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Murcko scaffold

Ring system with 3 rings and 22 atoms

194 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
194
With full pages
20
Scaffold SMILES

O=C(COc1ccccc1)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(COc1ccccc1)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 194 chemicals

Piperazine, 1-((4-acetylphenoxy)acetyl)-4-(4-chlorophenyl)- chemical structure, C20H21ClN2O3, CAS 31189-05-6
Piperazine, 1-((4-acetylphenoxy)acetyl)-4-(4-chlorophenyl)-
CAS 31189-05-6C20H21ClN2O3
1-(4-Phenylpiperazin-1-yl)-2-[4-(propan-2-yl)phenoxy]ethanone chemical structure, C21H26N2O2, CAS 432508-87-7
1-(4-Phenylpiperazin-1-yl)-2-[4-(propan-2-yl)phenoxy]ethanone
CAS 432508-87-7C21H26N2O2
1-[4-(4-Methoxyphenyl)piperazin-1-yl]-2-(2-methylphenoxy)ethanone chemical structure, C20H24N2O3, CAS 432528-11-5
1-[4-(4-Methoxyphenyl)piperazin-1-yl]-2-(2-methylphenoxy)ethanone
CAS 432528-11-5C20H24N2O3
2-(2,3-Dimethylphenoxy)-1-[4-(4-fluorophenyl)piperazin-1-yl]ethanone chemical structure, C20H23FN2O2, CAS 690973-26-3
2-(2,3-Dimethylphenoxy)-1-[4-(4-fluorophenyl)piperazin-1-yl]ethanone
CAS 690973-26-3C20H23FN2O2
1-[4-(3-Chlorophenyl)piperazin-1-yl]-2-phenoxyethanone chemical structure, C18H19ClN2O2, CAS 1044-41-3
1-[4-(3-Chlorophenyl)piperazin-1-yl]-2-phenoxyethanone
CAS 1044-41-3C18H19ClN2O2
2-(3,4-Dimethylphenoxy)-1-[4-(2-fluorophenyl)piperazin-1-yl]ethanone chemical structure, C20H23FN2O2, CAS 461445-32-9
2-(3,4-Dimethylphenoxy)-1-[4-(2-fluorophenyl)piperazin-1-yl]ethanone
CAS 461445-32-9C20H23FN2O2
1-[4-(2-Methoxyphenyl)piperazin-1-yl]-2-(2-methylphenoxy)ethanone chemical structure, C20H24N2O3, CAS 331639-61-3
1-[4-(2-Methoxyphenyl)piperazin-1-yl]-2-(2-methylphenoxy)ethanone
CAS 331639-61-3C20H24N2O3
1-[4-(4-Methoxyphenyl)piperazin-1-yl]-2-phenoxyethanone chemical structure, C19H22N2O3, CAS 433239-68-0
1-[4-(4-Methoxyphenyl)piperazin-1-yl]-2-phenoxyethanone
CAS 433239-68-0C19H22N2O3
2-(4-Ethylphenoxy)-1-[4-(2-fluorophenyl)piperazin-1-yl]ethanone chemical structure, C20H23FN2O2, CAS 462084-13-5
2-(4-Ethylphenoxy)-1-[4-(2-fluorophenyl)piperazin-1-yl]ethanone
CAS 462084-13-5C20H23FN2O2
2-(2,5-Dimethylphenoxy)-1-(4-phenylpiperazin-1-yl)ethanone chemical structure, C20H24N2O2, CAS 432003-22-0
2-(2,5-Dimethylphenoxy)-1-(4-phenylpiperazin-1-yl)ethanone
CAS 432003-22-0C20H24N2O2
1-(2-Fluorophenyl)-4-(phenoxyacetyl)piperazine chemical structure, C18H19FN2O2, CAS 438474-62-5
1-(2-Fluorophenyl)-4-(phenoxyacetyl)piperazine
CAS 438474-62-5C18H19FN2O2
