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Murcko scaffold

3-Phenyl-1-(4-phenylpiperazin-1-yl)propan-1-one scaffold

38 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
38
With full pages
10
Scaffold SMILES

O=C(CCc1ccccc1)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 3-Phenyl-1-(4-phenylpiperazin-1-yl)propan-1-one page
Murcko scaffold O=C(CCc1ccccc1)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 38 of 38 chemicals

Piperazine, 1-(o-chlorophenyl)-4-(3,4,5-trimethoxyhydrocinnamoyl)- chemical structure, C22H27ClN2O4, CAS 23770-94-7
Piperazine, 1-(o-chlorophenyl)-4-(3,4,5-trimethoxyhydrocinnamoyl)-
CAS 23770-94-7C22H27ClN2O4
Piperazine, 1-(o-methoxyphenyl)-4-(3,4,5-trimethoxyhydrocinnamoyl)- chemical structure, C23H30N2O5, CAS 23770-96-9
Piperazine, 1-(o-methoxyphenyl)-4-(3,4,5-trimethoxyhydrocinnamoyl)-
CAS 23770-96-9C23H30N2O5
Piperazine, 1-(o-tolyl)-4-(3,4,5-trimethoxyhydrocinnamoyl)- chemical structure, C23H30N2O4, CAS 23770-97-0
Piperazine, 1-(o-tolyl)-4-(3,4,5-trimethoxyhydrocinnamoyl)-
CAS 23770-97-0C23H30N2O4
Piperazine, 1-(beta-hydroxy-3,4,5-trimethoxyhydrocinnamoyl)-4-o-tolyl- chemical structure, C23H30N2O5, CAS 23776-32-1
Piperazine, 1-(beta-hydroxy-3,4,5-trimethoxyhydrocinnamoyl)-4-o-tolyl-
CAS 23776-32-1C23H30N2O5
3-Hydroxy-1-(4-(2-methoxyphenyl)-1-piperazinyl)-3-(3,4,5-trimethoxyphenyl)-1-propanone chemical structure, C23H30N2O6, CAS 23851-98-1
3-Hydroxy-1-(4-(2-methoxyphenyl)-1-piperazinyl)-3-(3,4,5-trimethoxyphenyl)-1-propanone
CAS 23851-98-1C23H30N2O6
3-Phenyl-1-(4-phenylpiperazin-1-yl)propan-1-one chemical structure, C19H22N2O, CAS 303066-54-8
3-Phenyl-1-(4-phenylpiperazin-1-yl)propan-1-one
CAS 303066-54-8C19H22N2O
1-[4-(4-Fluorophenyl)piperazin-1-yl]-3-phenylpropan-1-one chemical structure, C19H21FN2O, CAS 349087-81-6
1-[4-(4-Fluorophenyl)piperazin-1-yl]-3-phenylpropan-1-one
CAS 349087-81-6C19H21FN2O
1-[4-(3-Chlorophenyl)piperazin-1-yl]-3-phenylpropan-1-one chemical structure, C19H21ClN2O, CAS 136534-87-7
1-[4-(3-Chlorophenyl)piperazin-1-yl]-3-phenylpropan-1-one
CAS 136534-87-7C19H21ClN2O
1-[4-(2-Methoxyphenyl)piperazin-1-yl]-3-phenylpropan-1-one chemical structure, C20H24N2O2, CAS 349431-84-1
1-[4-(2-Methoxyphenyl)piperazin-1-yl]-3-phenylpropan-1-one
CAS 349431-84-1C20H24N2O2
1-[4-(4-Chlorophenyl)piperazin-1-yl]-3-phenylpropan-1-one chemical structure, C19H21ClN2O, CAS 419559-96-9
1-[4-(4-Chlorophenyl)piperazin-1-yl]-3-phenylpropan-1-one
CAS 419559-96-9C19H21ClN2O
1-[4-(2-Ethoxyphenyl)piperazin-1-yl]-3-phenylpropan-1-one chemical structure, C21H26N2O2, CAS 419560-25-1
1-[4-(2-Ethoxyphenyl)piperazin-1-yl]-3-phenylpropan-1-one
CAS 419560-25-1C21H26N2O2
3-Phenyl-1-(4-phenylpiperazin-1-yl)butan-1-one chemical structure, C20H24N2O, CAS 432525-56-9
3-Phenyl-1-(4-phenylpiperazin-1-yl)butan-1-one
CAS 432525-56-9C20H24N2O
