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Murcko scaffold

Ring system with 3 rings and 22 atoms

368 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
368
With full pages
75
Scaffold SMILES

O=C(CN1CCN(c2ccccc2)CC1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CN1CCN(c2ccccc2)CC1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 368 chemicals

4-[2-(4-Phenyl-piperazin-1-yl)-acetylamino]-benzoic acid methyl ester chemical structure, C20H23N3O3, CAS 312502-83-3
4-[2-(4-Phenyl-piperazin-1-yl)-acetylamino]-benzoic acid methyl ester
CAS 312502-83-3C20H23N3O3
N-(2-Chlorophenyl)-2-(4-phenylpiperazin-1-yl)acetamide chemical structure, C18H20ClN3O, CAS 361473-63-4
N-(2-Chlorophenyl)-2-(4-phenylpiperazin-1-yl)acetamide
CAS 361473-63-4C18H20ClN3O
N-(4-Fluorophenyl)-2-(4-phenylpiperazin-1-yl)acetamide chemical structure, C18H20FN3O, CAS 309922-92-7
N-(4-Fluorophenyl)-2-(4-phenylpiperazin-1-yl)acetamide
CAS 309922-92-7C18H20FN3O
N-(2-Chlorophenyl)-2-[4-(4-chlorophenyl)piperazin-1-yl]acetamide chemical structure, C18H19Cl2N3O, CAS 361473-54-3
N-(2-Chlorophenyl)-2-[4-(4-chlorophenyl)piperazin-1-yl]acetamide
CAS 361473-54-3C18H19Cl2N3O
2-[4-(4-Fluorophenyl)piperazin-1-yl]-N-(2-methoxy-5-methylphenyl)acetamide chemical structure, C20H24FN3O2, CAS 329079-98-3
2-[4-(4-Fluorophenyl)piperazin-1-yl]-N-(2-methoxy-5-methylphenyl)acetamide
CAS 329079-98-3C20H24FN3O2
N-(5-Fluoro-2-methylphenyl)-2-[4-(2-methoxyphenyl)piperazin-1-yl]acetamide chemical structure, C20H24FN3O2, CAS 842967-99-1
N-(5-Fluoro-2-methylphenyl)-2-[4-(2-methoxyphenyl)piperazin-1-yl]acetamide
CAS 842967-99-1C20H24FN3O2
N-(2-Cyanophenyl)-2-[4-(2-fluorophenyl)piperazin-1-yl]acetamide chemical structure, C19H19FN4O, CAS 329080-42-4
N-(2-Cyanophenyl)-2-[4-(2-fluorophenyl)piperazin-1-yl]acetamide
CAS 329080-42-4C19H19FN4O
N-(2,4-Difluorophenyl)-2-[4-(2-fluorophenyl)piperazin-1-yl]acetamide chemical structure, C18H18F3N3O, CAS 329080-45-7
N-(2,4-Difluorophenyl)-2-[4-(2-fluorophenyl)piperazin-1-yl]acetamide
CAS 329080-45-7C18H18F3N3O
N-(2-Cyanophenyl)-2-[4-(4-fluorophenyl)piperazino]acetamide chemical structure, C19H19FN4O, CAS 303091-63-6
N-(2-Cyanophenyl)-2-[4-(4-fluorophenyl)piperazino]acetamide
CAS 303091-63-6C19H19FN4O
2-(4-Phenylpiperazin-1-yl)-N-(2,4,5-trifluorophenyl)acetamide chemical structure, C18H18F3N3O, CAS 720667-91-4
2-(4-Phenylpiperazin-1-yl)-N-(2,4,5-trifluorophenyl)acetamide
CAS 720667-91-4C18H18F3N3O
N-(2,5-Difluorophenyl)-2-(4-phenylpiperazin-1-yl)acetamide chemical structure, C18H19F2N3O, CAS 720667-93-6
N-(2,5-Difluorophenyl)-2-(4-phenylpiperazin-1-yl)acetamide
CAS 720667-93-6C18H19F2N3O
