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Murcko scaffold

3-Phenyl-5-(piperazin-1-ylmethyl)-1,2,4-oxadiazole scaffold

34 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
34
With full pages
7
Scaffold SMILES

c1ccc(-c2noc(CN3CCNCC3)n2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 3-Phenyl-5-(piperazin-1-ylmethyl)-1,2,4-oxadiazole page
Murcko scaffold c1ccc(-c2noc(CN3CCNCC3)n2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 34 of 34 chemicals

Ethyl 4-[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]piperazine-1-carboxylate chemical structure, C17H22N4O3, CAS 700857-51-8
Ethyl 4-[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]piperazine-1-carboxylate
CAS 700857-51-8C17H22N4O3
1-{[3-(4-Methoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperazine chemical structure, C14H18N4O2, CAS 923770-89-2
1-{[3-(4-Methoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperazine
CAS 923770-89-2C14H18N4O2
1-{[3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl}piperazine chemical structure, C13H15ClN4O, CAS 923721-29-3
1-{[3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl}piperazine
CAS 923721-29-3C13H15ClN4O
1-({3-[3-(Trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl}methyl)piperazine chemical structure, C14H15F3N4O, CAS 923877-39-8
1-({3-[3-(Trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl}methyl)piperazine
CAS 923877-39-8C14H15F3N4O
1-{[3-(4-Methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperazine chemical structure, C14H18N4O, CAS 923767-43-5
1-{[3-(4-Methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperazine
CAS 923767-43-5C14H18N4O
1-{[3-(4-Methoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperazine hydrochloride chemical structure, C14H19ClN4O2, CAS 1052553-32-8
1-{[3-(4-Methoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperazine hydrochloride
CAS 1052553-32-8C14H19ClN4O2
3-Phenyl-5-(piperazin-1-ylmethyl)-1,2,4-oxadiazole chemical structure, C13H16N4O, CAS 1019108-02-1
3-Phenyl-5-(piperazin-1-ylmethyl)-1,2,4-oxadiazole
CAS 1019108-02-1C13H16N4O
1-{[3-(2-Methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperazine chemical structure, C14H18N4O, CAS 1098345-38-0
1-{[3-(2-Methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperazine
CAS 1098345-38-0C14H18N4O
4-[[3-(4-Methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester chemical structure, C19H26N4O3, CAS 1169982-16-4
4-[[3-(4-Methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester
CAS 1169982-16-4C19H26N4O3
tert-Butyl 4-{[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperazine-1-carboxylate chemical structure, C19H26N4O4, CAS 1170943-40-4
tert-Butyl 4-{[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperazine-1-carboxylate
CAS 1170943-40-4C19H26N4O4
4-[[3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester chemical structure, C18H23ClN4O3, CAS 1170433-01-8
4-[[3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester
CAS 1170433-01-8C18H23ClN4O3
1-((3-(3-(Trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)methyl)piperazine dihydrochloride chemical structure, C14H17Cl2F3N4O, CAS 1171190-56-9
1-((3-(3-(Trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)methyl)piperazine dihydrochloride
CAS 1171190-56-9C14H17Cl2F3N4O
1-[(3-Phenyl-1,2,4-oxadiazol-5-yl)methyl]piperazine dihydrochloride chemical structure, C13H18Cl2N4O, CAS 1172004-02-2
1-[(3-Phenyl-1,2,4-oxadiazol-5-yl)methyl]piperazine dihydrochloride
CAS 1172004-02-2C13H18Cl2N4O
1-{[3-(2-Methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperazine hydrochloride chemical structure, C14H19ClN4O, CAS 1171621-78-5
1-{[3-(2-Methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperazine hydrochloride
CAS 1171621-78-5C14H19ClN4O
1-(1-(3-(3-(Trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)ethyl)piperazine dihydrochloride chemical structure, C15H19Cl2F3N4O, CAS 1169989-01-8
1-(1-(3-(3-(Trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)ethyl)piperazine dihydrochloride
CAS 1169989-01-8C15H19Cl2F3N4O
1-(1-{3-[3-(Trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-YL}ethyl)piperazine chemical structure, C15H17F3N4O, CAS 1170356-19-0
1-(1-{3-[3-(Trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-YL}ethyl)piperazine
CAS 1170356-19-0C15H17F3N4O
1-{[3-(4-Fluorophenyl)-1,2,4-oxadiazol-5-yl]methyl}piperazine chemical structure, C13H15FN4O, CAS 1098360-23-6
1-{[3-(4-Fluorophenyl)-1,2,4-oxadiazol-5-yl]methyl}piperazine
CAS 1098360-23-6C13H15FN4O
1-{1-[3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl]ethyl}piperazine chemical structure, C14H17ClN4O, CAS 1000933-05-0
1-{1-[3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl]ethyl}piperazine
CAS 1000933-05-0C14H17ClN4O
1-{1-[3-(4-Methylphenyl)-1,2,4-oxadiazol-5-yl]ethyl}piperazine chemical structure, C15H20N4O, CAS 1000933-07-2
1-{1-[3-(4-Methylphenyl)-1,2,4-oxadiazol-5-yl]ethyl}piperazine
CAS 1000933-07-2C15H20N4O
1-{[3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl}piperazine hydrochloride chemical structure, C13H16Cl2N4O, CAS 1170477-01-6
1-{[3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl}piperazine hydrochloride
CAS 1170477-01-6C13H16Cl2N4O
1-[1-(3-Phenyl-1,2,4-oxadiazol-5-yl)ethyl]piperazine dihydrochloride chemical structure, C14H20Cl2N4O, CAS 1171316-30-5
1-[1-(3-Phenyl-1,2,4-oxadiazol-5-yl)ethyl]piperazine dihydrochloride
CAS 1171316-30-5C14H20Cl2N4O
1-[1-(3-Phenyl-1,2,4-oxadiazol-5-yl)ethyl]piperazine chemical structure, C14H18N4O, CAS 1171814-19-9
1-[1-(3-Phenyl-1,2,4-oxadiazol-5-yl)ethyl]piperazine
CAS 1171814-19-9C14H18N4O
1,2-Dimethyl-4-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]piperazine chemical structure, C15H20N4O, CAS 1066894-31-2
1,2-Dimethyl-4-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]piperazine
CAS 1066894-31-2C15H20N4O
3-{5-[(4-Ethylpiperazin-1-yl)methyl]-1,2,4-oxadiazol-3-yl}benzaldehyde hydrochloride chemical structure, C16H21ClN4O2, CAS 1184983-03-6
3-{5-[(4-Ethylpiperazin-1-yl)methyl]-1,2,4-oxadiazol-3-yl}benzaldehyde hydrochloride
CAS 1184983-03-6C16H21ClN4O2