2-(4-Ethylphenoxy)-1-(4-phenylpiperazin-1-yl)ethanone chemical structure, C20H24N2O2, CAS 432005-37-3
2-(4-Ethylphenoxy)-1-(4-phenylpiperazin-1-yl)ethanone
CAS 432005-37-3C20H24N2O2
1-[4-(4-Fluorophenyl)piperazin-1-yl]-2-(2-methoxyphenoxy)ethanone chemical structure, C19H21FN2O3, CAS 432009-55-7
1-[4-(4-Fluorophenyl)piperazin-1-yl]-2-(2-methoxyphenoxy)ethanone
CAS 432009-55-7C19H21FN2O3
2-(4-Chlorophenoxy)-1-[4-(2-fluorophenyl)piperazin-1-yl]ethanone chemical structure, C18H18ClFN2O2, CAS 442866-73-1
2-(4-Chlorophenoxy)-1-[4-(2-fluorophenyl)piperazin-1-yl]ethanone
CAS 442866-73-1C18H18ClFN2O2
2-(4-Methoxyphenoxy)-1-(4-phenylpiperazin-1-yl)ethanone chemical structure, C19H22N2O3, CAS 419553-76-7
2-(4-Methoxyphenoxy)-1-(4-phenylpiperazin-1-yl)ethanone
CAS 419553-76-7C19H22N2O3
2-(2-Methoxyphenoxy)-1-(4-phenylpiperazin-1-yl)ethanone chemical structure, C19H22N2O3, CAS 18018-81-0
2-(2-Methoxyphenoxy)-1-(4-phenylpiperazin-1-yl)ethanone
CAS 18018-81-0C19H22N2O3
2-(3,5-Dimethylphenoxy)-1-(4-phenylpiperazin-1-yl)ethanone chemical structure, C20H24N2O2, CAS 5687-88-7
2-(3,5-Dimethylphenoxy)-1-(4-phenylpiperazin-1-yl)ethanone
CAS 5687-88-7C20H24N2O2
2-(2,4-Dimethylphenoxy)-1-(4-phenylpiperazin-1-yl)ethanone chemical structure, C20H24N2O2, CAS 581779-94-4
2-(2,4-Dimethylphenoxy)-1-(4-phenylpiperazin-1-yl)ethanone
CAS 581779-94-4C20H24N2O2
2-(4-Chloro-3-methylphenoxy)-1-(4-phenylpiperazin-1-yl)ethanone chemical structure, C19H21ClN2O2, CAS 429627-34-9
2-(4-Chloro-3-methylphenoxy)-1-(4-phenylpiperazin-1-yl)ethanone
CAS 429627-34-9C19H21ClN2O2
1-[4-(2,3-Dimethylphenyl)piperazin-1-yl]-2-phenoxyethanone chemical structure, C20H24N2O2, CAS 349542-38-7
1-[4-(2,3-Dimethylphenyl)piperazin-1-yl]-2-phenoxyethanone
CAS 349542-38-7C20H24N2O2
2-(2,4-Dimethylphenoxy)-1-[4-(2-fluorophenyl)piperazin-1-yl]ethanone chemical structure, C20H23FN2O2, CAS 692288-83-8
2-(2,4-Dimethylphenoxy)-1-[4-(2-fluorophenyl)piperazin-1-yl]ethanone
CAS 692288-83-8C20H23FN2O2
2-(3,5-Dimethylphenoxy)-1-[4-(4-fluorophenyl)piperazin-1-yl]ethanone chemical structure, C20H23FN2O2, CAS 692289-78-4
2-(3,5-Dimethylphenoxy)-1-[4-(4-fluorophenyl)piperazin-1-yl]ethanone
CAS 692289-78-4C20H23FN2O2
2-(4-Bromo-3,5-dimethylphenoxy)-1-[4-(4-fluorophenyl)piperazin-1-yl]ethanone chemical structure, C20H22BrFN2O2, CAS 667874-39-7
2-(4-Bromo-3,5-dimethylphenoxy)-1-[4-(4-fluorophenyl)piperazin-1-yl]ethanone
CAS 667874-39-7C20H22BrFN2O2
1-[4-(3-Chlorophenyl)piperazin-1-yl]-2-(2,3-dimethylphenoxy)ethanone chemical structure, C20H23ClN2O2, CAS 667879-23-4
1-[4-(3-Chlorophenyl)piperazin-1-yl]-2-(2,3-dimethylphenoxy)ethanone
CAS 667879-23-4C20H23ClN2O2