS, CAS 678983-84-1
2-{[4-Ethyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}-1-phenylethanone
CAS 678983-84-1C17H16N4OS
2-((4-ET-5-(2-Pyridinyl)-4H-1,2,4-triazol-3-yl)thio)-1-(4-fluorophenyl)ethanone chemical structure, C17H15FN4OS, CAS 618414-05-4
2-((4-ET-5-(2-Pyridinyl)-4H-1,2,4-triazol-3-yl)thio)-1-(4-fluorophenyl)ethanone
CAS 618414-05-4C17H15FN4OS
2-((4-Allyl-5-(2-pyridinyl)-4H-1,2,4-triazol-3-yl)thio)-1-(4-F-PH)ethanone chemical structure, C18H15FN4OS, CAS 618880-07-2
2-((4-Allyl-5-(2-pyridinyl)-4H-1,2,4-triazol-3-yl)thio)-1-(4-F-PH)ethanone
CAS 618880-07-2C18H15FN4OS
2-{[4-Allyl-5-(2-pyridinyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-1-(2,3,4-trichlorophenyl)ethanone chemical structure, C18H13Cl3N4OS, CAS 618880-29-8
2-{[4-Allyl-5-(2-pyridinyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-1-(2,3,4-trichlorophenyl)ethanone
CAS 618880-29-8C18H13Cl3N4OS
1-(3,4-Dimethoxyphenyl)-2-((4-ethyl-5-(2-pyridinyl)-4H-1,2,4-triazol-3-yl)sulfanyl)ethanone chemical structure, C19H20N4O3S, CAS 618414-11-2
1-(3,4-Dimethoxyphenyl)-2-((4-ethyl-5-(2-pyridinyl)-4H-1,2,4-triazol-3-yl)sulfanyl)ethanone
CAS 618414-11-2C19H20N4O3S
1-Phenyl-2-{[4-(prop-2-en-1-yl)-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}ethanone chemical structure, C18H16N4OS, CAS 677025-13-7
1-Phenyl-2-{[4-(prop-2-en-1-yl)-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}ethanone
CAS 677025-13-7C18H16N4OS
2-{[4-Ethyl-5-(2-pyridinyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-1-(2,3,4-trichlorophenyl)ethanone chemical structure, C17H13Cl3N4OS, CAS 618414-95-2
2-{[4-Ethyl-5-(2-pyridinyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-1-(2,3,4-trichlorophenyl)ethanone
CAS 618414-95-2C17H13Cl3N4OS