1-[4-(4-Nitrophenyl)piperazin-1-yl]-3-phenylbutan-1-one chemical structure, C20H23N3O3, CAS 667409-05-4
1-[4-(4-Nitrophenyl)piperazin-1-yl]-3-phenylbutan-1-one
CAS 667409-05-4C20H23N3O3
N-Isobutyl-4-{3-[4-(2-methoxyphenyl)-1-piperazinyl]-3-oxopropyl}benzenesulfonamide chemical structure, C24H33N3O4S, CAS 700854-82-6
N-Isobutyl-4-{3-[4-(2-methoxyphenyl)-1-piperazinyl]-3-oxopropyl}benzenesulfonamide
CAS 700854-82-6C24H33N3O4S
4-{3-[4-(5-Chloro-2-methylphenyl)-1-piperazinyl]-3-oxopropyl}-N-isobutylbenzenesulfonamide chemical structure, C24H32ClN3O3S, CAS 700860-11-3
4-{3-[4-(5-Chloro-2-methylphenyl)-1-piperazinyl]-3-oxopropyl}-N-isobutylbenzenesulfonamide
CAS 700860-11-3C24H32ClN3O3S
4-[3-[4-(3-Chlorophenyl)piperazin-1-yl]-3-oxopropyl]-N-(2-methylpropyl)benzenesulfonamide chemical structure, C23H30ClN3O3S, CAS 701218-76-0
4-[3-[4-(3-Chlorophenyl)piperazin-1-yl]-3-oxopropyl]-N-(2-methylpropyl)benzenesulfonamide
CAS 701218-76-0C23H30ClN3O3S
4-[3-[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]-3-oxopropyl]-N-ethylbenzenesulfonamide chemical structure, C22H28ClN3O3S, CAS 838893-67-7
4-[3-[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]-3-oxopropyl]-N-ethylbenzenesulfonamide
CAS 838893-67-7C22H28ClN3O3S
4-[3-[4-(3-Chlorophenyl)-1-piperazinyl]-3-oxopropyl]-N-ethylbenzenesulfonamide chemical structure, C21H26ClN3O3S, CAS 889957-84-0
4-[3-[4-(3-Chlorophenyl)-1-piperazinyl]-3-oxopropyl]-N-ethylbenzenesulfonamide
CAS 889957-84-0C21H26ClN3O3S
N-{1-(4-Ethylphenyl)-3-[4-(2-fluorophenyl)piperazino]-3-oxopropyl}-2,2,2-trifluoroacetamide chemical structure, C23H25F4N3O2, CAS 866019-26-3
N-{1-(4-Ethylphenyl)-3-[4-(2-fluorophenyl)piperazino]-3-oxopropyl}-2,2,2-trifluoroacetamide
CAS 866019-26-3C23H25F4N3O2
1-[4-(4-Nitrophenyl)piperazin-1-yl]-3-phenylpropan-1-one chemical structure, C19H21N3O3, CAS 312319-63-4
1-[4-(4-Nitrophenyl)piperazin-1-yl]-3-phenylpropan-1-one
CAS 312319-63-4C19H21N3O3
N-Ethyl-4-{3-[4-(4-methoxyphenyl)piperazin-1-yl]-3-oxopropyl}benzenesulfonamide chemical structure, C22H29N3O4S, CAS 889957-88-4
N-Ethyl-4-{3-[4-(4-methoxyphenyl)piperazin-1-yl]-3-oxopropyl}benzenesulfonamide
CAS 889957-88-4C22H29N3O4S
1-[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]-3-phenylpropan-1-one chemical structure, C20H23ClN2O, CAS 801241-94-1
1-[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]-3-phenylpropan-1-one
CAS 801241-94-1C20H23ClN2O
1-[4-(4-Hydroxyphenyl)piperazin-1-yl]-3-phenylpropan-1-one chemical structure, C19H22N2O2, CAS 878914-09-1
1-[4-(4-Hydroxyphenyl)piperazin-1-yl]-3-phenylpropan-1-one
CAS 878914-09-1C19H22N2O2
N-((2r)-3(2,4-Dichlorophenyl)-1-(4-(2-((1-methoxypropan-2-ylamino)methyl)phenyl)piperazin-1-yl)-1-oxopropan-2-yl)propionamide chemical structure, C27H36Cl2N4O3, CAS 865303-45-3
N-((2r)-3(2,4-Dichlorophenyl)-1-(4-(2-((1-methoxypropan-2-ylamino)methyl)phenyl)piperazin-1-yl)-1-oxopropan-2-yl)propionamide
CAS 865303-45-3C27H36Cl2N4O3