2-[4-(3-Chlorophenyl)piperazin-1-yl]-N-(4-methylphenyl)acetamide chemical structure, C19H22ClN3O, CAS 301194-40-1
2-[4-(3-Chlorophenyl)piperazin-1-yl]-N-(4-methylphenyl)acetamide
CAS 301194-40-1C19H22ClN3O
N-(3-Chlorophenyl)-4-phenyl-1-piperazineacetamide chemical structure, C18H20ClN3O, CAS 303090-99-5
N-(3-Chlorophenyl)-4-phenyl-1-piperazineacetamide
CAS 303090-99-5C18H20ClN3O
N-(3-Chloro-4-fluorophenyl)-2-(4-phenyl-1-piperazinyl)acetamide chemical structure, C18H19ClFN3O, CAS 303091-00-1
N-(3-Chloro-4-fluorophenyl)-2-(4-phenyl-1-piperazinyl)acetamide
CAS 303091-00-1C18H19ClFN3O
2-[4-(3-Chlorophenyl)piperazin-1-yl]-N-(4-fluorophenyl)acetamide chemical structure, C18H19ClFN3O, CAS 303091-53-4
2-[4-(3-Chlorophenyl)piperazin-1-yl]-N-(4-fluorophenyl)acetamide
CAS 303091-53-4C18H19ClFN3O
N-(5-Fluoro-2-methylphenyl)-2-[4-(4-fluorophenyl)piperazin-1-yl]acetamide chemical structure, C19H21F2N3O, CAS 303091-61-4
N-(5-Fluoro-2-methylphenyl)-2-[4-(4-fluorophenyl)piperazin-1-yl]acetamide
CAS 303091-61-4C19H21F2N3O
N-(4-Fluorophenyl)-2-[4-(4-fluorophenyl)piperazin-1-yl]acetamide chemical structure, C18H19F2N3O, CAS 303091-62-5
N-(4-Fluorophenyl)-2-[4-(4-fluorophenyl)piperazin-1-yl]acetamide
CAS 303091-62-5C18H19F2N3O
2-[4-(4-Fluorophenyl)piperazin-1-yl]-N-(4-methoxyphenyl)acetamide chemical structure, C19H22FN3O2, CAS 303091-64-7
2-[4-(4-Fluorophenyl)piperazin-1-yl]-N-(4-methoxyphenyl)acetamide
CAS 303091-64-7C19H22FN3O2
2-[4-(4-Fluorophenyl)piperazin-1-yl]-N-(4-methylphenyl)acetamide chemical structure, C19H22FN3O, CAS 303091-80-7
2-[4-(4-Fluorophenyl)piperazin-1-yl]-N-(4-methylphenyl)acetamide
CAS 303091-80-7C19H22FN3O
N-(3,4-Difluorophenyl)-2-(4-(2-fluorophenyl)-1-piperazinyl)acetamide chemical structure, C18H18F3N3O, CAS 303091-72-7
N-(3,4-Difluorophenyl)-2-(4-(2-fluorophenyl)-1-piperazinyl)acetamide
CAS 303091-72-7C18H18F3N3O
2-[4-(4-Fluorophenyl)piperazin-1-yl]-N-phenylacetamide chemical structure, C18H20FN3O, CAS 486456-86-4
2-[4-(4-Fluorophenyl)piperazin-1-yl]-N-phenylacetamide
CAS 486456-86-4C18H20FN3O
N-(2,4-Dimethylphenyl)-2-[4-(4-fluorophenyl)piperazin-1-yl]acetamide chemical structure, C20H24FN3O, CAS 486456-88-6
N-(2,4-Dimethylphenyl)-2-[4-(4-fluorophenyl)piperazin-1-yl]acetamide
CAS 486456-88-6C20H24FN3O
2-[4-(4-Fluorophenyl)piperazin-1-yl]-N-(3-methoxyphenyl)acetamide chemical structure, C19H22FN3O2, CAS 486456-93-3
2-[4-(4-Fluorophenyl)piperazin-1-yl]-N-(3-methoxyphenyl)acetamide
CAS 486456-93-3C19H22FN3O2
2-[4-(4-Methoxyphenyl)piperazin-1-yl]-N-(3-methylphenyl)acetamide chemical structure, C20H25N3O2, CAS 483350-83-0
2-[4-(4-Methoxyphenyl)piperazin-1-yl]-N-(3-methylphenyl)acetamide
CAS 483350-83-0C20H25N3O2