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Murcko scaffold

1-(4-Phenylpiperazin-1-yl)-2-phenylsulfanylethanone scaffold

23 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
23
With full pages
10
Scaffold SMILES

O=C(CSc1ccccc1)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(4-Phenylpiperazin-1-yl)-2-phenylsulfanylethanone page
Murcko scaffold O=C(CSc1ccccc1)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 23 of 23 chemicals

1-[4-(3-Chlorophenyl)piperazin-1-yl]-2-phenylsulfanylethanone chemical structure, C18H19ClN2OS, CAS 432538-10-8
1-[4-(3-Chlorophenyl)piperazin-1-yl]-2-phenylsulfanylethanone
CAS 432538-10-8C18H19ClN2OS
1-[4-(2-Methoxyphenyl)piperazin-1-yl]-2-phenylsulfanylethanone chemical structure, C19H22N2O2S, CAS 409355-95-9
1-[4-(2-Methoxyphenyl)piperazin-1-yl]-2-phenylsulfanylethanone
CAS 409355-95-9C19H22N2O2S
1-(4-Phenylpiperazin-1-yl)-2-(p-tolylthio)ethanone chemical structure, C19H22N2OS, CAS 335212-65-2
1-(4-Phenylpiperazin-1-yl)-2-(p-tolylthio)ethanone
CAS 335212-65-2C19H22N2OS
1-(4-Phenylpiperazin-1-yl)-2-phenylsulfanylethanone chemical structure, C18H20N2OS, CAS 333413-07-3
1-(4-Phenylpiperazin-1-yl)-2-phenylsulfanylethanone
CAS 333413-07-3C18H20N2OS
1-[4-(4-Methoxyphenyl)piperazin-1-yl]-2-phenylsulfanylethanone chemical structure, C19H22N2O2S, CAS 432019-98-2
1-[4-(4-Methoxyphenyl)piperazin-1-yl]-2-phenylsulfanylethanone
CAS 432019-98-2C19H22N2O2S
1-[4-(4-Fluorophenyl)piperazin-1-yl]-2-(4-methylphenyl)sulfanylethanone chemical structure, C19H21FN2OS, CAS 431907-12-9
1-[4-(4-Fluorophenyl)piperazin-1-yl]-2-(4-methylphenyl)sulfanylethanone
CAS 431907-12-9C19H21FN2OS
2-(4-Chlorophenyl)sulfanyl-1-[4-(4-fluorophenyl)piperazin-1-yl]ethanone chemical structure, C18H18ClFN2OS, CAS 431983-61-8
2-(4-Chlorophenyl)sulfanyl-1-[4-(4-fluorophenyl)piperazin-1-yl]ethanone
CAS 431983-61-8C18H18ClFN2OS
1-[4-(3-Chlorophenyl)piperazin-1-yl]-2-(4-methylphenyl)sulfanylethanone chemical structure, C19H21ClN2OS, CAS 693798-26-4
1-[4-(3-Chlorophenyl)piperazin-1-yl]-2-(4-methylphenyl)sulfanylethanone
CAS 693798-26-4C19H21ClN2OS
1-[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]-2-(4-methylphenyl)sulfanylethanone chemical structure, C20H23ClN2OS, CAS 663166-23-2
1-[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]-2-(4-methylphenyl)sulfanylethanone
CAS 663166-23-2C20H23ClN2OS
2-(4-Methylsulfonyl-2-nitrophenyl)sulfanyl-1-(4-phenylpiperazin-1-yl)ethanone chemical structure, C19H21N3O5S2, CAS 459175-46-3
2-(4-Methylsulfonyl-2-nitrophenyl)sulfanyl-1-(4-phenylpiperazin-1-yl)ethanone
CAS 459175-46-3C19H21N3O5S2
1-[4-(2-Methoxyphenyl)piperazin-1-yl]-2-(4-methylphenyl)sulfanylethanone chemical structure, C20H24N2O2S, CAS 425677-26-5
1-[4-(2-Methoxyphenyl)piperazin-1-yl]-2-(4-methylphenyl)sulfanylethanone
