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Murcko scaffold

Ring system with 3 rings and 22 atoms

116 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 22
Chemicals: 116
With full pages: 12

Scaffold SMILES

O=C(C=Cc1ccccc1)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(C=Cc1ccccc1)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 116 chemicals

(2E)-3-(4-Chlorophenyl)-1-[4-(4-fluorophenyl)piperazinyl]prop-2-en-1-one chemical structure, C19H18ClFN2O, CAS 329080-13-9

(2E)-3-(4-Chlorophenyl)-1-[4-(4-fluorophenyl)piperazinyl]prop-2-en-1-one

CAS 329080-13-9C₁₉H₁₈ClFN₂O

(2E)-1-[4-(3-Chlorophenyl)piperazinyl]-3-(4-fluorophenyl)prop-2-en-1-one chemical structure, C19H18ClFN2O, CAS 420090-05-7

(2E)-1-[4-(3-Chlorophenyl)piperazinyl]-3-(4-fluorophenyl)prop-2-en-1-one

CAS 420090-05-7C₁₉H₁₈ClFN₂O

(2E)-1-[4-(4-Fluorophenyl)piperazinyl]-3-(3-methylphenyl)prop-2-en-1-one chemical structure, C20H21FN2O, CAS 329779-87-5

(2E)-1-[4-(4-Fluorophenyl)piperazinyl]-3-(3-methylphenyl)prop-2-en-1-one

CAS 329779-87-5C₂₀H₂₁FN₂O

1-(4-Fluorophenyl)-4-[(2E)-3-(4-methoxyphenyl)prop-2-enoyl]piperazine chemical structure, C20H21FN2O2, CAS 432535-65-4

1-(4-Fluorophenyl)-4-[(2E)-3-(4-methoxyphenyl)prop-2-enoyl]piperazine

CAS 432535-65-4C₂₀H₂₁FN₂O₂

1-(4-(2-Fluorophenyl)piperazinyl)-3-phenylprop-2-EN-1-one chemical structure, C19H19FN2O, CAS 1427863-79-3

1-(4-(2-Fluorophenyl)piperazinyl)-3-phenylprop-2-EN-1-one

CAS 1427863-79-3C₁₉H₁₉FN₂O

3-(4-Isobutylphenyl)-1-(4-phenylpiperazino)-2-propen-1-one chemical structure, C23H28N2O, CAS 329778-16-7

3-(4-Isobutylphenyl)-1-(4-phenylpiperazino)-2-propen-1-one

CAS 329778-16-7C₂₃H₂₈N₂O

(2E)-1-[4-(4-Chlorophenyl)piperazin-1-yl]-3-(4-methylphenyl)prop-2-en-1-one chemical structure, C20H21ClN2O, CAS 5695-41-0

(2E)-1-[4-(4-Chlorophenyl)piperazin-1-yl]-3-(4-methylphenyl)prop-2-en-1-one

CAS 5695-41-0C₂₀H₂₁ClN₂O

(E)-1-[4-(2-Methoxyphenyl)piperazin-1-yl]-3-(4-methylphenyl)prop-2-en-1-one chemical structure, C21H24N2O2, CAS 1164455-35-9

(E)-1-[4-(2-Methoxyphenyl)piperazin-1-yl]-3-(4-methylphenyl)prop-2-en-1-one

CAS 1164455-35-9C₂₁H₂₄N₂O₂

(2E)-1-[4-(3-Chlorophenyl)piperazin-1-yl]-3-phenylprop-2-en-1-one chemical structure, C19H19ClN2O, CAS 349417-98-7

(2E)-1-[4-(3-Chlorophenyl)piperazin-1-yl]-3-phenylprop-2-en-1-one

CAS 349417-98-7C₁₉H₁₉ClN₂O

(E)-3-Phenyl-1-(4-phenylpiperazin-1-yl)prop-2-en-1-one chemical structure, C19H20N2O, CAS 1427863-78-2

(E)-3-Phenyl-1-(4-phenylpiperazin-1-yl)prop-2-en-1-one

CAS 1427863-78-2C₁₉H₂₀N₂O

(E)-1-[4-(2,3-Dimethylphenyl)piperazin-1-yl]-3-phenylprop-2-en-1-one chemical structure, C21H24N2O, CAS 349538-29-0

(E)-1-[4-(2,3-Dimethylphenyl)piperazin-1-yl]-3-phenylprop-2-en-1-one

CAS 349538-29-0C₂₁H₂₄N₂O

(Z)-1-[4-(2-Fluorophenyl)piperazin-1-yl]-2-methyl-3-phenylprop-2-en-1-one chemical structure, C20H21FN2O, CAS 599188-97-3

(Z)-1-[4-(2-Fluorophenyl)piperazin-1-yl]-2-methyl-3-phenylprop-2-en-1-one

CAS 599188-97-3C₂₀H₂₁FN₂O

(E)-1-[4-(2,3-Dimethylphenyl)piperazin-1-yl]-3-(4-methylphenyl)prop-2-en-1-one chemical structure, C22H26N2O, CAS 543723-07-5

