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Murcko scaffold

Ring system with 3 rings and 22 atoms

74 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
74
With full pages
13
Scaffold SMILES

O=C(CNc1ccccc1)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CNc1ccccc1)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 74 chemicals

N-(2,6-Dimethylphenyl)-N-[2-[4-(4-fluorophenyl)piperazin-1-yl]-2-oxoethyl]methanesulfonamide chemical structure, C21H26FN3O3S, CAS 432504-23-9
N-(2,6-Dimethylphenyl)-N-[2-[4-(4-fluorophenyl)piperazin-1-yl]-2-oxoethyl]methanesulfonamide
CAS 432504-23-9C21H26FN3O3S
N-(2-Bromophenyl)-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]-2-oxoethyl]methanesulfonamide chemical structure, C20H24BrN3O4S, CAS 333440-37-2
N-(2-Bromophenyl)-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]-2-oxoethyl]methanesulfonamide
CAS 333440-37-2C20H24BrN3O4S
N-(3-Bromophenyl)-N-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]methanesulfonamide chemical structure, C19H22BrN3O3S, CAS 333745-93-0
N-(3-Bromophenyl)-N-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]methanesulfonamide
CAS 333745-93-0C19H22BrN3O3S
N-(2-Fluorophenyl)-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]-2-oxoethyl]methanesulfonamide chemical structure, C20H24FN3O4S, CAS 505072-09-3
N-(2-Fluorophenyl)-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]-2-oxoethyl]methanesulfonamide
CAS 505072-09-3C20H24FN3O4S
N-(2-Methoxy-5-methylphenyl)-N-[2-[4-(4-methoxyphenyl)piperazin-1-yl]-2-oxoethyl]methanesulfonamide chemical structure, C22H29N3O5S, CAS 432526-65-3
N-(2-Methoxy-5-methylphenyl)-N-[2-[4-(4-methoxyphenyl)piperazin-1-yl]-2-oxoethyl]methanesulfonamide
CAS 432526-65-3C22H29N3O5S
N-[2-[4-(2-Fluorophenyl)piperazin-1-yl]-2-oxoethyl]-N-(4-propan-2-ylphenyl)methanesulfonamide chemical structure, C22H28FN3O3S, CAS 505080-03-5
N-[2-[4-(2-Fluorophenyl)piperazin-1-yl]-2-oxoethyl]-N-(4-propan-2-ylphenyl)methanesulfonamide
CAS 505080-03-5C22H28FN3O3S
N-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]-2-oxoethyl]-N-(4-methylphenyl)methanesulfonamide chemical structure, C21H27N3O4S, CAS 312317-02-5
N-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]-2-oxoethyl]-N-(4-methylphenyl)methanesulfonamide
CAS 312317-02-5C21H27N3O4S
N-(4-Ethoxyphenyl)-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]-2-oxoethyl]methanesulfonamide chemical structure, C22H29N3O5S, CAS 5729-66-8
N-(4-Ethoxyphenyl)-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]-2-oxoethyl]methanesulfonamide
CAS 5729-66-8C22H29N3O5S
N-(2-Methylphenyl)-N-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]methanesulfonamide chemical structure, C20H25N3O3S, CAS 496937-13-4
N-(2-Methylphenyl)-N-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]methanesulfonamide
CAS 496937-13-4C20H25N3O3S
N-(3,4-Dimethylphenyl)-N-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]methanesulfonamide chemical structure, C21H27N3O3S, CAS 333747-99-2
N-(3,4-Dimethylphenyl)-N-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]methanesulfonamide
CAS 333747-99-2C21H27N3O3S
N-(2,5-Dimethylphenyl)-N-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]methanesulfonamide chemical structure, C21H27N3O3S, CAS 428463-48-3
N-(2,5-Dimethylphenyl)-N-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]methanesulfonamide
CAS 428463-48-3C21H27N3O3S
