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Murcko scaffold

Ring system with 3 rings and 20 atoms

29 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
29
With full pages
4
Scaffold SMILES

O=C1C(=Cc2ccccn2)SC(=S)N1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1C(=Cc2ccccn2)SC(=S)N1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 29 of 29 chemicals

(5Z)-3-(4-Chlorophenyl)-5-(pyridin-2-ylmethylidene)-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C15H9ClN2OS2, CAS 432529-32-3
(5Z)-3-(4-Chlorophenyl)-5-(pyridin-2-ylmethylidene)-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 432529-32-3C15H9ClN2OS2
(5E)-5-[(6-Methylpyridin-2-yl)methylidene]-3-phenyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C16H12N2OS2, CAS 101290-98-6
(5E)-5-[(6-Methylpyridin-2-yl)methylidene]-3-phenyl-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 101290-98-6C16H12N2OS2
3-(3-Chlorophenyl)-5-(2-pyridinylmethylene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C15H9ClN2OS2, CAS 5738-63-6
3-(3-Chlorophenyl)-5-(2-pyridinylmethylene)-2-thioxo-1,3-thiazolidin-4-one
CAS 5738-63-6C15H9ClN2OS2
3-(3-Chlorophenyl)-5-(2-pyridylmethylene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C15H9ClN2OS2, CAS 157325-80-9
3-(3-Chlorophenyl)-5-(2-pyridylmethylene)-2-thioxo-1,3-thiazolidin-4-one
CAS 157325-80-9C15H9ClN2OS2
(Z)-3-(3-Hydroxyphenyl)-5-(pyridin-2-ylmethylene)-2-thioxothiazolidin-4-one chemical structure, C15H10N2O2S2, CAS 840474-49-9
(Z)-3-(3-Hydroxyphenyl)-5-(pyridin-2-ylmethylene)-2-thioxothiazolidin-4-one
CAS 840474-49-9C15H10N2O2S2
3-(4-Bromophenyl)-5-(2-pyridylmethylene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C15H9BrN2OS2, CAS 524022-27-3
3-(4-Bromophenyl)-5-(2-pyridylmethylene)-2-thioxo-1,3-thiazolidin-4-one
CAS 524022-27-3C15H9BrN2OS2
4-[(5Z)-4-Oxo-5-(pyridin-2-ylmethylidene)-2-thioxo-1,3-thiazolidin-3-yl]benzoic acid chemical structure, C16H10N2O3S2, CAS 356568-99-5
4-[(5Z)-4-Oxo-5-(pyridin-2-ylmethylidene)-2-thioxo-1,3-thiazolidin-3-yl]benzoic acid
CAS 356568-99-5C16H10N2O3S2
3-Phenyl-5-(pyridin-2-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C15H10N2OS2, CAS 92427-59-3
3-Phenyl-5-(pyridin-2-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one
CAS 92427-59-3C15H10N2OS2
3-[(5Z)-4-Oxo-5-(pyridinium-2-ylmethylidene)-2-thioxo-1,3-thiazolidin-3-yl]benzoate chemical structure, C16H10N2O3S2, CAS 840462-27-3
3-[(5Z)-4-Oxo-5-(pyridinium-2-ylmethylidene)-2-thioxo-1,3-thiazolidin-3-yl]benzoate
CAS 840462-27-3C16H10N2O3S2
(Z)-5-(Pyridin-2-ylmethylene)-2-thioxo-3-(p-tolyl)thiazolidin-4-one chemical structure, C16H12N2OS2, CAS 444282-48-8
(Z)-5-(Pyridin-2-ylmethylene)-2-thioxo-3-(p-tolyl)thiazolidin-4-one
CAS 444282-48-8C16H12N2OS2
(Z)-3-(3-Fluorophenyl)-5-(pyridin-2-ylmethylene)-2-thioxothiazolidin-4-one chemical structure, C15H9FN2OS2, CAS 840463-11-8
(Z)-3-(3-Fluorophenyl)-5-(pyridin-2-ylmethylene)-2-thioxothiazolidin-4-one
CAS 840463-11-8C15H9FN2OS2