(E)-1-[4-(2,3-Dimethylphenyl)piperazin-1-yl]-3-(4-methylphenyl)prop-2-en-1-one

CAS 543723-07-5C₂₂H₂₆N₂O

(E)-3-(3-Bromo-4-methoxyphenyl)-1-[4-(4-methoxyphenyl)piperazin-1-yl]prop-2-en-1-one chemical structure, C21H23BrN2O3, CAS 723253-95-0

(E)-3-(3-Bromo-4-methoxyphenyl)-1-[4-(4-methoxyphenyl)piperazin-1-yl]prop-2-en-1-one

CAS 723253-95-0C₂₁H₂₃BrN₂O₃

(E)-3-(3,4-Dichlorophenyl)-1-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]prop-2-en-1-one chemical structure, C20H17Cl2F3N2O, CAS 545431-53-6

(E)-3-(3,4-Dichlorophenyl)-1-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]prop-2-en-1-one

CAS 545431-53-6C₂₀H₁₇Cl₂F₃N₂O

1-[3-(4-Methylphenyl)acryloyl]-4-[3-(trifluoromethyl)phenyl]piperazine chemical structure, C21H21F3N2O, CAS 1164477-61-5

1-[3-(4-Methylphenyl)acryloyl]-4-[3-(trifluoromethyl)phenyl]piperazine

CAS 1164477-61-5C₂₁H₂₁F₃N₂O

(E)-3-(4-Bromophenyl)-1-[4-(2-fluorophenyl)piperazin-1-yl]prop-2-en-1-one chemical structure, C19H18BrFN2O, CAS 546076-80-6

(E)-3-(4-Bromophenyl)-1-[4-(2-fluorophenyl)piperazin-1-yl]prop-2-en-1-one

CAS 546076-80-6C₁₉H₁₈BrFN₂O

(E)-1-[4-(2-Fluorophenyl)piperazin-1-yl]-3-(4-propan-2-ylphenyl)prop-2-en-1-one chemical structure, C22H25FN2O, CAS 546069-98-1

(E)-1-[4-(2-Fluorophenyl)piperazin-1-yl]-3-(4-propan-2-ylphenyl)prop-2-en-1-one

CAS 546069-98-1C₂₂H₂₅FN₂O

(E)-3-(3,4-Dichlorophenyl)-1-[4-(2-fluorophenyl)piperazin-1-yl]prop-2-en-1-one chemical structure, C19H17Cl2FN2O, CAS 546098-49-1

(E)-3-(3,4-Dichlorophenyl)-1-[4-(2-fluorophenyl)piperazin-1-yl]prop-2-en-1-one

CAS 546098-49-1C₁₉H₁₇Cl₂FN₂O

(E)-3-(4-tert-Butylphenyl)-1-[4-(2,3-dimethylphenyl)piperazin-1-yl]prop-2-en-1-one chemical structure, C25H32N2O, CAS 545364-42-9

(E)-3-(4-tert-Butylphenyl)-1-[4-(2,3-dimethylphenyl)piperazin-1-yl]prop-2-en-1-one

CAS 545364-42-9C₂₅H₃₂N₂O

(E)-3-(2,6-Dichlorophenyl)-1-[4-(4-fluorophenyl)piperazin-1-yl]prop-2-en-1-one chemical structure, C19H17Cl2FN2O, CAS 560105-76-2

(E)-3-(2,6-Dichlorophenyl)-1-[4-(4-fluorophenyl)piperazin-1-yl]prop-2-en-1-one

CAS 560105-76-2C₁₉H₁₇Cl₂FN₂O

1-[3-(4-Bromophenyl)acryloyl]-4-[3-(trifluoromethyl)phenyl]piperazine chemical structure, C20H18BrF3N2O, CAS 1164454-62-9

1-[3-(4-Bromophenyl)acryloyl]-4-[3-(trifluoromethyl)phenyl]piperazine

CAS 1164454-62-9C₂₀H₁₈BrF₃N₂O

(E)-3-(3,4-Dichlorophenyl)-1-(4-phenylpiperazin-1-yl)prop-2-en-1-one chemical structure, C19H18Cl2N2O, CAS 540791-75-1

(E)-3-(3,4-Dichlorophenyl)-1-(4-phenylpiperazin-1-yl)prop-2-en-1-one

CAS 540791-75-1C₁₉H₁₈Cl₂N₂O

(E)-3-(2-Chloro-6-fluorophenyl)-1-[4-(2-methoxyphenyl)piperazin-1-yl]prop-2-en-1-one chemical structure, C20H20ClFN2O2, CAS 540796-31-4

(E)-3-(2-Chloro-6-fluorophenyl)-1-[4-(2-methoxyphenyl)piperazin-1-yl]prop-2-en-1-one

CAS 540796-31-4C₂₀H₂₀ClFN₂O₂