N-(2,3-Dimethylphenyl)-N-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]methanesulfonamide chemical structure, C21H27N3O3S, CAS 431977-78-5
N-(2,3-Dimethylphenyl)-N-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]methanesulfonamide
CAS 431977-78-5C21H27N3O3S
N-(2-Methoxyphenyl)-N-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]methanesulfonamide chemical structure, C20H25N3O4S, CAS 432012-99-2
N-(2-Methoxyphenyl)-N-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]methanesulfonamide
CAS 432012-99-2C20H25N3O4S
N-(5-Chloro-2-methoxyphenyl)-N-{2-[4-(4-methoxyphenyl)piperazin-1-yl]-2-oxoethyl}methanesulfonamide chemical structure, C21H26ClN3O5S, CAS 432529-21-0
N-(5-Chloro-2-methoxyphenyl)-N-{2-[4-(4-methoxyphenyl)piperazin-1-yl]-2-oxoethyl}methanesulfonamide
CAS 432529-21-0C21H26ClN3O5S
N-(4-Methoxyphenyl)-N-{2-[4-(4-methoxyphenyl)piperazin-1-yl]-2-oxoethyl}methanesulfonamide chemical structure, C21H27N3O5S, CAS 432497-58-0
N-(4-Methoxyphenyl)-N-{2-[4-(4-methoxyphenyl)piperazin-1-yl]-2-oxoethyl}methanesulfonamide
CAS 432497-58-0C21H27N3O5S
N-(2-Ethylphenyl)-N-[2-[4-(4-fluorophenyl)piperazin-1-yl]-2-oxoethyl]methanesulfonamide chemical structure, C21H26FN3O3S, CAS 505080-08-0
N-(2-Ethylphenyl)-N-[2-[4-(4-fluorophenyl)piperazin-1-yl]-2-oxoethyl]methanesulfonamide
CAS 505080-08-0C21H26FN3O3S
N-(2,4-Dimethoxyphenyl)-N-{2-[4-(2-fluorophenyl)piperazin-1-yl]-2-oxoethyl}methanesulfonamide chemical structure, C21H26FN3O5S, CAS 505080-11-5
N-(2,4-Dimethoxyphenyl)-N-{2-[4-(2-fluorophenyl)piperazin-1-yl]-2-oxoethyl}methanesulfonamide
CAS 505080-11-5C21H26FN3O5S
N-(3,4-Dimethoxyphenyl)-N-{2-[4-(4-fluorophenyl)piperazin-1-yl]-2-oxoethyl}methanesulfonamide chemical structure, C21H26FN3O5S, CAS 592468-86-5
N-(3,4-Dimethoxyphenyl)-N-{2-[4-(4-fluorophenyl)piperazin-1-yl]-2-oxoethyl}methanesulfonamide
CAS 592468-86-5C21H26FN3O5S
N-(3-Chloro-4-methoxyphenyl)-N-{2-[4-(4-methoxyphenyl)piperazin-1-yl]-2-oxoethyl}methanesulfonamide chemical structure, C21H26ClN3O5S, CAS 432533-89-6
N-(3-Chloro-4-methoxyphenyl)-N-{2-[4-(4-methoxyphenyl)piperazin-1-yl]-2-oxoethyl}methanesulfonamide
CAS 432533-89-6C21H26ClN3O5S
N-(4-Chloro-2-methylphenyl)-N-{2-[4-(4-methoxyphenyl)piperazin-1-yl]-2-oxoethyl}methanesulfonamide chemical structure, C21H26ClN3O4S, CAS 432531-17-4
N-(4-Chloro-2-methylphenyl)-N-{2-[4-(4-methoxyphenyl)piperazin-1-yl]-2-oxoethyl}methanesulfonamide
CAS 432531-17-4C21H26ClN3O4S
N-(4-Chloro-2-methylphenyl)-N-[2-[4-(4-fluorophenyl)piperazin-1-yl]-2-oxoethyl]methanesulfonamide chemical structure, C20H23ClFN3O3S, CAS 432527-37-2
N-(4-Chloro-2-methylphenyl)-N-[2-[4-(4-fluorophenyl)piperazin-1-yl]-2-oxoethyl]methanesulfonamide
CAS 432527-37-2C20H23ClFN3O3S
N-(2,5-Dimethoxyphenyl)-N-{2-[4-(4-fluorophenyl)piperazin-1-yl]-2-oxoethyl}methanesulfonamide chemical structure, C21H26FN3O5S, CAS 432535-54-1
N-(2,5-Dimethoxyphenyl)-N-{2-[4-(4-fluorophenyl)piperazin-1-yl]-2-oxoethyl}methanesulfonamide
CAS 432535-54-1C21H26FN3O5S
N-{2-[4-(4-Fluorophenyl)piperazin-1-yl]-2-oxoethyl}-N-(3-methoxyphenyl)methanesulfonamide chemical structure, C20H24FN3O4S, CAS 432526-11-9
N-{2-[4-(4-Fluorophenyl)piperazin-1-yl]-2-oxoethyl}-N-(3-methoxyphenyl)methanesulfonamide
CAS 432526-11-9C20H24FN3O4S
N-(3-Chloro-4-methoxyphenyl)-N-[2-[4-(2-fluorophenyl)piperazin-1-yl]-2-oxoethyl]methanesulfonamide chemical structure, C20H23ClFN3O4S, CAS 432500-89-5
N-(3-Chloro-4-methoxyphenyl)-N-[2-[4-(2-fluorophenyl)piperazin-1-yl]-2-oxoethyl]methanesulfonamide
CAS 432500-89-5C20H23ClFN3O4S