3-(3-Bromophenyl)-5-(2-pyridylmethylene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C15H9BrN2OS2, CAS 840463-83-4
3-(3-Bromophenyl)-5-(2-pyridylmethylene)-2-thioxo-1,3-thiazolidin-4-one
CAS 840463-83-4C15H9BrN2OS2
(Z)-5-(Pyridin-2-ylmethylene)-2-thioxo-3-(o-tolyl)thiazolidin-4-one chemical structure, C16H12N2OS2, CAS 157325-77-4
(Z)-5-(Pyridin-2-ylmethylene)-2-thioxo-3-(o-tolyl)thiazolidin-4-one
CAS 157325-77-4C16H12N2OS2
(Z)-5-(Pyridin-2-ylmethylene)-2-thioxo-3-(m-tolyl)thiazolidin-4-one chemical structure, C16H12N2OS2, CAS 157325-78-5
(Z)-5-(Pyridin-2-ylmethylene)-2-thioxo-3-(m-tolyl)thiazolidin-4-one
CAS 157325-78-5C16H12N2OS2
3-(3,4-Dichlorophenyl)-5-(2-pyridylmethylene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C15H8Cl2N2OS2, CAS 840470-18-0
3-(3,4-Dichlorophenyl)-5-(2-pyridylmethylene)-2-thioxo-1,3-thiazolidin-4-one
CAS 840470-18-0C15H8Cl2N2OS2
(Z)-3-(3-Methoxyphenyl)-5-(pyridin-2-ylmethylene)-2-thioxothiazolidin-4-one chemical structure, C16H12N2O2S2, CAS 840472-97-1
(Z)-3-(3-Methoxyphenyl)-5-(pyridin-2-ylmethylene)-2-thioxothiazolidin-4-one
CAS 840472-97-1C16H12N2O2S2
(E)-3-(3,4-Dimethylphenyl)-5-(pyridin-2-ylmethylene)-2-thioxothiazolidin-4-one chemical structure, C17H14N2OS2, CAS 524022-62-6
(E)-3-(3,4-Dimethylphenyl)-5-(pyridin-2-ylmethylene)-2-thioxothiazolidin-4-one
CAS 524022-62-6C17H14N2OS2
(5Z)-3-(3-Chloro-4-fluorophenyl)-5-(pyridin-2-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C15H8ClFN2OS2, CAS 840476-55-3
(5Z)-3-(3-Chloro-4-fluorophenyl)-5-(pyridin-2-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one
CAS 840476-55-3C15H8ClFN2OS2
3-(2-Chlorophenyl)-5-(2-pyridylmethylene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C15H9ClN2OS2, CAS 854002-58-7
3-(2-Chlorophenyl)-5-(2-pyridylmethylene)-2-thioxo-1,3-thiazolidin-4-one
CAS 854002-58-7C15H9ClN2OS2
(Z)-3-(2,3-Dimethylphenyl)-5-(pyridin-2-ylmethylene)-2-thioxothiazolidin-4-one chemical structure, C17H14N2OS2, CAS 844833-59-6
(Z)-3-(2,3-Dimethylphenyl)-5-(pyridin-2-ylmethylene)-2-thioxothiazolidin-4-one
CAS 844833-59-6C17H14N2OS2
(Z)-3-(4-(Diethylamino)phenyl)-5-(pyridin-2-ylmethylene)-2-thioxothiazolidin-4-one chemical structure, C19H19N3OS2, CAS 847857-28-7
(Z)-3-(4-(Diethylamino)phenyl)-5-(pyridin-2-ylmethylene)-2-thioxothiazolidin-4-one
CAS 847857-28-7C19H19N3OS2
3-(2,4-Dimethylphenyl)-5-(2-pyridylmethylene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C17H14N2OS2, CAS 844656-39-9
3-(2,4-Dimethylphenyl)-5-(2-pyridylmethylene)-2-thioxo-1,3-thiazolidin-4-one
CAS 844656-39-9C17H14N2OS2
(E)-4-(4-Oxo-5-(pyridin-2-ylmethylene)-2-thioxothiazolidin-3-yl)benzenesulfonamide chemical structure, C15H11N3O3S3, CAS 304862-74-6
(E)-4-(4-Oxo-5-(pyridin-2-ylmethylene)-2-thioxothiazolidin-3-yl)benzenesulfonamide
CAS 304862-74-6C15H11N3O3S3
3-(4-Fluorophenyl)-5-(2-pyridinylmethylene)-2-thioxo-4-thiazolidinone chemical structure, C15H9FN2OS2, CAS 301683-63-6
3-(4-Fluorophenyl)-5-(2-pyridinylmethylene)-2-thioxo-4-thiazolidinone
CAS 301683-63-6C15H9FN2OS2