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Murcko scaffold

N-Phenyl-2-(4-pyridin-2-ylpiperazin-1-yl)acetamide scaffold

55 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
55
With full pages
21
Scaffold SMILES

O=C(CN1CCN(c2ccccn2)CC1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the N-Phenyl-2-(4-pyridin-2-ylpiperazin-1-yl)acetamide page
Murcko scaffold O=C(CN1CCN(c2ccccn2)CC1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 55 chemicals

N-(2-Cyanophenyl)-4-(2-pyridinyl)-1-piperazineacetamide chemical structure, C18H19N5O, CAS 329779-50-2
N-(2-Cyanophenyl)-4-(2-pyridinyl)-1-piperazineacetamide
CAS 329779-50-2C18H19N5O
N-(4-Chlorophenyl)-2-(4-pyridin-2-ylpiperazin-1-yl)acetamide chemical structure, C17H19ClN4O, CAS 303091-90-9
N-(4-Chlorophenyl)-2-(4-pyridin-2-ylpiperazin-1-yl)acetamide
CAS 303091-90-9C17H19ClN4O
N-(2-Methoxy-5-methylphenyl)-2-[4-(2-pyridinyl)piperazino]acetamide chemical structure, C19H24N4O2, CAS 303091-92-1
N-(2-Methoxy-5-methylphenyl)-2-[4-(2-pyridinyl)piperazino]acetamide
CAS 303091-92-1C19H24N4O2
N-[4-(Propan-2-yl)phenyl]-2-[4-(pyridin-2-yl)piperazin-1-yl]acetamide chemical structure, C20H26N4O, CAS 303091-94-3
N-[4-(Propan-2-yl)phenyl]-2-[4-(pyridin-2-yl)piperazin-1-yl]acetamide
CAS 303091-94-3C20H26N4O
N-(3,4-Difluorophenyl)-2-[4-(pyridin-2-yl)piperazin-1-yl]acetamide chemical structure, C17H18F2N4O, CAS 303091-91-0
N-(3,4-Difluorophenyl)-2-[4-(pyridin-2-yl)piperazin-1-yl]acetamide
CAS 303091-91-0C17H18F2N4O
2-[4-(Pyridin-2-yl)piperazin-1-yl]-N-(2,4,6-trimethylphenyl)acetamide chemical structure, C20H26N4O, CAS 313255-20-8
2-[4-(Pyridin-2-yl)piperazin-1-yl]-N-(2,4,6-trimethylphenyl)acetamide
CAS 313255-20-8C20H26N4O
N-(2-Fluorophenyl)-2-(4-pyridin-2-ylpiperazin-1-yl)acetamide chemical structure, C17H19FN4O, CAS 750600-69-2
N-(2-Fluorophenyl)-2-(4-pyridin-2-ylpiperazin-1-yl)acetamide
CAS 750600-69-2C17H19FN4O
N-(4-Bromophenyl)-2-[4-(pyridin-2-yl)piperazin-1-yl]acetamide chemical structure, C17H19BrN4O, CAS 797775-77-0
N-(4-Bromophenyl)-2-[4-(pyridin-2-yl)piperazin-1-yl]acetamide
CAS 797775-77-0C17H19BrN4O
N-(4-Bromo-3-methylphenyl)-2-[4-(2-pyridinyl)piperazino]acetamide chemical structure, C18H21BrN4O, CAS 329779-66-0
N-(4-Bromo-3-methylphenyl)-2-[4-(2-pyridinyl)piperazino]acetamide
CAS 329779-66-0C18H21BrN4O
2-(4-Pyridin-2-ylpiperazin-1-yl)-N-[4-(trifluoromethoxy)phenyl]acetamide chemical structure, C18H19F3N4O2, CAS 303091-93-2
2-(4-Pyridin-2-ylpiperazin-1-yl)-N-[4-(trifluoromethoxy)phenyl]acetamide
CAS 303091-93-2C18H19F3N4O2
N-(2,5-Dimethoxyphenyl)-2-(4-(2-pyridyl)piperazinyl)ethanamide chemical structure, C19H24N4O3, CAS 309736-08-1
