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Murcko scaffold

Ring system with 3 rings and 22 atoms

16 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
16
With full pages
3
Scaffold SMILES

O=C(CCc1ccccc1)Nc1ccc2ccc(=O)oc2c1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CCc1ccccc1)Nc1ccc2ccc(=O)oc2c1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 16 of 16 chemicals

N-Succinyl-Ala-Ala-Phe-7-amido-4-methylcoumarin chemical structure, C29H32N4O8, CAS 71973-79-0
N-Succinyl-Ala-Ala-Phe-7-amido-4-methylcoumarin
CAS 71973-79-0C29H32N4O8
Ala-Ala-Phe-7-amido-4-methylcoumarin chemical structure, C25H28N4O5, CAS 62037-41-6
Ala-Ala-Phe-7-amido-4-methylcoumarin
CAS 62037-41-6C25H28N4O5
H-Phe-AMC chemical structure, C19H18N2O3, CAS 98516-72-4
H-Phe-AMC
CAS 98516-72-4C19H18N2O3
L-Phenylalaninamide, glycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)- chemical structure, C21H21N3O4, CAS 201852-70-2
L-Phenylalaninamide, glycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
CAS 201852-70-2C21H21N3O4
L-Tyrosine 7-amido-4-methylcoumarin chemical structure, C19H18N2O4, CAS 94099-57-7
L-Tyrosine 7-amido-4-methylcoumarin
CAS 94099-57-7C19H18N2O4
Succinyl-leucyl-leucyl-valyl-tyrosyl-methylcoumarinamide chemical structure, C40H53N5O10, CAS 94367-21-2
Succinyl-leucyl-leucyl-valyl-tyrosyl-methylcoumarinamide
CAS 94367-21-2C40H53N5O10
Glutaryl-phe-amc chemical structure, C24H24N2O6, CAS 58632-47-6
Glutaryl-phe-amc
CAS 58632-47-6C24H24N2O6
(S)-2-Amino-N-(4-methyl-2-oxo-2H-chromen-7-yl)-3-phenylpropanamide 2,2,2-trifluoroacetate chemical structure, C21H19F3N2O5, CAS 108321-84-2
(S)-2-Amino-N-(4-methyl-2-oxo-2H-chromen-7-yl)-3-phenylpropanamide 2,2,2-trifluoroacetate
CAS 108321-84-2C21H19F3N2O5
3-(4-Isopropylphenyl)-N-(4-methyl-2-oxo-2H-chromen-7-yl)propanamide chemical structure, C22H23NO3, CAS 938011-78-0
3-(4-Isopropylphenyl)-N-(4-methyl-2-oxo-2H-chromen-7-yl)propanamide
CAS 938011-78-0C22H23NO3
H-Ser-tyr-amc hydrate chemical structure, C22H25N3O7, CAS 207735-67-9
H-Ser-tyr-amc hydrate
CAS 207735-67-9C22H25N3O7
N-succinyl-Leu-Tyr-7-amido-4-methylcoumarin chemical structure, C29H33N3O8, CAS 94367-20-1
N-succinyl-Leu-Tyr-7-amido-4-methylcoumarin
CAS 94367-20-1C29H33N3O8
L-Phenylalaninamide, L-alanyl-L-alanyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-, 2,2,2-trifluoroacetate (1:1) chemical structure, C27H29F3N4O7, CAS 62037-42-7
L-Phenylalaninamide, L-alanyl-L-alanyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-, 2,2,2-trifluoroacetate (1:1)
CAS 62037-42-7C27H29F3N4O7
Glutaryl-gly-gly-phe-amc chemical structure, C28H30N4O8, CAS 70996-06-4
Glutaryl-gly-gly-phe-amc
CAS 70996-06-4C28H30N4O8
(S)-2-Amino-3-(4-hydroxyphenyl)-N-(4-methyl-2-oxo-2H-chromen-7-yl)propanamide 2,2,2-trifluoroacetate chemical structure, C21H19F3N2O6, CAS 201860-68-6
(S)-2-Amino-3-(4-hydroxyphenyl)-N-(4-methyl-2-oxo-2H-chromen-7-yl)propanamide 2,2,2-trifluoroacetate
CAS 201860-68-6C21H19F3N2O6
H-D-Phe-amc hydrochloride chemical structure, C19H19ClN2O3, CAS 1998700-96-1
H-D-Phe-amc hydrochloride
CAS 1998700-96-1C19H19ClN2O3
(2S)-2-[(2S)-2-Amino-3-hydroxypropanamido]-3-(4-hydroxyphenyl)-N-(4-methyl-2-oxo-2H-chromen-7-yl)propanamide, trifluoroacetic acid chemical structure, C24H24F3N3O8, CAS 2490344-65-3
(2S)-2-[(2S)-2-Amino-3-hydroxypropanamido]-3-(4-hydroxyphenyl)-N-(4-methyl-2-oxo-2H-chromen-7-yl)propanamide, trifluoroacetic acid
CAS 2490344-65-3C24H24F3N3O8