CAS 425677-26-5C20H24N2O2S
2-(4-Fluorophenyl)sulfanyl-1-[4-(3-methoxyphenyl)piperazin-1-yl]ethanone chemical structure, C19H21FN2O2S, CAS 851186-55-5
2-(4-Fluorophenyl)sulfanyl-1-[4-(3-methoxyphenyl)piperazin-1-yl]ethanone
CAS 851186-55-5C19H21FN2O2S
2-(4-Chlorophenylthio)-1-(4-phenylpiperazinyl)propan-1-one chemical structure, C19H21ClN2OS, CAS 428476-73-7
2-(4-Chlorophenylthio)-1-(4-phenylpiperazinyl)propan-1-one
CAS 428476-73-7C19H21ClN2OS
2-(4-Chlorophenylthio)-1-(4-(2-fluorophenyl)piperazinyl)propan-1-one chemical structure, C19H20ClFN2OS, CAS 432525-62-7
2-(4-Chlorophenylthio)-1-(4-(2-fluorophenyl)piperazinyl)propan-1-one
CAS 432525-62-7C19H20ClFN2OS
1-(2-Chloro-4-nitrophenyl)-4-{[(4-chlorophenyl)thio]acetyl}piperazine chemical structure, C18H17Cl2N3O3S, CAS 461419-88-5
1-(2-Chloro-4-nitrophenyl)-4-{[(4-chlorophenyl)thio]acetyl}piperazine
CAS 461419-88-5C18H17Cl2N3O3S
1-[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]-2-phenylsulfanylpropan-1-one chemical structure, C20H23ClN2OS, CAS 693797-70-5
1-[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]-2-phenylsulfanylpropan-1-one
CAS 693797-70-5C20H23ClN2OS
2-(4-Methylphenyl)sulfanyl-1-[4-(4-nitrophenyl)piperazin-1-yl]ethanone chemical structure, C19H21N3O3S, CAS 824419-54-7
2-(4-Methylphenyl)sulfanyl-1-[4-(4-nitrophenyl)piperazin-1-yl]ethanone
CAS 824419-54-7C19H21N3O3S
1-[4-(4-Chloro-2-nitrophenyl)piperazin-1-yl]-2-(4-chlorophenyl)sulfanylethanone chemical structure, C18H17Cl2N3O3S, CAS 832687-62-4
1-[4-(4-Chloro-2-nitrophenyl)piperazin-1-yl]-2-(4-chlorophenyl)sulfanylethanone
CAS 832687-62-4C18H17Cl2N3O3S
1-[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]-2-[(4-chlorophenyl)sulfanyl]propan-1-one chemical structure, C20H22Cl2N2OS, CAS 768287-86-1
1-[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]-2-[(4-chlorophenyl)sulfanyl]propan-1-one
CAS 768287-86-1C20H22Cl2N2OS
2-((4-Chlorophenyl)thio)-1-(4-phenylpiperazin-1-yl)ethanone chemical structure, C18H19ClN2OS, CAS 403833-49-8
2-((4-Chlorophenyl)thio)-1-(4-phenylpiperazin-1-yl)ethanone
CAS 403833-49-8C18H19ClN2OS
2-(2,4-Dinitrophenylthio)-1-(4-phenylpiperazinyl)ethan-1-one chemical structure, C18H18N4O5S, CAS 459175-32-7
2-(2,4-Dinitrophenylthio)-1-(4-phenylpiperazinyl)ethan-1-one
CAS 459175-32-7C18H18N4O5S
2-((4-Methoxyphenyl)thio)-1-(4-phenylpiperazin-1-yl)ethanone chemical structure, C19H22N2O2S, CAS 941951-46-8
2-((4-Methoxyphenyl)thio)-1-(4-phenylpiperazin-1-yl)ethanone
CAS 941951-46-8C19H22N2O2S
[4-({2-[4-(2-Fluorophenyl)piperazin-1-yl]-1-methyl-2-oxoethyl}thio)phenyl]amine chemical structure, C19H22FN3OS, CAS 913247-58-2
[4-({2-[4-(2-Fluorophenyl)piperazin-1-yl]-1-methyl-2-oxoethyl}thio)phenyl]amine
CAS 913247-58-2C19H22FN3OS