N-(2,5-Dimethoxyphenyl)-2-(4-(2-pyridyl)piperazinyl)ethanamide
CAS 309736-08-1C19H24N4O3
N-(4-Cyanophenyl)-2-(4-pyridin-2-ylpiperazin-1-yl)acetamide chemical structure, C18H19N5O, CAS 746619-39-6
N-(4-Cyanophenyl)-2-(4-pyridin-2-ylpiperazin-1-yl)acetamide
CAS 746619-39-6C18H19N5O
N-(3-Chloro-2-methylphenyl)-2-(4-pyridin-2-ylpiperazin-1-yl)acetamide chemical structure, C18H21ClN4O, CAS 847839-54-7
N-(3-Chloro-2-methylphenyl)-2-(4-pyridin-2-ylpiperazin-1-yl)acetamide
CAS 847839-54-7C18H21ClN4O
N-(2,4-Difluorophenyl)-4-(2-pyridinyl)-1-piperazineacetamide chemical structure, C17H18F2N4O, CAS 477320-15-3
N-(2,4-Difluorophenyl)-4-(2-pyridinyl)-1-piperazineacetamide
CAS 477320-15-3C17H18F2N4O
N-[4-(Butan-2-yl)phenyl]-2-[4-(pyridin-2-yl)piperazin-1-yl]acetamide chemical structure, C21H28N4O, CAS 329779-65-9
N-[4-(Butan-2-yl)phenyl]-2-[4-(pyridin-2-yl)piperazin-1-yl]acetamide
CAS 329779-65-9C21H28N4O
N-(4-Fluorophenyl)-2-(4-pyridin-2-ylpiperazin-1-yl)acetamide chemical structure, C17H19FN4O, CAS 630119-25-4
N-(4-Fluorophenyl)-2-(4-pyridin-2-ylpiperazin-1-yl)acetamide
CAS 630119-25-4C17H19FN4O
N-(3-Chloro-4-methylphenyl)-2-(4-(2-pyridinyl)-1-piperazinyl)acetamide chemical structure, C18H21ClN4O, CAS 477333-98-5
N-(3-Chloro-4-methylphenyl)-2-(4-(2-pyridinyl)-1-piperazinyl)acetamide
CAS 477333-98-5C18H21ClN4O
N-(3,5-Dimethylphenyl)-2-(4-pyridin-2-ylpiperazin-1-yl)acetamide chemical structure, C19H24N4O, CAS 750609-60-0
N-(3,5-Dimethylphenyl)-2-(4-pyridin-2-ylpiperazin-1-yl)acetamide
CAS 750609-60-0C19H24N4O
N-(2,3-Dichlorophenyl)-2-[4-(2-pyridinyl)piperazino]acetamide chemical structure, C17H18Cl2N4O, CAS 329779-51-3
N-(2,3-Dichlorophenyl)-2-[4-(2-pyridinyl)piperazino]acetamide
CAS 329779-51-3C17H18Cl2N4O
N-(2-Bromophenyl)-2-[4-(pyridin-2-yl)piperazin-1-yl]acetamide chemical structure, C17H19BrN4O, CAS 848247-99-4
N-(2-Bromophenyl)-2-[4-(pyridin-2-yl)piperazin-1-yl]acetamide
CAS 848247-99-4C17H19BrN4O
N-(5-Fluoro-2-methylphenyl)-2-[4-(2-pyridinyl)piperazino]acetamide chemical structure, C18H21FN4O, CAS 380626-14-2
N-(5-Fluoro-2-methylphenyl)-2-[4-(2-pyridinyl)piperazino]acetamide
CAS 380626-14-2C18H21FN4O
N-Phenyl-2-(4-pyridin-2-ylpiperazin-1-yl)propanamide chemical structure, C18H22N4O, CAS 746619-40-9
N-Phenyl-2-(4-pyridin-2-ylpiperazin-1-yl)propanamide
CAS 746619-40-9C18H22N4O
N-Phenyl-2-(4-pyridin-2-ylpiperazin-1-yl)acetamide chemical structure, C17H20N4O, CAS 630116-43-7
N-Phenyl-2-(4-pyridin-2-ylpiperazin-1-yl)acetamide
CAS 630116-43-7C17H20N4O
N-(3-Methylphenyl)-2-[4-(pyridin-2-yl)piperazin-1-yl]acetamide chemical structure, C18H22N4O, CAS 630116-07-3
N-(3-Methylphenyl)-2-[4-(pyridin-2-yl)piperazin-1-yl]acetamide
CAS 630116-07-3C18H22N4O